NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1039776036|ref|XP_017177312|]
View 

MICOS complex subunit Mic60 isoform X1 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-740 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 571.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 363 QARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSA 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEE 331

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 443 VAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElef 518
Cdd:pfam09731 332 LSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER--- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 519 rrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCS 598
Cdd:pfam09731 409 --------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELAS 480

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 599 DNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPED 678
Cdd:pfam09731 481 DDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAG 556

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039776036 679 INTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 740
Cdd:pfam09731 557 DDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-740 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 571.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 363 QARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSA 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEE 331

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 443 VAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElef 518
Cdd:pfam09731 332 LSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER--- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 519 rrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCS 598
Cdd:pfam09731 409 --------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELAS 480

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 599 DNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPED 678
Cdd:pfam09731 481 DDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAG 556

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039776036 679 INTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 740
Cdd:pfam09731 557 DDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 196-571 1.08e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  196 RPPEEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQnaavQAVKAHSniLKTAMDNSEIAGEKKSAQWRT 275
Cdd:PTZ00121  1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE----EARKADE--LKKAEEKKKADEAKKAEEKKK 1303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  276 VEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAK------KREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAA 347
Cdd:PTZ00121  1304 ADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaeaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  348 QSEAKVVSQYHELVVQARDDfRKELDSITpditpgwKGMTGKLSTDDLNSLiAHAHRRIDQLNR--------ELAQQKAT 419
Cdd:PTZ00121  1384 KKKAEEKKKADEAKKKAEED-KKKADELK-------KAAAAKKKADEAKKK-AEEKKKADEAKKkaeeakkaDEAKKKAE 1454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  420 EKQHIELAleKHKLEEKRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMRTQLRRQA--AAHTDHLRDV-L 492
Cdd:PTZ00121  1455 EAKKAEEA--KKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKKKADEAKKAeeAKKADEAKKAeE 1532

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  493 KVQEQELKYEFEQGLSEKLSEQElEFRR----RSQEQMDSFTLDINTAYAR---LRGIEQA---------VQSHAVAEEE 556
Cdd:PTZ00121  1533 AKKADEAKKAEEKKKADELKKAE-ELKKaeekKKAEEAKKAEEDKNMALRKaeeAKKAEEArieevmklyEEEKKMKAEE 1611

                          410
                   ....*....|....*
gi 1039776036  557 ARKAHQLWLSVEALK 571
Cdd:PTZ00121  1612 AKKAEEAKIKAEELK 1626
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 271-571 2.41e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 351 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 430
Cdd:COG1196   304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 431 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 505
Cdd:COG1196   361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039776036 506 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 571
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 220-549 2.16e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  220 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 289
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  290 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 369
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  370 KELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK-------- 430
Cdd:TIGR02168  782 AEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeelsedie 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  431 ---HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQE 498
Cdd:TIGR02168  856 slaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEG 933

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039776036  499 LKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 549
Cdd:TIGR02168  934 LEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-740 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 571.70  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKtecpntnegkstsetteeafsssvrerppeeva 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAK--------------------------------- 116

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 203 arlAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKe 282
Cdd:pfam09731 117 ---AQLPKSEQEKEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALA- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 283 rrkavdeaadallkakeelEKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVV 362
Cdd:pfam09731 193 -------------------EKLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVA 253

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 363 QARDDFRKELDSITPDITPGWKGMtGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSA 442
Cdd:pfam09731 254 SERIVFQQELVSIFPDIIPVLKED-NLLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEE 331

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 443 VAKALEHHRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElef 518
Cdd:pfam09731 332 LSARLEEVRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER--- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 519 rrrsqeqmDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCS 598
Cdd:pfam09731 409 --------AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELAS 480

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 599 DNEFTQALTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPED 678
Cdd:pfam09731 481 DDEVVKAALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAG 556

                         650       660       670       680       690       700
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1039776036 679 INTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 740
Cdd:pfam09731 557 DDVESILARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
PTZ00121 PTZ00121
MAEBL; Provisional
 196-571 1.08e-08

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 59.00  E-value: 1.08e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  196 RPPEEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQnaavQAVKAHSniLKTAMDNSEIAGEKKSAQWRT 275
Cdd:PTZ00121  1230 KKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAE----EARKADE--LKKAEEKKKADEAKKAEEKKK 1303

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  276 VEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAK------KREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAA 347
Cdd:PTZ00121  1304 ADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKkaaeaaKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAA 1383

