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Conserved domains on  [gi|1039766289|ref|XP_017175385|]
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dyslexia-associated protein KIAA0319-like protein isoform X1 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 20244047)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Mus musculus dyslexia-associated protein KIAA0319-like protein

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
myxo_dep_M36 super family cl45606
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 3.21e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


The actual alignment was detected with superfamily member NF038112:

Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.42  E-value: 3.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766289  786 R 786
Cdd:NF038112  1562 R 1562
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 8.98e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


:

Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.98e-03
                           10        20
                   ....*....|....*....|.
gi 1039766289  890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 3.21e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.42  E-value: 3.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766289  786 R 786
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 282-692 1.84e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 134.01  E-value: 1.84e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  282 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 356
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  357 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 429
Cdd:NF038112  1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  430 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 505
Cdd:NF038112  1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  506 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 582
Cdd:NF038112  1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  583 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 660
Cdd:NF038112  1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1039766289  661 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 692
Cdd:NF038112  1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 288-599 4.34e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.49  E-value: 4.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  288 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 343
Cdd:NF038112  1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  344 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 417
Cdd:NF038112  1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  418 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 494
Cdd:NF038112  1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  495 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 571
Cdd:NF038112  1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                          330       340
                   ....*....|....*....|....*...
gi 1039766289  572 LTVTDTAGQQATAQVTVIVQPENNKPPQ 599
Cdd:NF038112  1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 689-779 2.00e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 55.35  E-value: 2.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  689 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 767
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 1039766289  768 AKG---ESDTDRTTV 779
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
472-774 3.13e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  472 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 549
Cdd:COG3401    205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  550 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 628
Cdd:COG3401    279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  629 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 704
Cdd:COG3401    356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  705 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 774
Cdd:COG3401    436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 503-591 7.52e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 7.52e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289   503 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 580
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1039766289   581 QATAQVTVIVQ 591
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 692-781 1.25e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  692 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 771
Cdd:cd00146      1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1039766289  772 SDTDRTTVEV 781
Cdd:cd00146     72 SSTKTTTVVV 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 8.98e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.98e-03
                           10        20
                   ....*....|....*....|.
gi 1039766289  890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Name Accession Description Interval E-value
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 404-786 3.21e-36

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 149.42  E-value: 3.21e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  404 NRPPVAVVSPQFQEisLPTTSTIIDGSQSTD-DDKIVQYHWEELKGP---LreekISEDTAilKLSKLVP-----GNYTF 474
Cdd:NF038112  1185 NRRPVANAGPDQTV--LERTTVTLNGSGSFDpDGDPLTYAWTQVSGPavtL----TGADTA--TPSFTAPevtadTVLTF 1256

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  475 SLTVvdSDGATNSTTASLTVNKA-VDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGV 553
Cdd:NF038112  1257 QLVV--SDGTKTSAPDTVTVLVRnVNRAPVAVAGAPATVD-ERSTVTLDGSGTDADGDALTYAWT---QTSGPAVTLTGA 1330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  554 RTPALQLSAMQ---EGDYTYQLTVTDTAgQQATAQVTVIVQPENnKPPQADAGPDKElTLPVDSTTLDGSKSTDDQRVVS 630
Cdd:NF038112  1331 TTATATFTAPEvtaDTQLTFTLTVSDGT-ASATDTVTVTVRNVN-RAPVANAGADQT-VDERSTVTLSGSATDPDGDALT 1407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  631 YLWEQSRGPDgVQLENANSSVATVTGLQVG---TYVFTLTVKDERNLQSQSSVNVIVKEeINKPPVAKiAGNVVVTLPTS 707
Cdd:NF038112  1408 YAWTQTAGPT-VTLTGADTATASFTAPEVAadtELTFQLTVSADGQASADVTVTVTVRN-VNRAPVAH-AGESITVDEGS 1484

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  708 TAELDGSRSSDDKGIVSYLWTRDETSPAAgevLNHSDHHPVLFLSNLVEG--TYTFHLKVTDAKGESDTDRTTVEVKPDP 785
Cdd:NF038112  1485 TVTLDASATDPDGDTLTYAWTQVAGPSVT---LTGADSAKLTFTAPEVSAdtTLTFSLTVTDGSGSSGPVVVTVTVKNVN 1561


                   .
gi 1039766289  786 R 786
Cdd:NF038112  1562 R 1562
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 282-692 1.84e-31

