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Conserved domains on  [gi|1370459704|ref|XP_024304368|]
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serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform isoform X4 [Homo sapiens]

Protein Classification

HEAT repeat domain-containing protein( domain architecture ID 1000213)

HEAT repeat domain-containing protein may function as a scaffold, anchoring and/or adaptor protein

Gene Ontology:  GO:0005515
PubMed:  10378263

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
116-276 5.22e-07

HEAT repeat [General function prediction only];


:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 116 VRDKAVESLRQIsqeHTPVALEAyfvpLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqqfrsLCSDDTPMVRR 195
Cdd:COG1413     1 VRRAAARALGRL---GDPAAVPA----LIAALADEDPDVRAAAARALGRLGDPRAVPALLE--------ALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 196 AAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVRYMV 275
Cdd:COG1413    66 AAAEALGRIGD--------PEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALL-----EALKDPDWEVRRAA 129


                  .
gi 1370459704 276 A 276
Cdd:COG1413   130 A 130
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 295-325 7.51e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


:

Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 7.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370459704 295 LIPAFQNLLKDCEAEVRAAAAHKVKELGENL 325
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
116-276 5.22e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 116 VRDKAVESLRQIsqeHTPVALEAyfvpLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqqfrsLCSDDTPMVRR 195
Cdd:COG1413     1 VRRAAARALGRL---GDPAAVPA----LIAALADEDPDVRAAAARALGRLGDPRAVPALLE--------ALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 196 AAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVRYMV 275
Cdd:COG1413    66 AAAEALGRIGD--------PEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALL-----EALKDPDWEVRRAA 129


                  .
gi 1370459704 276 A 276
Cdd:COG1413   130 A 130
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
187-322 1.18e-05

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 48.31  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 187 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 243
Cdd:PRK13800  662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370459704 244 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 322
Cdd:PRK13800  742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 217-316 2.57e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.10  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 217 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 296
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64

                          90       100
                  ....*....|....*....|.
gi 1370459704 297 PAFQNLLKDCEAE-VRAAAAH 316
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 295-325 7.51e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 7.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370459704 295 LIPAFQNLLKDCEAEVRAAAAHKVKELGENL 325
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
 
Name Accession Description Interval E-value
HEAT COG1413
HEAT repeat [General function prediction only];
116-276 5.22e-07

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 49.24  E-value: 5.22e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 116 VRDKAVESLRQIsqeHTPVALEAyfvpLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqqfrsLCSDDTPMVRR 195
Cdd:COG1413     1 VRRAAARALGRL---GDPAAVPA----LIAALADEDPDVRAAAARALGRLGDPRAVPALLE--------ALKDPDPEVRA 65

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 196 AAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVRYMV 275
Cdd:COG1413    66 AAAEALGRIGD--------PEAVPALIAALKDEDPEVRRAAAEA---LGRLGDPAAVPALL-----EALKDPDWEVRRAA 129


                  .
gi 1370459704 276 A 276
Cdd:COG1413   130 A 130
HEAT COG1413
HEAT repeat [General function prediction only];
176-316 1.17e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 48.09  E-value: 1.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 176 AEIRQQFRSLCSDDTPMVRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEACVSIAQllsqddleTL 255
Cdd:COG1413    15 PAAVPALIAALADEDPDVRAAAARALGRLGD--------PRAVPALLEALKDPDPEVRAAAAEALGRIGD--------PE 78

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370459704 256 VMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAH 316
Cdd:COG1413    79 AVPALIAALKDEDPEVRRAAA-------EALG-RLGDPAAVPALLEALKDPDWEVRRAAAR 131
HEAT COG1413
HEAT repeat [General function prediction only];
193-323 1.93e-06

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 47.32  E-value: 1.93e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 193 VRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDDLETLVmptlrQAAEDKSWRVR 272
Cdd:COG1413     1 VRRAAARALGRLGD--------PAAVPALIAALADEDPDVRAAAARA---LGRLGDPRAVPALL-----EALKDPDPEVR 64

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1370459704 273 YMVADrfselqkAMGpKITLNDLIPAFQNLLKDCEAEVRAAAAHKVKELGE 323
Cdd:COG1413    65 AAAAE-------ALG-RIGDPEAVPALIAALKDEDPEVRRAAAEALGRLGD 107
PRK13800 PRK13800
fumarate reductase/succinate dehydrogenase flavoprotein subunit;
187-322 1.18e-05

fumarate reductase/succinate dehydrogenase flavoprotein subunit;


Pssm-ID: 237512 [Multi-domain]  Cd Length: 897  Bit Score: 48.31  E-value: 1.18e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 187 SDDTPMVRRAAASKLGEFAKVLE--------LDS----VKSEIV-----------PLFTSLASDEQDSVRLLAVEACVSI 243
Cdd:PRK13800  662 GDGAAAVRRAAAEGLRELVEVLPpapalrdhLGSpdpvVRAAALdvlralragdaALFAAALGDPDHRVRIEAVRALVSV 741

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370459704 244 aqllsqDDLETLVMptlrqAAEDKSWRVRYMVADRFSELQKAMGPKitlndlIPAFQNLLKDCEAEVRAAAAHKVKELG 322
Cdd:PRK13800  742 ------DDVESVAG-----AATDENREVRIAVAKGLATLGAGGAPA------GDAVRALTGDPDPLVRAAALAALAELG 803
HEAT COG1413
HEAT repeat [General function prediction only];
102-239 2.28e-05

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 44.23  E-value: 2.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 102 LPPLENLATVEETVVRDKAVESLRQIsqeHTPVALEayfvPLVKRLASGDWFTSRTSACGLFSVCYPRASNAVKAeirqq 181
Cdd:COG1413    18 VPALIAALADEDPDVRAAAARALGRL---GDPRAVP----ALLEALKDPDPEVRAAAAEALGRIGDPEAVPALIA----- 85

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1370459704 182 frsLCSDDTPMVRRAAASKLGEFAKVleldsvksEIVPLFTSLASDEQDSVRLLAVEA 239
Cdd:COG1413    86 ---ALKDEDPEVRRAAAEALGRLGDP--------AAVPALLEALKDPDWEVRRAAARA 132
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 217-316 2.57e-05

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 43.10  E-value: 2.57e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 217 IVPLFTSLASDEQDSVRLLAVEAcvsIAQLLSQDdletlVMPTLRQAAEDKSWRVRYMVAdrfselqKAMGpKITLNDLI 296
Cdd:pfam13646   1 LPALLQALLRDPDPEVRAAAIRA---LGRIGDPE-----AVPALLELLKDEDPAVRRAAA-------EALG-KIGDPEAL 64

                          90       100
                  ....*....|....*....|.
gi 1370459704 297 PAFQNLLKDCEAE-VRAAAAH 316
Cdd:pfam13646  65 PALLELLRDDDDDvVRAAAAE 85
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 185-272 2.65e-03

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 2.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370459704 185 LCSDDTPMVRRAAASKLGEFAKvleldsvkSEIVPLFTSLASDEQDSVRLLAVEACVSIAqllSQDDLETLvmptLRQAA 264
Cdd:pfam13646   8 LLRDPDPEVRAAAIRALGRIGD--------PEAVPALLELLKDEDPAVRRAAAEALGKIG---DPEALPAL----LELLR 72


                  ....*...
gi 1370459704 265 EDKSWRVR 272
Cdd:pfam13646  73 DDDDDVVR 80
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 191-240 5.44e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 35.42  E-value: 5.44e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1370459704 191 PMVRRAAASKLGEFAKVLE--LDSVKSEIVPLFTSLASDEQDSVRLLAVEAC 240
Cdd:pfam13513   1 WRVREAAALALGSLAEGGPdlLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 295-325 7.51e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 7.51e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370459704 295 LIPAFQNLLKDCEAEVRAAAAHKVKELGENL 325
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
HEAT pfam02985
HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see ...
 178-208 7.66e-03

HEAT repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514).


Pssm-ID: 460773  Cd Length: 31  Bit Score: 34.43  E-value: 7.66e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 1370459704 178 IRQQFRSLCSDDTPMVRRAAASKLGEFAKVL 208
Cdd:pfam02985   1 LLPLLLKLLNDPSPEVREAAAEALGELAEVL 31
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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