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Conserved domains on  [gi|1034572963|ref|XP_016873008|]
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triokinase/FMN cyclase isoform X4 [Homo sapiens]

Protein Classification

dihydroxyacetone kinase family protein( domain architecture ID 1001500)

dihydroxyacetone kinase family protein similar to human triokinase/FMN cyclase and dihydroxyacetone kinase subunit L (DhaL), which is the ADP-binding subunit of dihydroxyacetone kinase that catalyzes the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone via a phosphoryl group transfer from DhaL-ATP

Gene Ontology:  GO:0004371|GO:0006071|GO:0005524
PubMed:  16505971|15476397

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK14479 super family cl29418
dihydroxyacetone kinase; Provisional
 4-526 0e+00

dihydroxyacetone kinase; Provisional


The actual alignment was detected with superfamily member TIGR02361:

Pssm-ID: 475197 [Multi-domain]  Cd Length: 574  Bit Score: 672.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:TIGR02361   1 KHFVNDPEHLVDDALKGLVAANPGLQLLESRKVVYRRDLN--KDKVSLISGGGSGHEPAHAGFVGKGMLTAAVAGDVFAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQaGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLK--KAGRRGLCGTVLIH 161
Cdd:TIGR02361  79 PSTKQILAAIRAVVG-SEAGTLLIVKNYTGDRLNFGLAAEKAKAEGYNVEMVIVGDDVSVGRKKggLVGRRGLAGTVLVH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGSKPTF-ELSADEVELGLGIHGEAGVRRIKMA-TADEIVK 239
Cdd:TIGR02361 158 KIAGAAAARGLSLAEVAKVAQAAADNLVTIGASLDHCHVPGETEAEpELKEDEMELGMGIHNEPGAKRISPIpSSDLVVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 240 LMLDHMTNTTNA-SHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARAL-VGTFMSALEMPGISLTLL 317
Cdd:TIGR02361 238 LMLKKLLDETDKrSYVKFNEGDEVVLLVNNLGGVSNLELGIIADEVVEQLALHYNIIPVRIySGTFMTSLNGPGFSITLL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 318 LVDE---PLLKLIDAETTAAAWPNVAAVSITGRKRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNA 394
Cdd:TIGR02361 318 NATEagkSILDLLDAPTEAPGWPVAAYSSKPWREKREVVSSSAPELIEETAVRSYDPQLVAAILESGCAALLELEPHLTK 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 395 LDRAAGDGDCGTTHSRAARAIQEWLK-EGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSLP---- 469
Cdd:TIGR02361 398 LDTKAGDGDCGSTLARGAEAILELLKsKKLPLNDPATLLAQISDVVEGVMGGTSGALYSIFFSAAAQSLKQNASKKeeit 477

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572963 470 --AWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPgadllqvLTKAVKA 526
Cdd:TIGR02361 478 peAWAAALKTALDALYKYTGARPGDRTMIDALQPFVEALEAGKSN-------LNAAVKA 529
 
Name Accession Description Interval E-value
dak_ATP TIGR02361
dihydroxyacetone kinase, ATP-dependent; This family consists of examples of the form of ...
 4-526 0e+00

dihydroxyacetone kinase, ATP-dependent; This family consists of examples of the form of dihydroxyacetone kinase (also called glycerone kinase) that uses ATP (2.7.1.29) as the phosphate donor, rather than a phosphoprotein as in E. coli. This form is composed of a single chain with separable domains homologous to the K and L subunits of the E. coli enzyme, and is found in yeasts and other eukaryotes and in some bacteria, including Citrobacter freundii. The member from tomato has been shown to phosphorylate dihydroxyacetone, 3,4-dihydroxy-2-butanone, and some other aldoses and ketoses ().


Pssm-ID: 274097 [Multi-domain]  Cd Length: 574  Bit Score: 672.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:TIGR02361   1 KHFVNDPEHLVDDALKGLVAANPGLQLLESRKVVYRRDLN--KDKVSLISGGGSGHEPAHAGFVGKGMLTAAVAGDVFAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQaGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLK--KAGRRGLCGTVLIH 161
Cdd:TIGR02361  79 PSTKQILAAIRAVVG-SEAGTLLIVKNYTGDRLNFGLAAEKAKAEGYNVEMVIVGDDVSVGRKKggLVGRRGLAGTVLVH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGSKPTF-ELSADEVELGLGIHGEAGVRRIKMA-TADEIVK 239
Cdd:TIGR02361 158 KIAGAAAARGLSLAEVAKVAQAAADNLVTIGASLDHCHVPGETEAEpELKEDEMELGMGIHNEPGAKRISPIpSSDLVVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 240 LMLDHMTNTTNA-SHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARAL-VGTFMSALEMPGISLTLL 317
Cdd:TIGR02361 238 LMLKKLLDETDKrSYVKFNEGDEVVLLVNNLGGVSNLELGIIADEVVEQLALHYNIIPVRIySGTFMTSLNGPGFSITLL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 318 LVDE---PLLKLIDAETTAAAWPNVAAVSITGRKRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNA 394
Cdd:TIGR02361 318 NATEagkSILDLLDAPTEAPGWPVAAYSSKPWREKREVVSSSAPELIEETAVRSYDPQLVAAILESGCAALLELEPHLTK 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 395 LDRAAGDGDCGTTHSRAARAIQEWLK-EGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSLP---- 469
Cdd:TIGR02361 398 LDTKAGDGDCGSTLARGAEAILELLKsKKLPLNDPATLLAQISDVVEGVMGGTSGALYSIFFSAAAQSLKQNASKKeeit 477

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572963 470 --AWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPgadllqvLTKAVKA 526
Cdd:TIGR02361 478 peAWAAALKTALDALYKYTGARPGDRTMIDALQPFVEALEAGKSN-------LNAAVKA 529
PRK14479 PRK14479
dihydroxyacetone kinase; Provisional
 4-526 1.47e-162

dihydroxyacetone kinase; Provisional


Pssm-ID: 237723 [Multi-domain]  Cd Length: 568  Bit Score: 475.46  E-value: 1.47e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:PRK14479    2 KKLINDPSTFVEEMLEGFVAAHPDLVRLVPGGVVRRTPTP--EGKVAVVSGGGSGHEPAFAGYVGPGMLDAAVCGNVFTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAF-TVLKKAGRRGLCGTVLIHK 162
Cdd:PRK14479   80 PSADQVYAAIRAADGGA--GVLLIVGNYAGDVMNFGLAAELARAEGIDVRTVVVTDDVASaPSGETAGRRGIAGTVLVFK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 163 VAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGS-KPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLM 241
Cdd:PRK14479  158 IAGAAAEAGLDLDEVAAIARKANARTRSMGVALDGCTLPGAgEPLFTLPEGEMELGLGIHGEPGIEREALPTADELADRL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 242 LDHMTNttnasHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVDE 321
Cdd:PRK14479  238 VDRILA-----DLPLGAGERVAVLVNGLGATPYEELFVVYGAVARLLAARGITVVRPEVGEFVTSLDMAGASLTLMKLDD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 322 PLLKLIDAETTAAAWPNVAAVSITGRkRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNALDRAAGD 401
Cdd:PRK14479  313 ELEELWDAPADTPAFRRGGAVEPVEY-VEAAEEDDAEEPPRASKASRATAANLVAALDAVAEALIDNEDELGELDAVAGD 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 402 GDCGTTHSRAARAIQEWLKEGPPP-ASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPL--KAKTSLPAWSAAMDAG 478
Cdd:PRK14479  392 GDHGIGMARGSKAALAAARAAVEAgAGAGSVLAAAGDAWADHAGGTSGPLWGTALRAAGKALgdKDEPTAADFAAAVRAA 471

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572963 479 LEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:PRK14479  472 VDAIQELGGAQVGDKTMVDALVPFADALEAAAAAGADLAEAWAAAAEA 519
Dak1 pfam02733
Dak1 domain; This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.
 19-335 4.01e-146

Dak1 domain; This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.


Pssm-ID: 460667  Cd Length: 312  Bit Score: 424.17  E-value: 4.01e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  19 AGLVACNPN-LQLLQGHRVALRSDlDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVA 97
Cdd:pfam02733   1 EGLAAAHPDlLRLVPGPRVVVRAD-APPKGKVALISGGGSGHEPAHAGYVGKGMLDAAVPGEVFASPSPDQILAAIKAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  98 QAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAF-TVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEE 176
Cdd:pfam02733  80 GGA--GVLLIVKNYTGDVLNFGMAAELARAEGIKVETVVVGDDVAVgDSGGTVGRRGVAGTVLVHKIAGAAAEAGASLDE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 177 IAKQVNVVAKAMGTLGVSLSSCSVPG-SKPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLMLDHMTNTTnashvP 255
Cdd:pfam02733 158 VARLAEKVNANTRTMGVALSPCTVPGaGKPTFELGEDEMELGMGIHGEPGVKREKLKPADELVEELLDKLLDDD-----P 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 256 VQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVDEPLLKLIDAETTAAA 335
Cdd:pfam02733 233 LLPGDEVAVLVNGLGGTPLLELYIVYRRVLELLEEKGIKVVRSLVGEYMTSLDMAGFSLTLLKLDDELLELLDAPVDTPA 312
DAK1 COG2376
Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is ...
 378-526 1.41e-18

Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441943 [Multi-domain]  Cd Length: 206  Bit Score: 84.48  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 378 LERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEwlKEGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTA 457
Cdd:COG2376     1 MKAVADVIAENRKFLNDLDAVVGDGDHGINMARGFDAVRA--ALDAAPADPGVVLRAAGMKVASVVGGGSGGLVGTGFLD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572963 458 AAQPLKAKTSLPA--WSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:COG2376    79 AAVALKGETSPTAdqVAAALRAADEGIQGRGVAYTGDKTNFDAAAPAAEAIEEAVAAGTAAAAALDEAAAA 149
 
Name Accession Description Interval E-value
dak_ATP TIGR02361
dihydroxyacetone kinase, ATP-dependent; This family consists of examples of the form of ...
 4-526 0e+00

dihydroxyacetone kinase, ATP-dependent; This family consists of examples of the form of dihydroxyacetone kinase (also called glycerone kinase) that uses ATP (2.7.1.29) as the phosphate donor, rather than a phosphoprotein as in E. coli. This form is composed of a single chain with separable domains homologous to the K and L subunits of the E. coli enzyme, and is found in yeasts and other eukaryotes and in some bacteria, including Citrobacter freundii. The member from tomato has been shown to phosphorylate dihydroxyacetone, 3,4-dihydroxy-2-butanone, and some other aldoses and ketoses ().


Pssm-ID: 274097 [Multi-domain]  Cd Length: 574  Bit Score: 672.55  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:TIGR02361   1 KHFVNDPEHLVDDALKGLVAANPGLQLLESRKVVYRRDLN--KDKVSLISGGGSGHEPAHAGFVGKGMLTAAVAGDVFAS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQaGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLK--KAGRRGLCGTVLIH 161
Cdd:TIGR02361  79 PSTKQILAAIRAVVG-SEAGTLLIVKNYTGDRLNFGLAAEKAKAEGYNVEMVIVGDDVSVGRKKggLVGRRGLAGTVLVH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGSKPTF-ELSADEVELGLGIHGEAGVRRIKMA-TADEIVK 239
Cdd:TIGR02361 158 KIAGAAAARGLSLAEVAKVAQAAADNLVTIGASLDHCHVPGETEAEpELKEDEMELGMGIHNEPGAKRISPIpSSDLVVQ 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 240 LMLDHMTNTTNA-SHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARAL-VGTFMSALEMPGISLTLL 317
Cdd:TIGR02361 238 LMLKKLLDETDKrSYVKFNEGDEVVLLVNNLGGVSNLELGIIADEVVEQLALHYNIIPVRIySGTFMTSLNGPGFSITLL 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 318 LVDE---PLLKLIDAETTAAAWPNVAAVSITGRKRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNA 394
Cdd:TIGR02361 318 NATEagkSILDLLDAPTEAPGWPVAAYSSKPWREKREVVSSSAPELIEETAVRSYDPQLVAAILESGCAALLELEPHLTK 397

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 395 LDRAAGDGDCGTTHSRAARAIQEWLK-EGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSLP---- 469
Cdd:TIGR02361 398 LDTKAGDGDCGSTLARGAEAILELLKsKKLPLNDPATLLAQISDVVEGVMGGTSGALYSIFFSAAAQSLKQNASKKeeit 477