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  348 QSEAKVVSQYHELVVQARDDfRKELDSITpditpgwKGMTGKLSTDDLNSLiAHAHRRIDQLNR--------ELAQQKAT 419
Cdd:PTZ00121  1384 KKKAEEKKKADEAKKKAEED-KKKADELK-------KAAAAKKKADEAKKK-AEEKKKADEAKKkaeeakkaDEAKKKAE 1454

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  420 EKQHIELAleKHKLEEKRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMRTQLRRQA--AAHTDHLRDV-L 492
Cdd:PTZ00121  1455 EAKKAEEA--KKKAEEAKKADEAKKKAEEAKKADeakkKAEEAKKKADEAKKAAEAKKKADEAKKAeeAKKADEAKKAeE 1532

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  493 KVQEQELKYEFEQGLSEKLSEQElEFRR----RSQEQMDSFTLDINTAYAR---LRGIEQA---------VQSHAVAEEE 556
Cdd:PTZ00121  1533 AKKADEAKKAEEKKKADELKKAE-ELKKaeekKKAEEAKKAEEDKNMALRKaeeAKKAEEArieevmklyEEEKKMKAEE 1611

                          410
                   ....*....|....*
gi 1039776036  557 ARKAHQLWLSVEALK 571
Cdd:PTZ00121  1612 AKKAEEAKIKAEELK 1626
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 271-571 2.41e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.56  E-value: 2.41e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 351 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmtgklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 430
Cdd:COG1196   304 -------IARLEERRRELEERLEEL----------------EEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 431 HKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 505
Cdd:COG1196   361 AEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAELEEEE 437

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039776036 506 GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 571
Cdd:COG1196   438 EEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
PTZ00121 PTZ00121
MAEBL; Provisional
 159-563 1.96e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 51.68  E-value: 1.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  159 APAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQvemESLAKSLEDALNRTSSVTLQTI 238
Cdd:PTZ00121  1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA---EAAADEAEAAEEKAEAAEKKKE 1374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  239 TAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQwrTVEGALKERRKAvDEA---ADALLKAKEelekMKTIIEDAKKRE 315
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD--ELKKAAAAKKKA-DEAkkkAEEKKKADE----AKKKAEEAKKAD 1447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  316 IAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQArDDFRKELDSITpditpgwKGMTGKLSTDDL 395
Cdd:PTZ00121  1448 EAKK----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA-EEAKKKADEAK-------KAAEAKKKADEA 1515

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  396 NSliAHAHRRIDQLnrelaqQKATEKQHIElalEKHKLEEKRTFDSaVAKALEHHRseiqAEQDRKVEEVRDAMENEMRT 475
Cdd:PTZ00121  1516 KK--AEEAKKADEA------KKAEEAKKAD---EAKKAEEKKKADE-LKKAEELKK----AEEKKKAEEAKKAEEDKNMA 1579

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  476 QLRRQAAAHTDHLR--DVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQ-------- 545
Cdd:PTZ00121  1580 LRKAEEAKKAEEARieEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkkaeeen 1659

                          410       420
                   ....*....|....*....|.
gi 1039776036  546 ---AVQSHAVAEEEARKAHQL 563
Cdd:PTZ00121  1660 kikAAEEAKKAEEDKKKAEEA 1680
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
271-494 5.34e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 49.91  E-value: 5.34e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  271 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 346
Cdd:COG4913    692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  347 ------AQSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG----WKGMTGKLSTDDLN 396
Cdd:COG4913    770 nleeriDALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerFKELLNENSIEFVA 849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  397 SL-------IAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAM 469
Cdd:COG4913    850 DLlsklrraIREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAALKRLI 929

                          250       260
                   ....*....|....*....|....*.
gi 1039776036  470 EnemrtQLRRQAAAHTDH-LRDVLKV 494
Cdd:COG4913    930 E-----RLRSEEEESDRRwRARVLDV 950
PTZ00121 PTZ00121
MAEBL; Provisional
 199-563 7.11e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 7.11e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  199 EEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEG 278
Cdd:PTZ00121  1408 DELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKAD 1486

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  279 ALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNV-----------VKKV 344
Cdd:PTZ00121  1487 EAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELkkaeelkkaeeKKKA 1566

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  345 QAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHI 424
Cdd:PTZ00121  1567 EEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  425 ELALEKHKLEEkrtfDSAVAKALEHHRSEiqaEQDRKVEEVRDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFE 504
Cdd:PTZ00121  1647 KKAEELKKAEE----ENKIKAAEEAKKAE---EDKKKAEEAKKAEEDEK-------------------KAAEALKKEAEE 1700