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 134.01  E-value: 1.84e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  282 PSYSYATPTP---QASSQSTSAPHPVVkelvvSAGKSVQItLPKNEVQLN--AFVLPEaepGETYTYDWqlithpTDYSG 356
Cdd:NF038112  1164 LKFTGITNTPftsLVAEPGVCNRRPVA-----NAGPDQTV-LERTTVTLNgsGSFDPD---GDPLTYAW------TQVSG 1228

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  357 -EVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQNAHGEGYVNVTVKpepRKNRPPVAVVSPQfQEISLPTTSTIiDG 429
Cdd:NF038112  1229 pAVTLTGADTATPSFTAPEVTAdtvltFQLVVsDGTKTSAPDTVTVLVR---NVNRAPVAVAGAP-ATVDERSTVTL-DG 1303

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  430 SQSTDDDKIVQYHWEELKGPLREEKiseDTAILKLSKLVP---GNYTFSLTVVDSDGaTNSTTASLTVN-KAVDYPPVAN 505
Cdd:NF038112  1304 SGTDADGDALTYAWTQTSGPAVTLT---GATTATATFTAPevtADTQLTFTLTVSDG-TASATDTVTVTvRNVNRAPVAN 1379

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  506 AGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSA---MQEGDYTYQLTVTdtAGQQA 582
Cdd:NF038112  1380 AGADQTVD-ERSTVTLSGSATDPDGDALTYAWT---QTAGPTVTLTGADTATASFTApevAADTELTFQLTVS--ADGQA 1453

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  583 TAQVTVIVQPEN-NKPPQADAGPDKELTlPVDSTTLDGSKSTDDQRVVSYLWEQSRGPdGVQLENANSSVATVTGLQVG- 660
Cdd:NF038112  1454 SADVTVTVTVRNvNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWTQVAGP-SVTLTGADSAKLTFTAPEVSa 1531

                          410       420       430
                   ....*....|....*....|....*....|....
gi 1039766289  661 --TYVFTLTVKDERNLQSQSSVNVIVKEEINKPP 692
Cdd:NF038112  1532 dtTLTFSLTVTDGSGSSGPVVVTVTVKNVNRAPD 1565
myxo_dep_M36 NF038112
myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family ...
 288-599 4.34e-18

myxosortase-dependent M36 family metallopeptidase; Members of this bacterial protein family have an M36 family metallopeptidase domain, like fungalysin (see PF02128), and a C-terminal MYXO-CTERM domain (see TIGR03901), suggesting processing and surface-anchoring by the still-unknown putative transpeptidase, myxosortase. Members of this family include MXAN_3564 (mepA), part of the effector cargo of outer membrane vesicles that the species produces in large numbers during predation on other microbes.


Pssm-ID: 468355 [Multi-domain]  Cd Length: 1597  Bit Score: 90.49  E-value: 4.34e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  288 TPTPQASSQSTSAPHPVVKELVVSAG------KSVQITLPK---------------NE---VQLNAFVlpEAEPGETYTY 343
Cdd:NF038112  1238 TATPSFTAPEVTADTVLTFQLVVSDGtktsapDTVTVLVRNvnrapvavagapatvDErstVTLDGSG--TDADGDALTY 1315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  344 DWQLITHPTdysgeVERKHSQSLQLSKLTPGLYE-----FKVTV-DGQnAHGEGYVNVTVKPeprKNRPPVAVVSPQfQE 417
Cdd:NF038112  1316 AWTQTSGPA-----VTLTGATTATATFTAPEVTAdtqltFTLTVsDGT-ASATDTVTVTVRN---VNRAPVANAGAD-QT 1385

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  418 ISLPTTSTIiDGSQSTDDDKIVQYHWEELKGPlREEKISEDTAILKL---SKLVPGNYTFSLTVVDSDGATNSTTASLTV 494
Cdd:NF038112  1386 VDERSTVTL-SGSATDPDGDALTYAWTQTAGP-TVTLTGADTATASFtapEVAADTELTFQLTVSADGQASADVTVTVTV 1463

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  495 NKaVDYPPVANAGPNQVITlPQNSITLFGNQSTDDHGITSYEWSlspSSKGKVVEMQGVRTPALQLSAMQEG---DYTYQ 571
Cdd:NF038112  1464 RN-VNRAPVAHAGESITVD-EGSTVTLDASATDPDGDTLTYAWT---QVAGPSVTLTGADSAKLTFTAPEVSadtTLTFS 1538

