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Conserved domains on  [gi|1370514401|ref|XP_024303298|]
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tenascin isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2163-2372 7.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


:

Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 369.16  E-value: 7.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2163 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2241
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2242 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2313
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514401 2314 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2372
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 1.36e-22

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 105.08  E-value: 1.36e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 1370514401 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1799-2142 1.64e-16

Fibronectin type 3 domain [General function prediction only];


:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1799 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISK 1878
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1879 GRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1957
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1958 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 2032
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2033 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 2104
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1370514401 2105 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 2142
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.42e-14

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514401 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
804-884 1.67e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1370514401  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
713-793 9.05e-12

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 9.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1370514401  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.50e-11

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1370514401 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
1716-1788 2.38e-10

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.38e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1716 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1788
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 super family cl27307
Fibronectin type 3 domain [General function prediction only];
624-779 2.29e-09

Fibronectin type 3 domain [General function prediction only];


The actual alignment was detected with superfamily member COG3401:

Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.71  E-value: 2.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 1370514401  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.52e-09

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.52e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
fn3 pfam00041
Fibronectin type III domain;
1533-1605 4.20e-08

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 4.20e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1533 SHLTVSNMTWGSVSISWEA---QESAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.93e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 47.68  E-value: 4.93e-07
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.34e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 45.75  E-value: 2.34e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
1619-1691 3.55e-06

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 3.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1619 PKPQLgtLIFSNITPKSFNMSWT---TQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVA 1691
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.63e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 45.37  E-value: 3.63e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 8.05e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 41.52  E-value: 8.05e-05
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.47e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 2.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 40.36  E-value: 2.17e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 3.04e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.04e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 3.69e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 39.59  E-value: 3.69e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 6.65e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.82  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 1.50e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 38.05  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....*....
gi 1370514401  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 1.96e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.66  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.05e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 37.28  E-value: 3.05e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin super family cl46594
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 6.25e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


The actual alignment was detected with superfamily member pfam18720:

Pssm-ID: 480934  Cd Length: 29  Bit Score: 36.12  E-value: 6.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2163-2372 7.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 369.16  E-value: 7.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2163 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2241
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2242 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2313
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514401 2314 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2372
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 2162-2371 5.79e-108

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 343.45  E-value: 5.79e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2162 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 2241
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2242 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 2320
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514401 2321 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2371
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 2163-2371 3.35e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 341.18  E-value: 3.35e-107
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  2163 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 2242
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  2243 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 2320
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1370514401  2321 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2371
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 1.36e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 105.08  E-value: 1.36e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 1370514401 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1799-2142 1.64e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1799 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISK 1878
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1879 GRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1957
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1958 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 2032
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2033 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 2104
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1370514401 2105 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 2142
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
2071-2143 3.82e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 3.82e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401 2071 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 2143
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514401 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
894-976 3.29e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 3.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 1370514401  970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2071-2143 4.19e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.87  E-value: 4.19e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401  2071 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 2143
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 1.49e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.60  E-value: 1.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1370514401  971 DKESNPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
804-884 1.67e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1370514401  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1894-1980 2.79e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 2.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1894 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1969
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1370514401 1970 ESEPV-SGSFTT 1980
Cdd:cd00063     82 ESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
713-793 9.05e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 9.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1370514401  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.50e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1370514401 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 4.03e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 4.03e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 7.82e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.33  E-value: 7.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  667 QFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401    264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401    341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401    418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*..
gi 1370514401  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401    498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
fn3 pfam00041
Fibronectin type III domain;
1716-1788 2.38e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.38e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1716 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1788
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 2.29e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.71  E-value: 2.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 1370514401  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.52e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.52e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 4.63e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.63e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401   881 SS 882
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 1.90e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.90e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1533-1605 4.20e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 4.20e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1533 SHLTVSNMTWGSVSISWEA---QESAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 5.64e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1370514401  700 KSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1344 2.27e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1260 GNLTVTEVSWDALRLNWTTPDGTY---DQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTR 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                   ....*...
gi 1370514401 1337 PLAVEVVT 1344
Cdd:cd00063     85 PSESVTVT 92
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 2173-2206 3.63e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 3.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1370514401 2173 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 2206
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 4.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 4.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 1370514401  790 TRGPGLKRVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.93e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 4.93e-07
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 5.35e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 5.35e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 1370514401   791 RGPG 794
Cdd:smart00060   80 AGEG 83
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.34e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.75  E-value: 2.34e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
1619-1691 3.55e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 3.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1619 PKPQLgtLIFSNITPKSFNMSWT---TQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVA 1691
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.63e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.37  E-value: 3.63e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1326 1.31e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.31e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514401  1261 NLTVTEVSWDALRLNWTTPD---GTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTL 1326
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 8.05e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 8.05e-05
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1596 1.29e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514401 1533 SHLTVSNMTWGSVSISWEAQE---SAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYT 1596
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.47e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 2.09e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 2.09e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401   624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 2.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 2.17e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 3.04e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.04e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 3.69e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.69e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1351-1435 5.65e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1351 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1426
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 1370514401 1427 PVLSAEAST 1435
Cdd:cd00063     85 PSESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 6.65e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1533-1596 1.25e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.25e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514401  1533 SHLTVSNMTWGSVSISWEA-QESAFDSFLIE--VSNSDHPHETMVLSVPGVSRSSVITNLKASSNYT 1596
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 1.50e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....*....
gi 1370514401  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514401  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 1.96e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
294-454 2.89e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.51  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  294 CVENECVCDEGFTgedcselICPNDCFD-RGRCINgtcyceegftgedCGkpTCPHACHTQGRCEEGQCVCDEGfaGVDC 372
Cdd:NF041328    14 CPEPGAVCPEGLS-------VCGGACVDlRSDPSN-------------CG--ACGVACGAGQTCVAGACGCGPG--TVAC 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  373 SekrcpadchnrGRCVDGRCEcddgftGADCGElkCPNGCSGHGRCVNGQC--VCDEGYT--GEDCSQLR--------CP 440
Cdd:NF041328    70 G-----------GACVDTASD------PAHCGA--CGAACAPGQVCEGGACreACSEGLTrcGGACVDLAtdplhcgaCG 130

