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Conserved domains on  [gi|1039755602|ref|XP_017173317|]
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fibrillin-2 isoform X1 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.07e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


:

Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.07e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602   76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1708-1751 1.32e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.52  E-value: 1.32e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602 1708 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1751
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 673-716 5.96e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 5.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  673 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 716
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2071-2115 1.84e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 1.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2071 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2115
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 970-1012 9.32e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.44  E-value: 9.32e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  970 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1012
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1372-1407 1.60e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.60e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1372 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1407
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2354-2397 5.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2354 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2397
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1553-1593 1.53e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039755602 1553 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1593
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 340-384 2.93e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 2.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039755602  340 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 384
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1331-1366 4.85e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


:

Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1331 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1366
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1206-1241 1.19e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1206 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1241
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2173-2212 4.13e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 4.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1039755602  2173 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2212
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2455-2490 5.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 5.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 2455 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2490
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 1.25e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.25e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1810 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1842
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-658 1.45e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.45e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   618 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 658
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1894-1928 1.71e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1894 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1928
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 865-895 2.21e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.21e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  865 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 895
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2131-2172 2.49e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.49e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2131 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2172
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
495-525 2.72e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.72e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602   495 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 525
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-576 3.51e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   535 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 576
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1610-1642 5.58e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.58e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1610 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1642
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 770-805 6.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602  770 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 805
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1118-1150 7.42e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.42e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1118 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2056 8.94e-04

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602  2016 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2056
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2788-2835 1.10e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039755602 2788 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2835
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1075-1109 1.16e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1039755602  1075 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1109
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1933-1975 1.21e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.21e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039755602  1933 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1975
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
577-617 1.34e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   577 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 617
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
2574-2603 1.41e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602  2574 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2603
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1492-1523 1.49e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1492 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1523
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2492-2521 1.58e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2492 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2521
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1160-1192 1.61e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.61e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1160 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1192
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1768-1800 1.91e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1768 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1800
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
vWFA super family cl00057
Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation ...
 1847-1889 2.31e-03

Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of fold. The vWA domain, since its discovery, has drawn great interest because of its widespread occurrence and its involvement in a wide variety of important cellular functions. These include basal membrane formation, cell migration, cell differentiation, adhesion, haemostasis, signaling, chromosomal stability, malignant transformation and in immune defenses In integrins these domains form heterodimers while in vWF it forms multimers. There are different interaction surfaces of this domain as seen by the various molecules it complexes with. Ligand binding in most cases is mediated by the presence of a metal ion dependent adhesion site termed as the MIDAS motif that is a characteristic feature of most, if not all A domains.


The actual alignment was detected with superfamily member cd01475:

Pssm-ID: 469594 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039755602 1847 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1889
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-769 4.36e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.36e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602   728 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 769
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
915-945 4.74e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  915 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 945
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
243-273 5.01e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.01e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602   243 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 273
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
1451-1486 5.53e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1451 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1486
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA smart00179
Calcium-binding EGF-like domain;
2409-2442 6.04e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1039755602  2409 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2442
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 191-224 6.59e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


:

Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.87  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602  191 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 224
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2254-2286 7.03e-03

Calcium-binding EGF domain;


:

Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 2254 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2286
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1976-2008 7.35e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1976 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2008
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2531-2573 8.12e-03