                          330       340
                   ....*....|....*....|....*...
gi 1039766289  572 LTVTDTAGQQATAQVTVIVQPENNKPPQ 599
Cdd:NF038112  1539 LTVTDGSGSSGPVVVTVTVKNVNRAPDG 1566
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 689-779 2.00e-09

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 55.35  E-value: 2.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  689 NKPPVAKIAGNVVVTlPTSTAELDGSRSSD-DKGIVSYLWTRDETSPAAGEVLNHSDHHPvlflsnlveGTYTFHLKVTD 767
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFGDGTTATGANVSHTYAAP---------GTYTVTLTVTD 70

                           90
                   ....*....|....*
gi 1039766289  768 AKG---ESDTDRTTV 779
Cdd:pfam18911   71 DSGasnSTATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 501-588 3.79e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 48.81  E-value: 3.79e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  501 PPVANAGPNQVITLPQnSITLFGNQSTD-DHGITSYEWSLS--PSSKGKVVemqgVRTpalqlsAMQEGDYTYQLTVTDT 577
Cdd:pfam18911    3 APVADAGGDRIVAEGE-TVTFDASASDDpDGDILSYRWDFGdgTTATGANV----SHT------YAAPGTYTVTLTVTDD 71

                           90
                   ....*....|....
gi 1039766289  578 AGQQ---ATAQVTV 588
Cdd:pfam18911   72 SGASnstATDTVTV 85
PKD_4 pfam18911
PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.
 595-684 9.60e-07

PKD domain; This entry is composed of PKD domains found in bacterial surface proteins.


Pssm-ID: 436824 [Multi-domain]  Cd Length: 85  Bit Score: 47.65  E-value: 9.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  595 NKPPQADAGPDKELTlPVDSTTLDGSKSTD-DQRVVSYLWEQSrgpDGvqlenanssvATVTGLQV-------GTYVFTL 666
Cdd:pfam18911    1 NAAPVADAGGDRIVA-EGETVTFDASASDDpDGDILSYRWDFG---DG----------TTATGANVshtyaapGTYTVTL 66

                           90
                   ....*....|....*...
gi 1039766289  667 TVKDERNLQSQSSVNVIV 684
Cdd:pfam18911   67 TVTDDSGASNSTATDTVT 84
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
472-774 3.13e-06

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.16  E-value: 3.13e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  472 YTFSLTVVDSDGATN-STTASLTVNKAvdyPPVANAGPNQVITLPqNSITLfgN-QSTDDHGITSYEWSLSPSSKGKVVE 549
Cdd:COG3401    205 YYYRVAATDTGGESApSNEVSVTTPTT---PPSAPTGLTATADTP-GSVTL--SwDPVTESDATGYRVYRSNSGDGPFTK 278

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  550 MQGVRTPALQLSAMQEG-DYTYQLTVTDTAGQQATAQVTVIVQPENNkPPQADAGPDKELTLPvDSTTLDGSKSTDDQrV 628
Cdd:COG3401    279 VATVTTTSYTDTGLTNGtTYYYRVTAVDAAGNESAPSNVVSVTTDLT-PPAAPSGLTATAVGS-SSITLSWTASSDAD-V 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  629 VSYLWEQSRGPDGVQ---LENANSSVATVTGLQVG-TYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTL 704
Cdd:COG3401    356 TGYNVYRSTSGGGTYtkiAETVTTTSYTDTGLTPGtTYYYKVTAVDAAGNESAPSEEVSATTASAASGESLTASVDAVPL 435

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  705 PTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVlflsNLVEGTYTFHLKVTDAKGESDT 774
Cdd:COG3401    436 TDVAGATAAASAASNPGVSAAVLADGGDTGNAVPFTTTSSTVTA----TTTDTTTANLSVTTGSLVGGSG 501
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 503-591 7.52e-06

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 44.75  E-value: 7.52e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289   503 VANAGPNQVITLPQNSITlFGNQSTDDHGITSYEWSLS--PSSKGKVVEMQGVRtpalqlsamqEGDYTYQLTVTDTAGq 580
Cdd:smart00089    1 VADVSASPTVGVAGESVT-FTATSSDDGSIVSYTWDFGdgTSSTGPTVTHTYTK----------PGTYTVTLTVTNAVG- 68

