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Conserved domains on  [gi|1039758859|ref|XP_017170630|]
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voltage-dependent N-type calcium channel subunit alpha-1B isoform X4 [Mus musculus]

Protein Classification

voltage-dependent calcium channel subunit alpha family protein( domain architecture ID 13634489)

voltage-dependent calcium channel subunit alpha family protein, similar to human P/Q-type calcium channel subunit alpha-1A

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1485-1732 2.35e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.95  E-value: 2.35e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1485 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1562
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1563 TDILVTEIaNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1642
Cdd:pfam00520   81 ISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1643 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1722
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228

                          250
                   ....*....|
gi 1039758859 1723 NFEYLTRDSS 1732
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 2.89e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.89e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859   94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039758859  330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 482-721 1.00e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 1.00e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 1039758859  718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1161-1395 1.19e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


:

Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.19e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1161 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1240
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1241 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1320
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039758859 1321 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1395
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1805-1882 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


:

Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039758859 1805 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1882
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1741-1794 1.32e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


:

Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.14  E-value: 1.32e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039758859 1741 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1794
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 super family cl33723
transcriptional regulator ICP4; Provisional
 1957-2324 6.10e-12

transcriptional regulator ICP4; Provisional


The actual alignment was detected with superfamily member PHA03307:

Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 6.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1957 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2036
Cdd:PHA03307    68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2037 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2110
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2111 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2189
Cdd:PHA03307   223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2190 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2263
Cdd:PHA03307   298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039758859 2264 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2324
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
Granin super family cl27033
Granin (chromogranin or secretogranin);
936-1041 3.48e-03

Granin (chromogranin or secretogranin);


The actual alignment was detected with superfamily member pfam01271:

Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  936 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1010
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039758859 1011 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1041
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1485-1732 2.35e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.95  E-value: 2.35e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1485 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1562
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1563 TDILVTEIaNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1642
Cdd:pfam00520   81 ISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1643 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1722
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228

                          250
                   ....*....|
gi 1039758859 1723 NFEYLTRDSS 1732
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 2.89e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.89e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859   94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039758859  330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 482-721 1.00e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 1.00e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 1039758859  718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1161-1395 1.19e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.19e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1161 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1240
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1241 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1320
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039758859 1321 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1395
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1805-1882 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039758859 1805 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1882
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1741-1794 1.32e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.14  E-value: 1.32e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039758859 1741 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1794
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1957-2324 6.10e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 6.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1957 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2036
Cdd:PHA03307    68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2037 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2110
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2111 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2189
Cdd:PHA03307   223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2190 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2263
Cdd:PHA03307   298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039758859 2264 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2324
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1860-1890 1.69e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 57.62  E-value: 1.69e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1039758859  1860 DEMTVGKVYAALMIFDFYKQNKTTRDQTHQA 1890
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
 2073-2341 1.08e-04

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 47.74  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2073 DKKQRSLEKG-PSLSVDPEGAPSTAAGPGlpHGEGSTACRrDRKQERGRSQERRQPSSSSSEkqrfySCDRFGSREP--- 2148
Cdd:pfam04388  259 DPKEASCEEGySSSAADPTASPYTDQQSS--YGSSTSTPS-STPRLQLSSSSGTSPPYLSPP-----SIRLKTDSFPlws 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2149 PQLMPSLSSHPTSPTaaLEPAPHPQGSGSvngSPLMSTSGASTPGRGGRRQLPQTPLT-PRPSITYKTANSSPVHFAEGQ 2227
Cdd:pfam04388  331 PSSVCGMTTPPTSPG--MVPTTPSELSPS---SSHLSSRGSSPPEAAGEATPETTPAKdSPYLKQPPPLSDSHVHRALPA 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2228 SGLPAfSPGRLSRGLSEHNALLQKEplsQPLAPGSRIGSDPyLGQRldSEASAHTLP----EDTLTFEEAVATNSGRSSR 2303
Cdd:pfam04388  406 SSQPS-SPPRKDGRSQSSFPPLSKQ---APTNPNSRGLLEP-PGDK--SSVTLSELPdfikDLALSSEDSVEGAEEEAAI 478