                          170
                   ....*....|....
gi 1370514401  441 NDCHSRGRCVEGKC 454
Cdd:NF041328   131 VACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.05e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 3.05e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-496 3.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514401  471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054      8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1352-1420 5.61e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 5.61e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514401  1352 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1420
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 381-403 6.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.12e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  381 CHNRGRCVDG----RCECDDGFTGADC 403
Cdd:cd00054     11 CQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 6.25e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.12  E-value: 6.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1716-1800 7.73e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1716 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKlLDPQEF-TLSGTQRKLELRGLITGIGYEVMVSGFTQGHQT 1791
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGS-GDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 1370514401 1792 KPLRAEIVT 1800
Cdd:cd00063     84 PPSESVTVT 92
 
Name Accession Description Interval E-value
Fibrinogen_C pfam00147
Fibrinogen beta and gamma chains, C-terminal globular domain;
2163-2372 7.53e-117

Fibrinogen beta and gamma chains, C-terminal globular domain;


Pssm-ID: 395095 [Multi-domain]  Cd Length: 221  Bit Score: 369.16  E-value: 7.53e-117
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2163 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGD-RREEFWLGL 2241
Cdd:pfam00147    1 FGRDCSDVYNKGAKTSGLYTIRPDGAT-KPFEVYCDMETDGGGWTVFQRRLDGSTNFKRNWKDYKAGFGNlSPGEFWLGN 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2242 DNLNKITAQGQYELRVDLRDH-GETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-------SMAYHNGRSFSTFDKDTD 2313
Cdd:pfam00147   80 DKIHLLTKQGPYVLRIDLEDWnGETVFALYDSFKVTNENDKYRLHVENYIGDAGDaldtagrSMTYHNGMQFSTWDRDND 159

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514401 2314 SAITNCALSYKGAFWYRNCHRVNLMGRY--GDNNHSQ-GVNWFHWKGHEHSIQFAEMKLRPS 2372
Cdd:pfam00147  160 SPDGNCALSYGGGWWYNNCHAANLNGVYyyGGTYSKQnGIIWATWKGRWYSMKKAEMKIRPL 221
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 2162-2371 5.79e-108

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 343.45  E-value: 5.79e-108
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2162 PFPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGL 2241
Cdd:cd00087      1 PLPRDCSEVLQRGGRTSGVYTIQPPGSN-EPFQVYCDMDTDGGGWTVIQRRGDGSVDFYRSWKEYKDGFGNLDGEFWLGL 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2242 DNLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYHNGRSFSTFDKDTDSAITNCA 2320
Cdd:cd00087     80 EKIHLLTSQGPYELRIDLEDwEGNTAYAEYDSFKVGSESEGYRLTLGGYSGTAGDALSYHNGMKFSTFDRDNDGASGNCA 159

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514401 2321 LSYKGAFWYRNCHRVNLMGRYG----DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2371
Cdd:cd00087    160 ESYSGGWWYNSCHASNLNGRYYsgghRNEYDNGINWATWKGSTYSLKFTEMKIRP 214
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 2163-2371 3.35e-107

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 341.18  E-value: 3.35e-107
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  2163 FPKDCSQAMLNGDTTSGLYTIYLNGDKaEALEVFCDMTSDGGGWIVFLRRKNGRENFYQNWKAYAAGFGDRREEFWLGLD 2242
Cdd:smart00186    1 LPRDCSDVLQNGGKTSGLYTIYPDGSS-RPLKVYCDMETDGGGWTVIQRRMDGSVDFYRDWKDYKEGFGNLAGEFWLGNE 79

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  2243 NLNKITAQGQYELRVDLRD-HGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGD-SMAYHNGRSFSTFDKDTDSAITNCA 2320
Cdd:smart00186   80 NIHLLTSQGKYELRIDLEDwEGNTAYALYDSFKVADEADGYRLHIGGYSGTAGDaSLTYHNGMQFSTYDRDNDKYSGNCA 159

                           170       180       190       200       210
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1370514401  2321 LSYKGAFWYRNCHRVNLMGRYG-DNNHSQGVNWFHWKGHEHSIQFAEMKLRP 2371
Cdd:smart00186  160 EEYGGGWWYNNCHAANLNGRYYpNNNYDNGINWATWKGSWYSLKFTEMKIRP 211
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
847-1241 1.36e-22

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 105.08  E-value: 1.36e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  847 TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDMSSNPAKE----TFTTGLDAPRNLRRVSQTDNSITLEWR-NGKAAID 921
Cdd:COG3401    183 TSLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDpVTESDAT 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  922 SYRIKYAPISGGDHAEVdvpksqqATTKTTL---TGLRPGTEYGIGVSAVKEDKE----SNPATINAATEL-DTPKDLQV 993
Cdd:COG3401    263 GYRVYRSNSGDGPFTKV-------ATVTTTSytdTGLTNGTTYYYRVTAVDAAGNesapSNVVSVTTDLTPpAAPSGLTA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  994 SETAETSLTLLW-KTPLAKFDRYRLNYS-LPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTA--EKGRHKSKPARVKA 1069
Cdd:COG3401    336 TAVGSSSITLSWtASSDADVTGYNVYRStSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAvdAAGNESAPSEEVSA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1070 STEQAPELENLTVTEVGWDGLR-LNWTAADQAYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVI 1148
Cdd:COG3401    416 TTASAASGESLTASVDAVPLTDvAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGS 495

