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Conserved domains on  [gi|1034640494|ref|XP_016863876|]
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teneurin-3 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
11-308 2.09e-175

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


:

Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 543.41  E-value: 2.09e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484   80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484  160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484  240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034640494  260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484  319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL super family cl18310
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1155-1514 2.07e-41

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


The actual alignment was detected with superfamily member cd14953:

Pssm-ID: 302697 [Multi-domain]  Cd Length: 323  Bit Score: 156.54  E-value: 2.07e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953      1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953     72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953    137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953    208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953    279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2631-2708 7.77e-40

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


:

Pssm-ID: 464783  Cd Length: 78  Bit Score: 142.75  E-value: 7.77e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1468-2408 1.43e-33

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


:

Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 142.59  E-value: 1.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209    109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209    189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209    269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209    349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209    429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209    509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209    589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209    667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209    747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209    825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209    895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209    954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
785-815 8.50e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


:

Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 50.21  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034640494  785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
DUF5885 super family cl44670
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
522-676 8.81e-08

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


The actual alignment was detected with superfamily member pfam19232:

Pssm-ID: 437064  Cd Length: 265  Bit Score: 56.17  E-value: 8.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232   34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232  107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232  186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260

                   ....*
gi 1034640494  672 TGPDC 676
Cdd:pfam19232  261 TGPRC 265
DSL super family cl19567
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
698-741 1.62e-05

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


The actual alignment was detected with superfamily member pfam01414:

Pssm-ID: 473190  Cd Length: 46  Bit Score: 44.15  E-value: 1.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034640494  698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414    1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
C_rich_MXAN6577 super family cl49352
MXAN_6577-like cysteine-rich domain;
681-776 1.65e-05

MXAN_6577-like cysteine-rich domain;


The actual alignment was detected with superfamily member NF041328:

Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 47.06  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328    45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034640494  751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328   104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
11-308 2.09e-175

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 543.41  E-value: 2.09e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484   80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484  160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484  240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034640494  260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484  319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1155-1514 2.07e-41

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 156.54  E-value: 2.07e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953      1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953     72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953    137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953    208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953    279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2631-2708 7.77e-40

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 142.75  E-value: 7.77e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1468-2408 1.43e-33

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 142.59  E-value: 1.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209    109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209    189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209    269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209    349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209    429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209    509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209    589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209    667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209    747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209    825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209    895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209    954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1184-1462 1.69e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 61.19  E-value: 1.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1184 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 1259
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1260 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAVDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1336
Cdd:COG4257     85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1337 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1390
Cdd:COG4257    142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640494 1391 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1462
Cdd:COG4257    217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2334-2408 4.08e-09

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 55.20  E-value: 4.08e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034640494 2334 YTAYGEIYFDSNIDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2408
Cdd:TIGR03696    1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
785-815 8.50e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 50.21  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034640494  785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
DUF5885 pfam19232
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
522-676 8.81e-08

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


Pssm-ID: 437064  Cd Length: 265  Bit Score: 56.17  E-value: 8.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232   34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232  107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232  186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260

                   ....*
gi 1034640494  672 TGPDC 676
Cdd:pfam19232  261 TGPRC 265
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
573-727 1.99e-07

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 52.45  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  573 TECDVPTTQCIDPQ--CGGRGICIMGScACNSGykgeSCEEAdcidpgCSNHGVCIHGECHCSPGwggsnceilKTMCPD 650
Cdd:NF041328    12 AGCPEPGAVCPEGLsvCGGACVDLRSD-PSNCG----ACGVA------CGAGQTCVAGACGCGPG---------TVACGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  651 QCSGHGTylqesgsctcDPNWTGPdcsneiCSVDCGSHGVCMGGTCR--CEEGWT--GPAC--------NQRACHPRCAE 718
Cdd:NF041328    72 ACVDTAS----------DPAHCGA------CGAACAPGQVCEGGACReaCSEGLTrcGGACvdlatdplHCGACGVACDP 135

                   ....*....
gi 1034640494  719 HGTCKDGKC 727
Cdd:NF041328   136 GESCRGGAC 144
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
1235-1518 8.29e-06

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 51.78  E-value: 8.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAVD-K 1309
Cdd:PLN02919   573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1310 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1375
Cdd:PLN02919   635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1376 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1401
Cdd:PLN02919   707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1402 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1478
Cdd:PLN02919   784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1034640494 1479 --DGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1518
Cdd:PLN02919   848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
698-741 1.62e-05

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 44.15  E-value: 1.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034640494  698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414    1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
681-776 1.65e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 47.06  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328    45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034640494  751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328   104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1483-1609 1.03e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.54  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1483 KDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1541
Cdd:cd05819      3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034640494 1542 INGTHQYTVSlVTGDYLYNFSY------SNDNDItAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1609
Cdd:cd05819     83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
667-709 1.46e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 41.46  E-value: 1.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034640494  667 CDPNWTGPDCSNEiCSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
Cdd:pfam01414    1 CDENYYGSTCSKF-CRPrdDKFGHYTCdANGNKVCLPGWTGPYCDK 45
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
753-782 3.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1034640494  753 PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 782
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
1631-1662 8.44e-03

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 36.04  E-value: 8.44e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034640494 1631 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1662
Cdd:pfam05593    5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
 
Name Accession Description Interval E-value
Ten_N pfam06484
Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of ...
11-308 2.09e-175

Teneurin Intracellular Region; This family is found in the intracellular N-terminal region of the Teneurin family of proteins. These proteins are 'pair-rule' genes and are involved in tissue patterning, specifically probably neural patterning. The intracellular domain is cleaved in response to homophilic interaction of the extracellular domain, and translocates to the nucleus. Here it probably carries out to some transcriptional regulatory activity. The length of this region and the conservation suggests that there may be two structural domains here (personal obs:C Yeats).


