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Conserved domains on  [gi|1039751940|ref|XP_017172648|]
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protein HEG homolog 1 isoform X6 [Mus musculus]

Protein Classification

EGF_CA domain-containing protein( domain architecture ID 10043351)

EGF_CA domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 132-499 4.48e-11

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.27  E-value: 4.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  132 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 211
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  212 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPrvtsvqmsTAISAIAliPSNQTANPk 291
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRR--------AARPTVG--SLTSLADP- 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  292 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 369
Cdd:PHA03247  2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  370 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 449
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039751940  450 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 499
Cdd:PHA03247  2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA smart00179
Calcium-binding EGF-like domain;
539-570 7.23e-10

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.95  E-value: 7.23e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039751940  539 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 570
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 500-536 8.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039751940 500 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 536
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 132-499 4.48e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.27  E-value: 4.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  132 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 211
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  212 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPrvtsvqmsTAISAIAliPSNQTANPk 291
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRR--------AARPTVG--SLTSLADP- 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  292 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 369
Cdd:PHA03247  2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  370 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 449
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039751940  450 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 499
Cdd:PHA03247  2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA smart00179
Calcium-binding EGF-like domain;
539-570 7.23e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.95  E-value: 7.23e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039751940  539 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 570
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 539-571 6.64e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 6.64e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1039751940 539 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 571
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
539-568 6.14e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 49.16  E-value: 6.14e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1039751940 539 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 568
Cdd:pfam07645   1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 500-536 8.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039751940 500 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 536
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 243-493 1.97e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 243 YSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTA-ISAIALIPSNQTANPKNQStPQQEKPITEAKSPSLVSPptdsTKAV 321
Cdd:pfam05109 439 FAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSP----TSAV 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 322 TVSLPPGAPWSPALTG---FSTGPALPATSTSLA---------QMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAVVV 389
Cdd:pfam05109 514 TTPTPNATSPTPAVTTptpNATSPTLGKTSPTSAvttptpnatSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSP 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 390 HTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERttelgraeessPSHFLTPSSPQTTDV 469
Cdd:pfam05109 594 TVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLR-----------PSSISETLSPSTSDN 662

                         250       260
                  ....*....|....*....|....*.
gi 1039751940 470 STAEM--LTSRYITFAAQSTSQSPTA 493
Cdd:pfam05109 663 STSHMplLTSAHPTGGENITQVTPAS 688
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 503-535 3.04e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 3.04e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039751940 503 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 535
Cdd:pfam00008   1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
500-536 6.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039751940  500 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 536
Cdd:smart00179   2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
 
Name Accession Description Interval E-value
PHA03247 PHA03247
large tegument protein UL36; Provisional
 132-499 4.48e-11

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 67.27  E-value: 4.48e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  132 PSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSAL 211
Cdd:PHA03247  2556 PPAAPPAAPDRSVPPPRPAPRPSEPAVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDP-PPPSPSPA 2634

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  212 PSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTlvPHRPREPrvtsvqmsTAISAIAliPSNQTANPk 291
Cdd:PHA03247  2635 ANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSP--PQRPRRR--------AARPTVG--SLTSLADP- 2701

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  292 nqstPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAqmSPALTSAMPQTT--HSP 369
Cdd:PHA03247  2702 ----PPPPPTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPA--RPPTTAGPPAPAppAAP 2775

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  370 VTSPSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGR 449
Cdd:PHA03247  2776 AAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGS 2855

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|
gi 1039751940  450 AEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPTALPPLTP 499
Cdd:PHA03247  2856 VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLARPAVSRSTESFALPPDQP 2905
EGF_CA smart00179
Calcium-binding EGF-like domain;
539-570 7.23e-10

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 54.95  E-value: 7.23e-10
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039751940  539 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQ 570
Cdd:smart00179   1 DIDECASgNPCQNGGTCVNTVGSYRCECPPGYT 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 539-571 6.64e-09

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 52.25  E-value: 6.64e-09
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1039751940 539 DVNECLS-SPCPPLATCNNTQGSFTCRCPVGYQL 571
Cdd:cd00054     1 DIDECASgNPCQNGGTCVNTVGSYRCSCPPGYTG 34
EGF_CA pfam07645
Calcium-binding EGF domain;
539-568 6.14e-08

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 49.16  E-value: 6.14e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1039751940 539 DVNECLSSP--CPPLATCNNTQGSFTCRCPVG 568
Cdd:pfam07645   1 DVDECATGThnCPANTVCVNTIGSFECRCPDG 32
PHA03247 PHA03247
large tegument protein UL36; Provisional
 145-477 1.02e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.02  E-value: 1.02e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  145 DDDEPAQSSTESP--VLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSRVPSTQPSPSqPQPFSSALP------STRS 216
Cdd:PHA03247  2652 PRDDPAPGRVSRPrrARRLGRAAQASSPPQRPRRRAARPTVGSLTSLADPPPPPPTPEPA-PHALVSATPlppgpaAARQ 2730

