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Conserved domains on  [gi|1034625559|ref|XP_016883474|]
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transcription factor COE4 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IPT super family cl15674
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 23-107 1.32e-51

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


The actual alignment was detected with superfamily member cd01175:

Pssm-ID: 472823  Cd Length: 85  Bit Score: 166.67  E-value: 1.32e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 102
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 1034625559 103 FVYTA 107
Cdd:cd01175    81 FVYTA 85
COE1_HLH super family cl24851
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 108-151 3.45e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


The actual alignment was detected with superfamily member pfam16423:

Pssm-ID: 406751  Cd Length: 44  Bit Score: 93.70  E-value: 3.45e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034625559 108 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 151
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 175-340 1.54e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  175 TPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGGYG 254
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASL 2791

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  255 APGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlRPP 330
Cdd:PHA03247  2792 SESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--RPP 2867

                          170
                   ....*....|
gi 1034625559  331 SSPPQACPRA 340
Cdd:PHA03247  2868 SRSPAAKPAA 2877
 
Name Accession Description Interval E-value
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 23-107 1.32e-51

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 166.67  E-value: 1.32e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 102
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 1034625559 103 FVYTA 107
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 108-151 3.45e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 93.70  E-value: 3.45e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034625559 108 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 151
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 23-105 1.30e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 68.63  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNF---FDGLQVVFGNVLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGc 99
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 1034625559 100 PGRFVY 105
Cdd:pfam01833  79 PLTFTY 84
IPT smart00429
ig-like, plexins, transcription factors;
23-87 3.40e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 3.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034625559   23 PCIKAISPGEGWTTGGATVIVIGDNFFDGlQVVFGNVLVWSELIT-----PHAIRVQTPPRH-IPGVVEVT 87
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVR 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 175-340 1.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  175 TPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGGYG 254
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASL 2791

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  255 APGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlRPP 330
Cdd:PHA03247  2792 SESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--RPP 2867

                          170
                   ....*....|
gi 1034625559  331 SSPPQACPRA 340
Cdd:PHA03247  2868 SRSPAAKPAA 2877
 
Name Accession Description Interval E-value
IPT_COE cd01175
IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing ...
 23-107 1.32e-51

IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved in the regulation of the early stages of B-cell differentiation, Drosophila collier is a regulator of the head patterning, and a related protein in Xenopus is involved in primary neurogenesis. All COE family members have a well conserved DNA binding domain that contains an atypical Zn finger motif. The function of the IPT domain is unknown.


Pssm-ID: 238580  Cd Length: 85  Bit Score: 166.67  E-value: 1.32e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNFFDGLQVVFGNVLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGCPGR 102
Cdd:cd01175     1 PCIKAISPSEGWTTGGATVIIIGDNFFDGLQVVFGTMLVWSELITPHAIRVQTPPRHIPGVVEVTLSYKSKQFCKGTPGR 80


                  ....*
gi 1034625559 103 FVYTA 107
Cdd:cd01175    81 FVYTA 85
COE1_HLH pfam16423
Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of ...
 108-151 3.45e-24

Transcription factor COE1 helix-loop-helix domain; This is the helix-loop-helix domain of transcription factor COE1. It is responsible for dimerization.


Pssm-ID: 406751  Cd Length: 44  Bit Score: 93.70  E-value: 3.45e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034625559 108 LNEPTIDYGFQRLQKVIPRHPGDPERLPKEVLLKRAADLAEALY 151
Cdd:pfam16423   1 LNEPTIDYGFQRLQKLVPRHPGDPERLPKEIILKRAADLAEALY 44
TIG pfam01833
IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These ...
 23-105 1.30e-14

IPT/TIG domain; This family consists of a domain that has an immunoglobulin like fold. These domains are found in cell surface receptors such as Met and Ron as well as in intracellular transcription factors where it is involved in DNA binding. CAUTION: This family does not currently recognize a significant number of members.


Pssm-ID: 460355 [Multi-domain]  Cd Length: 84  Bit Score: 68.63  E-value: 1.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNF---FDGLQVVFGNVLVWSELITPHAIRVQTPPrHIPGVVEVTLSYKSKQFCKGc 99
Cdd:pfam01833   1 PVITSISPSSGPASGGTTITITGSNFgtdSSDLKVTIGGTPCTVISVSSTTIVCTTPP-GTSGLVNVSVTVGGGGISSS- 78


                  ....*.
gi 1034625559 100 PGRFVY 105
Cdd:pfam01833  79 PLTFTY 84
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 23-106 2.41e-08

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 50.92  E-value: 2.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  23 PCIKAISPGEGWTTGGATVIVIGDNFFDG--LQVVFGNVLVWSEL-ITPHAIRVQTPPRHI--PGVVEVTLSYKSkQFCK 97
Cdd:cd00102     1 PVITSISPSSGPVSGGTEVTITGSNFGSGsnLRVTFGGGVPCSVLsVSSTAIVCTTPPYANpgPGPVEVTVDRGN-GGIT 79


                  ....*....
gi 1034625559  98 GCPGRFVYT 106
Cdd:cd00102    80 SSPLTFTYV 88
IPT smart00429
ig-like, plexins, transcription factors;
23-87 3.40e-05

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 42.02  E-value: 3.40e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034625559   23 PCIKAISPGEGWTTGGATVIVIGDNFFDGlQVVFGNVLVWSELIT-----PHAIRVQTPPRH-IPGVVEVT 87
Cdd:smart00429   2 PVITRISPTSGPVSGGTEITLCGKNLKSI-SVVFVEVGVGEAPCTfspssSTAIVCKTPPYHnIPGSVPVR 71
PHA03247 PHA03247
large tegument protein UL36; Provisional
 175-340 1.54e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.54e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  175 TPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPsPGSQQSGYGGGLGAGLGGYG 254
Cdd:PHA03247  2713 HALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAP-PAAPAAGPPRRLTRPAVASL 2791

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  255 APGVAGLGVPGSPS----FLNGSTATSPFAIMPSSPplAAASSMSLPAAAPTTSVFSFSPVNMISAVKQRSAFAPvlRPP 330
Cdd:PHA03247  2792 SESRESLPSPWDPAdppaAVLAPAAALPPAASPAGP--LPPPTSAQPTAPPPPPGPPPPSLPLGGSVAPGGDVRR--RPP 2867

                          170
                   ....*....|
gi 1034625559  331 SSPPQACPRA 340
Cdd:PHA03247  2868 SRSPAAKPAA 2877
PHA03247 PHA03247
large tegument protein UL36; Provisional
 163-346 3.09e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.92  E-value: 3.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  163 KRAADVAEALYSTPRAPGPLAPLAPSHPHPAVVGINAFSSPLAIAVGDATPGPEPGYARSCSSASPRGFAPSPGSQQSGY 242
Cdd:PHA03247  2759 RPPTTAGPPAPAPPAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTA 2838

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034625559  243 GGGLGAGLGGYGAPGvaGLGVPGSPSFLNGSTATSPfaIMPSSPPLAAASSMSLPAAAPTTSVFSFSPVNMisavkqrsa 322
Cdd:PHA03247  2839 PPPPPGPPPPSLPLG--GSVAPGGDVRRRPPSRSPA--AKPAAPARPPVRRLARPAVSRSTESFALPPDQP--------- 2905

                          170       180
                   ....*....|....*....|....
gi 1034625559  323 faPVLRPPSSPPQACPRAHGEGLP 346
Cdd:PHA03247  2906 --ERPPQPQAPPPPQPQPQPPPPP 2927
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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