                            90
                    ....*....|.
gi 1039766289   581 QATAQVTVIVQ 591
Cdd:smart00089   69 SASATVTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 692-781 1.25e-05

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 44.41  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  692 PVAKIAGNVVVTLPTStAELDGSRSSDDKgIVSYLWTRdetspaaGEVLNHSDHHPVLFLSNLVEGTYTFHLKVTDAKGE 771
Cdd:cd00146      1 PTASVSAPPVAELGAS-VTFSASDSSGGS-IVSYKWDF-------GDGEVSSSGEPTVTHTYTKPGTYTVTLTVTNAVGS 71

                           90
                   ....*....|
gi 1039766289  772 SDTDRTTVEV 781
Cdd:cd00146     72 SSTKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 693-782 2.46e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.59  E-value: 2.46e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289   693 VAKIAGNVVVTLPTSTAELDGSrSSDDKGIVSYLWTRDETSPAAGEVLNHSdhhpvlFLSnlvEGTYTFHLKVTDAKGeS 772
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDFGDGTSSTGPTVTHT------YTK---PGTYTVTLTVTNAVG-S 69

                            90
                    ....*....|
gi 1039766289   773 DTDRTTVEVK 782
Cdd:smart00089   70 ASATVTVVVQ 79
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 408-494 2.56e-05

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 43.59  E-value: 2.56e-05
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289   408 VAVVSPQFQEISLPTTSTIIDgsQSTDDDKIVQYHWEELKGPLREEKisedTAILKLSKlvPGNYTFSLTVVDSDGaTNS 487
Cdd:smart00089    1 VADVSASPTVGVAGESVTFTA--TSSDDGSIVSYTWDFGDGTSSTGP----TVTHTYTK--PGTYTVTLTVTNAVG-SAS 71


                    ....*..
gi 1039766289   488 TTASLTV 494
Cdd:smart00089   72 ATVTVVV 78
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 459-692 2.64e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 47.88  E-value: 2.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  459 TAILKLSKLVPGNYTFSLTVVDSDGATNSTTASLTVN-KAVDYPPVANAGPNQVITLpQNSITLFGNQSTD------DHG 531
Cdd:pfam02010   42 QLTIPSGTLPYGTYVFTLTVSLSSTPSLAGTDIITVTvQPSPLVAVIDGGSSRVVGY-NQDLTLDGSESYDpdvdpgSSS 120

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  532 ITSYEWS---------LSPSSKGKVVE------MQGVRTPALQLSA-MQEGDYTYQ--LTVTDTAGQQATAQVTVIVQPE 593
Cdd:pfam02010  121 GLTYLWScrrsssgdnPLLNNDPVCFSdqnegtLLQSTSSSLTIPAsTLQANVTYTfkLTVSKGSRNSASTTQTILVVDG 200

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  594 NnkPPQAD---AGPDKELTLPVDSTTLDGSKSTDDQRV---VSYLWE-QSRGPDGVQLENANSSVATVTG---------- 656
Cdd:pfam02010  201 N--PPIIIlscISNCNRKNNPVDRLVLLASTCLNCSSDlsdVTYRWLsLGSENTSLVLDQLNSQTSTGRSgpylvikagv 278

                          250       260       270
                   ....*....|....*....|....*....|....*..
gi 1039766289  657 LQVGT-YVFTLTVKDeRNLQSQSSVNVIVKeeINKPP 692
Cdd:pfam02010  279 LQSGVsYRFTLIVTV-YPGLVSGLASISFI--TNAPP 312
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
469-734 5.07e-05

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 46.59  E-value: 5.07e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  469 PGNYTFSLTVVDSDGATNSTTASLTVNKAVDYPPVA--NAGPNQVITLPQNSITLFGNQSTDDHGITSYEWSLSPSSKGK 546
Cdd:COG3291     49 PGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVttSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGG 128

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  547 VVEMQGVRTPALQLSAMQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQADAGPDKELTLPVDSTTLDGSKSTDDQ 626
Cdd:COG3291    129 GTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVTSDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTA 208

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  627 RVVSYlWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIVKEEINKPPVAKIAGNVVVTLPT 706
Cdd:COG3291    209 GVTTG-ATSGTSGTGSATSGVAVTDVTLTGISTGDAGTPGTNTVTTSGANTAGTSTITGGTSGVVTTSAATGTSTNGTGG 287

