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Conserved domains on  [gi|1034631760|ref|XP_016861362|]
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5-aminolevulinate synthase, non-specific, mitochondrial isoform X3 [Homo sapiens]

Protein Classification

Preseq_ALAS and KBL_like domain-containing protein( domain architecture ID 11181659)

Preseq_ALAS and KBL_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AAT_I super family cl18945
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 197-547 0e+00

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


The actual alignment was detected with superfamily member TIGR01821:

Pssm-ID: 450240 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 197 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 276
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 277 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 356
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 357 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 389
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 461
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 462 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 1034631760 542 VGLELK 547
Cdd:TIGR01821 397 LGLPLS 402
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 2-137 3.58e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


:

Pssm-ID: 462658  Cd Length: 114  Bit Score: 179.61  E-value: 3.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760   2 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 80
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631760  81 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 137
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
 
Name Accession Description Interval E-value
5aminolev_synth TIGR01821
5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an ...
 197-547 0e+00

5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an enzyme for one of two routes to the heme precursor 5-aminolevulinate. The protein is a pyridoxal phosphate-dependent enzyme related to 2-amino-3-ketobutyrate CoA tranferase and 8-amino-7-oxononanoate synthase. This enzyme appears restricted to the alpha Proteobacteria and mitochondrial derivatives. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273820 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 197 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 276
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 277 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 356
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 357 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 389
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 461
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 462 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 1034631760 542 VGLELK 547
Cdd:TIGR01821 397 LGLPLS 402
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 197-553 8.04e-141

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 414.25  E-value: 8.04e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 197 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 276
Cdd:PRK13392    2 MNYDSYFDAALAQLHQEGRYRVFADLEREAGRFPRARDHGPD--GPRRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 277 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 356
Cdd:PRK13392   80 AGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALSTLGKLLPGCVILSDALNHASMIEGIRRSGAEKQVF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 357 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 389
Cdd:PRK13392  160 RHNDLADLEEQLASVDPDRPKLIAFESVYSMDGdiapieaicdladrynaltyvdevhavglygargggiaerdglmdri 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLM 461
Cdd:PRK13392  240 dmiqgtlaKAFGCLGGYIAASADLIDFVRSFAPGFIFTTALPPAVAAGATAAIRHLKTSQTE--RDAHQDRVAALKAKLN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 462 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:PRK13392  318 ANGIPVMPSPSHIVPVMVGDPTLCKAISDRLMSEHGIYIQPINYPTVPRGTERLRITPTPLHDDEDIDALVAALVAIWDR 397

                         410
                  ....*....|..
gi 1034631760 542 VGLELKPHSSAE 553
Cdd:PRK13392  398 LELPRWREAAQA 409
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 243-543 3.29e-138

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 405.41  E-value: 3.29e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 243 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 322
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 323 LakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSD-PSVPKIVAFETVHSMDG------------ 389
Cdd:cd06454    81 L--AGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLREARrPYGKKLIVTEGVYSMDGdiaplpelvdla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 426
Cdd:cd06454   159 kkygailfvdeahsvgvygphgrgveefggltddvdiimgtlgKAFGAVGGYIAGSKELIDYLRSYARGFIFSTSLPPAV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 427 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVAD-AAKNTEVCDELMSRhNIYVQAINY 505
Cdd:cd06454   239 AAAALAALEVLQGGPER--RERLQENVRYLRRGLKELGFPVGGSPSHIIPPLIGDdPAKAVAFSDALLER-GIYVQAIRY 315

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1034631760 506 PTVPRGEELLRIAPTPHHTPQMMNYFLENLlvtwKQVG 543
Cdd:cd06454   316 PTVPRGTARLRISLSAAHTKEDIDRLLEAL----KEVG 349
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 199-541 6.66e-126

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 375.16  E-value: 6.66e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 199 YDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 278
Cdd:COG0156     1 LLDRLEAELAALKAAGLYRYLRVLESPQGPRVTIDG--------REVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 279 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 358
Cdd:COG0156    73 GSRLVSGTTPLHEELEEELAEFLGKEAALLFSSGYAANLGVISALAG--RGDLIFSDELNHASIIDGARLSGAKVVRFRH 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 359 NDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------------------------------------------- 389
Cdd:COG0156   151 NDMDDLERLLKKARAARRKLIVTDGVFSMDGdiaplpeivelaekygallyvddahgtgvlgetgrglvehfgledrvdi 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 ------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDA 463
Cdd:COG0156   231 imgtlsKALGSSGGFVAGSKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPEL--RERLWENIAYFREGLKEL 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034631760 464 GLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:COG0156   309 GFDLGPSESPIVPVIVGDAERALALADALLER-GIYVSAIRPPTVPKGTARLRITLSAAHTEEDIDRLLEALAEVGKE 385
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 2-137 3.58e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