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1149 QGYRTPVLSAEASTGETPNLGEVVVAEV-GWDALKLNWTAPEGAYEYFfiQVQEADTV-EAAQNLTVPGGLRSTDLPGLK 1226
Cdd:COG3401    496 LVGGSGASSVTNSVSVIGASAAAAVGGApDGTPNVTGASPVTVGASTG--DVLITDLVsLTTSASSSVSGAGLGSGNLYL 573

                          410
                   ....*....|....*
gi 1370514401 1227 AATHYTITIRGVTQD 1241
Cdd:COG3401    574 ITTLGGSLLTTTSTN 588
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1799-2142 1.64e-16

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 85.82  E-value: 1.64e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1799 VTEAEPEVDNLLVSDATPDGFRLSWTADEGVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISK 1878
Cdd:COG3401     45 SVTTKESPGTLLVAAGLSSGGGLGTGGRAGTTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPAVGT 124

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1879 GRRSQTVSAIATTAMGSPKEVIFSDITENSATVSWRAPTAQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVE 1957
Cdd:COG3401    125 ATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATtSLTVTSTTLVDGGGDIEPGTT 204

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1958 YLVSIIAMKGFEESEPVSG----SFTTALDGPSGLVTANITDSEALARWQPAIAT-VDSYVISYTGEKVPEITRTVSGNT 2032
Cdd:COG3401    205 YYYRVAATDTGGESAPSNEvsvtTPTTPPSAPTGLTATADTPGSVTLSWDPVTESdATGYRVYRSNSGDGPFTKVATVTT 284

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2033 VEYALTDLEPATEYTLRIFAE----KGPQKSSTITAkfTTDL---DSPRDLTATEVQSETALLTWRPPRAS-VTGYLlVY 2104
Cdd:COG3401    285 TSYTDTGLTNGTTYYYRVTAVdaagNESAPSNVVSV--TTDLtppAAPSGLTATAVGSSSITLSWTASSDAdVTGYN-VY 361

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|
gi 1370514401 2105 --ESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALN 2142
Cdd:COG3401    362 rsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVD 401
fn3 pfam00041
Fibronectin type III domain;
2071-2143 3.82e-15

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 72.45  E-value: 3.82e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401 2071 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVDGT--VKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 2143
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
fn3 pfam00041
Fibronectin type III domain;
1260-1327 1.42e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 70.91  E-value: 1.42e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1370514401 1260 GNLTVTEVSWDALRLNWTTP---DGTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLH 1327
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
fn3 pfam00041
Fibronectin type III domain;
894-976 3.29e-14

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 69.75  E-value: 3.29e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHA-EVDVPKSqqaTTKTTLTGLRPGTEYGIGVSAVK 969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtppPDGNGPITGYEVEYRPKNSGEPWnEITVPGT---TTSVTLTGLKPGTEYEVRVQAVN 77


                   ....*..
gi 1370514401  970 EDKESNP 976
Cdd:pfam00041   78 GGGEGPP 84
fn3 pfam00041
Fibronectin type III domain;
1075-1154 3.04e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 3.04e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1075 PELENLTVTEVGWDGLRLNWTAADQ---AYEHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGY 1151
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1370514401 1152 RTP 1154
Cdd:pfam00041   81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
1894-1973 3.16e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 3.16e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1894 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPS-MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1969
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWnEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1370514401 1970 ESEP 1973
Cdd:pfam00041   81 EGPP 84
fn3 pfam00041
Fibronectin type III domain;
986-1064 3.45e-13

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 67.05  E-value: 3.45e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYSLPTGQ--WVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGepWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1370514401 1061 KSKP 1064
Cdd:pfam00041   81 EGPP 84
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 2071-2143 4.19e-13

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 66.87  E-value: 4.19e-13
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401  2071 DSPRDLTATEVQSETALLTWRPPRAS-----VTGYLLVYESVDGTVKEVIVGPDTTSYSLADLSPSTHYTAKIQALNG 2143
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgitgyIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 894-978 1.49e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 65.60  E-value: 1.49e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  894 DAPRNLRRVSQTDNSITLEW---RNGKAAIDSYRIKYAPISGGDHAEVDVPKSQqaTTKTTLTGLRPGTEYGIGVSAVKE 970
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppEDDGGPITGYVVEYREKGSGDWKEVEVTPGS--ETSYTLTGLKPGTEYEFRVRAVNG 79


                   ....*...
gi 1370514401  971 DKESNPAT 978
Cdd:cd00063     80 GGESPPSE 87
fn3 pfam00041
Fibronectin type III domain;
804-884 1.67e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 65.13  E-value: 1.67e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ....
gi 1370514401  881 SSNP 884
Cdd:pfam00041   81 EGPP 84
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1894-1980 2.79e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.83  E-value: 2.79e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1894 GSPKEVIFSDITENSATVSWRAPT---AQVESFRITYVPITGGTPSMVTV-DGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1969
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVtPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1370514401 1970 ESEPV-SGSFTT 1980
Cdd:cd00063     82 ESPPSeSVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
713-793 9.05e-12

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.82  E-value: 9.05e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDP---LDIAFETWEIIFRNMNKEDEgEITKSLRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEP-WNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79


                   ....
gi 1370514401  790 TRGP 793
Cdd:pfam00041   80 GEGP 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 986-1065 9.99e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 9.99e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  986 DTPKDLQVSETAETSLTLLWKTPL---AKFDRYRLNYS-LPTGQWVGVQLPR-NTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYReKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81