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1039758859 2304 TSYVSSLTsQSHPLRRVPNG------YHCTLGLSTGVRARHSYH 2341
Cdd:pfam04388  479 SQELSEIT-TEKNETDCSRGgldmpfSRTMESLAGSQRSRNRIA 521
Granin pfam01271
Granin (chromogranin or secretogranin);
936-1041 3.48e-03

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  936 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1010
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039758859 1011 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1041
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Name Accession Description Interval E-value
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1485-1732 2.35e-74

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 247.95  E-value: 2.35e-74
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1485 SPPFEYFIMAMIALNTVVLMMKFYDAPYE-YELMLKCLNIVFTSMFSMECILKIIAFGV-LNYFRDAWNVFDFVTVLGSI 1562
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEEpLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1563 TDILVTEIaNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIALDDD 1642
Cdd:pfam00520   81 ISLVLSSV-GSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTWE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1643 TSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLGnracdphanasECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMD 1722
Cdd:pfam00520  160 NPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTID-----------GKGEFWAYIYFVSFIILGGFLLLNLFIAVIID 228

                          250
                   ....*....|
gi 1039758859 1723 NFEYLTRDSS 1732
Cdd:pfam00520  229 NFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 94-367 2.89e-66

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 224.84  E-value: 2.89e-66
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859   94 WPPFEYMILATIIANCIVLALEQHLPDgdKTPMSERLDDTEPYFIGIFCFEAGIKIIALGFVFHkgsYLRNGWNVMDFVV 173
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQP--EEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVV 75

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  174 VLTGIL----ATAGTDFDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKF 249
Cdd:pfam00520   76 VLPSLIslvlSSVGSLSGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKL 155

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  250 HKacfpnstdtepvgdfpcgkdpparqcdgdtecreyWPGPNFGITNFDNILFAILTVFQCITMEGWTDILYNTNDAAGN 329
Cdd:pfam00520  156 KT-----------------------------------WENPDNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200

                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1039758859  330 TWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVE 367
Cdd:pfam00520  201 FWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELTERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 482-721 1.00e-55

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 194.41  E-value: 1.00e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  482 AQSFYWVVLCVVALNTLCVAMVHYNQPQ-RLTTALYFAEFVFLGLFLTEMSLKMYGLGP-RSYFRSSFNCFDFGVIVGSI 559
Cdd:pfam00520    1 SRYFELFILLLILLNTIFLALETYFQPEePLTTVLEILDYVFTGIFTLEMLLKIIAAGFkKRYFRSPWNILDFVVVLPSL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  560 FEVVWAAIKPGtsFGISVLRALRLLRIFKVTKYWNSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFQ 639
Cdd:pfam00520   81 ISLVLSSVGSL--SGLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFGGKLKTW 158

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  640 DE--TPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGgvskGMFSSFYFIVLTLFGNYTLLNVFLAIAVDNLANAQ 717
Cdd:pfam00520  159 ENpdNGRTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKG----EFWAYIYFVSFIILGGFLLLNLFIAVIIDNFQELT 234


                   ....
gi 1039758859  718 ELTK 721
Cdd:pfam00520  235 ERTE 238
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 1161-1395 1.19e-54

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 191.33  E-value: 1.19e-54
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1161 RYFEMVILVVIALSSIALAAEDPVRTDSFRNNALKYMDYIFTGVFTFEMVIKMIDLGLLLHpgaYFRDLWNILDFIVVSG 1240
Cdd:pfam00520    2 RYFELFILLLILLNTIFLALETYFQPEEPLTTVLEILDYVFTGIFTLEMLLKIIAAGFKKR---YFRSPWNILDFVVVLP 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1241 ALVAFAFSSFMGGSkgkdinTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLKNVLNILIVYMLFMFIFAVIAVQLFK 1320
Cdd:pfam00520   79 SLISLVLSSVGSLS------GLRVLRLLRLLRLLRLIRRLEGLRTLVNSLIRSLKSLGNLLLLLLLFLFIFAIIGYQLFG 152