Pssm-ID: 462658  Cd Length: 114  Bit Score: 179.61  E-value: 3.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760   2 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 80
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631760  81 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 137
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
248-533 5.33e-45

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 162.86  E-value: 5.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 248 WCSNDYLGMsrhprVCGAVMDTLKQhgAGAGGTRNISGTSKFHVDLERELADLHG--------KDAALLFSSCFVANDST 319
Cdd:pfam00155   6 LGSNEYLGD-----TLPAVAKAEKD--ALAGGTRNLYGPTDGHPELREALAKFLGrspvlkldREAAVVFGSGAGANIEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 320 LFTLAKMmPGCEIYSDSGNHASMIQGIRNSRVPKYIFR-------HNDVSHLRELLQRSdpsvPKIVAFETVHSMDG--- 389
Cdd:pfam00155  79 LIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK----PKVVLHTSPHNPTGtva 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 -------------------------------------------------------KAFGCVG---GYIASTSSLIDTVRS 411
Cdd:pfam00155 154 tleeleklldlakehnilllvdeayagfvfgspdavatrallaegpnllvvgsfsKAFGLAGwrvGYILGNAAVISQLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 412 YAAGFIFTTSLPPMLLAGALESvrILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDE 491
Cdd:pfam00155 234 LARPFYSSTHLQAAAAAALSDP--LLVASELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFFLLTGLDPETAKELAQV 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1034631760 492 LMSRHNIYVQAINYPTVPrgeELLRIAPTpHHTPQMMNYFLE 533
Cdd:pfam00155 312 LLEEVGVYVTPGSSPGVP---GWLRITVA-GGTEEELEELLE 349
 
Name Accession Description Interval E-value
5aminolev_synth TIGR01821
5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an ...
 197-547 0e+00

5-aminolevulinic acid synthase; This model represents 5-aminolevulinic acid synthase, an enzyme for one of two routes to the heme precursor 5-aminolevulinate. The protein is a pyridoxal phosphate-dependent enzyme related to 2-amino-3-ketobutyrate CoA tranferase and 8-amino-7-oxononanoate synthase. This enzyme appears restricted to the alpha Proteobacteria and mitochondrial derivatives. [Biosynthesis of cofactors, prosthetic groups, and carriers, Heme, porphyrin, and cobalamin]


Pssm-ID: 273820 [Multi-domain]  Cd Length: 402  Bit Score: 548.95  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 197 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 276
Cdd:TIGR01821   1 MDYDQFFNKEIDKLHLEGRYRVFADLERQAGEFPFAQWHRPD--GAKDVTVWCSNDYLGMGQHPEVLQAMHETLDKYGAG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 277 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 356
Cdd:TIGR01821  79 AGGTRNISGTNIPHVELEAELADLHGKESALVFTSGYVANDATLATLAKIIPGCVIFSDELNHASMIEGIRHSGAEKFIF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 357 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 389
Cdd:TIGR01821 159 RHNDVAHLEKLLQSVDPNRPKIIAFESVYSMDGdiapieeicdladkygaltyldevhavglygprgggiaerdglmhri 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEgrVLRRQHQRNVKLMRQMLM 461
Cdd:TIGR01821 239 diiegtlaKAFGVVGGYIAASRKLIDAIRSYAPGFIFTTSLPPAIAAGATASIRHLKESQ--DLRRAHQENVKRLKNLLE 316

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 462 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:TIGR01821 317 ALGIPVIPNPSHIVPVIIGDAALCKKVSDLLLNKHGIYVQPINYPTVPRGTERLRITPTPAHTDKMIDDLVEALLLVWDR 396


                  ....*.
gi 1034631760 542 VGLELK 547
Cdd:TIGR01821 397 LGLPLS 402
PRK13392 PRK13392
5-aminolevulinate synthase; Provisional
 197-553 8.04e-141