Pssm-ID: 461932 [Multi-domain]  Cd Length: 367  Bit Score: 543.41  E-value: 2.09e-175
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   11 SLTKSRREKERRYTNSSADNEECRVPTQKSYSSSETLKAFDHDSsRLLYGNRVKDLVHREADEFTRQGQNFTLRQLGVCE 90
Cdd:pfam06484    1 SLTKRRRDKERRYTSSSADSEECRVPTQKSYSSSETLKAFDHDS-RMLYGNRVKDMVHKEADEFSRQGQNFSLRELGICE 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494   91 PATRRGLAFCAEMGLPHRGYSISAGSDADTENEAVMSPEHAMRLWGRGVKSGRSSCLSSRSNSALTLTDTEHENKSDSEN 170
Cdd:pfam06484   80 PSPRHGLAYCTEMGLPHRGYSISTGSDADTETDGPMSPEHAVRLWGRGTKSGRSSCLSSRSNSALTLTDTEHENKSDNEN 159
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  171 -------------------------------------------------------------------EQPASNQGQSTLQ 183
Cdd:pfam06484  160 gppippsssssspveqhsppppslnenqrpllgnnashpildsdpdeefspnsylvrtgsgpqsapsEQPPNFQNHSRLR 239
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  184 ----PLPPSHKQHSaQHHPSITSLNRNSLTNRRNQSPAPPAALPAELQTTPESVQLQDSWVLGSNVPLESRHFLFKTGTG 259
Cdd:pfam06484  240 tpppPLPPPHKQNQ-HHHPSINSLNRSSLTNRRNPSPAPTASLPAELQSTQESVQLQDSWVLNSNVPLETRHFLFKTGTG 318
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*....
gi 1034640494  260 TTPLFSTATPGYTMASGSVYSPPTRPLPRNTLSRSAFKFKKSSKYCSWK 308
Cdd:pfam06484  319 TTPLFCTASPGYPLTSGTVYSPPPRPLPRNTFSRPAFKLKKPYKYCSWK 367
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1155-1514 2.07e-41

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 156.54  E-value: 2.07e-41
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1155 VSSIMGNGRRrsiscpscnGQADGNKLLA----PVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSN 1228
Cdd:cd14953      1 VSTVAGSGTA---------GFSGGGGTAArfnsPSGVAVDAAGNLYVADRgnHRIRKITPDGVVTTVAGTGTAGFADGGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1229 PAHRYY----LATDPvTGDLYVSDTNTRRIYRpksLTGAKDLTknaeVVAGTGEqclpfdeARCGDGGKAVEATLMSPKG 1304
Cdd:cd14953     72 AAAQFNtpsgVAVDA-AGNLYVADTGNHRIRK---ITPDGVVS----TLAGTGT-------AGFSDDGGATAAQFNYPTG 136
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1305 MAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLTSAR--PLTcdtsmhisQVRLEWPTDLAINPMDNsIYVLD--N 1378
Cdd:cd14953    137 VAVDAAGNLYVADTGnhRIRKITPDGVVTTVAGTGGAGYAGdgPAT--------AAQFNNPTGVAVDAAGN-LYVADrgN 207
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1379 NVVLQITENRQVRIAAGRPmhcqvpGVEYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVA 1458
Cdd:cd14953    208 HRIRKITPDGVVTTVAGTG------TAGFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGN---HRIRKITPAGVVTTVA 278
                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034640494 1459 GIPSEcdckndancdcyQSGD-GYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAV 1514
Cdd:cd14953    279 GGGAG------------FSGDgGPATSAQFNNPTGVAVDAAGNLYVADTGNNRIRKI 323
Tox-GHH pfam15636
GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH ...
2631-2708 7.77e-40

GHH signature containing HNH/Endo VII superfamily nuclease toxin; A predicted toxin of the HNH/Endonuclease VII fold present in bacterial polymorphic toxin systems with a characteriztic sG[HQ]H signature motif. In bacterial polymorphic toxin systems, the toxin is exported by the type 2, type 6, type 7 or TcdB/TcaC-type secretion system. The metazoan teneurin proteins possess an inactive of this domain at their C-terminus.


Pssm-ID: 464783  Cd Length: 78  Bit Score: 142.75  E-value: 7.77e-40
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 2631 EEKARILEQARQRALARAWAREQQRVRDGEEGARLWTEGEKRQLLSAGKVQGYDGYYVLSVEQYPELADSANNIQFLR 2708
Cdd:pfam15636    1 EERKRLLEHAKKRAVREAWHRERQLLRNGLPGSRDWTDEEKEELLSTGSVPGYDGEYIHPVEQYPELADDPSNIRFRK 78
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1235-1515 2.13e-38

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 147.68  E-value: 2.13e-38
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPvTGDLYVSDTNTRRIYRpksltgakdLTKNAEV--VAGTGEqclpfdEARCGDGGKAveATLMSPKGMAVDKNGL 1312
Cdd:cd14953     28 VAVDA-AGNLYVADRGNHRIRK---------ITPDGVVttVAGTGT------AGFADGGGAA--AQFNTPSGVAVDAAGN 89
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1313 IYFVDGT--MIRKVDQNGIISTLLGsndlTSARPLTCDTSMhiSQVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENR 1388
Cdd:cd14953     90 LYVADTGnhRIRKITPDGVVSTLAG----TGTAGFSDDGGA--TAAQFNYPTGVAVDAAGN-LYVADtgNHRIRKITPDG 162
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1389 QVRIAAGRPmhcqVPGveYPVGKHAVQTTLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckn 1468
Cdd:cd14953    163 VVTTVAGTG----GAG--YAGDGPATAAQFNNPTGVAVDAAGNLYVADRGN---HRIRKITPDGVVTTVAGTGTA----- 228
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1034640494 1469 dancdcYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVS 1515
Cdd:cd14953    229 ------GFSGDGGATAAQLNNPTGVAVDAAGNLYVADSGNHRIRKIT 269
RhsA COG3209
Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction ...
1468-2408 1.43e-33

Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only];