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1039758859 1321 GKFfyctdeskelerdcrgqyldyeKEEVEAQPRqwkkyDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYE 1395
Cdd:pfam00520  153 GKL----------------------KTWENPDNG-----RTNFDNFPNAFLWLFQTMTTEGWGDIMYDTIDGKGE 200
Ca_chan_IQ pfam08763
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1805-1882 1.89e-41

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 462591  Cd Length: 77  Bit Score: 147.36  E-value: 1.89e-41
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1039758859 1805 TSTLMALIRTALEIKLAPAGtKQHQCDAELRKEISSVWANLPQKTLDLLVPPHKPDEMTVGKVYAALMIFDFYKQNKT 1882
Cdd:pfam08763    1 TATLFALIRTSLKIKLAPAG-EMDQADAELRKIIKKIWPRLSQKTLDLLVPPPSDDEMTVGKIYAALLIQDYYRQNKA 77
GPHH pfam16905
Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in ...
 1741-1794 1.32e-31

Voltage-dependent L-type calcium channel, IQ-associated; GPHH is a sequence motif found in this short domain on voltage-dependent L-type calcium channel proteins in eukaryotes. The domain is closely associated with the IQ-domain, pfam08763.


Pssm-ID: 465306  Cd Length: 54  Bit Score: 118.14  E-value: 1.32e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1039758859 1741 EFIRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMP 1794
Cdd:pfam16905    1 EFVRVWAEYDPAATGRISYQDMYELLRRISPPLGFGKKCPARVAYKRLVRMNMP 54
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 1957-2324 6.10e-12

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 71.74  E-value: 6.10e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1957 TQDALYEARAPLERGHSAEIPVGQSGTLAVdVQMQNMTLRGPDGePQPGLesqGRAASMPRLAAETQPAPNASPMKRSIS 2036
Cdd:PHA03307    68 PTGPPPGPGTEAPANESRSTPTWSLSTLAP-ASPAREGSPTPPG-PSSPD---PPPPTPPPASPPPSPAPDLSEMLRPVG 142

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2037 TLAPRPHGTQLCSTVLDRPPPS-QASHHHHHRCHRRRDKKQRSLEKGPS---LSVDPEGAPSTAAGPGLP--HGEGSTAC 2110
Cdd:PHA03307   143 SPGPPPAASPPAAGASPAAVASdAASSRQAALPLSSPEETARAPSSPPAeppPSTPPAAASPRPPRRSSPisASASSPAP 222

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2111 RRDRKQERGRSQERRqpSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAPHPQGSGSV-NGSPLMSTSGA 2189
Cdd:PHA03307   223 APGRSAADDAGASSS--DSSSSESSG---CGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPGPAsSSSSPRERSPS 297

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2190 STPGRGGRRQLPQTPLT------PRPSITYKTANSSPVhfAEGQSGLPAFSPGRlSRGLSEHNALLQKEPLSQPLAPGSR 2263
Cdd:PHA03307   298 PSPSSPGSGPAPSSPRAssssssSRESSSSSTSSSSES--SRGAAVSPGPSPSR-SPSPSRPPPPADPSSPRKRPRPSRA 374

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1039758859 2264 IGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATNSGRSSRTSYVSSLTSqSHPLRRVPNGY 2324
Cdd:PHA03307   375 PSSPAASAGRPTRRRARAAVAGRARRRDATGRFPAGRPRPSPLDAGAAS-GAFYARYPLLT 434
PKD_channel pfam08016
Polycystin cation channel; This family contains the cation channel region from group II of ...
 1508-1725 3.30e-11

Polycystin cation channel; This family contains the cation channel region from group II of Transient receptor potential (TRP) channels, the TRPP subfamily, including PKD1, PKD2, PKD2L and mucolipin proteins.