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039776036  505 QGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQShavAEEEARKAHQL 563
Cdd:PTZ00121  1701 AKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKKE---AEEDKKKAEEA 1749
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 220-549 2.16e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.16e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  220 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 289
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  290 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 369
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  370 KELDSITPDITpgwkgmTGKLSTDDLNSLIAHAHRRIDQLNRELAQQK-----------ATEKQHIELALEK-------- 430
Cdd:TIGR02168  782 AEIEELEAQIE------QLKEELKALREALDELRAELTLLNEEAANLRerleslerriaATERRLEDLEEQIeelsedie 855

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  431 ---HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQE 498
Cdd:TIGR02168  856 slaAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEG 933

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039776036  499 LKYEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 549
Cdd:TIGR02168  934 LEVRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
PTZ00121 PTZ00121
MAEBL; Provisional
 186-529 2.81e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.83  E-value: 2.81e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  186 EEAFSSSVRERPPEEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIA 265
Cdd:PTZ00121  1434 DEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKAD 1513

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  266 GEKKSAQWRTVEGALK-ERRKAVDEAADALLKAK-EELEKMktiiEDAKKREIAGATPHITAAEGRlHNMIVDLDNVVKK 343
Cdd:PTZ00121  1514 EAKKAEEAKKADEAKKaEEAKKADEAKKAEEKKKaDELKKA----EELKKAEEKKKAEEAKKAEED-KNMALRKAEEAKK 1588

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  344 VQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPgwKGMTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQH 423
Cdd:PTZ00121  1589 AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELK--KAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  424 IELALE-KHKLEEKRTFDSAVAKALEHHRSEiqAEQDRKVEEVRDAMENEMRT----------------QLRRQAAAH-- 484
Cdd:PTZ00121  1667 AKKAEEdKKKAEEAKKAEEDEKKAAEALKKE--AEEAKKAEELKKKEAEEKKKaeelkkaeeenkikaeEAKKEAEEDkk 1744

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039776036  485 --------------TDHLRDVLKVQEQELKYE----FEQGLSEKLSEQELEFRRRSQEQMDSF 529
Cdd:PTZ00121  1745 kaeeakkdeeekkkIAHLKKEEEKKAEEIRKEkeavIEEELDEEDEKRRMEVDKKIKDIFDNF 1807
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
279-539 3.22e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 47.60  E-value: 3.22e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  279 ALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAgatpHITAAE--------GRLHNMIVDLDNVVKKVQAAQSE 350
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREA----LQRLAEyswdeidvASAEREIAELEAELERLDASSDD 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  351 AKVVSQYHELVVQARDDFRKELDSITPDITpgwkgmtgklstdDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK 430
Cdd:COG4913    687 LAALEEQLEELEAELEELEEELDELKGEIG-------------RLEKELEQAEEELDELQDRLEAAEDLARLELRALLEE 753

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  431 HKLEE-KRTFDSAVAKALEHHRSEIQAEQDRKveevRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQglSE 509
Cdd:COG4913    754 RFAAAlGDAVERELRENLEERIDALRARLNRA----EEELERAMRAFNREWPAETADLDADLESLPEYLALLDRLE--ED 827

                          250       260       270
                   ....*....|....*....|....*....|
gi 1039776036  510 KLSEQELEFRRRSQEQMDSFTLDINTAYAR 539
Cdd:COG4913    828 GLPEYEERFKELLNENSIEFVADLLSKLRR 857
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 443-562 1.14e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 43.12  E-value: 1.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 443 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 522
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1039776036 523 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 562
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 199-514 1.33e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 45.60  E-value: 1.33e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  199 EEVAARLAQQEKQEQ----VEMESLAKSLEDALN---RTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSA 271
Cdd:pfam12128  641 ETFARTALKNARLDLrrlfDEKQSEKDKKNKALAerkDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQA 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  272 QWRTVEGALKERRKAVDEAADAL-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQS 349
Cdd:pfam12128  719 YWQVVEGALDAQLALLKAAIAARrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVR 790

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  350 EAKVVSQ---YHELVVQARDDFRKELDSITPDITPgwkgmtgklSTDDLNSLIAHAHRRIDQLNRELaqqKATEKQHIEL 426
Cdd:pfam12128  791 RQEVLRYfdwYQETWLQRRPRLATQLSNIERAISE---------LQQQLARLIADTKLRRAKLEMER---KASEKQQVRL 858