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.12e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2531 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2573
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.07e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.07e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602   76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1708-1751 1.32e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.52  E-value: 1.32e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602 1708 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1751
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 673-716 5.96e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 5.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  673 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 716
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2071-2115 1.84e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 1.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2071 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2115
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 970-1012 9.32e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.44  E-value: 9.32e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  970 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1012
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1372-1407 1.60e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.60e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1372 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1407
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2354-2397 5.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2354 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2397
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1553-1593 1.53e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039755602 1553 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1593
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 340-384 2.93e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 2.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039755602  340 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 384
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1331-1366 4.85e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1331 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1366
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1206-1241 1.19e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1206 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1241
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
2173-2212 4.13e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 4.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1039755602  2173 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2212
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2455-2490 5.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 5.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 2455 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2490
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 1.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.25e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1810 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1842
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-658 1.45e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.45e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   618 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 658
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1894-1928 1.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1894 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1928
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2449-2489 1.88e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 1.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039755602 2449 CVDLDECSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKT 2489
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1368-1403 2.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1368 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTGD 1403
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1810-1844 2.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 1810 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1844
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 865-895 2.21e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.21e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  865 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 895
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2131-2172 2.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.49e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2131 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2172
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
495-525 2.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.72e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602   495 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 525
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1894-1927 2.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.73e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1894 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1927
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-576 3.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   535 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 576
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1368-1407 3.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.80e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1039755602  1368 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1407
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 618-647 4.01e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.01e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1039755602  618 DVDECQTPGICMNGH-CINNEGSFRCDCPPG 647
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2173-2204 4.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.74e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 2173 DTDECSIGNPCGN-GTCTNVIGSFECTCNEGFE 2204
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1200-1240 4.92e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039755602 1200 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1240
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1610-1642 5.58e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.58e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1610 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1642
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 770-805 6.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602  770 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 805
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1118-1150 7.42e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.42e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1118 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2056 8.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602  2016 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2056
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1118-1151 9.25e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1118 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1151
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1810-1841 9.46e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.46e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1810 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1841
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2788-2835 1.10e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039755602 2788 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2835
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1075-1109 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1039755602  1075 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1109
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1933-1975 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.21e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039755602  1933 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1975
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-525 1.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602  495 DVDECTS-NPCSN-GDCVNTPGSYYCKCHAGFQ 525
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
577-617 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   577 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 617
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
770-801 1.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.35e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602   770 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 801
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2574-2603 1.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602  2574 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2603
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2131-2172 1.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039755602 2131 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2172
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1492-1523 1.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1492 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1523
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2492-2521 1.58e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2492 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2521
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1160-1192 1.61e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.61e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1160 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1192
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 535-570 1.77e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602  535 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 570
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2487-2523 1.88e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602 2487 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2523
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
1768-1800 1.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1768 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1800
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1610-1643 2.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.13e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1610 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1643
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 577-609 2.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602  577 DHDECTTTNMCLN-GMCINEDGSFKCVCKPGFIL 609
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1847-1889 2.31e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039755602 1847 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1889
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1327-1361 2.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 1327 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGWVG 1361
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
Cadherin pfam00028
Cadherin domain;
2788-2834 2.72e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 2.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039755602 2788 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTAK--KKLAPGTYTLEI 2834
Cdd:pfam00028   25 LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKplDRESIGEYELTV 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2788-2835 3.51e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.51e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1039755602  2788 EPLNNHIRYVISQGNEDGVFRIHQRNGlsyLHTAKKKL---APGTYTLEIT 2835
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLdreEQPEYTLTVE 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2016-2049 3.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 2016 DINECdEDPNICLF-GSCTNTPGGFQCICPPGFVL 2049
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-769 4.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.36e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602   728 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 769
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
915-945 4.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  915 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 945
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
243-273 5.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.01e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602   243 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 273
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1492-1524 5.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1492 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1524
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1160-1192 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1160 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1192
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1451-1486 5.53e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1451 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1486
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
2131-2161 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2131 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2161
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1075-1105 6.01e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1075 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1105
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2409-2442 6.04e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1039755602  2409 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2442
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1451-1485 6.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1451 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1485
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2574-2603 6.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.56e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2574 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2603
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 191-224 6.59e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.87  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602  191 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 224
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2254-2286 7.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 2254 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2286
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1976-2008 7.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1976 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2008
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
1768-1798 7.76e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 7.76e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1768 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1327-1359 7.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.80e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1327 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGW 1359
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1768-1800 7.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.91e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 1768 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1800
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2531-2573 8.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.12e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2531 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2573
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
 