                         490       500       510       520       530
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034572963 470 --AWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPgadllqvLTKAVKA 526
Cdd:TIGR02361 478 peAWAAALKTALDALYKYTGARPGDRTMIDALQPFVEALEAGKSN-------LNAAVKA 529
PRK14479 PRK14479
dihydroxyacetone kinase; Provisional
 4-526 1.47e-162

dihydroxyacetone kinase; Provisional


Pssm-ID: 237723 [Multi-domain]  Cd Length: 568  Bit Score: 475.46  E-value: 1.47e-162
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:PRK14479    2 KKLINDPSTFVEEMLEGFVAAHPDLVRLVPGGVVRRTPTP--EGKVAVVSGGGSGHEPAFAGYVGPGMLDAAVCGNVFTS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAF-TVLKKAGRRGLCGTVLIHK 162
Cdd:PRK14479   80 PSADQVYAAIRAADGGA--GVLLIVGNYAGDVMNFGLAAELARAEGIDVRTVVVTDDVASaPSGETAGRRGIAGTVLVFK 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 163 VAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGS-KPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLM 241
Cdd:PRK14479  158 IAGAAAEAGLDLDEVAAIARKANARTRSMGVALDGCTLPGAgEPLFTLPEGEMELGLGIHGEPGIEREALPTADELADRL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 242 LDHMTNttnasHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVDE 321
Cdd:PRK14479  238 VDRILA-----DLPLGAGERVAVLVNGLGATPYEELFVVYGAVARLLAARGITVVRPEVGEFVTSLDMAGASLTLMKLDD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 322 PLLKLIDAETTAAAWPNVAAVSITGRkRSRVAPAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHLNALDRAAGD 401
Cdd:PRK14479  313 ELEELWDAPADTPAFRRGGAVEPVEY-VEAAEEDDAEEPPRASKASRATAANLVAALDAVAEALIDNEDELGELDAVAGD 391

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 402 GDCGTTHSRAARAIQEWLKEGPPP-ASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPL--KAKTSLPAWSAAMDAG 478
Cdd:PRK14479  392 GDHGIGMARGSKAALAAARAAVEAgAGAGSVLAAAGDAWADHAGGTSGPLWGTALRAAGKALgdKDEPTAADFAAAVRAA 471

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*...
gi 1034572963 479 LEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:PRK14479  472 VDAIQELGGAQVGDKTMVDALVPFADALEAAAAAGADLAEAWAAAAEA 519
Dak1 pfam02733
Dak1 domain; This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.
 19-335 4.01e-146

Dak1 domain; This is the kinase domain of the dihydroxyacetone kinase family EC:2.7.1.29.


Pssm-ID: 460667  Cd Length: 312  Bit Score: 424.17  E-value: 4.01e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  19 AGLVACNPN-LQLLQGHRVALRSDlDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTSPAVGSILAAIRAVA 97
Cdd:pfam02733   1 EGLAAAHPDlLRLVPGPRVVVRAD-APPKGKVALISGGGSGHEPAHAGYVGKGMLDAAVPGEVFASPSPDQILAAIKAVD 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  98 QAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAF-TVLKKAGRRGLCGTVLIHKVAGALAEAGVGLEE 176
Cdd:pfam02733  80 GGA--GVLLIVKNYTGDVLNFGMAAELARAEGIKVETVVVGDDVAVgDSGGTVGRRGVAGTVLVHKIAGAAAEAGASLDE 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 177 IAKQVNVVAKAMGTLGVSLSSCSVPG-SKPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLMLDHMTNTTnashvP 255
Cdd:pfam02733 158 VARLAEKVNANTRTMGVALSPCTVPGaGKPTFELGEDEMELGMGIHGEPGVKREKLKPADELVEELLDKLLDDD-----P 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 256 VQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVDEPLLKLIDAETTAAA 335
Cdd:pfam02733 233 LLPGDEVAVLVNGLGGTPLLELYIVYRRVLELLEEKGIKVVRSLVGEYMTSLDMAGFSLTLLKLDDELLELLDAPVDTPA 312
PTZ00375 PTZ00375
dihydroxyacetone kinase-like protein; Provisional
 1-526 7.56e-144

dihydroxyacetone kinase-like protein; Provisional


Pssm-ID: 185583 [Multi-domain]  Cd Length: 584  Bit Score: 428.46  E-value: 7.56e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   1 MTSKKLVNSVAGCADDALAGLVACNPN-LQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGA 79
Cdd:PTZ00375    1 MVSKKFINSPEKVVSEAVDGLCMTNNDsLKRIENTNVVVRSDID--KTKVLLISGGGSGHEPAHAGFVGKGWLTAAVCGS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  80 VFTSPAVGSILAAIRAVAqaGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLKKAGRRGLCGTVL 159
Cdd:PTZ00375   79 VFASPSTKHVLAAIEYVP--NGPGCLLIVKNYTGDILNFELAVEQARARGIQVETVLVADDAAFGTKDIANRRGIAGTVL 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 160 IHKVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGSKPTFELSADEVELGLGIHGEAGVRRIKMATADEIVK 239
Cdd:PTZ00375  157 LYKILGAAAEKGASLTQLKKLADRISSNMRSIGVSLSSCSLPGNDPSSTVPPGTMEVGLGIHGEKGLARIPFQGAKDLVK 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 240 LMLDHMTNTTNA----SHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLT 315
Cdd:PTZ00375  237 FLIGILLGKGKKrgggKTTAIREGAKVALLVNNLGSTTDLEMSILAHHALRQLAQAGLTVVGVHSGRLMTSLEMHGFSLT 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 316 LLLV-DEPLLKLIDAETTAAAWPNVAAVSITGRKRSRVA--PAEPQEAPDSTAAGGSASKRMALVLERVCSTLLGLEEHL 392
Cdd:PTZ00375  317 LLPIeDEDDLQLLDTNQKPLLNFHTPQSSWATAKGPLSAlqLAKPEAEAASRKAATPTNSLLRSVLERVFETLIESENYL 396

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 393 NALDRAAGDGDCGTTHSRAARAIQEWLKEGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLT----AAAQPLKAKTSL 468
Cdd:PTZ00375  397 NELDAEVGDGDLGSGLERSSKAVLESLPYLPLEANVRKTLTLISKAVADAFGGSSGPLYGAFLLgganALAEALNGGNAV 476

                         490       500       510       520       530       540
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572963 469 PAWSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQEL-----QAWKSPGADLLQVLTKAVKA 526
Cdd:PTZ00375  477 DAVRAALAAGSHSIQELGGARVGDRTMVDVLIPFAEALnscpsVNEAASSPELLKACSEEARE 539
PRK14481 PRK14481
dihydroxyacetone kinase subunit DhaK; Provisional
 4-336 3.56e-122

dihydroxyacetone kinase subunit DhaK; Provisional


Pssm-ID: 237724  Cd Length: 331  Bit Score: 363.75  E-value: 3.56e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNL-QLLQGHRVALRSDLDSlkGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFT 82
Cdd:PRK14481    2 KKLINDPETVVDEMLEGLVAAHPDLvTRIDDTDVIVRKDKPP--GKVALVSGGGSGHEPAHAGFVGEGMLDAAVCGAVFT 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  83 SPAVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFT-VLKKAGRRGLCGTVLIH 161
Cdd:PRK14481   80 SPTPDQILEAIKAVDTGA--GVLLIVKNYSGDVMNFEMAAELAEMEGIEVASVVVDDDVAVEdSLYTQGRRGVAGTVFVH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGS-KPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKL 240
Cdd:PRK14481  158 KIAGAAAEAGASLDEVKALAEKVNPNIRSMGVALSPCTVPAVgKPGFDLGDDEIEIGIGIHGEPGRRREKLKPADEIAEE 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 241 MLDHMTNTtnashVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVD 320
Cdd:PRK14481  238 LLEKILED-----LKLVAGDEVLVLVNGMGATPLMELYIVYNDVAELLEERGVTVARSLVGNYMTSLDMAGFSITLLKLD 312

                         330
                  ....*....|....*.
gi 1034572963 321 EPLLKLIDAETTAAAW 336
Cdd:PRK14481  313 DELLELLDAPVDTPAL 328
dhaK1 TIGR02363
dihydroxyacetone kinase, DhaK subunit; Two types of dihydroxyacetone kinase (glycerone kinase) ...
 4-336 2.43e-116

dihydroxyacetone kinase, DhaK subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the DhaK subunit of the latter type of dihydroxyacetone kinase, but it specifically excludes the DhaK paralog DhaK2 (TIGR02362) found in the same operon as DhaK and DhaK in the Firmicutes.


Pssm-ID: 274098  Cd Length: 329  Bit Score: 348.58  E-value: 2.43e-116
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNL-QLLQGHRVALRSDLDSlKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFT 82
Cdd:TIGR02363   2 KKLINDPEDVVAEMLDGLVKAHPELvTLVADTRVIVRKDKKV-NGKVALVSGGGSGHEPAHAGFVGYGMLDAAVPGEVFT 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  83 SPAVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFT-VLKKAGRRGLCGTVLIH 161
Cdd:TIGR02363  81 SPTPDQILEAIKAVDQGA--GVLLIVKNYTGDVMNFEMAAELAEDEGIKVATVVVDDDIAVEdSLYTAGRRGVAGTVFVH 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGS-KPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKL 240
Cdd:TIGR02363 159 KIAGAAAEKGASLDELKSLGEKVNPNTKSIGVALTACTVPAVgKPGFDLADDEMEIGVGIHGEPGIRREKMKSSDEIADE 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 241 MLDHMtnttnASHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLLLVD 320
Cdd:TIGR02363 239 LLDKL-----LDDLGLQSGDRVIVLVNGMGATPLMELYIFYNDVQRLLEQRGVNVARTLVGNYMTSLDMAGFSLTLLKLD 313

                         330
                  ....*....|....*.
gi 1034572963 321 EPLLKLIDAETTAAAW 336
Cdd:TIGR02363 314 DELLELWDAPVTTIAL 329
PRK11468 PRK11468
dihydroxyacetone kinase subunit DhaK; Provisional
 4-336 5.90e-96

dihydroxyacetone kinase subunit DhaK; Provisional


Pssm-ID: 183150  Cd Length: 356  Bit Score: 297.31  E-value: 5.90e-96
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDsLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:PRK11468    2 KKLINDVEDVLDEQLAGLAKAHPELTLHQDPVYVTRADAP-VAGKVALLSGGGSGHEPMHCGFVGQGMLDGACPGEIFTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVaqAGTVGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFT-VLKKAGRRGLCGTVLIHK 162
Cdd:PRK11468   81 PTPDQMFECAMQV--DGGEGVLLIIKNYTGDVLNFETATELLHDSGVKVTTVLIDDDVAVKdSLYTAGRRGVANTVLIEK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 163 VAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPGS-KPTFELSADEVELGLGIHGEAGVRRIKMATADEIVKLM 241
Cdd:PRK11468  159 LVGAAAERGYSLDQCAELGRKLNNQGHSIGIALGACTVPAAgKPSFTLADNEMEFGVGIHGEPGIDRRPFSSLDQTVDEM 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 242 LDHMTNTTNASHV-------------------PVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGT 302
Cdd:PRK11468  239 FDTLLENGSYHRTlrfwdrqqgswqeeeqtkqPLQSGDRVIALVNNLGATPLSELYGVYNRLATRCEQAGLTIERNLIGA 318

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1034572963 303 FMSALEMPGISLTLLLVDEPLLKLIDAETTAAAW 336
Cdd:PRK11468  319 YCTSLDMQGFSITLLKVDDETLALWDAPVHTPAL 352
PRK14483 PRK14483
DhaKLM operon coactivator DhaQ; Provisional
 4-336 5.59e-80

DhaKLM operon coactivator DhaQ; Provisional


Pssm-ID: 172956  Cd Length: 329  Bit Score: 254.97  E-value: 5.59e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPNLQllQGHRVALRSDLDSLKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTS 83
Cdd:PRK14483    2 KKIMNDVQNIVQDMLHGFYFAHPNLD--ETNNIPYVYDIEKDDQLVPIISGGGSGHEPAHIGYVGKGMLTAAVNGSIFTP 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  84 PAVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDDSAFTVLK--KAGRRGLCGTVLIH 161
Cdd:PRK14483   80 PTAEQILAATRLVPKGK--GVFFIIKNFEADVAEFSAAIQIARQEGRQIKYIIVHDDISVEDDAsfNKRRRGVAGTVLLH 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 162 KVAGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPG-SKPTFELSADEVELGLGIHGEAGVRRIKMAT----ADE 236
Cdd:PRK14483  158 KILGAAALEGASLDELEQLGLSLTENIATLGVALSPANLPVaGLPSFDLNEDEISYGIGIHGEPGYRKEPFSSseilAIE 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 237 IV-KLmldhmtnttnASHVPVQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLT 315
Cdd:PRK14483  238 LVnKL----------KSKYRWQKGDNFILLINGLGATTLMEQYIFANDIRRLLELEGLQITFVKVGTLLTSLDMKGISLT 307