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  217 PGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTF--PHPSSTLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKNQS 294
Cdd:PHA03247  2731 ASPALPAAPAPPAVPAGPATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAA 2810

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  295 TPQQEKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWSPALTGFSTGPALPATSTSLAQMSPALTSAMPQTTHS----PV 370
Cdd:PHA03247  2811 VLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRSPAAKPAAPARPPVRrlarPA 2890

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  371 TSPSTLSHveALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAITTEGnREHTDPTTQPIPLTTSTTSAGERTTELG-- 448
Cdd:PHA03247  2891 VSRSTESF--ALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPP-RPQPPLAPTTDPAGAGEPSGAVPQPWLGal 2967

                          330       340       350
                   ....*....|....*....|....*....|....*....
gi 1039751940  449 ----------RAEESSPSHFLTPSSPQTTDVSTAEMLTS 477
Cdd:PHA03247  2968 vpgrvavprfRVPQPAPSREAPASSTPPLTGHSLSRVSS 3006
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 542-573 7.68e-06

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 43.23  E-value: 7.68e-06
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039751940 542 EC-LSSPCPPLATCNNTQGSFTCRCPVGYQLEK 573
Cdd:cd00053     1 ECaASNPCSNGGTCVNTPGSYRCVCPPGYTGDR 33
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 500-536 8.32e-06

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 43.39  E-value: 8.32e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1039751940 500 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQGENC 536
Cdd:cd00054     2 IDECaSGNPCQNGGTCV-NTVG-SYRCSCPPGYTGRNC 37
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 243-493 1.97e-05

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 48.37  E-value: 1.97e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 243 YSVSQTTFPHPSSTLVPHRPREPRVTSVQMSTA-ISAIALIPSNQTANPKNQStPQQEKPITEAKSPSLVSPptdsTKAV 321
Cdd:pfam05109 439 FAAPNTTTGLPSSTHVPTNLTAPASTGPTVSTAdVTSPTPAGTTSGASPVTPS-PSPRDNGTESKAPDMTSP----TSAV 513

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 322 TVSLPPGAPWSPALTG---FSTGPALPATSTSLA---------QMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAVVV 389
Cdd:pfam05109 514 TTPTPNATSPTPAVTTptpNATSPTLGKTSPTSAvttptpnatSPTPAVTTPTPNATIPTLGKTSPTSAVTTPTPNATSP 593

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 390 HTTPKKPHLPTNPEILVPHISTEGAITTEGNREHTDPTTQPIPLTTSTTSAGERttelgraeessPSHFLTPSSPQTTDV 469
Cdd:pfam05109 594 TVGETSPQANTTNHTLGGTSSTPVVTSPPKNATSAVTTGQHNITSSSTSSMSLR-----------PSSISETLSPSTSDN 662

                         250       260
                  ....*....|....*....|....*.
gi 1039751940 470 STAEM--LTSRYITFAAQSTSQSPTA 493
Cdd:pfam05109 663 STSHMplLTSAHPTGGENITQVTPAS 688
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 503-535 3.04e-05

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 41.60  E-value: 3.04e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1039751940 503 CTVNPCLHDGKCIVdlTGRGYRCVCPPAWQGEN 535
Cdd:pfam00008   1 CAPNPCSNGGTCVD--TPGGYTCICPEGYTGKR 31
EGF_3 pfam12947
EGF domain; This family includes a variety of EGF-like domain homologs. This family includes ...
 547-570 3.43e-05

EGF domain; This family includes a variety of EGF-like domain homologs. This family includes the C-terminal domain of the malaria parasite MSP1 protein.


Pssm-ID: 463759 [Multi-domain]  Cd Length: 36  Bit Score: 41.43  E-value: 3.43e-05
                          10        20
                  ....*....|....*....|....
gi 1039751940 547 PCPPLATCNNTQGSFTCRCPVGYQ 570
Cdd:pfam12947   7 GCHPNATCTNTGGSFTCTCNDGYT 30
DUF5585 pfam17823
Family of unknown function (DUF5585); This is a family of unknown function found in chordata.
 149-474 5.33e-04

Family of unknown function (DUF5585); This is a family of unknown function found in chordata.