5-aminolevulinate synthase; Provisional


Pssm-ID: 184023 [Multi-domain]  Cd Length: 410  Bit Score: 414.25  E-value: 8.04e-141
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 197 FQYDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDYSDSliTKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAG 276
Cdd:PRK13392    2 MNYDSYFDAALAQLHQEGRYRVFADLEREAGRFPRARDHGPD--GPRRVTIWCSNDYLGMGQHPDVIGAMVDALDRYGAG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 277 AGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKMMPGCEIYSDSGNHASMIQGIRNSRVPKYIF 356
Cdd:PRK13392   80 AGGTRNISGTSHPHVLLERELADLHGKESALLFTSGYVSNDAALSTLGKLLPGCVILSDALNHASMIEGIRRSGAEKQVF 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 357 RHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG----------------------------------------------- 389
Cdd:PRK13392  160 RHNDLADLEEQLASVDPDRPKLIAFESVYSMDGdiapieaicdladrynaltyvdevhavglygargggiaerdglmdri 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLM 461
Cdd:PRK13392  240 dmiqgtlaKAFGCLGGYIAASADLIDFVRSFAPGFIFTTALPPAVAAGATAAIRHLKTSQTE--RDAHQDRVAALKAKLN 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 462 DAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:PRK13392  318 ANGIPVMPSPSHIVPVMVGDPTLCKAISDRLMSEHGIYIQPINYPTVPRGTERLRITPTPLHDDEDIDALVAALVAIWDR 397

                         410
                  ....*....|..
gi 1034631760 542 VGLELKPHSSAE 553
Cdd:PRK13392  398 LELPRWREAAQA 409
KBL_like cd06454
KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate ...
 243-543 3.29e-138

KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS), 8-amino-7-oxononanoate synthase (AONS), and 2-amino-3-ketobutyrate CoA ligase (KBL). SPT is responsible for the condensation of L-serine with palmitoyl-CoA to produce 3-ketodihydrospingosine, the reaction of the first step in sphingolipid biosynthesis. ALAS is involved in heme biosynthesis; it catalyzes the synthesis of 5-aminolevulinic acid from glycine and succinyl-coenzyme A. AONS catalyses the decarboxylative condensation of l-alanine and pimeloyl-CoA in the first committed step of biotin biosynthesis. KBL catalyzes the second reaction step of the metabolic degradation pathway for threonine converting 2-amino-3-ketobutyrate, to glycine and acetyl-CoA. The members of this CD are widely found in all three forms of life.


Pssm-ID: 99747 [Multi-domain]  Cd Length: 349  Bit Score: 405.41  E-value: 3.29e-138
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 243 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 322
Cdd:cd06454     1 KKVLNFCSNDYLGLANHPEVIEAAKEALDKYGVGAGGSRLISGTSDLHEELEEELAEFHGKEAALVFSSGYAANDGVLST 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 323 LakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSD-PSVPKIVAFETVHSMDG------------ 389
Cdd:cd06454    81 L--AGKGDLIISDSLNHASIIDGIRLSGAKKRIFKHNDMEDLEKLLREARrPYGKKLIVTEGVYSMDGdiaplpelvdla 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 426
Cdd:cd06454   159 kkygailfvdeahsvgvygphgrgveefggltddvdiimgtlgKAFGAVGGYIAGSKELIDYLRSYARGFIFSTSLPPAV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 427 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVAD-AAKNTEVCDELMSRhNIYVQAINY 505
Cdd:cd06454   239 AAAALAALEVLQGGPER--RERLQENVRYLRRGLKELGFPVGGSPSHIIPPLIGDdPAKAVAFSDALLER-GIYVQAIRY 315

                         330       340       350
                  ....*....|....*....|....*....|....*...
gi 1034631760 506 PTVPRGEELLRIAPTPHHTPQMMNYFLENLlvtwKQVG 543
Cdd:cd06454   316 PTVPRGTARLRISLSAAHTKEDIDRLLEAL----KEVG 349
BioF COG0156
7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; ...
 199-541 6.66e-126

7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]; 7-keto-8-aminopelargonate synthetase or related enzyme is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 439926 [Multi-domain]  Cd Length: 385  Bit Score: 375.16  E-value: 6.66e-126
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 199 YDRFFEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 278
Cdd:COG0156     1 LLDRLEAELAALKAAGLYRYLRVLESPQGPRVTIDG--------REVLNFSSNDYLGLANHPRVIEAAAEALDRYGTGSG 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 279 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 358
Cdd:COG0156    73 GSRLVSGTTPLHEELEEELAEFLGKEAALLFSSGYAANLGVISALAG--RGDLIFSDELNHASIIDGARLSGAKVVRFRH 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 359 NDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------------------------------------------- 389
Cdd:COG0156   151 NDMDDLERLLKKARAARRKLIVTDGVFSMDGdiaplpeivelaekygallyvddahgtgvlgetgrglvehfgledrvdi 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 ------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDA 463
Cdd:COG0156   231 imgtlsKALGSSGGFVAGSKELIDYLRNRARPFIFSTALPPAVAAAALAALEILREEPEL--RERLWENIAYFREGLKEL 308

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034631760 464 GLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQ 541
Cdd:COG0156   309 GFDLGPSESPIVPVIVGDAERALALADALLER-GIYVSAIRPPTVPKGTARLRITLSAAHTEEDIDRLLEALAEVGKE 385
PRK05958 PRK05958
8-amino-7-oxononanoate synthase; Reviewed
 203-535 2.04e-73

8-amino-7-oxononanoate synthase; Reviewed


Pssm-ID: 235655 [Multi-domain]  Cd Length: 385  Bit Score: 239.67  E-value: 2.04e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 203 FEKKIDEKKNDHTYRVFKTVNRRAHIFPMADDysdslitkKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRN 282
Cdd:PRK05958    7 LEAALAQRRAAGLYRSLRPREGGAGRWLVVDG--------RRMLNFASNDYLGLARHPRLIAAAQQAARRYGAGSGGSRL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 283 ISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVS 362
Cdd:PRK05958   79 VTGNSPAHEALEEELAEWFGAERALLFSSGYAANLAVLTAL--AGKGDLIVSDKLNHASLIDGARLSRARVRRYPHNDVD 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 363 HLRELLQRSDPSvPKIVAFETVHSMDG----------------------------------------------------- 389
Cdd:PRK05958  157 ALEALLAKWRAG-RALIVTESVFSMDGdlaplaelvalarrhgawllvdeahgtgvlgpqgrglaaeaglagepdvilvg 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 ---KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKSAEGrvlRRQH-QRNVKLMRQMLMDAGL 465
Cdd:PRK05958  236 tlgKALGSSGAAVLGSETLIDYLINRARPFIFTTALPPAQAAAARAALRILRREPE---RRERlAALIARLRAGLRALGF 312

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 466 PVVHCPSHIIPVRVADAAKNTEVCDELmSRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENL 535
Cdd:PRK05958  313 QLMDSQSAIQPLIVGDNERALALAAAL-QEQGFWVGAIRPPTVPAGTSRLRITLTAAHTEADIDRLLEAL 381
bioF TIGR00858
8-amino-7-oxononanoate synthase; 7-keto-8-aminopelargonic acid synthetase is an alternate name. ...
 243-535 1.23e-71

8-amino-7-oxononanoate synthase; 7-keto-8-aminopelargonic acid synthetase is an alternate name. This model represents 8-amino-7-oxononanoate synthase, the BioF protein of biotin biosynthesis. This model is based on a careful phylogenetic analysis to separate members of this family from 2-amino-3-ketobutyrate and other related pyridoxal phosphate-dependent enzymes. In several species, including Staphylococcus and Coxiella, a candidate 8-amino-7-oxononanoate synthase is confirmed by location in the midst of a biotin biosynthesis operon but scores below the trusted cutoff of this model. [Biosynthesis of cofactors, prosthetic groups, and carriers, Biotin]


Pssm-ID: 273303 [Multi-domain]  Cd Length: 360  Bit Score: 234.08  E-value: 1.23e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 243 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 322
Cdd:TIGR00858  16 RRLLNFSSNDYLGLASHPEVIQAAQQGAEQYGAGSTASRLVSGNSPLHEELEEELAEWKGTEAALLFSSGYLANVGVISA 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 323 LAKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSVPKIVAFETVHSMDG------------- 389
Cdd:TIGR00858  96 LVG--KGDLILSDALNHASLIDGCRLSGARVRRYRHNDVEHLERLLEKNRGERRKLIVTDGVFSMDGdiaplpqlvalae 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 -------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPML 426
Cdd:TIGR00858 174 rygawlmvddahgtgvlgedgrgtlehfglkpepvdiqvgtlsKALGSYGAYVAGSQALIDYLINRARTLIFSTALPPAV 253

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 427 LAGALESVRILksAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYP 506
Cdd:TIGR00858 254 AAAALAALELI--QEEPWRREKLLALIARLRAGLEALGFTLMPSCTPIVPVIIGDNASALALAEELQQQ-GIFVGAIRPP 330

                         330       340
                  ....*....|....*....|....*....
gi 1034631760 507 TVPRGEELLRIAPTPHHTPQMMNYFLENL 535
Cdd:TIGR00858 331 TVPAGTSRLRLTLSAAHTPGDIDRLAEAL 359
PRK06939 PRK06939
2-amino-3-ketobutyrate coenzyme A ligase; Provisional
 202-547 5.78e-58

2-amino-3-ketobutyrate coenzyme A ligase; Provisional


Pssm-ID: 235893 [Multi-domain]  Cd Length: 397  Bit Score: 199.27  E-value: 5.78e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 202 FFEKKIDEKKNDHTY---RVFKTVNRrAHIfpmaddysdSLITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAG 278
Cdd:PRK06939    8 QLREELEEIKAEGLYkeeRVITSPQG-ADI---------TVADGKEVINFCANNYLGLANHPELIAAAKAALDSHGFGMA 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 279 GTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMPGCEIYSDSGNHASMIQGIRNSRVPKYIFRH 358
Cdd:PRK06939   78 SVRFICGTQDLHKELEEKLAKFLGTEDAILYSSCFDANGGLFETL--LGKEDAIISDALNHASIIDGVRLCKAKRYRYAN 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 359 NDVSHLRELLQRSDPSVP--KIVAFETVHSMDG----------------------------------------------- 389
Cdd:PRK06939  156 NDMADLEAQLKEAKEAGArhKLIATDGVFSMDGdiaplpeicdladkydalvmvddshavgfvgengrgtvehfgvmdrv 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 --------KAF-GCVGGYIASTSSLIDTVRSYAAGFIFTTSLPPMLLAGALESVRILKsaEGRVLRRQHQRNVKLMRQML 460
Cdd:PRK06939  236 diitgtlgKALgGASGGYTAGRKEVIDWLRQRSRPYLFSNSLAPAIVAASIKVLELLE--ESDELRDRLWENARYFREGM 313

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 461 MDAGLPVVHCPSHIIPVRVADAAKNTEVCDELMSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLEnllvTWK 540
Cdd:PRK06939  314 TAAGFTLGPGEHPIIPVMLGDAKLAQEFADRLLEE-GVYVIGFSFPVVPKGQARIRTQMSAAHTKEQLDRAID----AFE 388


                  ....*..
gi 1034631760 541 QVGLELK 547
Cdd:PRK06939  389 KVGKELG 395
Preseq_ALAS pfam09029
5-aminolevulinate synthase presequence; The N terminal presequence domain found in ...
 2-137 3.58e-54

5-aminolevulinate synthase presequence; The N terminal presequence domain found in 5-aminolevulinate synthase exists as an amphipathic helix, with a positively charged surface provided by lysine residues and no stable helix at the N-terminus. The domain is essential for the import process by which ALAS is transported into the mitochondria: translocase of the outer membrane (Tom) and translocase of the inner membrane protein complexes appear responsible for recognition and import through the mitochondrial membrane. The protein Tom20 is anchored to the mitochondrial outer membrane, and its interaction with presequences is thought to be the recognition step which allows subsequent import.


Pssm-ID: 462658  Cd Length: 114  Bit Score: 179.61  E-value: 3.58e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760   2 ESVVRRCPFLSRVPQAFLQKAGKSLLFYAQNCPKMMevgakpaPRALSTAAVHYQQIKE-TPPASEKDKTAKAkvqqtpd 80
Cdd:pfam09029   1 ASVLRRCPFLSRVPQAFLQKARKSLLSYAQRCPVMM-------TRALSTSSANLQGEKEeTPVAGPTAKQAKA------- 66

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1034631760  81 gsqqspdgtqLPSGHPLPATSQGTASKCPFLAAQMNQRGSSVFCKASLELQEDVQEM 137
Cdd:pfam09029  67 ----------LPLGHPSPQAGQSVASKCPFLAAEMGQKNSNVVRKASPEVQEDVQEV 113
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
248-533 5.33e-45

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 162.86  E-value: 5.33e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 248 WCSNDYLGMsrhprVCGAVMDTLKQhgAGAGGTRNISGTSKFHVDLERELADLHG--------KDAALLFSSCFVANDST 319
Cdd:pfam00155   6 LGSNEYLGD-----TLPAVAKAEKD--ALAGGTRNLYGPTDGHPELREALAKFLGrspvlkldREAAVVFGSGAGANIEA 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 320 LFTLAKMmPGCEIYSDSGNHASMIQGIRNSRVPKYIFR-------HNDVSHLRELLQRSdpsvPKIVAFETVHSMDG--- 389
Cdd:pfam00155  79 LIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPlydsndfHLDFDALEAALKEK----PKVVLHTSPHNPTGtva 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 -------------------------------------------------------KAFGCVG---GYIASTSSLIDTVRS 411
Cdd:pfam00155 154 tleeleklldlakehnilllvdeayagfvfgspdavatrallaegpnllvvgsfsKAFGLAGwrvGYILGNAAVISQLRK 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 412 YAAGFIFTTSLPPMLLAGALESvrILKSAEGRVLRRQHQRNVKLMRQMLMDAGLPVVHCPSHIIPVRVADAAKNTEVCDE 491
Cdd:pfam00155 234 LARPFYSSTHLQAAAAAALSDP--LLVASELEEMRQRIKERRDYLRDGLQAAGLSVLPSQAGFFLLTGLDPETAKELAQV 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|..
gi 1034631760 492 LMSRHNIYVQAINYPTVPrgeELLRIAPTpHHTPQMMNYFLE 533
Cdd:pfam00155 312 LLEEVGVYVTPGSSPGVP---GWLRITVA-GGTEEELEELLE 349
PLN02955 PLN02955
8-amino-7-oxononanoate synthase
 243-526 7.08e-29

8-amino-7-oxononanoate synthase


Pssm-ID: 178541 [Multi-domain]  Cd Length: 476  Bit Score: 120.16  E-value: 7.08e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 243 KQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 322
Cdd:PLN02955  102 KKLLLFSGNDYLGLSSHPTISNAAANAAKEYGMGPKGSALICGYTTYHRLLESSLADLKKKEDCLVCPTGFAANMAAMVA 181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 323 L--------AKMMP----GCEIYSDSGNHASMIQGI----RNSRVPKYIFRHNDVSHLRELLQRSDPSvPKIVAFETVHS 386
Cdd:PLN02955  182 IgsvasllaASGKPlkneKVAIFSDALNHASIIDGVrlaeRQGNVEVFVYRHCDMYHLNSLLSSCKMK-RKVVVTDSLFS 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 387 MDG-------------------------------------------------------KAFGCVGGYIASTSSLIDTVRS 411
Cdd:PLN02955  261 MDGdfapmeelsqlrkkygfllviddahgtfvcgengggvaeefnceadvdlcvgtlsKAAGCHGGFIACSKKWKQLIQS 340

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 412 YAAGFIFTTSLPPMLLAGALESVRILKSAEGRvlRRQHQRNVKLMRQMlmdAGLPVvhcPSHIIPVRVADAAKNTEVCDE 491
Cdd:PLN02955  341 RGRSFIFSTAIPVPMAAAAYAAVVVARKEKWR--RKAIWERVKEFKAL---SGVDI---SSPIISLVVGNQEKALKASRY 412

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1034631760 492 LMsRHNIYVQAINYPTVPRGEELLRIAPTPHHTPQ 526
Cdd:PLN02955  413 LL-KSGFHVMAIRPPTVPPNSCRLRVTLSAAHTTE 446
PLN02483 PLN02483
serine palmitoyltransferase
 250-553 2.85e-28

serine palmitoyltransferase


Pssm-ID: 178101 [Multi-domain]  Cd Length: 489  Bit Score: 118.33  E-value: 2.85e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 250 SNDYLGMSRHPRVCGA-VMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLakMMP 328
Cdd:PLN02483  107 SYNYLGFAAADEYCTPrVIESLKKYSASTCSSRVDGGTTKLHRELEELVARFVGKPAAIVFGMGYATNSTIIPAL--IGK 184

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 329 GCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQ--------RSDPSVPKI-VAFETVHSMDG---------- 389
Cdd:PLN02483  185 GGLIISDSLNHNSIVNGARGSGATIRVFQHNTPSHLEEVLReqiaegqpRTHRPWKKIiVIVEGIYSMEGelcklpeiva 264

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 ----------------------------------------------KAFGCVGGYIASTSSLIDTVRSYAAGFIFTTSLP 423
Cdd:PLN02483  265 vckkykayvyldeahsigavgktgrgvcellgvdpadvdimmgtftKSFGSCGGYIAGSKELIQYLKRTCPAHLYATSMS 344

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 424 PMLLAGALESVRILKSAEG-----RVLRRQHQrNVKLMRQMLMDAGLPVV-HCPSHIIPVRVADAAKNTEVCDELMSRhN 497
Cdd:PLN02483  345 PPAVQQVISAIKVILGEDGtnrgaQKLAQIRE-NSNFFRSELQKMGFEVLgDNDSPVMPIMLYNPAKIPAFSRECLKQ-N 422

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034631760 498 IYVQAINYPTVPRGEELLRIAPTPHHTPQMMNYFLENLLVTWKQVGLELKPHSSAE 553
Cdd:PLN02483  423 VAVVVVGFPATPLLLARARICISASHSREDLIKALEVISEVGDLVGIKYFPAEPKK 478
PRK07179 PRK07179
quorum-sensing autoinducer synthase;
250-533 8.99e-27

quorum-sensing autoinducer synthase;


Pssm-ID: 180866 [Multi-domain]  Cd Length: 407  Bit Score: 112.80  E-value: 8.99e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 250 SNDYLGMSRHPRVCGAVMDTLKQHGagaggtRNISGTSKFHVD------LERELADLHGKDAALLFSSCFVANDSTLFTL 323
Cdd:PRK07179   61 SNDYLNLSGHPDIIKAQIAALQEEG------DSLVMSAVFLHDdspkpqFEKKLAAFTGFESCLLCQSGWAANVGLLQTI 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 324 AKmmPGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQRSDPSvpkIVAFETVHSMDG------------KA 391
Cdd:PRK07179  135 AD--PNTPVYIDFFAHMSLWEGVRAAGAQAHPFRHNDVDHLRRQIERHGPG---IIVVDSVYSTTGtiapladivdiaEE 209

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 392 FGCV-------------------------------------------GGYIASTSSLIDTVR--SYAAgfIFTTSLPPML 426
Cdd:PRK07179  210 FGCVlvvdeshslgthgpqgaglvaelgltsrvhfitaslakafagrAGIITCPRELAEYVPfvSYPA--IFSSTLLPHE 287

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 427 LAGALESVRILKSAEGRvlRRQHQRNVKLMRQMLMDAGLPvVHCPSHIIPVrVADAAKNTEVC-DELMSRhNIYVQAINY 505
Cdd:PRK07179  288 IAGLEATLEVIESADDR--RARLHANARFLREGLSELGYN-IRSESQIIAL-ETGSERNTEVLrDALEER-NVFGAVFCA 362

                         330       340
                  ....*....|....*....|....*...
gi 1034631760 506 PTVPRGEELLRIAPTPHHTPQMMNYFLE 533
Cdd:PRK07179  363 PATPKNRNLIRLSLNADLTASDLDRVLE 390
PLN03227 PLN03227
serine palmitoyltransferase-like protein; Provisional
 247-498 1.45e-17

serine palmitoyltransferase-like protein; Provisional


Pssm-ID: 178766 [Multi-domain]  Cd Length: 392  Bit Score: 84.96  E-value: 1.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 247 VWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFTLAKM 326
Cdd:PLN03227    2 NFATHDFLSTSSSPTLRQTALESLSHYGCGSCGPRGFYGTIDAHLELEQCMAEFLGTESAILYSDGASTTSSTVAAFAKR 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 327 mpGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQR---SDPS------------------------VP--K 377
Cdd:PLN03227   82 --GDLLVVDRGVNEALLVGVSLSRANVRWFRHNDMKDLRRVLEQvraQDVAlkrkptdqrrflvveglykntgtlAPlkE 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 378 IVAFETVHS----MD--------GK--------------------------AFGCVGGYIASTSSLIDTVRSYAAGFIFT 419
Cdd:PLN03227  160 LVALKEEFHyrliLDesfsfgtlGKsgrgslehaglkpmvhaeivtfslenAFGSVGGMTVGSEEVVDHQRLSGSGYCFS 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 420 TSLPPMLLAGALESVRILKsAEGRVLRRQHQrNVKLMRQMLMDAGLPVVHCP-----------SHIIPVRVADAAKnTEV 488
Cdd:PLN03227  240 ASAPPFLAKADATATAGEL-AGPQLLNRLHD-SIANLYSTLTNSSHPYALKLrnrlvitsdpiSPIIYLRLSDQEA-TRR 316