                   ....*
gi 1370514401 1061 KSKPA 1065
Cdd:cd00063     82 ESPPS 86
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 2071-2156 1.02e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.28  E-value: 1.02e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2071 DSPRDLTATEVQSETALLTWRPPR---ASVTGYLLVYESVD-GTVKEVIVGP-DTTSYSLADLSPSTHYTAKIQALNGPL 2145
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGsGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1370514401 2146 RSNMIQTI-FTT 2156
Cdd:cd00063     82 ESPPSESVtVTT 93
fn3 pfam00041
Fibronectin type III domain;
1169-1241 1.72e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 62.05  E-value: 1.72e-11
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1169 GEVVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQD 1241
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1348-1427 2.50e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 61.66  E-value: 2.50e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1348 PQLGDLAVSEVGWDGLRLNWTAADN---AYEHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGY 1424
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1370514401 1425 RTP 1427
Cdd:pfam00041   81 EGP 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 986-1062 4.03e-11

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 61.09  E-value: 4.03e-11
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   986 DTPKDLQVSETAETSLTLLWKTP-----LAKFDRYRLNYSLPTGQWVGVQLPRNTTSYVLRGLEPGQEYNVLLTAEKGRH 1060
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPpddgiTGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401  1061 KS 1062
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 804-891 6.55e-11

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 60.97  E-value: 6.55e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  804 DAPSQIEVKDVTDTTALITWFKPL---AEIDGIELTYGIKDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1370514401  881 SSNPAK-ETFTT 891
Cdd:cd00063     82 ESPPSEsVTVTT 93
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
667-988 7.82e-11

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 67.33  E-value: 7.82e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  667 QFRVPGDQTSTIIQELEPGVEYFIRVFAILENKKSIP---VSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETW 742
Cdd:COG3401    184 SLTVTSTTLVDGGGDIEPGTTYYYRVAATDTGGESAPsneVSVTTPTTPPsAPTGLTATADTPGSVTLSWDPVTESDATG 263

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  743 EIIFRNMNKEDEGE-ITKSlrrPETSYRQTGLAPGQEYE--ISLHIVKNNTRGP-GLKRVTT--TRLDAPSQIEVKDVTD 816
Cdd:COG3401    264 YRVYRSNSGDGPFTkVATV---TTTSYTDTGLTNGTTYYyrVTAVDAAGNESAPsNVVSVTTdlTPPAAPSGLTATAVGS 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  817 TTALITWFKPLaeiDGIELTYGI---KDVPGDRTTIDLTEDENQYSIGNLKPDTEYEVSLISRRGD-MSSNPAKETFTTG 892
Cdd:COG3401    341 SSITLSWTASS---DADVTGYNVyrsTSGGGTYTKIAETVTTTSYTDTGLTPGTTYYYKVTAVDAAgNESAPSEEVSATT 417

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  893 LDAPR-----------NLRRVSQTDNSITLEWRNGKAAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEY 961
Cdd:COG3401    418 ASAASgesltasvdavPLTDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTATTTDTTTANLSVTTGSLV 497

                          330       340
                   ....*....|....*....|....*..
gi 1370514401  962 GIGVSAVKEDKESNPATINAATELDTP 988
Cdd:COG3401    498 GGSGASSVTNSVSVIGASAAAAVGGAP 524
fn3 pfam00041
Fibronectin type III domain;
1804-1883 1.25e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 59.74  E-value: 1.25e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1804 PEVDNLLVSDATPDGFRLSWTADE---GVFDNFVLKIRDTKKQSEPLEITLLAPERTRDITGLREATEYEIELYGISKGR 1880
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPPPdgnGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                   ...
gi 1370514401 1881 RSQ 1883
Cdd:pfam00041   81 EGP 83
fn3 pfam00041
Fibronectin type III domain;
1716-1788 2.38e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.97  E-value: 2.38e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1716 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKLLDPQEFTLSGTQRKLELRGLITGIGYEVMVSGFTQG 1788
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPPPDgngPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
fn3 pfam00041
Fibronectin type III domain;
1985-2055 2.92e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.58  E-value: 2.92e-10
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1985 PSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKG 2055
Cdd:pfam00041    3 PSNLTVTDVTSTSLTVSWTPPpdgNGPITGYEVEYrpKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNG 78
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
1884-2143 6.80e-10

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 64.25  E-value: 6.80e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1884 TVSAIATTAMGSPKEVIFSDITENSATVSWRAP-TAQVESFRITYVPITGGTPSMVTVDGTKTQTRLVKLIPGVEYLVSI 1962
Cdd:COG3401     42 VVLSVTTKESPGTLLVAAGLSSGGGLGTGGRAGtTSGVAAVAVAAAPPTATGLTTLTGSGSVGGATNTGLTSSDEVPSPA 121

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1963 IAMKGFEESEPVSGSFTTALDGPSGLVTANITDSEALARWQPAIATVDSYVISYTGEKVPEITRTVSGNTVEYALTDLEP 2042
Cdd:COG3401    122 VGTATTATAVAGGAATAGTYALGAGLYGVDGANASGTTASSVAGAGVVVSPDTSATAAVATTSLTVTSTTLVDGGGDIEP 201

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2043 ATEYTLRIFA---EKGPQKSSTITA-KFTTDLDSPRDLTATEVQSETALLTWRP-PRASVTGYLLVYESVDGTVKEVIVG 2117
Cdd:COG3401    202 GTTYYYRVAAtdtGGESAPSNEVSVtTPTTPPSAPTGLTATADTPGSVTLSWDPvTESDATGYRVYRSNSGDGPFTKVAT 281