Pssm-ID: 442442 [Multi-domain]  Cd Length: 1103  Bit Score: 142.59  E-value: 1.43e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1468 NDANCDCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNKPLLNSMNFYEVASPTDQELYIFDINGTHQ 1547
Cdd:COG3209    109 AAATASAGRLVSTGAGAGGTVTAATGGTLGATAGSATTGSTDGGRGGVAVTGLAGGGASAYGLTLGGAAAGPATGVGTGA 188
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1548 YTVSLVTGDYLYNFSYSNDNDITAVTDSNGNTLRIRRDPNRMPVRVVSPDNQVIWLTIGTNGCLKSMTAQGLELVLFTYH 1627
Cdd:COG3209    189 VTLATGLAGSALLALGSGAILGGLAGAYSGSATTATGTALGTPASVAATVTGSATGAAGAGAAVATAATTLGGTTGAGTG 268
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1628 GNSGLLATK---SDETGWTTFFDYDSEGRLTNVTFPTGVVTNLHGDMDKAITVDIESSSREEDVSITSNLSSIDSFYTMV 1704
Cdd:COG3209    269 ASGAGLDAStgtGGAGGSNAAATAGGLGGAGLGSGGAGGGGTAGGTTTAAGTTGTAAVSGAADAGTTTTTGTGTGGTTTT 348
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1705 QDQLRNSYQIGYDGSLRIIYASGLDSHYQTEPHVLAGTANPTVAKRNMTLPGENGQNLVEWRFRKEQAQGKVNVFGRKLR 1784
Cdd:COG3209    349 VGGGGSLTLGGYGAAGGLTTSVGAGGGGSTSGSTTTVGGGGTATGSGGGSSTTGVGAGTTTTSTTGGDGGPATAAGALTA 428
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1785 VNGRNLLSVDFDRTTKTEKIYDDHRKFLLRIAYDTSGHPTLWLPSSKLMAVNVTYSSTGQIASIQRGTTSEKVDYDGQGR 1864
Cdd:COG3209    429 GGTATGTGTGGGGTTAGTDATTTTGGAGASGTLTTTGGAATGATTGGGTEAGTGGGTLTSGSAGATTLGTDTTLDDTLGG 508
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1865 IVSRVFADGKTWSYTYLEKSMVLLLHSQRQYIFEYDMWDRLSAITMPSVARHTMQTIRSIGYYRNIYNPPESNASIITDY 1944
Cdd:COG3209    509 TTTTTAGARGLVVTTGTTLTLGTTTTATLSATDATGTGDTTTTGTVGTGTSTGTGGTGTVTTTGDGTGGASTTTGTTGGT 588
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1945 NEEGLLLQTAFLGTSRRVLFKYRRQTRLSEILYDSTRVSFTYDETAGVLKTVNLQSDGFicTIRYRQIGPLIDRQIFRFS 2024
Cdd:COG3209    589 ATTTTVTTTTTTSTAGTTTTTTSGYTRAGLTLTLGTGTASGLERATASTGSTTGGTTGT--GVTTTGTTTTRATGTTGTG 666
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2025 EDGMVNARFDYSYDNSFRVTSMQGVINETPLPIDLYQFDDISGKVEQFGKFGVIYYDINQIISTAVMTYTKHFDAHGRIK 2104
Cdd:COG3209    667 TGVTAGLTTLATGGTTVGGGTGTTSTATTGATTGGTETGTTVTTLAGGTTTRLGTTTTGGGGGTTTDGTGTGGTTGTLTT 746
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2105 EIQYEifRSLMYWITIQYDNMGRVTKREIKIGPFANTTKYAYEYDVDGQLQTVYLNEKIMWRYNYDLNGNLHLLNPSNSA 2184
Cdd:COG3209    747 TSTTT--TTTAGALTYTYDALGRLTSETTPGGVTQGTYTTRYTYDALGRLTSVTYPDGETVTYTYDALGRLTSVITVGSG 824
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2185 RLTPL-----RYDLRDRITRLgdvqyrldEDGFLRQRGTEIFEYSSKGLLTRVYSKGSGWTviYRYDGLGRRVSSKTSLG 2259
Cdd:COG3209    825 GGTDLqdrtyTYDAAGNITSI--------TDALRAGTLTQTYTYDALGRLTSATDPGTTES--YTYDANGNLTSRTDGGT 894
                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 2260 QHLQFFYADLtyPTRITHvynhSSSEITSLYYDLQGHlfameissgdefyiaSDNTGTPLAVFSSNGLMLKQIQYTAYGE 2339
Cdd:COG3209    895 TTYTYDALGR--LVSVTK----PDGTTTTYTYDALGH---------------TDHLGSVRALTDASGQVVWRYDYDPFGN 953
                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1034640494 2340 IYFDSNIDFQLVIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDPAPfNLYMFRNNNP 2408
Cdd:COG3209    954 LLAETSGAAANPLRFTGQEYDAETGLYYNGARYYDPALGRFLSPD-----PIGLAGGL-NLYAYVGNNP 1016
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1272-1515 1.81e-31

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 127.65  E-value: 1.81e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1272 VVAGTGeqclpfdeARCGDGGKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNGIISTLLG------SNDLTSAr 1343
Cdd:cd14953      3 TVAGSG--------TAGFSGGGGTAARFNSPSGVAVDAAGNLYVADRGnhRIRKITPDGVVTTVAGtgtagfADGGGAA- 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1344 pltcdtsmhisqVRLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGrpmhcqVPGVEYPVGKHAVQTTLESA 1421
Cdd:cd14953     74 ------------AQFNTPSGVAVDAAGN-LYVADtgNHRIRKITPDGVVSTLAG------TGTAGFSDDGGATAAQFNYP 134
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1422 TAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISLVAGIPSEcdckndancdcYQSGDGYAKDAKLSAPSSLAASPDGTL 1501
Cdd:cd14953    135 TGVAVDAAGNLYVADTGN---HRIRKITPDGVVTTVAGTGGA-----------GYAGDGPATAAQFNNPTGVAVDAAGNL 200
                          250
                   ....*....|....
gi 1034640494 1502 YIADLGNIRIRAVS 1515
Cdd:cd14953    201 YVADRGNHRIRKIT 214
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1174-1512 2.75e-19