Pssm-ID: 465521 [Multi-domain]  Cd Length: 506  Bit Score: 43.41  E-value: 5.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 149 PAQSSTESPVLHTSNLPTytsTVNMPNTLVLDTGTKPVEDPSDSRVPST------QPSPSQPQPFSSALPSTRSPGSTSE 222
Cdd:pfam17823 115 LAAAASSSPSSAAQSLPA---AIAALPSEAFSAPRAAACRANASAAPRAaiaaasAPHAASPAPRTAASSTTAASSTTAA 191

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 223 TTTSSPSPSPISLLVSTLAPYSVSQTTFPHPS----------STLVPHRPREPRVTSVQMSTAISAIALIPSNQTANPKN 292
Cdd:pfam17823 192 SSAPTTAASSAPATLTPARGISTAATATGHPAagtalaavgnSSPAAGTVTAAVGTVTPAALATLAAAAGTVASAAGTIN 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 293 QSTPQQEKPiteakspslvsPPTDSTKAVTVSLPPGAPwspaltgfsTGPALPATSTSLAQMSPALTSAMPQTTHSPVTS 372
Cdd:pfam17823 272 MGDPHARRL-----------SPAKHMPSDTMARNPAAP---------MGAQAQGPIIQVSTDQPVHNTAGEPTPSPSNTT 331

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 373 PSTLSHVEALTSGAVVVHTTPKKPHLPTNPEILVPHISTEGAIttegnrEHTDPTTQPIPLTTSTTSAGE---RTTELGR 449
Cdd:pfam17823 332 LEPNTPKSVASTNLAVVTTTKAQAKEPSASPVPVLHTSMIPEV------EATSPTTQPSPLLPTQGAAGPgilLAPEQVA 405

                         330       340
                  ....*....|....*....|....*
gi 1039751940 450 AEESSPSHFLTPSSPQTTDVSTAEM 474
Cdd:pfam17823 406 TEATAGTASAGPTPRSSGDPKTLAM 430
EGF_CA smart00179
Calcium-binding EGF-like domain;
500-536 6.50e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 38.00  E-value: 6.50e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1039751940  500 VNSC-TVNPCLHDGKCIvDLTGrGYRCVCPPAWQ-GENC 536
Cdd:smart00179   2 IDECaSGNPCQNGGTCV-NTVG-SYRCECPPGYTdGRNC 38
EGF smart00181
Epidermal growth factor-like domain;
542-573 7.05e-04

Epidermal growth factor-like domain;


Pssm-ID: 214544  Cd Length: 35  Bit Score: 37.88  E-value: 7.05e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 1039751940  542 ECLS-SPCPPlATCNNTQGSFTCRCPVGYQLEK 573
Cdd:smart00181   1 ECASgGPCSN-GTCINTPGSYTCSCPPGYTGDK 32
PLN03209 PLN03209
translocon at the inner envelope of chloroplast subunit 62; Provisional
 192-437 1.22e-03

translocon at the inner envelope of chloroplast subunit 62; Provisional


Pssm-ID: 178748 [Multi-domain]  Cd Length: 576  Bit Score: 42.61  E-value: 1.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 192 SRVPSTQPSPSQPQPFS--SALPSTRSPGSTSETTTSSPSPSPISLLVSTLAPYSVSQTTFPHPSSTLVPHRPREPRVTS 269
Cdd:PLN03209  321 AKIPSQRVPPKESDAADgpKPVPTKPVTPEAPSPPIEEEPPQPKAVVPRPLSPYTAYEDLKPPTSPIPTPPSSSPASSKS 400

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 270 VQMSTAISAIALIPSNQTANPKNQSTP-----QQEKPIT------EAKSPSLVSPPTDSTKAVTVSLPPGAPWSPaltgf 338
Cdd:PLN03209  401 VDAVAKPAEPDVVPSPGSASNVPEVEPaqveaKKTRPLSpyaryeDLKPPTSPSPTAPTGVSPSVSSTSSVPAVP----- 475

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 339 STGPALPATSTSL---AQMSPaLTSAMPQTTHSPVTSPSTLShvealtsgavvvhTTPKKPHLPTNPEILVPHISTEGAI 415
Cdd:PLN03209  476 DTAPATAATDAAApppANMRP-LSPYAVYDDLKPPTSPSPAA-------------PVGKVAPSSTNEVVKVGNSAPPTAL 541

                         250       260
                  ....*....|....*....|..
gi 1039751940 416 TTEGNreHTDPttQPIPLTTST 437
Cdd:PLN03209  542 ADEQH--HAQP--KPRPLSPYT 559
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 543-569 1.45e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 36.98  E-value: 1.45e-03
                          10        20
                  ....*....|....*....|....*..
gi 1039751940 543 CLSSPCPPLATCNNTQGSFTCRCPVGY 569
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGY 27
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 506-536 1.78e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 36.69  E-value: 1.78e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1039751940 506 NPCLHDGKCIVdlTGRGYRCVCPPAWQGE-NC 536
Cdd:cd00053     6 NPCSNGGTCVN--TPGSYRCVCPPGYTGDrSC 35
PHA03247 PHA03247
large tegument protein UL36; Provisional
 253-550 2.41e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 2.41e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  253 PSSTLVPhRPREPRVTSVQMSTAIsaialipsnqtanPKNQSTPQqeKPITEAKSPSLVSPPTDSTKAVTVSLPPGAPWS 332
Cdd:PHA03247  2569 PPPRPAP-RPSEPAVTSRARRPDA-------------PPQSARPR--APVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS 2632