                          250       260
                   ....*....|....*....|....*.
gi 1370514401 2118 PDTTSYSLADLSPSTHYTAKIQALNG 2143
Cdd:COG3401    282 VTTTSYTDTGLTNGTTYYYRVTAVDA 307
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 894-974 1.48e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 56.47  E-value: 1.48e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   894 DAPRNLRRVSQTDNSITLEWRNGK-AAIDSYRIKYAPISGGDHAEVDVPKSQQATTKTTLTGLRPGTEYGIGVSAVKEDK 972
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401   973 ES 974
Cdd:smart00060   82 EG 83
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
624-779 2.29e-09

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 62.71  E-value: 2.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  624 SPPKDLVVTEVTEETVNLAWD--NEMRVTEYLVVYTPTHEGGLEmqfRVPGDQTSTII-QELEPGVEYFIRVFAI----L 696
Cdd:COG3401    234 SAPTGLTATADTPGSVTLSWDpvTESDATGYRVYRSNSGDGPFT---KVATVTTTSYTdTGLTNGTTYYYRVTAVdaagN 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  697 ENKKSIPVSARVATYLP-APEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDE-GEITKSLRrpETSYRQTGLA 774
Cdd:COG3401    311 ESAPSNVVSVTTDLTPPaAPSGLTATAVGSSSITLSWTASSDADVTGYNVYRSTSGGGTyTKIAETVT--TTSYTDTGLT 388


                   ....*
gi 1370514401  775 PGQEY 779
Cdd:COG3401    389 PGTTY 393
fn3 pfam00041
Fibronectin type III domain;
1439-1508 3.52e-09

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 3.52e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401 1439 PEIGNLNVSDITPESFNLSWMA---TDGIFETFTIEIIDSNRLLETVEYNISGAERTAHISGLPPSTDFIVYL 1508
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRV 73
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 804-882 4.63e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 55.31  E-value: 4.63e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   804 DAPSQIEVKDVTDTTALITWFKPLAE-IDGIELTYGIKDVPGDR--TTIDLTEDENQYSIGNLKPDTEYEVSLISRRGDM 880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDgITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401   881 SS 882
Cdd:smart00060   82 EG 83
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1894-1971 9.55e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 54.16  E-value: 9.55e-09
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  1894 GSPKEVIFSDITENSATVSWRAPT-AQVESFRITYVPITGGTPS---MVTVDGTKTQTRLVKLIPGVEYLVSIIAMKGFE 1969
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPdDGITGYIVGYRVEYREEGSewkEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401  1970 ES 1971
Cdd:smart00060   82 EG 83
fn3 pfam00041
Fibronectin type III domain;
624-695 1.90e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 53.57  E-value: 1.90e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:pfam00041    1 SAPSNLTVTDVTSTSLTVSWtpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAV 76
fn3 pfam00041
Fibronectin type III domain;
1533-1605 4.20e-08

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 52.42  E-value: 4.20e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1533 SHLTVSNMTWGSVSISWEA---QESAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYTAHLHGLIGG 1605
Cdd:pfam00041    4 SNLTVTDVTSTSLTVSWTPppdGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 624-710 5.64e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 52.50  E-value: 5.64e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  624 SPPKDLVVTEVTEETVNLAW----DNEMRVTEYLVVYTPTHEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAILENK 699
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWtppeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|.
gi 1370514401  700 KSIPVSARVAT 710
Cdd:cd00063     82 ESPPSESVTVT 92
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1983-2059 9.48e-08

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 51.46  E-value: 9.48e-08
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  1983 DGPSGLVTANITDSEALARWQ-PAIATVDSYVISYTGEKVPEITR----TVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 2057
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpPPDDGITGYIVGYRVEYREEGSEwkevNVTPSSTSYTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401  2058 KS 2059
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1260-1344 2.27e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.57  E-value: 2.27e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1260 GNLTVTEVSWDALRLNWTTPDGTY---DQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTLHGEVRGHSTR 1336
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESP 84


                   ....*...
gi 1370514401 1337 PLAVEVVT 1344
Cdd:cd00063     85 PSESVTVT 92
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1983-2068 3.33e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 50.19  E-value: 3.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1983 DGPSGLVTANITDSEALARWQPA---IATVDSYVISY--TGEKVPEITRTVSGNTVEYALTDLEPATEYTLRIFAEKGPQ 2057
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPeddGGPITGYVVEYreKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG 81

                           90
                   ....*....|..
gi 1370514401 2058 KS-STITAKFTT 2068
Cdd:cd00063     82 ESpPSESVTVTT 93
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 2173-2206 3.63e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 3.63e-07
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1370514401 2173 NGDTTSGLYTIYLNGD-KAEALEVFCDMTSDGGGW 2206
Cdd:NF040941     9 GPSAPSGVYWIDPDGMgGLAPFQVYCDMTTDGGGW 43
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 713-801 4.59e-07

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 49.80  E-value: 4.59e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDPLD---IAFETWEIIFRNMNKEDEGEITKSlRRPETSYRQTGLAPGQEYEISLHIVKNN 789
Cdd:cd00063      2 SPPTNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVT-PGSETSYTLTGLKPGTEYEFRVRAVNGG 80

                           90
                   ....*....|..
gi 1370514401  790 TRGPGLKRVTTT 801
Cdd:cd00063     81 GESPPSESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 408-435 4.93e-07

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 47.68  E-value: 4.93e-07
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  408 CPNGCSGHGRCVNGQCVCDEGYTGEDCS 435
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 713-794 5.35e-07

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 49.54  E-value: 5.35e-07
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401   713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWEIIFRNMNKEDEGEITKSLRRP--ETSYRQTGLAPGQEYEISLHIVknNT 790
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWKEVNVTpsSTSYTLTGLKPGTEYEFRVRAV--NG 79


                    ....
gi 1370514401   791 RGPG 794
Cdd:smart00060   80 AGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1806-1891 1.23e-06