Pssm-ID: 462341 [Multi-domain]  Cd Length: 225  Bit Score: 65.38  E-value: 3.30e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1508 YDAPYEYELMLkCLNI--VFTSMFSMECILKIIAFGvLNYFRDAWNVFDFVTVLGSIT--------DILVTEIANNFI-- 1575
Cdd:pfam08016    2 YVTNRSLFILL-CEIVfvVFFLYFVVEEILKIRKHR-PSYLRSVWNLLDLAIVILSVVlivlniyrDFLADRLIKSVEas 79

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1576 ---NLSFLRLFRAA----------------RLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGN 1636
Cdd:pfam08016   80 pvtFIDFDRVAQLDnlyriilaflvfltwlKLFKVLRFNKTMSLFTKTLSRAWKDLAGFALMFVIFFFAYAQFGYLLFGT 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1637 ialdddtsinRHNNFRTFLQALMLLFRsatgeawheIMLSCLGNRACDphanasECGSDFAYFYFVSFIFLCSFLMLNLF 1716
Cdd:pfam08016  160 ----------QAPNFSNFVKSILTLFR---------TILGDFGYNEIF------SGNRVLGPLLFLTFVFLVIFILLNLF 214


                   ....*....
gi 1039758859 1717 VAVIMDNFE 1725
Cdd:pfam08016  215 LAIINDSYV 223
Ca_chan_IQ smart01062
Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular ...
 1860-1890 1.69e-10

Voltage gated calcium channel IQ domain; Voltage gated calcium channels control cellular calcium entry in response to changes in membrane potential. The isoleucine-glutamine (IQ) motif in the voltage gated calcium channel IQ domain interacts with hydrophobic pockets of Ca2+/calmodulin. The interaction regulates two self-regulatory calcium dependent feedback mechanism, calcium dependent inactivation (CDI), and calcium-dependent facilitation (CDF).


Pssm-ID: 198130  Cd Length: 31  Bit Score: 57.62  E-value: 1.69e-10
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1039758859  1860 DEMTVGKVYAALMIFDFYKQNKTTRDQTHQA 1890
Cdd:smart01062    1 DELTVGKIYAAMLIQDYFRQFKSRKEQELLG 31
PHA03247 PHA03247
large tegument protein UL36; Provisional
 2000-2321 2.87e-08

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 59.57  E-value: 2.87e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2000 GEPQPGLESQGRAASMPRLAAETQPAPNasPMKRSISTLAPRP----HGTQLCSTVLDR-PPPSQASHHHHHRCHRRRDK 2074
Cdd:PHA03247  2549 GDPPPPLPPAAPPAAPDRSVPPPRPAPR--PSEPAVTSRARRPdappQSARPRAPVDDRgDPRGPAPPSPLPPDTHAPDP 2626

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2075 KQRSlekgPSLSVDPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSSSSEKQR-------FYSCDRFGSRE 2147
Cdd:PHA03247  2627 PPPS----PSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRrraarptVGSLTSLADPP 2702

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2148 PPQLMPSLSSHPTSPTAALEPAPHPQGSGS----VNGSPLMSTSGASTPG---RGGRRQLPQTPLTPRPSITYKTANSSP 2220
Cdd:PHA03247  2703 PPPPTPEPAPHALVSATPLPPGPAAARQASpalpAAPAPPAVPAGPATPGgpaRPARPPTTAGPPAPAPPAAPAAGPPRR 2782

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2221 VHFAEGQSGLPAFSPGRLSRGLSEHNALLQKEPLSQPLAPGSRIGSDPYLGQRLDSEASAHTLPEDTLTFEEAVATN--- 2297
Cdd:PHA03247  2783 LTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGgdv 2862

                          330       340
                   ....*....|....*....|....*
gi 1039758859 2298 SGRSSRTSYVSSLTSQSHP-LRRVP 2321
Cdd:PHA03247  2863 RRRPPSRSPAAKPAAPARPpVRRLA 2887
PHA03247 PHA03247
large tegument protein UL36; Provisional
 1996-2290 4.99e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 49.17  E-value: 4.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 1996 RGPDGEPQPGLESQGRAASMPRL-------------AAETQPAPNASPMKRSISTLAPRPHGTQLCSTVldRPPPSQASH 2062
Cdd:PHA03247  2773 AAPAAGPPRRLTRPAVASLSESReslpspwdpadppAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPP--PPGPPPPSL 2850