Name Accession Description Interval E-value
Fibrillin_U_N pfam18193
Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. ...
 76-112 6.07e-15

Fibrillin 1 unique N-terminal domain; This is the N-terminal domain of human fibrillin-1. Fibrillin is a primary constituent of microfibrils in the extracellular matrix of many elastic and non-elastic connective tissues. This domain, known as the fibrillin unique N-terminal (FUN) domain, constitutes the minimal interaction site for the fibrillin C terminus. The FUN domain has homologs in the human proteins LTBP-1L/2 and VWCE, which are also associated with a C-terminal EGF-like domain.


Pssm-ID: 436338  Cd Length: 37  Bit Score: 70.70  E-value: 6.07e-15
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602   76 RRGQQEILRGPNVCGSRFHSYCCPGWKTLPGGNQCIV 112
Cdd:pfam18193    1 RRGGADVLRGPNVCGSRFHAYCCPGWKTLPGGNQCIV 37
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1708-1751 1.32e-11

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 61.52  E-value: 1.32e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602 1708 TCENELPFNVTKRMCCCTYnVGKAWNKPCEPCPTPGTADFKTIC 1751
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTS-VGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 673-716 5.96e-10

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 56.52  E-value: 5.96e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  673 GVCVRPFPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGLC 716
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2071-2115 1.84e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 55.36  E-value: 1.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2071 GKCSVPKAFNTTKAKCCCSKMpGEGWGDPCELCPKDDEVAFQDLC 2115
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTSV-GRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 970-1012 9.32e-09

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 53.44  E-value: 9.32e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1039755602  970 DECIHPVPGKFRMDACCCA-VGAAWGTECEECPKPGTKEYETLC 1012
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1372-1407 1.60e-08

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 52.22  E-value: 1.60e-08
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1372 CANGTHQCSINAQCVNTPGSYRCACSEGFTGDGFTC 1407
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 2354-2397 5.22e-08

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 51.12  E-value: 5.22e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1039755602 2354 MCQMASSSRnlVTKSECCCD-GGRGWGHQCELCPLPGTAQYKKIC 2397
Cdd:pfam00683    2 RCSNPLPGN--VTKSECCCTsVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 1553-1593 1.53e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.97  E-value: 1.53e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039755602 1553 CNTEVGVGVSRSSCCC-SLGKAWGNPCETCPPVNSTEYYTLC 1593
Cdd:pfam00683    3 CSNPLPGNVTKSECCCtSVGRAWGSPCELCPPPGTDEFRELC 44
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 340-384 2.93e-07

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 49.20  E-value: 2.93e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1039755602  340 GRCAQELPGRMAKAQCCCE-PGRCWsiGTIPEACPVRGSEEYRRLC 384
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCCTsVGRAW--GSPCELCPPPGTDEFRELC 44
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 1331-1366 4.85e-06

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 45.28  E-value: 4.85e-06
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1331 CEIGAHNCDMHASCLNVPGSFKCSCREGWVGNGIKC 1366
Cdd:pfam12947    1 CSDNNGGCHPNATCTNTGGSFTCTCNDGYTGDGVTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 1206-1241 1.19e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 1.19e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1206 CMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRSC 1241
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA pfam07645
Calcium-binding EGF domain;
1327-1358 4.09e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.09e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1327 DVDECEIGAHNCDMHASCLNVPGSFKCSCREG 1358
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2173-2212 4.13e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 43.00  E-value: 4.13e-05
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1039755602  2173 DTDECSIGNPCGNG-TCTNVIGSFECTCNEGFEPGpmMNCE 2212
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDG--RNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
1368-1399 4.42e-05

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 42.61  E-value: 4.42e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1368 DLDECANGTHQCSINAQCVNTPGSYRCACSEG 1399
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 2455-2490 5.16e-05

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 42.61  E-value: 5.16e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 2455 CSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKTC 2490
Cdd:pfam14670    1 CSVNNGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
1810-1842 1.25e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.25e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1810 DIDECSNGdNLCQRNADCINSPGSYRCECAAGF 1842
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
618-658 1.45e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.46  E-value: 1.45e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   618 DVDECQTPGICMNG-HCINNEGSFRCDCPPGLavgVDGRVCV 658
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1894-1928 1.71e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 1.71e-04
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1894 DVDECE-RHPCGNG-TCKNTVGSYNCLCYPGFELTHN 1928
Cdd:smart00179    1 DIDECAsGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2449-2489 1.88e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 1.88e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039755602 2449 CVDLDECSQSPKPCNFICKNTKGSYQCSCPRGYVLQEDGKT 2489
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1368-1403 2.10e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.10e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1368 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTGD 1403
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTGR 35
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1810-1844 2.18e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 2.18e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 1810 DIDECSNGdNLCQRNADCINSPGSYRCECAAGFKL 1844
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 865-895 2.21e-04

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 40.72  E-value: 2.21e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  865 NRCEVNINGATLKSECC-ATLGAAWGSPCERC 895
Cdd:pfam00683    1 GRCSNPLPGNVTKSECCcTSVGRAWGSPCELC 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2131-2172 2.49e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.49e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2131 DVNEClESPGICSNG-QCINTDGSFRCECPMGYnldYTGVRCV 2172
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
495-525 2.72e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 2.72e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602   495 DVDECTS-NPCSNG-DCVNTPGSYYCKCHAGFQ 525
Cdd:smart00179    1 DIDECASgNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1894-1927 2.73e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 2.73e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1894 DVDECE-RHPCGN-GTCKNTVGSYNCLCYPGFELTH 1927
Cdd:cd00054      1 DIDECAsGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
535-576 3.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.31  E-value: 3.51e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   535 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFeltTDGKNCV 576
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY---TDGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
1368-1407 3.80e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.92  E-value: 3.80e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1039755602  1368 DLDECANGtHQCSINAQCVNTPGSYRCACSEGFTgDGFTC 1407
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGYT-DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 618-647 4.01e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.01e-04
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1039755602  618 DVDECQTPGICMNGH-CINNEGSFRCDCPPG 647
Cdd:cd00054      1 DIDECASGNPCQNGGtCVNTVGSYRCSCPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2173-2204 4.74e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.74e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 2173 DTDECSIGNPCGN-GTCTNVIGSFECTCNEGFE 2204
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1200-1240 4.92e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 44.30  E-value: 4.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1039755602 1200 CTDIDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGRS 1240
Cdd:cd01475    184 CVVPDLCATLSHVCQQVCISTPGSYLCACTEGYALLEDNKT 224
EGF_CA smart00179
Calcium-binding EGF-like domain;
1610-1642 5.58e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.54  E-value: 5.58e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1610 DIDECQELPGLCQGGNCINTFGSFQCECPQGYY 1642
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1366-1401 6.07e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.91  E-value: 6.07e-04
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602 1366 CIDLDECANGTHQCsinAQ-CVNTPGSYRCACSEGFT 1401
Cdd:cd01475    184 CVVPDLCATLSHVC---QQvCISTPGSYLCACTEGYA 217
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 770-805 6.36e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.36e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602  770 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRT 805
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1807-1848 6.83e-04

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 43.91  E-value: 6.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1039755602 1807 VCEDIDECSNGDNLCQRNadCINSPGSYRCECAAGFKLSPNG 1848
Cdd:cd01475    183 ICVVPDLCATLSHVCQQV--CISTPGSYLCACTEGYALLEDN 222
EGF_CA smart00179
Calcium-binding EGF-like domain;
1118-1150 7.42e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 7.42e-04
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1118 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHE 1150
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2016-2056 8.94e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 39.15  E-value: 8.94e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602  2016 DINECdEDPNICLFGS-CTNTPGGFQCICPPGFVlsdNGRRC 2056
Cdd:smart00179    1 DIDEC-ASGNPCQNGGtCVNTVGSYRCECPPGYT---DGRNC 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1118-1151 9.25e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.16  E-value: 9.25e-04
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1118 DIDECERNPLLCRGGTCVNTEGSFQCDCPLGHEL 1151
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
1810-1841 9.46e-04