                         330       340
                  ....*....|....*....|..
gi 1034572963 316 LLLV-DEPLLKLIDAETTAAAW 336
Cdd:PRK14483  308 LLKVkDPDWLDWLKAPTRAAAW 329
dhaK1b TIGR02362
probable dihydroxyacetone kinase DhaK1b subunit; Two types of dihydroxyacetone kinase ...
 5-336 1.26e-68

probable dihydroxyacetone kinase DhaK1b subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form with a phosphoprotein donor related to PTS transport proteins. This family represents a protein, unique to the Firmicutes (low GC Gram-positives), that appears to be a divergent second copy of the K subunit of that complex; its gene is always found in operons with the other three proteins of the complex.


Pssm-ID: 213706  Cd Length: 326  Bit Score: 225.06  E-value: 1.26e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   5 KLVNSVAGCADDALAGLVACNPNLQLLQGHRVALRSDLDslKGRVALLSGGGSGHEPAHAGFIGKGMLTGVIAGAVFTSP 84
Cdd:TIGR02362   1 KIINEPQNAVSQAIQGIQWAYPNLVQVPDLPGIYDSNFD--DQQIPIISGGGSGHEPAHWGYVGEGMLSAAIMGDVFVPP 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  85 AVGSILAAIRAVAQAGtvGTLLIVKNYTGDRLNFGLAREQARAEGIPVEMVVIGDD-SAFTVLKKAGRRGLCGTVLIHKV 163
Cdd:TIGR02362  79 TAQDILEAIRQVDRGK--GVFVIIKNFEADLSEFSQAIQQARQEGRQIKYIIVHDDiSVEHESFKQRRRGVAGTILVHKI 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 164 AGALAEAGVGLEEIAKQVNVVAKAMGTLGVSLSSCSVPG-SKPTFELSADEVELGLGIHGEAGVRRIKMAT----ADEIV 238
Cdd:TIGR02362 157 LGAAAAEGASLDELEHIAAALVTNIATIGVAAKSARIPGqSTPSFDLEEGEIYYGIGIHGEPGYRTEPFVSsehlAVELV 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 239 -KLMLDHMTnttnashvpvQPGSSVVMMVNNLGGLSFLELGIIADATVRSLEGRGVKIARALVGTFMSALEMPGISLTLL 317
Cdd:TIGR02362 237 nKLKLKFRW----------QADDHYAVLVNNLGGTTPMEQMVFNNDVHELLALEALHLPFIKVGTFLTSLDMHGLSLTLL 306

                         330       340
                  ....*....|....*....|
gi 1034572963 318 -LVDEPLLKLIDAETTAAAW 336
Cdd:TIGR02362 307 rLKDPQWLDYLNAPVDAAAW 326
Dak2 pfam02734
DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase ...
 398-526 1.21e-32

DAK2 domain; This domain is the predicted phosphatase domain of the dihydroxyacetone kinase family.


Pssm-ID: 460668 [Multi-domain]  Cd Length: 175  Bit Score: 123.45  E-value: 1.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 398 AAGDGDCGTTHSRAARAIQEWLKEGPPpASPAQLLSKLSVLLLEKMGGSSGALYGLFLTAAAQPLKAKTSL--PAWSAAM 475
Cdd:pfam02734   1 PVGDGDHGTNMARGFEAALKALEDLEP-ASLAEVLKALAMALLSGAGGNSGPLYGQFFRGAAKALKGKEELdaEDLAAAL 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1034572963 476 DAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:pfam02734  80 EAALEAIQARGKARPGDKTMLDVLRPAAEALEAAAEAGEDLAEALEAAVKA 130
DAK1 COG2376
Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is ...
 378-526 1.41e-18

Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441943 [Multi-domain]  Cd Length: 206  Bit Score: 84.48  E-value: 1.41e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 378 LERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEwlKEGPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTA 457
Cdd:COG2376     1 MKAVADVIAENRKFLNDLDAVVGDGDHGINMARGFDAVRA--ALDAAPADPGVVLRAAGMKVASVVGGGSGGLVGTGFLD 78

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572963 458 AAQPLKAKTSLPA--WSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:COG2376    79 AAVALKGETSPTAdqVAAALRAADEGIQGRGVAYTGDKTNFDAAAPAAEAIEEAVAAGTAAAAALDEAAAA 149
dha_L_ycgS TIGR02365
dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone ...
 378-526 8.77e-17

dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Two types of dihydroxyacetone kinase (glycerone kinase) are described. In yeast and a few bacteria, e.g. Citrobacter freundii, the enzyme is a single chain that uses ATP as phosphoryl donor and is designated EC 2.7.1.29. By contract, E. coli and many other bacterial species have a multisubunit form (EC 2.7.1.-) with a phosphoprotein donor related to PTS transport proteins. This family represents the subunit homologous to the E. coli YcgS subunit.


Pssm-ID: 274099 [Multi-domain]  Cd Length: 194  Bit Score: 78.93  E-value: 8.77e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 378 LERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEWLKEgPPPASPAQLLSKLSVLLLEKMGGSSGALYGLFLTA 457
Cdd:TIGR02365   5 LKNCGDLIIENKEYLTELDRAIGDGDHGINMARGFSEVKEKLDA-FKDKTIGEILKNTGMTLISKVGGASGPLYGTAFLK 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034572963 458 AAQPLKAKTSLPAWSAA--MDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:TIGR02365  84 ASKALKDDEILDAEDLAeiLQAGLEGIQSRGKATPGEKTMVDVWAPVVEALRKAADEPDALAAAREAAEQG 154
DAK1 COG2376
Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is ...
 4-202 2.26e-13

Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Dihydroxyacetone kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441943 [Multi-domain]  Cd Length: 206  Bit Score: 69.07  E-value: 2.26e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963   4 KKLVNSVAGCADDALAGLVACNPN---LQLLQGHRVALRSDLDSLKGRVALLSGGGSGhepahaGFIGKGMLTGVIAGAV 80
Cdd:COG2376    12 RKFLNDLDAVVGDGDHGINMARGFdavRAALDAAPADPGVVLRAAGMKVASVVGGGSG------GLVGTGFLDAAVALKG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963  81 FTSPAVGSILAAIRAVAQA-GTVGtllivKNYTGDRLNFGLAREQARAegipVEMVVIGDDSAftvlkkagrrglcgtvl 159
Cdd:COG2376    86 ETSPTADQVAAALRAADEGiQGRG-----VAYTGDKTNFDAAAPAAEA----IEEAVAAGTAA----------------- 139

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1034572963 160 ihkvAGALAEAgvglEEIAKQvnvVAKAMGTLGVSLSSCSVPG 202
Cdd:COG2376   140 ----AAALDEA----AAAAEK---GAEATRSMGAALGRATYPG 171
PRK10005 PRK10005
dihydroxyacetone kinase ADP-binding subunit DhaL;
378-526 1.62e-10

dihydroxyacetone kinase ADP-binding subunit DhaL;


Pssm-ID: 182192 [Multi-domain]  Cd Length: 210  Bit Score: 60.91  E-value: 1.62e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034572963 378 LERVCSTLLGLEEHLNALDRAAGDGDCGTTHSRAARAIQEWLkegPPPASP--AQLLSKLSVLLLEKMGGSSGALYGLFL 455
Cdd:PRK10005   12 LTRCGDIFTEESDYLTGLDREIGDADHGLNMNRGFSKVVEKL---PAIADKdiGFILKNTGMTLLSSVGGASGPLYGTFF 88

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034572963 456 TAAAQPLKAKTSLPA--WSAAMDAGLEAMQKYGKAAPGDRTMLDSLWAAGQELQAWKSPGADLLQVLTKAVKA 526
Cdd:PRK10005   89 IRAAQATQARQSLTLeeLYQMFRDGADGVISRGKAEPGDKTMCDVWVPVVESLRQSSEQNLSVPAALNAAVSI 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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