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  333 PALTGFSTGPALPATSTSLAQMSPALTSAMPqttHSPVTSPSTLSHVEALTSGavvvhttPKKPHLPtnpeilvphiSTE 412
Cdd:PHA03247  2633 PAANEPDPHPPPTVPPPERPRDDPAPGRVSR---PRRARRLGRAAQASSPPQR-------PRRRAAR----------PTV 2692

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  413 GAITTEGNREHTDPTTQPIPltTSTTSAGERTTELGRAEESSPSHFLTPSSPQTTDVSTAEMLTSRYITFAAQSTSQSPT 492
Cdd:PHA03247  2693 GSLTSLADPPPPPPTPEPAP--HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPA 2770

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940  493 --ALPPLTPVNSCTVNPCLHDGKCIVDLTGRGYRCVCPPAWQGENCSVDVNECLSSPCPP 550
Cdd:PHA03247  2771 ppAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPP 2830
EB pfam01683
EB module; This domain has no known function. It is found in several C. elegans proteins. The ...
 503-576 3.08e-03

EB module; This domain has no known function. It is found in several C. elegans proteins. The domain contains 8 conserved cysteines that probably form four disulphide bridges. This domain is found associated with kunitz domains pfam00014.


Pssm-ID: 460294  Cd Length: 52  Bit Score: 36.64  E-value: 3.08e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1039751940 503 CTVNPCLHDGKCIvdltgrgyrcvcPPAWQGENCSVDVNeclsspCPPLATCNNTqgsfTCRCPVGYQLEKGIC 576
Cdd:pfam01683   1 CPPGQVLVNGQCV------------PKVAPGESCEADEQ------CPGGSVCVNG----VCQCPPGFTPVNGRC 52
Herpes_BLLF1 pfam05109
Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 ...
 131-495 8.24e-03

Herpes virus major outer envelope glycoprotein (BLLF1); This family consists of the BLLF1 viral late glycoprotein, also termed gp350/220. It is the most abundantly expressed glycoprotein in the viral envelope of the Herpesviruses and is the major antigen responsible for stimulating the production of neutralising antibodies in vivo.


Pssm-ID: 282904 [Multi-domain]  Cd Length: 886  Bit Score: 39.90  E-value: 8.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 131 SPSQAQPKQSSMSSDDDEPAQSSTESPVLHTSNLPTYTSTVNMPNTLVLDTGTKPVEDPSDSrvpSTQPSPSQPQPFSSA 210
Cdd:pfam05109 460 APASTGPTVSTADVTSPTPAGTTSGASPVTPSPSPRDNGTESKAPDMTSPTSAVTTPTPNAT---SPTPAVTTPTPNATS 536

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 211 LPSTRSPGSTSetttsspspspisllVSTLAPYSVSQT---TFPHPSSTlvphrpreprVTSVQMSTAISAIALIPSNQT 287
Cdd:pfam05109 537 PTLGKTSPTSA---------------VTTPTPNATSPTpavTTPTPNAT----------IPTLGKTSPTSAVTTPTPNAT 591

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 288 ANPKNQSTPQQEKPI----TEAKSPSLVSPPTDSTKAVT-------------VSLPPGA---PWSPALTGFSTG------ 341
Cdd:pfam05109 592 SPTVGETSPQANTTNhtlgGTSSTPVVTSPPKNATSAVTtgqhnitssstssMSLRPSSiseTLSPSTSDNSTShmpllt 671

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 342 PALPATSTSLAQMSPALTSAMPQTTHSPVTSPSTLSHVEALTSGAV--------VVHTTPKK----PHLPTNPEILVPHI 409
Cdd:pfam05109 672 SAHPTGGENITQVTPASTSTHHVSTSSPAPRPGTTSQASGPGNSSTstkpgevnVTKGTPPKnatsPQAPSGQKTAVPTV 751

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039751940 410 -STEGAITTEGNREHTDPTTQPIPLTTSTTSAGERTTELGRAEESSpshFLTPSSpqTTDVSTAEMLTSRYITFAAQSTS 488
Cdd:pfam05109 752 tSTGGKANSTTGGKHTTGHGARTSTEPTTDYGGDSTTPRTRYNATT---YLPPST--SSKLRPRWTFTSPPVTTAQATVP 826


                  ....*..
gi 1039751940 489 QSPTALP 495
Cdd:pfam05109 827 VPPTSQP 833
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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