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  427 ALEKHKLeekRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQELKYE 502
Cdd:pfam12128  859 SENLRGL---RCEMSKLATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSGSGLAE 930

                          330
                   ....*....|..
gi 1039776036  503 FEQGLSEKLSEQ 514
Cdd:pfam12128  931 TWESLREEDHYQ 942
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 393-561 4.94e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 4.94e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  393 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 458
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  459 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 526
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1039776036  527 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 561
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 199-517 5.11e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.77  E-value: 5.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 199 EEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQW 273
Cdd:COG1196   441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGL 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 274 RTVEGAL-------KERRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVK 342
Cdd:COG1196   520 RGLAGAVavligveAAYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGA 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 343 KVQAAQSEAkvvsQYHELVVQARDDFRKELDSITPDITPGWKGMTGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQ 422
Cdd:COG1196   600 AVDLVASDL----READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 423 HIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYE 502
Cdd:COG1196   676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEE 755

                         330
                  ....*....|....*
gi 1039776036 503 FEQGLSEKLSEQELE 517
Cdd:COG1196   756 LPEPPDLEELERELE 770
PTZ00121 PTZ00121
MAEBL; Provisional
 404-580 1.25e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  404 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 482
Cdd:PTZ00121  1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  483 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 562
Cdd:PTZ00121  1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                          170
                   ....*....|....*...
gi 1039776036  563 LWLSVEALKYSMKTSSAE 580
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAE 1388
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
400-543 1.38e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 1.38e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  400 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 474
Cdd:COG4913    647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  475 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 543
Cdd:COG4913    723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 199-563 1.93e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 1.93e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 199 EEVAARLAQQEKQEQVEMESLAKSLEDALnrtssvtlQTITAQNAAVQAVKAHSNILKtamdnSEIAGEKKSAQwrtveg 278
Cdd:COG1196   245 EAELEELEAELEELEAELAELEAELEELR--------LELEELELELEEAQAEEYELL-----AELARLEQDIA------ 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 279 ALKERRKAVDEAADALLKAKEELEKmktiiedakkreiagatpHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 358
Cdd:COG1196   306 RLEERRRELEERLEELEEELAELEE------------------ELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 359 ELVVQARDDFRKELDsitpditpgwkgmtgklstDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRT 438
Cdd:COG1196   368 LEAEAELAEAEEELE-------------------ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEE 428

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 439 FDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQELEF 518
Cdd:COG1196   429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLE 508

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 1039776036 519 RRRSQEQMDSFTLdINTAYARLRGIEQAVQSHAVAEEEARKAHQL 563
Cdd:COG1196   509 GVKAALLLAGLRG-LAGAVAVLIGVEAAYEAALEAALAAALQNIV 552
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
507-741 2.29e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 40.42  E-value: 2.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 507 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 586
Cdd:COG4223    39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 587 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 666
Cdd:COG4223   110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039776036 667 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 741
Cdd:COG4223   180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 412-584 3.67e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 3.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 412 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 491
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 492 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 565
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 1039776036 566 SVEALK--YSMKTSSAEMPTI 584
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 407-525 5.51e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 5.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036  407 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 486
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039776036  487 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 525
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
HMMR_N pfam15905
Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of ...
 369-524 6.25e-03

Hyaluronan mediated motility receptor N-terminal; HMMR_N is the N-terminal region of eukaryotic hyaluronan-mediated motility receptor proteins. The protein is functionally associated with BRCA1 and thus predicted to be a common, low-penetrance breast cancer candidate.


Pssm-ID: 464932 [Multi-domain]  Cd Length: 329  Bit Score: 39.41  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039776036 369 RKELDSITPDITPGWKGMTGKLSTDDLNslIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLEEKRTFDSAVAKALE 448
Cdd:pfam15905 165 RNKLEAKMKEVMAKQEGMEGKLQVTQKN--LEHSKGKVAQLEEKL---VSTEKEKIEEKSETEKLLEYITELSCVSEQVE 239

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039776036 449 HHRSEIQaeqdrKVEEVRDAMENEMRTqLRRQAAAHTDHLRDVLKVQEQELKyEFEQGLSEKLSEQELEFRRRSQE 524
Cdd:pfam15905 240 KYKLDIA-----QLEELLKEKNDEIES-LKQSLEEKEQELSKQIKDLNEKCK-LLESEKEELLREYEEKEQTLNAE 308
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH