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Conserved domains on  [gi|1034581752|ref|XP_016875495|]
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protein O-mannosyl-transferase TMTC1 isoform X5 [Homo sapiens]

Protein Classification

DUF1736 and TPR domain-containing protein( domain architecture ID 12091460)

DUF1736 and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMTC_DUF1736 pfam08409
Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in ...
 353-427 8.02e-35

Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3.


:

Pssm-ID: 462468  Cd Length: 75  Bit Score: 126.49  E-value: 8.02e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 353 GGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMA 427
Cdd:pfam08409   1 GGQLPVFSASDNPAAFSPSLLTRTLTYNYLPALNAWLLLFPSWLCFDWSMGSIPLIESLSDPRNLATLAFYGALA 75
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
531-660 4.80e-28

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 113.18  E-value: 4.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG0457    28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAlqaLGRYEEALEDYDKALELDP 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG0457   108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRY 160
 
Name Accession Description Interval E-value
TMTC_DUF1736 pfam08409
Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in ...
 353-427 8.02e-35

Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3.


Pssm-ID: 462468  Cd Length: 75  Bit Score: 126.49  E-value: 8.02e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 353 GGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMA 427
Cdd:pfam08409   1 GGQLPVFSASDNPAAFSPSLLTRTLTYNYLPALNAWLLLFPSWLCFDWSMGSIPLIESLSDPRNLATLAFYGALA 75
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
531-660 4.80e-28

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 113.18  E-value: 4.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG0457    28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAlqaLGRYEEALEDYDKALELDP 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG0457   108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRY 160
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 519-651 3.59e-14

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 76.28  E-value: 3.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 519 KTVKQNEIWLSREslfrsgvqtlPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG--TLTRDTAEAK 596
Cdd:TIGR02917 754 EAVKTLEAWLKTH----------PNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAwlYLELKDPRAL 823

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 597 MYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLA 651
Cdd:TIGR02917 824 EYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLA 878
TPR_12 pfam13424
Tetratricopeptide repeat;
545-608 4.66e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 4.66e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLY--------PRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQ 608
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLelgRYEEALELLERALALAEK 77
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 552-620 9.45e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.93  E-value: 9.45e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 552 ANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHN-RALFNLGNLL 620
Cdd:cd24142     7 AEELLDQGNFELALKFLQRALELEPNNVEALELLGEIlleLGDVEEAREVLLRAIELDPDGGyEKYLYLGQLS 79
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 558-657 6.03e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 43.15  E-value: 6.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752  558 QGRNKEAIYHYRTALKLYPRHASALNNLGTLT---RDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEkkeeaitllk 634
Cdd:PRK11447   364 ANNLAQAERLYQQARQVDNTDSYAVLGLGDVAmarKDYAAAERYYQQALRMDPGNTNAVRGLANLYRQQS---------- 433

                           90       100
                   ....*....|....*....|...
gi 1034581752  635 dsikygPEFADAYssLASLLAEQ 657
Cdd:PRK11447   434 ------PEKALAF--IASLSASQ 448
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 545-578 4.25e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 4.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034581752  545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRH 578
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
 
Name Accession Description Interval E-value
TMTC_DUF1736 pfam08409
Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in ...
 353-427 8.02e-35

Protein O-mannosyl-transferase TMTC, DUF1736; This domain of unknown function is found in O-mannosyl -transferases TMTC1-4, and constitutes a loop between TM7 and TM8 located in the ER lumen that contains a small hydrophobic, but not membrane-embedded helix. This loop is critical for catalysis and binding of ligands, especially the lipid-linked sugar moiety. TMTCs transfers mannosyl residues to the hydroxyl group of serine or threonine residues. The 4 members of the TMTC family are O-mannosyl-transferases acting primarily on the cadherin superfamily; each member has distinct roles in decorating the cadherin domains with O-linked mannose glycans at specific regions. These proteins also act as O-mannosyl-transferase on other proteins such as PDIA3.


Pssm-ID: 462468  Cd Length: 75  Bit Score: 126.49  E-value: 8.02e-35
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 353 GGSMPLFSEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNLATIFLAVVMA 427
Cdd:pfam08409   1 GGQLPVFSASDNPAAFSPSLLTRTLTYNYLPALNAWLLLFPSWLCFDWSMGSIPLIESLSDPRNLATLAFYGALA 75
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
531-660 4.80e-28

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 113.18  E-value: 4.80e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG0457    28 IEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLAlqaLGRYEEALEDYDKALELDP 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG0457   108 DDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRY 160
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
542-657 2.61e-27

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 110.87  E-value: 2.61e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:COG0457     5 PDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAylrLGRYEEALADYEQALELDPDDAEALNNLGL 84

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG0457    85 ALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLEL 123
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 542-658 2.90e-23

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 104.69  E-value: 2.90e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:COG3914   109 PDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEAlrrLGRLEEAIAALRRALELDPDNAEALNNLGN 188

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQA 658
Cdd:COG3914   189 ALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQAC 228
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 541-660 6.24e-22

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 100.45  E-value: 6.24e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 541 LPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLG 617
Cdd:COG3914    74 LLLLAALLELAALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLllaLGRLEEALAALRRALALNPDFAEAYLNLG 153

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1034581752 618 NLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG3914   154 EALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRL 196
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 545-660 7.92e-21

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 89.10  E-value: 7.92e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLK 621
Cdd:COG4783     4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEIllqLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034581752 622 SQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG4783    84 KAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRP 122
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
531-658 1.46e-20

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 91.61  E-value: 1.46e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG0457    62 LADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlleLGRYDEAIEAYERALELDP 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQA 658
Cdd:COG0457   142 DDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAA 192
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-657 3.31e-20

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 90.94  E-value: 3.31e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG2956    96 EELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELyleQGDYDEAIEALEKALKLDP 175

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG2956   176 DCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKL 225
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 534-656 3.79e-20

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 86.60  E-value: 3.79e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 534 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHN 610
Cdd:COG4235     6 LRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEAllaAGDTEEAEELLERALALDPDNP 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1034581752 611 RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYsSLASLLAE 656
Cdd:COG4235    86 EALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPAR-LLEASIAE 130
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 531-643 7.15e-19

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 83.32  E-value: 7.15e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG4783    24 EALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLAllkAGDYDEALALLEKALKLDP 103

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEF 643
Cdd:COG4783   104 EHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 555-641 2.04e-18

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 82.70  E-value: 2.04e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 555 LKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAIT 631
Cdd:COG5010    64 YNKLGDFEESLALLEQALQLDPNNPELYYNLALLysrSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKA 143

                          90
                  ....*....|
gi 1034581752 632 LLKDSIKYGP 641
Cdd:COG5010   144 ALQRALGTSP 153
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
557-642 1.36e-17

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 78.29  E-value: 1.36e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 557 DQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYyQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLL 633
Cdd:COG3063     4 KLGDLEEAEEYYEKALELDPDNADALNNLGLLlleQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYL 82


                  ....*....
gi 1034581752 634 KDSIKYGPE 642
Cdd:COG3063    83 ERALELDPS 91
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
572-660 3.59e-17

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 81.59  E-value: 3.59e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 572 LKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYS 648
Cdd:COG0457     1 LELDPDDAEAYNNLGLAyrrLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALN 80

                          90
                  ....*....|..
gi 1034581752 649 SLASLLAEQAHF 660
Cdd:COG0457    81 NLGLALQALGRY 92
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 533-657 6.09e-17

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 81.31  E-value: 6.09e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 533 LFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQH 609
Cdd:COG2956    30 LLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDylkAGLLDRAEELLEKLLELDPDD 109

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1034581752 610 NRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG2956   110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQ 157
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
538-650 7.78e-17

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 79.96  E-value: 7.78e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 538 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG---TLTRDTAEAKMYYQRALQLHPQHNRALF 614
Cdd:COG4785    66 ALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGlayLLLGDYDAALEDFDRALELDPDYAYAYL 145

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034581752 615 NLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSL 650
Cdd:COG4785   146 NRGIALYYLGRYELAIADLEKALELDPNDPERALWL 181
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-657 2.73e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.39  E-value: 2.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG2956    62 IRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIyeqEGDWEKAIEVLERLLKLGP 141

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034581752 608 QHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG2956   142 ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQ 191
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 542-657 3.96e-16

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 79.00  E-value: 3.96e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:COG2956   141 PENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELyleQGDYEEAIAALERALEQDPDYLPALPRLAE 220

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGPEfADAYSSLASLLAEQ 657
Cdd:COG2956   221 LYEKLGDPEEALELLRKALELDPS-DDLLLALADLLERK 258
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 531-660 1.03e-15

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 80.81  E-value: 1.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDT---AEAKMYYQRALQLHP 607
Cdd:COG3914   132 LAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLgrlEEAIAAYRRALELDP 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034581752 608 QHNRALFNLGNLLKSQ------EKKEEAITLLKDSIKYGPEFADAYS---SLASLLAEQAHF 660
Cdd:COG3914   212 DNADAHSNLLFALRQAcdwevyDRFEELLAALARGPSELSPFALLYLpddDPAELLALARAW 273
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
531-607 7.03e-15

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 70.58  E-value: 7.03e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIyHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG3063    12 EEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELlleLGDYDEALAYLERALELDP 90
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 563-660 2.30e-14

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 70.03  E-value: 2.30e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 563 EAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKY 639
Cdd:COG4235     1 EAIARLRQALAANPNDAEGWLLLGRAylrLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALAL 80

                          90       100
                  ....*....|....*....|.
gi 1034581752 640 GPEFADAYSSLASLLAEQAHF 660
Cdd:COG4235    81 DPDNPEALYLLGLAAFQQGDY 101
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 519-651 3.59e-14

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 76.28  E-value: 3.59e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 519 KTVKQNEIWLSREslfrsgvqtlPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG--TLTRDTAEAK 596
Cdd:TIGR02917 754 EAVKTLEAWLKTH----------PNDAVLRTALAELYLAQKDYDKAIKHYQTVVKKAPDNAVVLNNLAwlYLELKDPRAL 823

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 597 MYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLA 651
Cdd:TIGR02917 824 EYAERALKLAPNIPAILDTLGWLLVEKGEADRALPLLRKAVNIAPEAAAIRYHLA 878
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 563-660 4.61e-14

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 75.41  E-value: 4.61e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 563 EAIYHYRTALKLYPRHASALNNLGtltrDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPE 642
Cdd:COG3914    69 AAAAALLLLAALLELAALLLQALG----RYEEALALYRRALALNPDNAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                          90
                  ....*....|....*...
gi 1034581752 643 FADAYSSLASLLAEQAHF 660
Cdd:COG3914   145 FAEAYLNLGEALRRLGRL 162
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 549-657 1.07e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.68  E-value: 1.07e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 549 YNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEK 625
Cdd:COG2956    12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVEAHLALGNLYRrrgEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGL 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1034581752 626 KEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG2956    92 LDRAEELLEKLLELDPDDAEALRLLAEIYEQE 123
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 533-638 1.30e-13

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 71.68  E-value: 1.30e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 533 LFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQh 609
Cdd:COG2956   166 ALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEklgDPEEALELLRKALELDPS- 244

                          90       100
                  ....*....|....*....|....*....
gi 1034581752 610 NRALFNLGNLLKSQEKKEEAITLLKDSIK 638
Cdd:COG2956   245 DDLLLALADLLERKEGLEAALALLERQLR 273
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
591-657 1.75e-13

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 66.35  E-value: 1.75e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034581752 591 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKdSIKYGPEFADAYSSLASLLAEQ 657
Cdd:COG3063     7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAIALEK-ALKLDPNNAEALLNLAELLLEL 72
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 531-607 1.82e-13

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 68.45  E-value: 1.82e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHP 607
Cdd:COG5010    74 LALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALllsLGQDDEAKAALQRALGTSP 153
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 551-660 2.82e-12

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 64.98  E-value: 2.82e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 551 YANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGtltrDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAI 630
Cdd:COG5010    33 GANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLG----DFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAK 108

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034581752 631 TLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG5010   109 EYYEKALALSPDNPNAYSNLAALLLSLGQD 138
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 557-653 2.06e-11

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 61.16  E-value: 2.06e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 557 DQGRNKEAIYHYRTALKLYPRH---ASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNR---ALFNLGNLLKSQEKKE 627
Cdd:COG1729     5 KAGDYDEAIAAFKAFLKRYPNSplaPDALYWLGEAyyaLGDYDEAAEAFEKLLKRYPDSPKapdALLKLGLSYLELGDYD 84

                          90       100
                  ....*....|....*....|....*....
gi 1034581752 628 EAITLLKDSIK-Y--GPEFADAYSSLASL 653
Cdd:COG1729    85 KARATLEELIKkYpdSEAAKEARARLARL 113
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
542-658 3.30e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 63.87  E-value: 3.30e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:COG0457   107 PDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIAlekLGRYEEALELLEKLEAAALAALLAAALGEA 186

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQA 658
Cdd:COG0457   187 ALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLA 226
type_IV_pilW TIGR02521
type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF ...
 542-663 1.14e-09

type IV pilus biogenesis/stability protein PilW; Members of this family are designated PilF and PilW. This outer membrane protein is required both for pilus stability and for pilus function such as adherence to human cells. Members of this family contain copies of the TPR (tetratricopeptide repeat) domain.


Pssm-ID: 131573 [Multi-domain]  Cd Length: 234  Bit Score: 59.27  E-value: 1.14e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRAL--QLHPQHNRALFNL 616
Cdd:TIGR02521  62 PDDYLAYLALALYYQQLGELEKAEDSFRRALTLNPNNGDVLNNYGTFlcqQGKYEQAMQQFEQAIedPLYPQPARSLENA 141

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034581752 617 GNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHFIST 663
Cdd:TIGR02521 142 GLCALKAGDFDKAEKYLTRALQIDPQRPESLLELAELYYLRGQYKDA 188
TPR_12 pfam13424
Tetratricopeptide repeat;
545-608 4.66e-08

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 50.46  E-value: 4.66e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLY--------PRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQ 608
Cdd:pfam13424   3 ATALNNLAAVLRRLGRYDEALELLEKALEIArrllgpdhPLTATTLLNLGRLYLelgRYEEALELLERALALAEK 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 558-658 4.95e-08

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 56.25  E-value: 4.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 558 QGRNKEAIYHYRTALKLYPRHASA--LNNLGTLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKD 635
Cdd:TIGR02917 716 QKDYPAAIQAYRKALKRAPSSQNAikLHRALLASGNTAEAVKTLEAWLKTHPNDAVLRTALAELYLAQKDYDKAIKHYQT 795

                          90       100
                  ....*....|....*....|...
gi 1034581752 636 SIKYGPEFADAYSSLASLLAEQA 658
Cdd:TIGR02917 796 VVKKAPDNAVVLNNLAWLYLELK 818
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 531-619 2.65e-07

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 49.60  E-value: 2.65e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 531 ESLFRSGVQTLPHN---AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRH---ASALNNLGTL---TRDTAEAKMYYQR 601
Cdd:COG1729    13 IAAFKAFLKRYPNSplaPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSpkaPDALLKLGLSyleLGDYDKARATLEE 92

                          90       100
                  ....*....|....*....|.
gi 1034581752 602 ALQLHPQH---NRALFNLGNL 619
Cdd:COG1729    93 LIKKYPDSeaaKEARARLARL 113
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 581-660 4.84e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.65  E-value: 4.84e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 581 ALNNLgtLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG2956    15 GLNYL--LNGQPDKAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLL 92
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 529-636 8.28e-07

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 52.29  E-value: 8.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 529 SRESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKL-------YPRHASALNNLGTLTR---DTAEAKMY 598
Cdd:TIGR00990 451 SSMATFRRCKKNFPEAPDVYNYYGELLLDQNKFDEAIEKFDTAIELeketkpmYMNVLPLINKALALFQwkqDFIEAENL 530

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1034581752 599 YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDS 636
Cdd:TIGR00990 531 CEKALIIDPECDIAVATMAQLLLQQGDVDEALKLFERA 568
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 542-641 9.80e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.01  E-value: 9.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDT---AEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:TIGR02917 462 PDNASLHNLLGAIYLGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEgnpDDAIQRFEKVLTIDPKNLRAILALAG 541

                          90       100
                  ....*....|....*....|...
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGP 641
Cdd:TIGR02917 542 LYLRTGNEEEAVAWLEKAAELNP 564
TPR_12 pfam13424
Tetratricopeptide repeat;
579-638 1.66e-06

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 46.23  E-value: 1.66e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034581752 579 ASALNNLGTLTR---DTAEAKMYYQRALQL--------HPQHNRALFNLGNLLKSQEKKEEAITLLKDSIK 638
Cdd:pfam13424   3 ATALNNLAAVLRrlgRYDEALELLEKALEIarrllgpdHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 557-659 2.06e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 51.24  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 557 DQGRNKEAIYHYRTALKLYPRHASALNNLGT---LTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLL 633
Cdd:TIGR02917 443 RSGQFDKALAAAKKLEKKQPDNASLHNLLGAiylGKGDLAKAREAFEKALSIEPDFFPAAANLARIDIQEGNPDDAIQRF 522

                          90       100
                  ....*....|....*....|....*.
gi 1034581752 634 KDSIKYGPEFADAYSSLASLLAEQAH 659
Cdd:TIGR02917 523 EKVLTIDPKNLRAILALAGLYLRTGN 548
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 558-660 5.42e-06

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 49.70  E-value: 5.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 558 QGRNKEAIYHYRTALKLYPRHASALNNLG---TLTRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 634
Cdd:TIGR02917 614 AGDLNKAVSSFKKLLALQPDSALALLLLAdayAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAK 693

                          90       100
                  ....*....|....*....|....*.
gi 1034581752 635 DSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:TIGR02917 694 SLQKQHPKAALGFELEGDLYLRQKDY 719
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 590-657 1.22e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 44.60  E-value: 1.22e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034581752 590 RDTAEAKMYYQRALQLHPQHN---RALFNLGNLLKSQEKKEEAITLLKDSIKYGPE---FADAYSSLASLLAEQ 657
Cdd:COG1729     7 GDYDEAIAAFKAFLKRYPNSPlapDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDspkAPDALLKLGLSYLEL 80
TPR_19 pfam14559
Tetratricopeptide repeat;
591-653 1.27e-05

Tetratricopeptide repeat;


Pssm-ID: 434038 [Multi-domain]  Cd Length: 65  Bit Score: 43.34  E-value: 1.27e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 591 DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASL 653
Cdd:pfam14559   3 DYAEALELLEQALAEDPDNAEARLGLAEALLALGRLDEAEALLAALPAADPDDPRYAALLAKL 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 534-656 1.30e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.30e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 534 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEA---------------------IYHY-------------RTALKLYPRHA 579
Cdd:TIGR02917 522 FEKVLTIDPKNLRAILALAGLYLRTGNEEEAvawlekaaelnpqeiepalalAQYYlgkgqlkkalailNEAADAAPDSP 601

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 580 SALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAE 656
Cdd:TIGR02917 602 EAWLMLGRAqlaAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALELKPDNTEAQIGLAQLLLA 681
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 558-660 1.41e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.41e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 558 QGRNKEAIYHYRTALKLYPRHASALNNLGTLT---RDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 634
Cdd:TIGR02917 138 LGQLELAQKSYEQALAIDPRSLYAKLGLAQLAlaeNRFDEARALIDEVLTADPGNVDALLLKGDLLLSLGNIELALAAYR 217

                          90       100
                  ....*....|....*....|....*.
gi 1034581752 635 DSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:TIGR02917 218 KAIALRPNNIAVLLALATILIEAGEF 243
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 558-654 1.46e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 1.46e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 558 QGRNKEAIYHYRTALKLYPRHASALNNLGTLTR---DTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLK 634
Cdd:TIGR02917 172 ENRFDEARALIDEVLTADPGNVDALLLKGDLLLslgNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEKHAD 251