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2063 HHHHRCHRRRDKKQRslekGPSLSvdPEGAPSTAAGPGLPHGEGSTACRRDRKQERGRSQERRQPSSSSSEKQRFYSCDR 2142
Cdd:PHA03247  2851 PLGGSVAPGGDVRRR----PPSRS--PAAKPAAPARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPP 2924

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2143 FGSREPPQLMPslsshPTSPTAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGG--RRQLPQtpltPRPSITYKTANSSP 2220
Cdd:PHA03247  2925 PPPQPQPPPPP-----PPRPQPPLAPTTDPAGAGEPSGAVPQPWLGALVPGRVAvpRFRVPQ----PAPSREAPASSTPP 2995

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2221 VHfaegQSGLPAFSPGRLSRGLSEHNAllqKEPLS--QPLAP---------GSRIGSDPylgQRLDSEASAHTLPEDTLT 2289
Cdd:PHA03247  2996 LT----GHSLSRVSSWASSLALHEETD---PPPVSlkQTLWPpddtedsdaDSLFDSDS---ERSDLEALDPLPPEPHDP 3065


                   .
gi 1039758859 2290 F 2290
Cdd:PHA03247  3066 F 3066
Hamartin pfam04388
Hamartin protein; This family includes the hamartin protein which is thought to function as a ...
 2073-2341 1.08e-04

Hamartin protein; This family includes the hamartin protein which is thought to function as a tumour suppressor. The hamartin protein interacts with the tuberin protein pfam03542. Tuberous sclerosis complex (TSC) is an autosomal dominant disorder and is characterized by the presence of hamartomas in many organs, such as brain, skin, heart, lung, and kidney. It is caused by mutation either TSC1 or TSC2 tumour suppressor gene. TSC1 encodes a protein, hamartin, containing two coiled-coil regions, which have been shown to mediate binding to tuberin. The TSC2 gene codes for tuberin pfam03542. These two proteins function within the same pathway(s) regulating cell cycle, cell growth, adhesion, and vesicular trafficking.


Pssm-ID: 461287 [Multi-domain]  Cd Length: 730  Bit Score: 47.74  E-value: 1.08e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2073 DKKQRSLEKG-PSLSVDPEGAPSTAAGPGlpHGEGSTACRrDRKQERGRSQERRQPSSSSSEkqrfySCDRFGSREP--- 2148
Cdd:pfam04388  259 DPKEASCEEGySSSAADPTASPYTDQQSS--YGSSTSTPS-STPRLQLSSSSGTSPPYLSPP-----SIRLKTDSFPlws 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2149 PQLMPSLSSHPTSPTaaLEPAPHPQGSGSvngSPLMSTSGASTPGRGGRRQLPQTPLT-PRPSITYKTANSSPVHFAEGQ 2227
Cdd:pfam04388  331 PSSVCGMTTPPTSPG--MVPTTPSELSPS---SSHLSSRGSSPPEAAGEATPETTPAKdSPYLKQPPPLSDSHVHRALPA 405

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2228 SGLPAfSPGRLSRGLSEHNALLQKEplsQPLAPGSRIGSDPyLGQRldSEASAHTLP----EDTLTFEEAVATNSGRSSR 2303
Cdd:pfam04388  406 SSQPS-SPPRKDGRSQSSFPPLSKQ---APTNPNSRGLLEP-PGDK--SSVTLSELPdfikDLALSSEDSVEGAEEEAAI 478