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 48.65  E-value: 1.23e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1806 VDNLLVSDATPDGFRLSWTA---DEGVFDNFVLKIRDtKKQSEPLEITLLAPERTR-DITGLREATEYEIELYGISKGRR 1881
Cdd:cd00063      4 PTNLRVTDVTSTSVTLSWTPpedDGGPITGYVVEYRE-KGSGDWKEVEVTPGSETSyTLTGLKPGTEYEFRVRAVNGGGE 82

                           90
                   ....*....|.
gi 1370514401 1882 SQ-TVSAIATT 1891
Cdd:cd00063     83 SPpSESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 501-528 2.34e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.75  E-value: 2.34e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  501 CPRDCSNRGLCVDGQCVCEDGFTGPDCA 528
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3 pfam00041
Fibronectin type III domain;
1619-1691 3.55e-06

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 47.02  E-value: 3.55e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1370514401 1619 PKPQLgtLIFSNITPKSFNMSWT---TQAGLFAKIVINVSDAHSLHESQQFTVSGDAKQAHITGLVENTGYDVSVA 1691
Cdd:pfam00041    1 SAPSN--LTVTDVTSTSLTVSWTpppDGNGPITGYEVEYRPKNSGEPWNEITVPGTTTSVTLTGLKPGTEYEVRVQ 74
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 190-217 3.63e-06

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 45.37  E-value: 3.63e-06
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  190 CPGNCHLRGRCIDGQCICDDGFTGEDCS 217
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1078-1162 1.28e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 45.95  E-value: 1.28e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1078 ENLTVTEVGWDGLRLNWTAADQAY---EHFIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYR-T 1153
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 1370514401 1154 PVLSAEAST 1162
Cdd:cd00063     85 PSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1261-1326 1.31e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 45.30  E-value: 1.31e-05
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514401  1261 NLTVTEVSWDALRLNWTTPD---GTYDQFTIQVQEADQVEEAHNLTVPGSLRSMEIPGLRAGTPYTVTL 1326
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPPPddgITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRV 74
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1804-1882 4.77e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 43.76  E-value: 4.77e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  1804 PEVDNLLVSDATPDGFRLSWTA-DEGVFDNFVLKIRDTKKQSEPLEITLLAPERTR--DITGLREATEYEIELYGISKGR 1880
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEWKEVNVTPSSTsyTLTGLKPGTEYEFRVRAVNGAG 81


                    ..
gi 1370514401  1881 RS 1882
Cdd:smart00060   82 EG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1171-1253 5.98e-05

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 44.02  E-value: 5.98e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1171 VVVAEVGWDALKLNWTAPE---GAYEYFFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQDFSTTPL 1247
Cdd:cd00063      7 LRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGESPPS 86


                   ....*.
gi 1370514401 1248 SVEVLT 1253
Cdd:cd00063     87 ESVTVT 92
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 594-621 8.05e-05

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 41.52  E-value: 8.05e-05
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  594 CPSDCNNLGQCVSGRCICNEGYSGEDCS 621
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1171-1240 9.18e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 9.18e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401  1171 VVVAEVGWDALKLNWTAPEGAYEYFFI---QVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVTQ 1240
Cdd:smart00060    7 LRVTDVTSTSVTLSWEPPPDDGITGYIvgyRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAVNG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1078-1147 9.46e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.99  E-value: 9.46e-05
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401  1078 ENLTVTEVGWDGLRLNWTA-ADQAYEHFIIQVQEANKVEAAR--NLTVPGSLRAVDIPGLKAATPYTVSIYGV 1147
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSEwkEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1533-1596 1.29e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.87  E-value: 1.29e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514401 1533 SHLTVSNMTWGSVSISWEAQE---SAFDSFLIEVSNSDHPHETMVLSVPGVSRSSVITNLKASSNYT 1596
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEddgGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYE 71
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 380-403 1.47e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.79  E-value: 1.47e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  380 DCHNRGRCVD--GRCECDDGFTGADC 403
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 412-434 1.99e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.41  E-value: 1.99e-04
                           10        20
                   ....*....|....*....|....*
gi 1370514401  412 CSGHGRCVN--GQCVCDEGYTGEDC 434
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 624-695 2.09e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 2.09e-04
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1370514401   624 SPPKDLVVTEVTEETVNLAWD------NEMRVTEYLVVYTPthEGGLEMQFRVPGDQTSTIIQELEPGVEYFIRVFAI 695
Cdd:smart00060    2 SPPSNLRVTDVTSTSVTLSWEpppddgITGYIVGYRVEYRE--EGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 439-466 2.17e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 2.17e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  439 CPNDCHSRGRCVEGKCVCEQGFKGYDCS 466
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 377-403 2.21e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 40.36  E-value: 2.21e-04
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  377 CPADCHNRGRCVDGRCECDDGFTGADC 403
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 473-496 3.04e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 40.02  E-value: 3.04e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  473 DCHQHGRCVN--GMCVCDDGYTGEDC 496
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 470-496 3.62e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.62e-04
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  470 CPNDCHQHGRCVNGMCVCDDGYTGEDC 496
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 346-373 3.69e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 39.59  E-value: 3.69e-04
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  346 CPHACHTQGRCEEGQCVCDEGFAGVDCS 373
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
fn3_2 pfam16893
Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin ...
 713-783 5.29e-04

Fibronectin type III domain; This fibronectin type III domain is found in fungal chitin biosynthesis protein CHS5 where, together with the neighbouring BRCT domain (pfam00533), it binds to the Arf1 GTPase.


Pssm-ID: 435634  Cd Length: 89  Bit Score: 41.03  E-value: 5.29e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1370514401  713 PAPEGLKFKSIKETSVEVEWDPLDIAFETWE--IIFRNMNKedEGEITKSLRRpeTSYRQTGLAPGQEYEISL 783
Cdd:pfam16893    3 PKAPVLKVRNVTQTSVVLEWDPLELGTAKLKslDLYRNGQR--LGVIPNPLTN--TSTKLSGLSVDTEYTFQL 71
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1351-1435 5.65e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 40.94  E-value: 5.65e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1351 GDLAVSEVGWDGLRLNWTAADNAY---EHFVIQVQEVNKVEAAQNLTLPGSLRAVDIPGLEAATPYRVSIYGVIRGYR-T 1426
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDDGgpiTGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGEsP 84


                   ....*....
gi 1370514401 1427 PVLSAEAST 1435
Cdd:cd00063     85 PSESVTVTT 93
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 563-589 6.65e-04

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.82  E-value: 6.65e-04
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  563 CPSDCHGQGRCVDGQCICHEGFTGLDC 589
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
868-1239 7.43e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 44.94  E-value: 7.43e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  868 EYEVSL--ISRRGDMSSNPAKETFTTGLD-----APRNLRrVSQTDNSITLEWRNGK-AAIDSYRIKYAPisGGDHAEVD 939
Cdd:COG4733    598 DYEVRVraINALGVSSAWAASSETTVTGKtapppAPTGLT-ATGGLGGITLSWSFPVdADTLRTEIRYST--TGDWASAT 674

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  940 VPKSQQATTKTTLTGLRPGTEYGIGVSAVkeDKESN--PATINAATELDTPKDLQVSETAETsltllwKTPLAKfdryRL 1017
Cdd:COG4733    675 VAQALYPGNTYTLAGLKAGQTYYYRARAV--DRSGNvsAWWVSGQASADAAGILDAITGQIL------ETELGQ----EL 742

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1018 NYSLPTGQWVGVQLPRNTTsyvlrglepgqeynvlLTAEKGRHKSKPARVKASTEQAPELENLTVTEVGWDGLRLNWTAA 1097
Cdd:COG4733    743 DAIIQNATVAEVVAATVTD----------------VTAQIDTAVLFAGVATAAAIGAEARVAATVAESATAAAATGTAAD 806

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1098 DQAYEH-FIIQVQEANKVEAARNLTVPGSLRAVDIPGLKAATPYTVSIYGVIQGYRTPVLSAEASTGETPNLGEVVVAEV 1176
Cdd:COG4733    807 AAGDASgGVTAGTSGTTGAGDTAASTTRVAAAVVLAGVVVYGDAIIESGNTGDIVATGDIASAAAGAVATTVSGTTAADV 886

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1370514401 1177 GWDALKLNWTAPEGAYEY--FFIQVQEADTVEAAQNLTVPGGLRSTDLPGLKAATHYTITIRGVT 1239
Cdd:COG4733    887 SAVADSTAASLTAIVIAAttIIDAIGDGTTREPAGDIGASGGAQGFAVTIVGSFDGAGAVATVDA 951
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 504-527 8.76e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.76e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  504 DCSNRGLCVD--GQCVCEDGFTGPDC 527
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 535-558 8.93e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 8.93e-04
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  535 DCHGQGRCVN--GQCVCHEGFMGKDC 558
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1533-1596 1.25e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 39.91  E-value: 1.25e-03
                            10        20        30        40        50        60
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1370514401  1533 SHLTVSNMTWGSVSISWEA-QESAFDSFLIE--VSNSDHPHETMVLSVPGVSRSSVITNLKASSNYT 1596
Cdd:smart00060    5 SNLRVTDVTSTSVTLSWEPpPDDGITGYIVGyrVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYE 71
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 252-280 1.50e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 38.05  E-value: 1.50e-03
                           10        20
                   ....*....|....*....|....*....
gi 1370514401  252 CPVPCSEEhGTCVDGLCVCHDGFAGDDCN 280
Cdd:pfam18720    2 CPLGCSSR-GVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 409-434 1.82e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.82e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514401  409 PNGCSGHGRCVNG----QCVCDEGYTGEDC 434
Cdd:cd00054      8 GNPCQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 221-248 1.96e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.66  E-value: 1.96e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  221 CPSDCNDQGKCVNGVCICFEGYAGADCS 248
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
294-454 2.89e-03

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 40.51  E-value: 2.89e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  294 CVENECVCDEGFTgedcselICPNDCFD-RGRCINgtcyceegftgedCGkpTCPHACHTQGRCEEGQCVCDEGfaGVDC 372
Cdd:NF041328    14 CPEPGAVCPEGLS-------VCGGACVDlRSDPSN-------------CG--ACGVACGAGQTCVAGACGCGPG--TVAC 69

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  373 SekrcpadchnrGRCVDGRCEcddgftGADCGElkCPNGCSGHGRCVNGQC--VCDEGYT--GEDCSQLR--------CP 440
Cdd:NF041328    70 G-----------GACVDTASD------PAHCGA--CGAACAPGQVCEGGACreACSEGLTrcGGACVDLAtdplhcgaCG 130

                          170
                   ....*....|....
gi 1370514401  441 NDCHSRGRCVEGKC 454
Cdd:NF041328   131 VACDPGESCRGGAC 144
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 284-311 3.05e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 37.28  E-value: 3.05e-03
                           10        20
                   ....*....|....*....|....*...
gi 1370514401  284 CLNNCYNRGRCVENECVCDEGFTGEDCS 311
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDCS 29
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 471-496 3.26e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.26e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1370514401  471 PNDCHQHGRCVNGM----CVCDDGYTGEDC 496
Cdd:cd00054      8 GNPCQNGGTCVNTVgsyrCSCPPGYTGRNC 37
Nar1 COG4624
Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];
277-424 4.72e-03

Iron only hydrogenase large subunit, C-terminal domain [Energy production and conversion];