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1034581752 635 DSIKYGP-----------------EFADAYSSLASLL 654
Cdd:TIGR02917 252 ALLKKAPnsplahylkalvdfqkkNYEDARETLQDAL 288
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 538-643 1.90e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.16  E-value: 1.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 538 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALF 614
Cdd:TIGR02917 186 LTADPGNVDALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATIlieAGEFEEAEKHADALLKKAPNSPLAHY 265

                          90       100       110
                  ....*....|....*....|....*....|
gi 1034581752 615 nLGNLLKSQEKK-EEAITLLKDSIKYGPEF 643
Cdd:TIGR02917 266 -LKALVDFQKKNyEDARETLQDALKSAPEY 294
HemYx COG3071
Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to ...
 539-657 4.42e-05

Uncharacterized protein HemY, contains HemY_N domain and TPR repeats (unrelated to protoporphyrinogen oxidase HemY) [Function unknown];


Pssm-ID: 442305 [Multi-domain]  Cd Length: 323  Bit Score: 46.06  E-value: 4.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 539 QTLP----HNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRH--ASALNNLGTLTRDTAEAKMyyQRALQLHPQHNRA 612
Cdd:COG3071   183 KALPraerRDPELAAAYARALIALGDHDEAERLLREALKRQWDPrlVRLYGRLQGGDPAKQLKRA--EKWLKKHPNDPDL 260

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1034581752 613 LFNLGNLLKSQEKKEEAITLLKDSIKYGPEfADAYSSLASLLAEQ 657
Cdd:COG3071   261 LLALGRLCLRNQLWGKAREYLEAALALRPS-AEAYAELARLLEQL 304
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 545-577 4.70e-05

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 40.58  E-value: 4.70e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034581752 545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPR 577
Cdd:pfam07719   1 AEALYNLGLAYYKLGDYEEALEAYEKALELDPN 33
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
564-660 5.15e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.91  E-value: 5.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 564 AIYHYRTALKLYPRHASALNNLGT---LTRDTAEAKMYYQRALQLhPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYG 640
Cdd:COG4785    25 LLAALLFAAVLALAIALADLALALaaaALAAAALAAERIDRALAL-PDLAQLYYERGVAYDSLGDYDLAIADFDQALELD 103

                          90       100
                  ....*....|....*....|
gi 1034581752 641 PEFADAYSSLASLLAEQAHF 660
Cdd:COG4785   104 PDLAEAYNNRGLAYLLLGDY 123
TPR COG0790
TPR repeat [General function prediction only];
568-656 6.72e-05

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 44.92  E-value: 6.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 568 YRTALKLYPR-----HASALNNLGTL-------TRDTAEAKMYYQRALQLhpQHNRALFNLGNLLKS----QEKKEEAIT 631
Cdd:COG0790    83 YEKALEWFEKaaeqgDAEAQYNLGLMyeeglgvPQDYAKALEWYEKAAEQ--GDADAQYNLGLLYLNgegvPKDPAKAAE 160

                          90       100
                  ....*....|....*....|....*
gi 1034581752 632 LLKDSIKYGpeFADAYSSLASLLAE 656
Cdd:COG0790   161 WYRKAAEQG--DADAQYNLGVLYEN 183
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
549-651 7.71e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.52  E-value: 7.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 549 YNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEK 625
Cdd:COG4785    43 DLALALAAAALAAAALAAERIDRALALPDLAQLYYERGVAydsLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGD 122

                          90       100
                  ....*....|....*....|....*.
gi 1034581752 626 KEEAITLLKDSIKYGPEFADAYSSLA 651
Cdd:COG4785   123 YDAALEDFDRALELDPDYAYAYLNRG 148
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 542-657 9.17e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.84  E-value: 9.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASAlNNLGTLTR----DTAEAKMYYQRALQLHPQHNRALFNLG 617
Cdd:TIGR02917 224 PNNIAVLLALATILIEAGEFEEAEKHADALLKKAPNSPLA-HYLKALVDfqkkNYEDARETLQDALKSAPEYLPALLLAG 302