                          250       260
                   ....*....|....*....|....*...
gi 1039766289  707 STAELDGSRSSDDKGIVSYLWTRDETSP 734
Cdd:COG3291    288 LGTTTAITPGNVSTTADVTGGTATLAVS 315
REJ pfam02010
REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor ...
 365-711 7.58e-05

REJ domain; The REJ (Receptor for Egg Jelly) domain is found in PKD1, and the sperm receptor for egg jelly Swiss:Q26627. The function of this domain is unknown. The domain is 600 amino acids long so is probably composed of multiple structural domains. There are six completely conserved cysteine residues that may form disulphide bridges. This region contains tandem PKD-like domains.


Pssm-ID: 366875 [Multi-domain]  Cd Length: 448  Bit Score: 46.34  E-value: 7.58e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  365 SLQLSKLTPGLYEFKVTV---DGQNAHGEGYVNVTVKPEPRknrppVAVVSPQfQEISLPTTSTII-DGSQSTDDDK--- 437
Cdd:pfam02010   44 TIPSGTLPYGTYVFTLTVslsSTPSLAGTDIITVTVQPSPL-----VAVIDGG-SSRVVGYNQDLTlDGSESYDPDVdpg 117

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  438 ---IVQYHWEELKGPLREEKISEDTA-----------------ILKL--SKLVPG-NYTFSLTVVDSDGATNSTTASLTV 494
Cdd:pfam02010  118 sssGLTYLWSCRRSSSGDNPLLNNDPvcfsdqnegtllqstssSLTIpaSTLQANvTYTFKLTVSKGSRNSASTTQTILV 197

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  495 nkaVDYPP-------VANAGPnqvITLPQNSITLFGNQSTDDHGITS---YEWSLSPSSKGKVVE-------MQGVRTPA 557
Cdd:pfam02010  198 ---VDGNPpiiilscISNCNR---KNNPVDRLVLLASTCLNCSSDLSdvtYRWLSLGSENTSLVLdqlnsqtSTGRSGPY 271

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  558 LQLSA--MQEG-DYTYQLTVTDTAGQ-QATAQVTVIvqpeNNKPPQ---ADAGPDKELTLpVDSTTLDGSKSTDDQRVVS 630
Cdd:pfam02010  272 LVIKAgvLQSGvSYRFTLIVTVYPGLvSGLASISFI----TNAPPTggtCSVTPTEGTAL-ETKFTVTCQGWTDDDLPLT 346

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  631 Y----LWEQSRGPDGVQLENANSSVATVTGLQVGT----YVFTL--TVKDerNLQSQSSVNVIVKeeinkppvakiagnv 700
Cdd:pfam02010  347 YqfgdISFREASEEWFLLYEGSSQISISTFLPPGLpandYQVTVvvVVYD--SLGAATSVSLTIT--------------- 409

                          410
                   ....*....|.
gi 1039766289  701 vVTLPTSTAEL 711
Cdd:pfam02010  410 -VTPPSSSDEL 419
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 502-590 2.27e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 40.94  E-value: 2.27e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  502 PVANAGPNQVITLPQnSITLFGNqSTDDHGITSYEWSLSpsskGKVVEMQGVRTPalQLSAMQEGDYTYQLTVTDTAGQQ 581
Cdd:cd00146      1 PTASVSAPPVAELGA-SVTFSAS-DSSGGSIVSYKWDFG----DGEVSSSGEPTV--THTYTKPGTYTVTLTVTNAVGSS 72


                   ....*....
gi 1039766289  582 ATAQVTVIV 590
Cdd:cd00146     73 STKTTTVVV 81
PKD smart00089
Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 ...
 600-685 4.18e-04

Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Polycystic kidney disease 1 protein contains 14 repeats, present elsewhere such as in microbial collagenases.