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 90.46  E-value: 2.75e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1174 GQADGnKLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPAHryyLATDPvTGDLYVSDTNT 1251
Cdd:cd05819      1 GTGPG-ELNNPQGIAVDSSGNIYVADTgnNRIQVFDPDGNFITSFGSFGSGDGQFNEPAG---VAVDS-DGNLYVADTGN 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1252 RRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcGDGGKAVEatLMSPKGMAVDKNGLIYFVDgTM---IRKVDQNG 1328
Cdd:cd05819     76 HRIQK---------FDPDGNFLASFG-----------GSGDGDGE--FNGPRGIAVDSSGNIYVAD-TGnhrIQKFDPDG 132
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1329 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPGVE 1406
Cdd:cd05819    133 EFLTTFGSGGSGPGQ--------------FNGPTGVAVDS-DGNIYVAD-------TGNHRIQVfdPDGNFLT-TFGSTG 189
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1407 YPVGKhavqttLESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEISlvagipsecdckndancdcYQSGDGYAKDAK 1486
Cdd:cd05819    190 TGPGQ------FNYPTGIAVDSDGNIYVADSGN---NRVQVFDPDGAGF-------------------GGNGNFLGSDGQ 241
                          330       340
                   ....*....|....*....|....*.
gi 1034640494 1487 LSAPSSLAASPDGTLYIADLGNIRIR 1512
Cdd:cd05819    242 FNRPSGLAVDSDGNLYVADTGNNRIQ 267
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1173-1445 4.36e-16

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 80.83  E-value: 4.36e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1173 NGQADGNkLLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLELRNKDFRHSSNPahrYYLATDPvTGDLYVSDTN 1250
Cdd:cd05819     47 FGSGDGQ-FNEPAGVAVDSDGNLYVADTgnHRIQKFDPDGNFLASFGGSGDGDGEFNGP---RGIAVDS-SGNIYVADTG 121
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1251 TRRIYRpksltgakdLTKNAEVVAGTGeqclpfdearcgdGGKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNG 1328
Cdd:cd05819    122 NHRIQK---------FDPDGEFLTTFG-------------SGGSGPGQFNGPTGVAVDSDGNIYVADTGnhRIQVFDPDG 179
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1329 IISTLLGSNDLTSARpltcdtsmhisqvrLEWPTDLAINPMDNsIYVLD--NNVVLQITENRQVRIAAGRPMhCQVPGVE 1406
Cdd:cd05819    180 NFLTTFGSTGTGPGQ--------------FNYPTGIAVDSDGN-IYVADsgNNRVQVFDPDGAGFGGNGNFL-GSDGQFN 243
                          250       260       270
                   ....*....|....*....|....*....|....*....
gi 1034640494 1407 YPVGkhavqttlesataIAVSYSGVLYITETDEKKINRI 1445
Cdd:cd05819    244 RPSG-------------LAVDSDGNLYVADTGNNRIQVF 269
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1235-1511 1.14e-09

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 61.45  E-value: 1.14e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEQ-CLPFDEarcgdggkaveatLMSPKGMAVDKNGLI 1313
Cdd:cd14952     15 VAVDA-AGNVYVADSGNNRVLK---------------LAAGSTTQtVLPFTG-------------LYQPQGVAVDAAGTV 65
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1314 YFVDGtmirkvDQNGIISTLLGSNDLTsARPLTcdtsmhisqvRLEWPTDLAINPMDNsIYVLDNnvvlqiTENRQVRIA 1393
Cdd:cd14952     66 YVTDF------GNNRVLKLAAGSTTQT-VLPFT----------GLNDPTGVAVDAAGN-VYVADT------GNNRVLKLA 121
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1394 AGRPMHCQVPgveypvgkhavQTTLESATAIAVSYSGVLYITETDEkkiNRIRQvttdgeisLVAGipsecdckndANCD 1473
Cdd:cd14952    122 AGSNTQTVLP-----------FTGLSNPDGVAVDGAGNVYVTDTGN---NRVLK--------LAAG----------STTQ 169
                          250       260       270
                   ....*....|....*....|....*....|....*...
gi 1034640494 1474 CYQSGDGyakdakLSAPSSLAASPDGTLYIADLGNIRI 1511
Cdd:cd14952    170 TVLPFTG------LNSPSGVAVDTAGNVYVTDHGNNRV 201
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1184-1462 1.69e-09

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 61.19  E-value: 1.69e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1184 PVALACGIDGSLYVGDF--NYVRRIFP-SGNVTsvlelrnkdfRHSSNPAHRYY-LATDPvTGDLYVSDTNTRRIYRpks 1259
Cdd:COG4257     19 PRDVAVDPDGAVWFTDQggGRIGRLDPaTGEFT----------EYPLGGGSGPHgIAVDP-DGNLWFTDNGNNRIGR--- 84
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1260 LTGAkdlTKNAEVVAGTGEQCLPFdearcgdggkaveatlmspkGMAVDKNGLIYFVDGT--MIRKVD-QNGIISTLLGS 1336
Cdd:COG4257     85 IDPK---TGEITTFALPGGGSNPH--------------------GIAFDPDGNLWFTDQGgnRIGRLDpATGEVTEFPLP 141
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1337 NDLTSARPLTCD--------------------TSMHISQVRLE----WPTDLAINPmDNSIYVLD--NNVVLQITEnrqv 1390
Cdd:COG4257    142 TGGAGPYGIAVDpdgnlwvtdfganaigridpDTGTLTEYALPtpgaGPRGLAVDP-DGNLWVADtgSGRIGRFDP---- 216
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1034640494 1391 riAAGRpmhcqvpgveypVGKHAVQTTLESATAIAVSYSGVLYITETDekkINRIRQVTTDGEISLVAgIPS 1462
Cdd:COG4257    217 --KTGT------------VTEYPLPGGGARPYGVAVDGDGRVWFAESG---ANRIVRFDPDTELTEYV-LPS 270
Rhs_assc_core TIGR03696
RHS repeat-associated core domain; This model represents a conserved unique core sequence ...
2334-2408 4.08e-09

RHS repeat-associated core domain; This model represents a conserved unique core sequence shared by large numbers of proteins. It is occasional in the Archaea Methanosarcina barkeri) but common in bacteria and eukaryotes. Most fall into two large classes. One class consists of long proteins in which two classes of repeats are abundant: an FG-GAP repeat (pfam01839) class, and an RHS repeat (pfam05593) or YD repeat (TIGR01643). This class includes secreted bacterial insecticidal toxins and intercellular signalling proteins such as the teneurins in animals. The other class consists of uncharacterized proteins shorter than 400 amino acids, where this core domain of about 75 amino acids tends to occur in the N-terminal half. Over twenty such proteins are found in Pseudomonas putida alone; little sequence similarity or repeat structure is found among these proteins outside the region modeled by this domain.


Pssm-ID: 274730 [Multi-domain]  Cd Length: 77  Bit Score: 55.20  E-value: 4.08e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1034640494 2334 YTAYGEIYFDSNIDFQLvIGFHGGLYDPLTKLIHFGERDYDILAGRWTTPDieiwkRIGKDpAPFNLYMFRNNNP 2408
Cdd:TIGR03696    1 YDPYGEVLSESGAAPNP-LRFTGQYYDAETGLYYNGARYYDPELGRFLSPD-----PIGLG-GGLNLYAYVGNNP 68
NHL_like_2 cd14957
Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and ...
1299-1609 4.34e-08

Uncharacterized NHL-repeat domain in bacterial and archaeal proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271327 [Multi-domain]  Cd Length: 280  Bit Score: 57.28  E-value: 4.34e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1299 LMSPKGMAVDKNGLIYFVD--GTMIRKVDQNGIISTLLGSNDltsarpltcdtsmhISQVRLEWPTDLAINPMDNsIYVL 1376
Cdd:cd14957     17 FNTPRGIAVDSAGNIYVADtgNNRIQVFTSSGVYSYSIGSGG--------------TGSGQFNSPYGIAVDSNGN-IYVA 81
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1377 DNNvvlqitENR-QVRIAAGrpmhcqvpGVEYPVGKHAVQTT-LESATAIAVSYSGVLYITETDEkkiNRIRQVTTDGEI 1454
Cdd:cd14957     82 DTD------NNRiQVFNSSG--------VYQYSIGTGGSGDGqFNGPYGIAVDSNGNIYVADTGN---HRIQVFTSSGTF 144
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1455 slvagipsecdckndancdCYQSGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRavsknkpllnsmnfyevasptd 1534
Cdd:cd14957    145 -------------------SYSIGSGGTGPGQFNGPQGIAVDSDGNIYVADTGNHRIQ---------------------- 183
                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1034640494 1535 qelyIFDINGTHQYTV-SLVTGDYLynFSYSNDNDItavtDSNGNTLRIRRDPNRmpVRVVSPDNqVIWLTIGTNG 1609
Cdd:cd14957    184 ----VFTSSGTFQYTFgSSGSGPGQ--FSDPYGIAV----DSDGNIYVADTGNHR--IQVFTSSG-AYQYSIGTSG 246
acid_disulf_rpt NF033662
acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with ...
785-815 8.50e-08

acidic double-disulfide repeat; The acidic double-disulfide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids.


Pssm-ID: 411265 [Multi-domain]  Cd Length: 32  Bit Score: 50.21  E-value: 8.50e-08
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1034640494  785 AMETLCTDSKDNEGDGLIDCMDPDCCLQSSC 815
Cdd:NF033662     2 ATDTTCSDGIDNDGDGLTDCADPDCAGNPVC 32
DUF5885 pfam19232
Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown ...
522-676 8.81e-08

Family of unknown function (DUF5885); This is a family of uncharacterized proteins of unknown function found in viruses.


Pssm-ID: 437064  Cd Length: 265  Bit Score: 56.17  E-value: 8.81e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  522 CHGNGECvsGTCH-CFPGFLGPDCSraACPVLCSGNGQ----------YSKGRC----LCFSGwkgTECDVPTTQCI-DP 585
Cdd:pfam19232   34 CTTDAQC--GTCMtCVAGACTPKAS--CCGGVTCGAGQtcdaktntcvYVKGYCsadhPCPSG---SACDTAKNACIaQP 106
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  586 QCG---GRGiCIMG-------------------SCACNSGYK-GESCE--------EADCIDP---------------GC 619
Cdd:pfam19232  107 PYGpdsGKG-CVRGfgawiweldpatnsgvwrcRCANGSLYNsAHECSpladqtlcAAENLDPnalvpassvpafaayGW 185
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  620 SNHGVCIH-------------GECHCSPGWGGSNCEILKTmcpdqCSGHGTYLQESGSCTCD------------PN---W 671
Cdd:pfam19232  186 GNQPVLINkstagaavpsplaGVCPCKPGWAGGSCTEDRT-----CNGRGTWNETTGQCACNidfsghnscgddNNctsW 260

                   ....*
gi 1034640494  672 TGPDC 676
Cdd:pfam19232  261 TGPRC 265
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
573-727 1.99e-07

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 52.45  E-value: 1.99e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  573 TECDVPTTQCIDPQ--CGGRGICIMGScACNSGykgeSCEEAdcidpgCSNHGVCIHGECHCSPGwggsnceilKTMCPD 650
Cdd:NF041328    12 AGCPEPGAVCPEGLsvCGGACVDLRSD-PSNCG----ACGVA------CGAGQTCVAGACGCGPG---------TVACGG 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  651 QCSGHGTylqesgsctcDPNWTGPdcsneiCSVDCGSHGVCMGGTCR--CEEGWT--GPAC--------NQRACHPRCAE 718
Cdd:NF041328    72 ACVDTAS----------DPAHCGA------CGAACAPGQVCEGGACReaCSEGLTrcGGACvdlatdplHCGACGVACDP 135

                   ....*....
gi 1034640494  719 HGTCKDGKC 727
Cdd:NF041328   136 GESCRGGAC 144
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1233-1512 6.44e-07

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 53.48  E-value: 6.44e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1233 YYLATDPvTGDLYVSDTNTRRIYRpksltgakdltknaeVVAGTGEqclpFDEARCGDGGkaveatlmSPKGMAVDKNGL 1312
Cdd:COG4257     20 RDVAVDP-DGAVWFTDQGGGRIGR---------------LDPATGE----FTEYPLGGGS--------GPHGIAVDPDGN 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1313 IYFVDGT--MIRKVD-QNGIISTLLGSNDLTSarpltcdtsmhisqvrlewPTDLAINPmDNSIYVLD--NNVVLQIT-E 1386
Cdd:COG4257     72 LWFTDNGnnRIGRIDpKTGEITTFALPGGGSN-------------------PHGIAFDP-DGNLWFTDqgGNRIGRLDpA 131
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1387 NRQVRiaagrpmhcqvpgvEYPVGKHAVQTTlesatAIAVSYSGVLYITETdekKINRIRQVTTD-GEISLvagipsecd 1465
Cdd:COG4257    132 TGEVT--------------EFPLPTGGAGPY-----GIAVDPDGNLWVTDF---GANAIGRIDPDtGTLTE--------- 180
                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*..
gi 1034640494 1466 ckndancdcyqsgdgYAKDAKLSAPSSLAASPDGTLYIADLGNIRIR 1512
Cdd:COG4257    181 ---------------YALPTPGAGPRGLAVDPDGNLWVADTGSGRIG 212
NHL_PKND_like cd14952
NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein ...
1181-1442 9.04e-07

NHL repeat domain of the protein kinase PknD; PknD is a mycobacterial transmembrane protein with a cytosolic kinase domain and an extracellular sensor domain that contains NHL repeats. It plays a key role in the development of central nervous system tuberculosis, by mediating the invasion of host brain endothelia. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271322 [Multi-domain]  Cd Length: 247  Bit Score: 52.60  E-value: 9.04e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1181 LLAPVALACGIDGSLYVGDF--NYVRRIFPSGNVTSVLElrnkdFRHSSNPAHryyLATDPVtGDLYVSDTNTRRIyrpk 1258
Cdd:cd14952     51 LYQPQGVAVDAAGTVYVTDFgnNRVLKLAAGSTTQTVLP-----FTGLNDPTG---VAVDAA-GNVYVADTGNNRV---- 117
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1259 sltgakdltknAEVVAGTGEQC-LPFdearcgdggkaveATLMSPKGMAVDKNGLIYFVDGtmirkvDQNGIISTLLGSN 1337
Cdd:cd14952    118 -----------LKLAAGSNTQTvLPF-------------TGLSNPDGVAVDGAGNVYVTDT------GNNRVLKLAAGST 167
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1338 DLTsARPLTCDTSmhisqvrlewPTDLAINPMDNsIYVLDNNvvlqitENRQVRIAAGRPMHCQVP--GVEYPVGkhavq 1415
Cdd:cd14952    168 TQT-VLPFTGLNS----------PSGVAVDTAGN-VYVTDHG------NNRVLKLAAGSTTPTVLPftGLNGPLG----- 224
                          250       260
                   ....*....|....*....|....*..
gi 1034640494 1416 ttlesataIAVSYSGVLYITETDEKKI 1442
Cdd:cd14952    225 --------VAVDAAGNVYVADRGNDRV 243
PLN02919 PLN02919
haloacid dehalogenase-like hydrolase family protein
1235-1518 8.29e-06

haloacid dehalogenase-like hydrolase family protein


Pssm-ID: 215497 [Multi-domain]  Cd Length: 1057  Bit Score: 51.78  E-value: 8.29e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1235 LATDPVTGDLYVSDTNTRRIYrpksltgAKDLTKNAEV-VAGTGEQCL---PFDEArcgdggkaveaTLMSPKGMAVD-K 1309
Cdd:PLN02919   573 LAIDLLNNRLFISDSNHNRIV-------VTDLDGNFIVqIGSTGEEGLrdgSFEDA-----------TFNRPQGLAYNaK 634
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1310 NGLIYFVD--GTMIRKVD-QNGIISTLLGS----NDLTSARPLTcdtsmhiSQVrLEWPTDLAINPMDNSIYV------- 1375
Cdd:PLN02919   635 KNLLYVADteNHALREIDfVNETVRTLAGNgtkgSDYQGGKKGT-------SQV-LNSPWDVCFEPVNEKVYIamagqhq 706
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1376 ------LD-------------------------------------NNVVLQITENRQVR-----------IAAGRPMhcq 1401
Cdd:PLN02919   707 iweyniSDgvtrvfsgdgyernlngssgtstsfaqpsgislspdlKELYIADSESSSIRaldlktggsrlLAGGDPT--- 783
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1402 VPGVEYPVGKH---AVQTTLESATAIAVSYSGVLYITETDEKKINRIRQVTtdGEISLVAGIPsecdckndancdcyQSG 1478
Cdd:PLN02919   784 FSDNLFKFGDHdgvGSEVLLQHPLGVLCAKDGQIYVADSYNHKIKKLDPAT--KRVTTLAGTG--------------KAG 847
                          330       340       350       360
                   ....*....|....*....|....*....|....*....|..
gi 1034640494 1479 --DGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKNK 1518
Cdd:PLN02919   848 fkDGKALKAQLSEPAGLALGENGRLFVADTNNSLIRYLDLNK 889
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
698-741 1.62e-05

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 44.15  E-value: 1.62e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1034640494  698 CEEGWTGPACNqRACHPRCAE--HGTC-KDGKCECSQGWNGEHCTIA 741
Cdd:pfam01414    1 CDENYYGSTCS-KFCRPRDDKfgHYTCdANGNKVCLPGWTGPYCDKP 46
C_rich_MXAN6577 NF041328
MXAN_6577-like cysteine-rich domain;
681-776 1.65e-05

MXAN_6577-like cysteine-rich domain;


Pssm-ID: 469225 [Multi-domain]  Cd Length: 145  Bit Score: 47.06  E-value: 1.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  681 CSVDCGSHGVCMGGTCRCEEGWT--GPAC--------NQRACHPRCAEHGTCKDGKCecsqgwngehctiahyldkivKE 750
Cdd:NF041328    45 CGVACGAGQTCVAGACGCGPGTVacGGACvdtasdpaHCGACGAACAPGQVCEGGAC---------------------RE 103
                           90       100       110
                   ....*....|....*....|....*....|...
gi 1034640494  751 GCP-GLCNSNGRCT-LDQNGWHC-----VCQPG 776
Cdd:NF041328   104 ACSeGLTRCGGACVdLATDPLHCgacgvACDPG 136
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1180-1437 4.64e-05