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1039758859 2304 TSYVSSLTsQSHPLRRVPNG------YHCTLGLSTGVRARHSYH 2341
Cdd:pfam04388  479 SQELSEIT-TEKNETDCSRGgldmpfSRTMESLAGSQRSRNRIA 521
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 2024-2245 1.98e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 47.09  E-value: 1.98e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2024 PAPNASPMKRSISTLAPRPHGTQLCSTVLDRPPPSQASHHHHHRCHRRRDKKQRSLEKGPSLSVDPEGAPStAAGPGLPh 2103
Cdd:PHA03307   761 PSLVPAKLAEALALLEPAEPQRGAGSSPPVRAEAAFRRPGRLRRSGPAADAASRTASKRKSRSHTPDGGSE-SSGPARP- 838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2104 gEGSTACRRDRKQERGRSQERRQPSSSSSEKQRfysCDRFGSREPPQLMPSLSSHPTSPTAALEPAP----HPQGSGSVN 2179
Cdd:PHA03307   839 -PGAAARPPPARSSESSKSKPAAAGGRARGKNG---RRRPRPPEPRARPGAAAPPKAAAAAPPAGAPaprpRPAPRVKLG 914

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1039758859 2180 GSPLmstsGASTPGRGGRRQLPQTPLTPRPSityktansspvhfaegQSGLPAFSPGRLSRGLSEH 2245
Cdd:PHA03307   915 PMPP----GGPDPRGGFRRVPPGDLHTPAPS----------------AAALAAYCPPEVVAELVDH 960
CLEC16A_C pfam19439
CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A ...
 2083-2301 3.48e-04

CLEC16A C-terminal; This is the C-terminal domain of C-type lectin domain family 16, member A (CLEC16A, the Drosophila orthologue Ema and GOP-1 in C. elegans), an evolutionarily conserved endosomal membrane protein required for trafficking of fluid-phase and receptor-mediated endocytic cargos. It is required for mitophagy, autophagy and endosome maturation. This protein has been identified as a susceptibility gene for autoimmune diseases like type 1 diabetes, multiple sclerosis and adrenal dysfunction. This domain is also present in GFS9/TT9 (TRANSPARENT TESTA 9) a protein from Arabidopsis required for vacuolar development through membrane fusion at vacuoles and for membrane trafficking machinery and accumulation of flavonoids in the seed coat.


Pssm-ID: 466083  Cd Length: 762  Bit Score: 46.03  E-value: 3.48e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2083 PSLSVDPEGAPSTAAGPGLPHgegstacrrdrkqeRGRSQERRQPSSSSSEKQRFYSCDRFGSREPPQLMPSlssHPTSP 2162
Cdd:pfam19439  583 PSTEVLGFGQTSSASSQHLPF--------------RFYEQSRRGPSDPTVQRSVFASVDKVPGFAVAQCINQ---HSPSP 645

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859 2163 TAALEPAPHPQGSGSVNGSPLMSTSGASTPGRGGRrqlPQTPLTPRPSITYKTANSSPVHFAEGQSGLPAfspgrlsrgl 2242
Cdd:pfam19439  646 LSSPSPPSSSSGSGSTGRCDSVTASSTSTPSPSDD---GSTPEQPQLPDELAFLDSTPAVSKPGKSSASS---------- 712

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1039758859 2243 sehnallQKEPLSqpLAPGSRIGSDPYLGqrLDSEASAHTLPEDTLTFEEAVATNSGRS 2301
Cdd:pfam19439  713 -------ETEPAA--LAPSLTPAPQPTIS--LLSDDSTDALSVESLTLLPPADSPHLRS 760
Granin pfam01271
Granin (chromogranin or secretogranin);
936-1041 3.48e-03

Granin (chromogranin or secretogranin);


Pssm-ID: 279595 [Multi-domain]  Cd Length: 584  Bit Score: 42.71  E-value: 3.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1039758859  936 GSPEEATEREP---RRHRAHRHAQDSSKEGTAPVlvpkGERRARHRGPRtgPREAENNEEPTRRHRARHKVPPT--LQPP 1010
Cdd:pfam01271  264 GLEEEASEEEEeygEESRGLSAVQTYLLRLVNAR----GRGRSEKRAER--ERSEESEEEELKRASPYEELEITanLQIP 337

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1039758859 1011 ERE-------AAEKESNAVEGDK--ETRNHQPKEPHCDLE 1041
Cdd:pfam01271  338 PSEeermlkkAGRSPRGRVDEAGalEALEALEEKRKLDLD 377
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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