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1034581752 618 NLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:TIGR02917 303 ASEYQLGNLEQAYQYLNQILKYAPNSHQARRLLASIQLRL 342
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 552-620 9.45e-05

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 44.93  E-value: 9.45e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034581752 552 ANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHN-RALFNLGNLL 620
Cdd:cd24142     7 AEELLDQGNFELALKFLQRALELEPNNVEALELLGEIlleLGDVEEAREVLLRAIELDPDGGyEKYLYLGQLS 79
TPR_11 pfam13414
TPR repeat;
552-586 9.97e-05

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 40.15  E-value: 9.97e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034581752 552 ANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLG 586
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLG 35
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 542-657 1.30e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 45.46  E-value: 1.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 542 PHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTL---TRDTAEAKMYYQRALQLHPQHNRALFNLGN 618
Cdd:TIGR02917 496 PDFFPAAANLARIDIQEGNPDDAIQRFEKVLTIDPKNLRAILALAGLylrTGNEEEAVAWLEKAAELNPQEIEPALALAQ 575

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1034581752 619 LLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:TIGR02917 576 YYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAA 614
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 531-581 2.28e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.53  E-value: 2.28e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASA 581
Cdd:COG4235    71 EELLERALALDPDNPEALYLLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
TPR_1 pfam00515
Tetratricopeptide repeat;
545-578 2.98e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.56  E-value: 2.98e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1034581752 545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRH 578
Cdd:pfam00515   1 AKALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 541-660 3.31e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 3.31e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 541 LPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDT---AEAKMYYQRALQLHPQHNRALFNLG 617
Cdd:COG3914     6 LLALAALAAAALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAallALAAGEAAAAAAALLLLAALLELAA 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1034581752 618 NLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAHF 660
Cdd:COG3914    86 LLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLALGRL 128
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 594-657 5.65e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.62  E-value: 5.65e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752 594 EAKMYYQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLLKDSIKYGPE-FADAYSSLASLLAEQ 657
Cdd:cd24142    18 LALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDPDgGYEKYLYLGQLSGGE 82
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 558-657 6.03e-04

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 43.15  E-value: 6.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752  558 QGRNKEAIYHYRTALKLYPRHASALNNLGTLT---RDTAEAKMYYQRALQLHPQHNRALFNLGNLLKSQEkkeeaitllk 634
Cdd:PRK11447   364 ANNLAQAERLYQQARQVDNTDSYAVLGLGDVAmarKDYAAAERYYQQALRMDPGNTNAVRGLANLYRQQS---------- 433

                           90       100
                   ....*....|....*....|...
gi 1034581752  635 dsikygPEFADAYssLASLLAEQ 657
Cdd:PRK11447   434 ------PEKALAF--IASLSASQ 448
TPR_11 pfam13414
TPR repeat;
617-657 8.69e-04

TPR repeat;


Pssm-ID: 315977 [Multi-domain]  Cd Length: 42  Bit Score: 37.45  E-value: 8.69e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1034581752 617 GNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQ 657
Cdd:pfam13414   1 GDAYYEQGKYEEAIEAYKKALKLDPDNPEAYYNLGLAYYKL 41
TPR COG0790
TPR repeat [General function prediction only];
544-638 1.86e-03

TPR repeat [General function prediction only];


Pssm-ID: 440553 [Multi-domain]  Cd Length: 241  Bit Score: 40.68  E-value: 1.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 544 NAKVHYNYANFLKDqGRN-----KEAIYHYRTALKLypRHASALNNLGTL-------TRDTAEAKMYYQRALQLhpQHNR 611
Cdd:COG0790   134 DADAQYNLGLLYLN-GEGvpkdpAKAAEWYRKAAEQ--GDADAQYNLGVLyengrgvPKDPAKALEWYRKAAEQ--GDAD 208