Pssm-ID: 443663 [Multi-domain]  Cd Length: 450  Bit Score: 41.94  E-value: 4.72e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401  277 DDCNKPLCLNNCYNRGRCVENECVCDEGFTGEDCSELICPNDCFDRGRCINGTCYCeegftgedcgkptCPHACHTQGRC 356
Cdd:COG4624      3 LLLRACCCCCIEEGDELLLLEEAERVLRIIILEALLPEHVDDDSACSCCPRCCLCC-------------CCCCRCCVAIS 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1370514401  357 EEGQCVCDEGFaGVDCSEKRCPADCHNRGRCVDgrcECDDGFTGADCGELKcpngcSGHGRCVN-GQCV 424
Cdd:COG4624     70 CIQVRGIIIID-KRGPSIIRDKEKCKNCYPCVR---ACPVKAIKVDDGKAE-----IDEEKCIScGQCV 129
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 224-247 5.44e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.17  E-value: 5.44e-03
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  224 DCNDQGKCVN--GVCICFEGYAGADC 247
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 194-216 5.49e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.17  E-value: 5.49e-03
                           10        20
                   ....*....|....*....|....*
gi 1370514401  194 CHLRGRCID--GQCICDDGFTGEDC 216
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 1352-1420 5.61e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.98  E-value: 5.61e-03
                            10        20        30        40        50        60        70
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1370514401  1352 DLAVSEVGWDGLRLNWTA-ADNAYEHFVIQVQEVNKVEAA--QNLTLPGSLRAVDIPGLEAATPYRVSIYGV 1420
Cdd:smart00060    6 NLRVTDVTSTSVTLSWEPpPDDGITGYIVGYRVEYREEGSewKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 532-558 5.66e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.51  E-value: 5.66e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  532 CPNDCHGQGRCVNGQCVCHEGFMGKDC 558
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 566-589 5.89e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.17  E-value: 5.89e-03
                           10        20
                   ....*....|....*....|....*.
gi 1370514401  566 DCHGQGRCVD--GQCICHEGFTGLDC 589
Cdd:pfam07974    1 ICSGRGTCVNqcGKCVCDSGYQGATC 26
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 381-403 6.12e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.12e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  381 CHNRGRCVDG----RCECDDGFTGADC 403
Cdd:cd00054     11 CQNGGTCVNTvgsyRCSCPPGYTGRNC 37
EGF_Tenascin pfam18720
Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.
 315-341 6.25e-03

Tenascin EGF domain; This entry represents the EGF-like domains found in tenascin proteins.


Pssm-ID: 376143  Cd Length: 29  Bit Score: 36.12  E-value: 6.25e-03
                           10        20
                   ....*....|....*....|....*..
gi 1370514401  315 CPNDCFDRGRCINGTCYCEEGFTGEDC 341
Cdd:pfam18720    2 CPLGCSSRGVCVDGQCICDSEYSGDDC 28
COG3979 COG3979
Chitodextrinase [Carbohydrate transport and metabolism];
1985-2355 7.65e-03

Chitodextrinase [Carbohydrate transport and metabolism];


Pssm-ID: 443178 [Multi-domain]  Cd Length: 369  Bit Score: 41.30  E-value: 7.65e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1985 PSGLVTANITDSEALARWQPAIAT--VDSYVISYTGEKVpeitRTVSGNTvEYALTDLEPATEYTLRIFA-EKGPQKSST 2061
Cdd:COG3979      6 PTGLTASNVTSSSVSLSWDASTDNvgVTGYDVYRGGDQV----ATVTGLT-AWTVTGLTPGTEYTFTVGAcDAAGNVSAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2062 ITAKFTTDLDSPRDLTATEVQSETALLTWRPPRASVTGYLLVYESVDGTVKEVIVGPDTTSYSLADLS-PSTHYTAKIQA 2140
Cdd:COG3979     81 SGTSTAMFGGSSTTLGSAEGVADTSGNLAASGAFFGVTTPPTPSSTLVVDGTTTVNAAATANGGTGGSgGTTTIITTGVE 160

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2141 LNGPLRSNMIQTIFTTIGLLYPFPKDCSQAMLNGDTTSGLYTIYLNGDKAEALEVFCDMTSDGGGWIVflrrkngreNFY 2220
Cdd:COG3979    161 GGGGSKTAQSLNAITAAGTAALNGGVVGGADEVLTCSAVKDDGSGGAGAGNTYWALNTLGVSDTPSGT---------TAT 231

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 2221 QNWKAYAAGFGDRREEFWLGLDNLNKITAQGQYELRVDLRDHGETAFAVYDKFSVGDAKTRYKLKVEGYSGTAGDSMAYH 2300
Cdd:COG3979    232 GGTVGITSAYGAGVSGNAAVNVNAGFVVGNVGGAAGNTGTTSGTATSDAATNDVGDAAVTGLNDGAANGPTGGYGATGTT 311

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1370514401 2301 NGRSFSTFDKDTDSAITNCALSYKGAFWYRNCHRVNLMGRYGDNNHSQGVNWFHW 2355
Cdd:COG3979    312 VAGAAGVGGTKSGTGALGLSGAGGAGAAVSGTATGDDDAGADDSTAGVSGAGSTT 366
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 1716-1800 7.73e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 37.86  E-value: 7.73e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1370514401 1716 ENLTISDINPYGFTVSWMASEN---AFDSFLVTVVDSGKlLDPQEF-TLSGTQRKLELRGLITGIGYEVMVSGFTQGHQT 1791
Cdd:cd00063      5 TNLRVTDVTSTSVTLSWTPPEDdggPITGYVVEYREKGS-GDWKEVeVTPGSETSYTLTGLKPGTEYEFRVRAVNGGGES 83


                   ....*....
gi 1370514401 1792 KPLRAEIVT 1800
Cdd:cd00063     84 PPSESVTVT 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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