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 38.76  E-value: 9.46e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1810 DIDECSNGDNLCQRNADCINSPGSYRCECAAG 1841
Cdd:pfam07645    1 DVDECATGTHNCPANTVCVNTIGSFECRCPDG 32
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 2788-2835 1.10e-03

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 40.76  E-value: 1.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1039755602 2788 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTaKKKL---APGTYTLEIT 2835
Cdd:cd11304     26 SGENGEVTYSIVSGNEDGLFSIDPSTGE--ITT-AKPLdreEQSSYTLTVT 73
EGF_CA smart00179
Calcium-binding EGF-like domain;
1075-1109 1.16e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.16e-03
                            10        20        30
                    ....*....|....*....|....*....|....*.
gi 1039755602  1075 DIDECRiSPDLCGSG-ICVNTPGSFECECFEGYESG 1109
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTDG 35
EGF_CA smart00179
Calcium-binding EGF-like domain;
1933-1975 1.21e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.77  E-value: 1.21e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....
gi 1039755602  1933 DIDECSSffGQVCRNG-RCFNEIGSFKCLCNEGYEltpDGKNCI 1975
Cdd:smart00179    1 DIDECAS--GNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 495-525 1.22e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.77  E-value: 1.22e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602  495 DVDECTS-NPCSN-GDCVNTPGSYYCKCHAGFQ 525
Cdd:cd00054      1 DIDECASgNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
577-617 1.34e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.34e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 1039755602   577 DHDECTTTNMCLNG-MCINEDGSFKCVCKPGFIlapNGRYCT 617
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA smart00179
Calcium-binding EGF-like domain;
770-801 1.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.35e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602   770 DIDECLVNRLLCDNGLCRNTPGSYSCTCPPGY 801
Cdd:smart00179    1 DIDECASGNPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2574-2603 1.41e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.41e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602  2574 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2603
Cdd:smart00179    1 DIDECASGNPCQNGgtCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2131-2172 1.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.39  E-value: 1.44e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039755602 2131 DVNEClESPGICSN-GQCINTDGSFRCECPMGynldYTGVRCV 2172
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPG----YTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
1492-1523 1.49e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.49e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1492 DIDECADPINCVNG-LCVNTPGRYECNCPPDFQ 1523
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA pfam07645
Calcium-binding EGF domain;
2492-2521 1.58e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 37.99  E-value: 1.58e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2492 DLDECQTKQHNCQ--FLCVNTLGGFTCKCPPG 2521
Cdd:pfam07645    1 DVDECATGTHNCPanTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1160-1192 1.61e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.38  E-value: 1.61e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1160 DINECSlSDNLCRNG-KCVNMIGTYQCSCNPGYQ 1192
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 535-570 1.77e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 1.77e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602  535 DIDECIQNGVLCKNGRCVNTDGSFQCICNAGFELTT 570
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTGRN 36
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 2487-2523 1.88e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 42.37  E-value: 1.88e-03
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 1039755602 2487 GKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2523
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQVCISTPGSYLCACTEGYA 217
EGF_CA smart00179
Calcium-binding EGF-like domain;
1768-1800 1.91e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 1.91e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1768 DIDECKEiPGICANG-VCINQIGSFRCECPTGFS 1800
Cdd:smart00179    1 DIDECAS-GNPCQNGgTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1610-1643 2.13e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.13e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1610 DIDECQELPGLCQGGNCINTFGSFQCECPQGYYL 1643
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 577-609 2.20e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 38.00  E-value: 2.20e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602  577 DHDECTTTNMCLN-GMCINEDGSFKCVCKPGFIL 609
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1847-1889 2.31e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.99  E-value: 2.31e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1039755602 1847 NGACVDRNECLEIPNVCSHGlCVDLQGSYQCICNNGFKASQDQ 1889
Cdd:cd01475    181 GKICVVPDLCATLSHVCQQV-CISTPGSYLCACTEGYALLEDN 222
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1327-1361 2.45e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.62  E-value: 2.45e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 1327 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGWVG 1361
Cdd:cd00054      1 DIDECASG-NPCQNGGTCVNTVGSYRCSCPPGYTG 34
Cadherin pfam00028
Cadherin domain;
2788-2834 2.72e-03

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 39.21  E-value: 2.72e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1039755602 2788 EPLNNHIRYVISQGNEDGVFRIHQRNGLsyLHTAK--KKLAPGTYTLEI 2834
Cdd:pfam00028   25 LGPNGRIFYSILGGGPGGNFRIDPDTGD--ISTTKplDRESIGEYELTV 71
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 2788-2835 3.51e-03

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 38.87  E-value: 3.51e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1039755602  2788 EPLNNHIRYVISQGNEDGVFRIHQRNGlsyLHTAKKKL---APGTYTLEIT 2835
Cdd:smart00112    7 SGENGKVTYSILSGNDDGLFSIDPETG---EITTTKPLdreEQPEYTLTVE 54
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2016-2049 3.93e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.93e-03
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1039755602 2016 DINECdEDPNICLF-GSCTNTPGGFQCICPPGFVL 2049
Cdd:cd00054      1 DIDEC-ASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA smart00179
Calcium-binding EGF-like domain;
728-769 4.36e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.23  E-value: 4.36e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602   728 DINECAlDPDICANG-ICENLRGSYRCNCNSGYEpdaSGRNCI 769
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA pfam07645
Calcium-binding EGF domain;
915-945 4.74e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.83  E-value: 4.74e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602  915 DVNECEVFPGVCP-NGRCVNSKGSFHCECPEG 945
Cdd:pfam07645    1 DVDECATGTHNCPaNTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
243-273 5.01e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.01e-03
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1039755602   243 DVDECqAIPGLCQ-GGNCINTVGSFECRCPAG 273
Cdd:smart00179    1 DIDEC-ASGNPCQnGGTCVNTVGSYRCECPPG 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1492-1524 5.03e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1492 DIDECADPINCVN-GLCVNTPGRYECNCPPDFQL 1524
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTG 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1160-1192 5.44e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 5.44e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602 1160 DINECSlSDNLCRN-GKCVNMIGTYQCSCNPGYQ 1192
Cdd:cd00054      1 DIDECA-SGNPCQNgGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
1451-1486 5.53e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 5.53e-03
                            10        20        30
                    ....*....|....*....|....*....|....*..
gi 1039755602  1451 DIDECSFQNICVFG-TCNNLPGMFHCICDDGYELDRT 1486
Cdd:smart00179    1 DIDECASGNPCQNGgTCVNTVGSYRCECPPGYTDGRN 37
EGF_CA pfam07645
Calcium-binding EGF domain;
2131-2161 5.61e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 5.61e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2131 DVNECLESPGIC-SNGQCINTDGSFRCECPMG 2161
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA pfam07645
Calcium-binding EGF domain;
1075-1105 6.01e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 6.01e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1075 DIDECRISPDLC-GSGICVNTPGSFECECFEG 1105
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
2409-2442 6.04e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.84  E-value: 6.04e-03
                            10        20        30
                    ....*....|....*....|....*....|....*
gi 1039755602  2409 DIDECKvMPSLCTNG-QCVNTMGSFRCFCKVGYTT 2442
Cdd:smart00179    1 DIDECA-SGNPCQNGgTCVNTVGSYRCECPPGYTD 34
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1451-1485 6.49e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.49e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1451 DIDECSFQNICVF-GTCNNLPGMFHCICDDGYELDR 1485
Cdd:cd00054      1 DIDECASGNPCQNgGTCVNTVGSYRCSCPPGYTGRN 36
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 2574-2603 6.56e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 6.56e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 2574 DVDECDGNHRCQHG--CQNILGGYRCGCPQGY 2603
Cdd:cd00054      1 DIDECASGNPCQNGgtCVNTVGSYRCSCPPGY 32
TB pfam00683
TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid ...
 191-224 6.59e-03