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1034581752 612 ALFNLGNLLKSQEK----KEEAITLLKDSIK 638
Cdd:COG0790   209 AQYNLGRLYLNGEGvekdLEKALRWLRKAAE 239
COG3899 COG3899
Predicted ATPase [General function prediction only];
531-659 2.25e-03

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 41.38  E-value: 2.25e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752  531 ESLFRSGVQTLPHNAKVHYNY------ANFLKDQGRNKEAIYHYRTALKLY-------------PRHASALNNLGTLTR- 590
Cdd:COG3899    725 LRYLERALELLPPDPEEEYRLalllelAEALYLAGRFEEAEALLERALAARalaalaalrhgnpPASARAYANLGLLLLg 804

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752  591 DTAEAKMYYQRALQLHPQHN------RALFNLGNLLKSQEKKEEAITLLKDSIKYGPEFADAYSSLASLLAEQAH 659
Cdd:COG3899    805 DYEEAYEFGELALALAERLGdrrleaRALFNLGFILHWLGPLREALELLREALEAGLETGDAALALLALAAAAAA 879
PRK11447 PRK11447
cellulose synthase subunit BcsC; Provisional
 557-608 2.28e-03

cellulose synthase subunit BcsC; Provisional


Pssm-ID: 183140 [Multi-domain]  Cd Length: 1157  Bit Score: 41.22  E-value: 2.28e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1034581752  557 DQGRNKEAIYHYRTALKLYPRHASALNNLG-TLTR--DTAEAKMYYQRALQLHPQ 608
Cdd:PRK11447   281 DSGQGGKAIPELQQAVRANPKDSEALGALGqAYSQqgDRARAVAQFEKALALDPH 335
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
534-577 3.23e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.46  E-value: 3.23e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 1034581752 534 FRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPR 577
Cdd:COG3063    48 LEKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDPS 91
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 545-578 4.25e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 35.11  E-value: 4.25e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034581752  545 AKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRH 578
Cdd:smart00028   1 AEALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_16 pfam13432
Tetratricopeptide repeat; This family is found predominantly at the C-terminus of ...
 552-609 6.11e-03

Tetratricopeptide repeat; This family is found predominantly at the C-terminus of transglutaminase enzyme core regions.


Pssm-ID: 433202 [Multi-domain]  Cd Length: 68  Bit Score: 35.77  E-value: 6.11e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034581752 552 ANFLKDQGRNKEAIYHYRTALKLY---PRHASALNNLG---TLTRDTAEAKMYYQRALQLHPQH 609
Cdd:pfam13432   4 ARAALRAGDYDDAAAALEAALARFpesPDAAAALLLLGlaaLRQGRLAEAAAAYRAALRAAPGD 67
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 531-606 6.47e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 6.47e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034581752 531 ESLFRSGVQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRhASALNNLGTL---TRDTAEAKMYYQRALQLH 606
Cdd:COG2956   198 IAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPS-DDLLLALADLlerKEGLEAALALLERQLRRH 275
TPR_17 pfam13431
Tetratricopeptide repeat;
598-630 8.57e-03

Tetratricopeptide repeat;


Pssm-ID: 433201 [Multi-domain]  Cd Length: 34  Bit Score: 34.44  E-value: 8.57e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1034581752 598 YYQRALQLHPQHNRALFNLGNLLKSQEKKEEAI 630
Cdd:pfam13431   1 LYLKALELDPNNADAYYNLAVLLLELGQSETAL 33
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
548-657 9.37e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 38.32  E-value: 9.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034581752 548 HYNYANFLKDQGRNKEAIYHYRTALK-LYPRHASALNNLG---TLTRDTAEAKMYYQRALQLHPQHNR--ALFNLGNLLK 621
Cdd:COG4700    92 RVRLADALLELGRYDEAIELYEEALTgIFADDPHILLGLAqalFELGRYAEALETLEKLIAKNPDFKSsdAHLLYARALE 171

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1034581752 622 SQEKKEEAITLLKDSIKYGPeFADAYSSLASLLAEQ 657
Cdd:COG4700   172 ALGDLEAAEAELEALARRYS-GPEARYRYAKFLARQ 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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