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 47.67  E-value: 4.64e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1180 KLLAPVALACGIDGSLYVGDFnYVRRI--F-PSGNVTSVLElRNKDFRHSSNPAHryyLATDpvTGDLYVSDTNTRRIYr 1256
Cdd:cd14963     54 EFKYPYGIAVDSDGNIYVADL-YNGRIqvFdPDGKFLKYFP-EKKDRVKLISPAG---LAID--DGKLYVSDVKKHKVI- 125
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1257 pksltgakdltknaeVVAGTGEQCLPFdearcGDGGKAvEATLMSPKGMAVDKNGLIYFVD--GTMIRKVDQNG-IISTL 1333
Cdd:cd14963    126 ---------------VFDLEGKLLLEF-----GKPGSE-PGELSYPNGIAVDEDGNIYVADsgNGRIQVFDKNGkFIKEL 184
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1334 LGSNDLTSArpltcdtsmhisqvrLEWPTDLAINPmDNSIYVLDN--NVVLQITENRQVRIAAGRpmhcqvPGVEypvgk 1411
Cdd:cd14963    185 NGSPDGKSG---------------FVNPRGIAVDP-DGNLYVVDNlsHRVYVFDEQGKELFTFGG------RGKD----- 237
                          250       260
                   ....*....|....*....|....*.
gi 1034640494 1412 havQTTLESATAIAVSYSGVLYITET 1437
Cdd:cd14963    238 ---DGQFNLPNGLFIDDDGRLYVTDR 260
NHL cd05819
NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in ...
1483-1609 1.03e-04

NHL repeat unit of beta-propeller proteins; The NHL(NCL-1, HT2A and LIN-41)-repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures. The repeats have a catalytic activity in Peptidyl-glycine alpha-amidating monooxygenase; proteolysis has shown that the Peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) activity is localized to the repeats. Tripartite motif-containing protein 32 interacts with the activation domain of Tat. This interaction is mediated by the NHL repeats.


Pssm-ID: 271320 [Multi-domain]  Cd Length: 269  Bit Score: 46.54  E-value: 1.03e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1483 KDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN-KPLLN-------SMNFYE---VASPTDQELYI----------FD 1541
Cdd:cd05819      3 GPGELNNPQGIAVDSSGNIYVADTGNNRIQVFDPDgNFITSfgsfgsgDGQFNEpagVAVDSDGNLYVadtgnhriqkFD 82
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034640494 1542 INGTHQYTVSlVTGDYLYNFSY------SNDNDItAVTDSNGNtlRIrrdpnrmpvRVVSPDNQVIwLTIGTNG 1609
Cdd:cd05819     83 PDGNFLASFG-GSGDGDGEFNGprgiavDSSGNI-YVADTGNH--RI---------QKFDPDGEFL-TTFGSGG 142
DSL pfam01414
Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain ...
667-709 1.46e-04

Delta serrate ligand; This family has been redefined to correspond to the EGF-like domain defined by structure.


Pssm-ID: 460202  Cd Length: 46  Bit Score: 41.46  E-value: 1.46e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1034640494  667 CDPNWTGPDCSNEiCSV--DCGSHGVC-MGGTCRCEEGWTGPACNQ 709
Cdd:pfam01414    1 CDENYYGSTCSKF-CRPrdDKFGHYTCdANGNKVCLPGWTGPYCDK 45
NHL_like_1 cd14953
Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat ...
1477-1517 2.04e-04

Uncharacterized NHL-repeat domain in bacterial proteins; This bacterial family of NHL-repeat domains is found in a variety of domain architectures. The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271323 [Multi-domain]  Cd Length: 323  Bit Score: 45.98  E-value: 2.04e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1034640494 1477 SGDGYAKDAKLSAPSSLAASPDGTLYIADLGNIRIRAVSKN 1517
Cdd:cd14953     12 FSGGGGTAARFNSPSGVAVDAAGNLYVADRGNHRIRKITPD 52
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
522-544 4.87e-04

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 39.25  E-value: 4.87e-04
                           10        20
                   ....*....|....*....|....*
gi 1034640494  522 CHGNGECVS--GTCHCFPGFLGPDC 544
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
YD_repeat_2x TIGR01643
YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular ...
1839-1879 1.02e-03

YD repeat (two copies); This model describes two tandem copies of a 21-residue extracellular repeat found in Gram-negative, Gram-positive, and animal proteins. The repeat is named for a YD dipeptide, the most strongly conserved motif of the repeat. These repeats appear in general to be involved in binding carbohydrate; the chicken teneurin-1 YD-repeat region has been shown to bind heparin.


Pssm-ID: 273728 [Multi-domain]  Cd Length: 42  Bit Score: 38.73  E-value: 1.02e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1034640494 1839 YSSTGQ-IASIQRGTTSEKVDYDGQGRIVSRVFADGKTWSYT 1879
Cdd:TIGR01643    1 YDAAGRlTGSTDADGTTTRYTYDAAGRLVEITDADGGSTRYE 42
YvrE COG3386
Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase ...
1187-1330 1.10e-03

Sugar lactone lactonase YvrE [Carbohydrate transport and metabolism]; Sugar lactone lactonase YvrE is part of the Pathway/BioSystem: Non-phosphorylated Entner-Doudoroff pathway


Pssm-ID: 442613 [Multi-domain]  Cd Length: 266  Bit Score: 43.34  E-value: 1.10e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1187 LACGIDGSLYVGDFNYVR------RIFPSGNVTSVLElrnkDFrHSSN-----PAHRYylatdpvtgdLYVSDTNTRRIY 1255
Cdd:COG3386     98 GVVDPDGRLYFTDMGEYLptgalyRVDPDGSLRVLAD----GL-TFPNgiafsPDGRT----------LYVADTGAGRIY 162
                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034640494 1256 R-PKSLTGAkdLTkNAEVVAgtgeqclpfdEARCGDGGkaveatlmsPKGMAVDKNGLIY--FVDGTMIRKVDQNGII 1330
Cdd:COG3386    163 RfDLDADGT--LG-NRRVFA----------DLPDGPGG---------PDGLAVDADGNLWvaLWGGGGVVRFDPDGEL 218
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
652-676 1.18e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 38.48  E-value: 1.18e-03
                           10        20
                   ....*....|....*....|....*
gi 1034640494  652 CSGHGTYLQESGSCTCDPNWTGPDC 676
Cdd:pfam07974    2 CSGRGTCVNQCGKCVCDSGYQGATC 26
Keratin_B2 pfam01500
Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized ...
609-727 1.19e-03

Keratin, high sulfur B2 protein; High sulfur proteins are cysteine-rich proteins synthesized during the differentiation of hair matrix cells, and form hair fibres in association with hair keratin intermediate filaments. This family has been divided up into four regions, with the second region containing 8 copies of a short repeat. This family is also known as B2 or KAP1.