TB domain; This domain is also known as the 8 cysteine domain. This family includes the hybrid domains. This cysteine rich repeat is found in TGF binding protein and fibrillin.


Pssm-ID: 459903  Cd Length: 44  Bit Score: 36.87  E-value: 6.59e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1039755602  191 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPAQ 224
Cdd:pfam00683    2 RCSNPLPGNVTKSECCCTSVGRAWGSPCELCPPP 35
EGF_CA pfam07645
Calcium-binding EGF domain;
2254-2286 7.03e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.45  E-value: 7.03e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 2254 DLDECAEGLHDCeSRGMMCKNLIGTFMCICPPG 2286
Cdd:pfam07645    1 DVDECATGTHNC-PANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1976-2008 7.35e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.35e-03
                            10        20        30
                    ....*....|....*....|....*....|....
gi 1039755602  1976 DTNECvALPGSCSPG-TCQNLEGSFRCICPPGYE 2008
Cdd:smart00179    1 DIDEC-ASGNPCQNGgTCVNTVGSYRCECPPGYT 33
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 2474-2495 7.69e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 35.85  E-value: 7.69e-03
                           10        20
                   ....*....|....*....|..
gi 1039755602 2474 QCSCPRGYVLQEDGKTCKDLDE 2495
Cdd:pfam12662    1 TCSCPPGYQLDPDGRTCVDIDE 22
EGF_CA pfam07645
Calcium-binding EGF domain;
1768-1798 7.76e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 36.06  E-value: 7.76e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1039755602 1768 DIDECKEIPGIC-ANGVCINQIGSFRCECPTG 1798
Cdd:pfam07645    1 DVDECATGTHNCpANTVCVNTIGSFECRCPDG 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
1327-1359 7.80e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 7.80e-03
                            10        20        30
                    ....*....|....*....|....*....|...
gi 1039755602  1327 DVDECEIGaHNCDMHASCLNVPGSFKCSCREGW 1359
Cdd:smart00179    1 DIDECASG-NPCQNGGTCVNTVGSYRCECPPGY 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 1768-1800 7.91e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.46  E-value: 7.91e-03
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039755602 1768 DIDECKEIPGICANGVCINQIGSFRCECPTGFS 1800
Cdd:cd00054      1 DIDECASGNPCQNGGTCVNTVGSYRCSCPPGYT 33
EGF_CA smart00179
Calcium-binding EGF-like domain;
2531-2573 8.12e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 8.12e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|...
gi 1039755602  2531 DNNECgSQPSLCGAKGICQNTPGSFSCECQRGFSldaSGLNCE 2573
Cdd:smart00179    1 DIDEC-ASGNPCQNGGTCVNTVGSYRCECPPGYT---DGRNCE 39
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 1325-1360 8.31e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 40.45  E-value: 8.31e-03
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1039755602 1325 CTDVDECEIGAHNCDmHAsCLNVPGSFKCSCREGWV 1360
Cdd:cd01475    184 CVVPDLCATLSHVCQ-QV-CISTPGSYLCACTEGYA 217
EGF smart00181
Epidermal growth factor-like domain;
2176-2204 9.59e-03

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 35.96  E-value: 9.59e-03
                            10        20
                    ....*....|....*....|....*....
gi 1039755602  2176 ECSIGNPCGNGTCTNVIGSFECTCNEGFE 2204
Cdd:smart00181    1 ECASGGPCSNGTCINTPGSYTCSCPPGYT 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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