Pssm-ID: 214510 [Multi-domain]  Cd Length: 79  Bit Score: 40.13  E-value: 4.18e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289   600 ADAGPDKELTLPVDSTTLDGSkSTDDQRVVSYLWEQsrgPDGVQLENANssvATVTGLQVGTYVFTLTVKDErNLQSQSS 679
Cdd:smart00089    2 ADVSASPTVGVAGESVTFTAT-SSDDGSIVSYTWDF---GDGTSSTGPT---VTHTYTKPGTYTVTLTVTNA-VGSASAT 73


                    ....*.
gi 1039766289   680 VNVIVK 685
Cdd:smart00089   74 VTVVVQ 79
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 622-684 7.96e-04

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 39.40  E-value: 7.96e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1039766289  622 STDDQRVVSYLWeqSRGPDGVQLENAnsSVATVTGLQVGTYVFTLTVKDERNLQSQSSVNVIV 684
Cdd:cd00146     23 DSSGGSIVSYKW--DFGDGEVSSSGE--PTVTHTYTKPGTYTVTLTVTNAVGSSSTKTTTVVV 81
Big_13 pfam19077
Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in ...
 478-588 3.10e-03

Bacterial Ig-like domain; Presumed domain found as tandem repeats of high sequence identity in bacterial cell surface proteins.


Pssm-ID: 465968 [Multi-domain]  Cd Length: 102  Bit Score: 38.02  E-value: 3.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  478 VVDSDGATNSTTASLTVnKAVDyppvanagpNQVITLpqnSITLFGNQST-----DDHGItsyeWSLSPSSkgkvvemqg 552
Cdd:pfam19077   17 VSDSDNITNDTTPTFTG-TNED---------GDVVTV---TVSIDGNGVTgtataGADGN----WSFTPPA--------- 70

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1039766289  553 vrtpalqlsAMQEGDYTYQLTVTDTAGQQATA---QVTV 588
Cdd:pfam19077   71 ---------ALADGTYTLTVTVTDIAGNTATSsplSFTI 100
COG3291 COG3291
Uncharacterized conserved protein, PKD repeat domain [Function unknown];
522-781 5.40e-03

Uncharacterized conserved protein, PKD repeat domain [Function unknown];


Pssm-ID: 442520 [Multi-domain]  Cd Length: 333  Bit Score: 40.42  E-value: 5.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  522 FGNQSTDDhgITSYEWSLSPSSKGkvVEMQGVRTPAlqlsamQEGDYTYQLTVTDTAGQQATAQVTVIVQPENNKPPQAD 601
Cdd:COG3291     16 FTDTSSGN--ATSYEWDFGDGTTS--TEANPSHTYT------TPGTYTVTLTVTDAAGCSDTTTKTITVGAPNPGVTTVT 85

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  602 AGPDKELTLPVDSTTLDGSKSTDDQRVVSYLWEQSRGPDGVQLENANSSVATVTGLQVGTYVFTLTVKDERNLQSQSSVN 681
Cdd:COG3291     86 TSTTVTTLANTANGGATTVVAGSTVGTGVATSTTTAAAPGGGGGTGTTTTTGTDTGLTGSTGTASDTATVTTSVSTTDVT 165

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  682 VIVKEEINKPPVAKIAGNVVVTLPTSTAELDGSRSSDDKGIVSYLWTRDETSPAAGEVLNHSDHHPVLFLSNLVEGTYTF 761
Cdd:COG3291    166 SDGTTSASTNPSVTTDTVTTLTGSYTGTIVGGSGSGTVTSGTAGVTTGATSGTSGTGSATSGVAVTDVTLTGISTGDAGT 245

                          250       260
                   ....*....|....*....|
gi 1039766289  762 HLKVTDAKGESDTDRTTVEV 781
Cdd:COG3291    246 PGTNTVTTSGANTAGTSTIT 265
PKD cd00146
polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an ...
 406-494 8.13e-03

polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is presented here. The domain is also found in microbial collagenases and chitinases.


Pssm-ID: 238084 [Multi-domain]  Cd Length: 81  Bit Score: 36.32  E-value: 8.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039766289  406 PPVAVVSPQFQEISLPTTSTIidgsQSTDDDKIVQYHWEELKGPLreekISEDTAILKLSKLVPGNYTFSLTVVDSDGAT 485
Cdd:cd00146      1 PTASVSAPPVAELGASVTFSA----SDSSGGSIVSYKWDFGDGEV----SSSGEPTVTHTYTKPGTYTVTLTVTNAVGSS 72


                   ....*....
gi 1039766289  486 NSTTASLTV 494
Cdd:cd00146     73 STKTTTVVV 81
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
 890-910 8.98e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 34.63  E-value: 8.98e-03
                           10        20
                   ....*....|....*....|.
gi 1039766289  890 CSDHGHCDSFTKRCVCDPFWM 910
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQ 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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