Pssm-ID: 366678 [Multi-domain]  Cd Length: 161  Bit Score: 42.09  E-value: 1.19e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494  609 CEEADCIDPGCSNHGVCihGECHCSPGWGGSNCeILKTMCPDQCSGHGTYLQESGSCTCDPNwTGPDCSNEICSVDCGSH 688
Cdd:pfam01500    4 CGTSFCGFPTCSTGGTC--GSGCCQPCCCQSSC-CRPSCCQTSCCQPTTFQSSCCRPTCQPC-CQTSCCQPTCCQTSSCQ 79
                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1034640494  689 GVCMGGTCRCEEGWTGPACNQRACHPRCAEHGTCKDGKC 727
Cdd:pfam01500   80 TGCGGIGYGQEGSSGAVSSRTRWCRPDCRVEGTCLPPCC 118
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
619-641 1.87e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 37.71  E-value: 1.87e-03
                           10        20
                   ....*....|....*....|....*
gi 1034640494  619 CSNHGVCIH--GECHCSPGWGGSNC 641
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
NHL_like_5 cd14963
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1486-1582 1.97e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271333 [Multi-domain]  Cd Length: 268  Bit Score: 42.66  E-value: 1.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1486 KLSAPSSLAASPDGTLYIADLGNIRIRAVSKN----------KPLLNSM----------NFYeVASPTDQELYIFDINGT 1545
Cdd:cd14963     54 EFKYPYGIAVDSDGNIYVADLYNGRIQVFDPDgkflkyfpekKDRVKLIspaglaiddgKLY-VSDVKKHKVIVFDLEGK 132
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1034640494 1546 HQYTVSLVtGDYLYNFSYSN------DNDItAVTDSNGNtlRI 1582
Cdd:cd14963    133 LLLEFGKP-GSEPGELSYPNgiavdeDGNI-YVADSGNG--RI 171
Vgb COG4257
Streptogramin lyase [Defense mechanisms];
1179-1256 2.60e-03

Streptogramin lyase [Defense mechanisms];


Pssm-ID: 443399 [Multi-domain]  Cd Length: 270  Bit Score: 42.31  E-value: 2.60e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1179 NKLLAPVALACGIDGSLYVGDF--NYVRRIFP-SGNVTSvlelrnkdFRHSSNPAHRYYLATDPvTGDLYVSDTNTRRIY 1255
Cdd:COG4257    185 TPGAGPRGLAVDPDGNLWVADTgsGRIGRFDPkTGTVTE--------YPLPGGGARPYGVAVDG-DGRVWFAESGANRIV 255

                   .
gi 1034640494 1256 R 1256
Cdd:COG4257    256 R 256
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
753-782 3.57e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 3.57e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1034640494  753 PGLCNSNGRCTLDQNGWHCVCQPGWRGAGC 782
Cdd:cd00054      8 GNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
NHL_like_6 cd14962
Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) ...
1292-1511 5.03e-03

Uncharacterized NHL-repeat domain in bacterial proteins; The NHL (NCL-1, HT2A and LIN-41) repeat is found in multiple tandem copies, typically as 6 instances. It is about 40 residues long and resembles the WD repeat and other beta-propeller structures.


Pssm-ID: 271332 [Multi-domain]  Cd Length: 271  Bit Score: 41.42  E-value: 5.03e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1292 GKAVEATLMSPKGMAVDKNGLIYFVDGT--MIRKVDQNGIISTLLGSNDLtsarpltcdtsmhisQVRlewPTDLAINPM 1369
Cdd:cd14962     49 GNAGPNRFVSPIGVAIDANGNLYVSDAElgKVFVFDRDGKFLRAIGAGAL---------------FKR---PTGIAVDPA 110
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1370 DNSIYVLDnnvvlqiTENRQVRI--AAGRPMHcQVPgveyPVGKHAVQttLESATAIAVSYSGVLYITETDEKKINRI-- 1445
Cdd:cd14962    111 GKRLYVVD-------TLAHKVKVfdLDGRLLF-DIG----KRGSGPGE--FNLPTDLAVDRDGNLYVTDTMNFRVQIFda 176
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034640494 1446 --RQVTTDGEISLVAG---IPSECDCKNDAN---CDCYQS---------------GDGYAKDAKLSAPSSLAASPDGTLY 1502
Cdd:cd14962    177 dgKFLRSFGERGDGPGsfaRPKGIAVDSEGNiyvVDAAFDnvqifnpegellltvGGPGSGPGEFYLPSGIAIDKDDRIY 256

                   ....*....
gi 1034640494 1503 IADLGNIRI 1511
Cdd:cd14962    257 VVDQFNRRI 265
EGF_2 pfam07974
EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.
587-609 7.69e-03

EGF-like domain; This family contains EGF domains found in a variety of extracellular proteins.


Pssm-ID: 400365  Cd Length: 26  Bit Score: 36.17  E-value: 7.69e-03
                           10        20
                   ....*....|....*....|....*
gi 1034640494  587 CGGRGICIM--GSCACNSGYKGESC 609
Cdd:pfam07974    2 CSGRGTCVNqcGKCVCDSGYQGATC 26
RHS_repeat pfam05593
RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be ...
1631-1662 8.44e-03

RHS Repeat; RHS proteins contain extended repeat regions. These repeats often appear to be involved in ligand binding. Note that this model may not find all the repeats in a protein and that it covers two RHS repeats. The 3D structure of an RHS-repeat-containing protein (the B and C components of an ABC toxin complex) has been determined. The RHS repeats form an extended strip of beta-sheet that spirals around to form a hollow shell, encapsulating the variable C-terminal domain.


Pssm-ID: 461685 [Multi-domain]  Cd Length: 37  Bit Score: 36.04  E-value: 8.44e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1034640494 1631 GLLATKSDETGWTTFFDYDSEGRLTNVTFPTG 1662
Cdd:pfam05593    5 GRLTSVTDPDGRVTTYTYDAAGRLTAVTDPDG 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
756-779 8.91e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.82  E-value: 8.91e-03
                           10        20
                   ....*....|....*....|....
gi 1034640494  756 CNSNGRCTLDQNGWHCVCQPGWRG 779
Cdd:pfam00008    6 CSNGGTCVDTPGGYTCICPEGYTG 29
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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