                         330
                  ....*....|
gi 1034631760 489 CDELMSRHNI 498
Cdd:PLN03227  317 TDETLILDQI 326
PLN02822 PLN02822
serine palmitoyltransferase
 240-462 9.55e-14

serine palmitoyltransferase


Pssm-ID: 178417 [Multi-domain]  Cd Length: 481  Bit Score: 73.62  E-value: 9.55e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 240 ITKKQVSVWCSNDYLGMSRHPRVCGAVMDTLKQHGAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDST 319
Cdd:PLN02822  106 INGKDVVNFASANYLGLIGNEKIKESCTSALEKYGVGSCGPRGFYGTIDVHLDCETKIAKFLGTPDSILYSYGLSTIFSV 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 320 LFTLAKMmpGCEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELL-----------------------QRSDPSVP 376
Cdd:PLN02822  186 IPAFCKK--GDIIVADEGVHWGIQNGLYLSRSTIVYFKHNDMESLRNTLekltaenkrkkklrryivveaiyQNSGQIAP 263

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 377 ---------------------------------------KIVAFETVHSMDGKAFGCVGGYIASTSSLIDTVRSYAAGFI 417
Cdd:PLN02822  264 ldeivrlkekyrfrvlldesnsfgvlgksgrglsehfgvPIEKIDIITAAMGHALATEGGFCTGSARVVDHQRLSSSGYV 343

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1034631760 418 FTTSLPPMLLAGALESVRILKSaEGRVLRRQHQrNVKLMRQMLMD 462
Cdd:PLN02822  344 FSASLPPYLASAAITAIDVLED-NPSVLAKLKE-NIALLHKGLSD 386
PRK07505 PRK07505
hypothetical protein; Provisional
 249-526 1.63e-12

hypothetical protein; Provisional


Pssm-ID: 181006 [Multi-domain]  Cd Length: 402  Bit Score: 69.62  E-value: 1.63e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 249 CSNDYLGMSRHPRVCGAVMDTLKqhgagAGGTRNISgTSKFHV------DLERELADLHGKDAaLLFSSCFVANDSTLFT 322
Cdd:PRK07505   52 VSCSYLGLDTHPAIIEGAVDALK-----RTGSLHLS-SSRTRVrsqilkDLEEALSELFGASV-LTFTSCSAAHLGILPL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 323 LAK--MMPGCEIYS--DSGNHASM--IQGIRNSRVPKYIFRHNDVSHLRELLQRSdpsvpKIVAF--ETVHSMDG----- 389
Cdd:PRK07505  125 LASghLTGGVPPHMvfDKNAHASLniLKGICADETEVETIDHNDLDALEDICKTN-----KTVAYvaDGVYSMGGiapvk 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 390 ---------------------------------------------------KAFGCVGGYIA-STSSLIDTVRSYAAGFI 417
Cdd:PRK07505  200 ellrlqekyglflyiddahglsiygkngegyvrseldyrlnertiiaaslgKAFGASGGVIMlGDAEQIELILRYAGPLA 279

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 418 FTTSLPPMLLAGALESVRILKSAEGRVLRRQHQRNVKLMRQMLMD--AGLPVvhcpshiiPVRVA---DAAKNTEVCDEL 492
Cdd:PRK07505  280 FSQSLNVAALGAILASAEIHLSEELDQLQQKLQNNIALFDSLIPTeqSGSFL--------PIRLIyigDEDTAIKAAKQL 351

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1034631760 493 MSRhNIYVQAINYPTVPRGEELLRIAPTPHHTPQ 526
Cdd:PRK07505  352 LDR-GFYTSPVFFPVVAKGRAGLRIMFRASHTND 384
PRK05937 PRK05937
8-amino-7-oxononanoate synthase; Provisional
 250-369 2.05e-10

8-amino-7-oxononanoate synthase; Provisional


Pssm-ID: 102071 [Multi-domain]  Cd Length: 370  Bit Score: 62.88  E-value: 2.05e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034631760 250 SNDYLGMSRHPRVCGAVMDTLKQH-------GAGAGGTRNISGTSKFHVDLERELADLHGKDAALLFSSCFVANDSTLFT 322
Cdd:PRK05937   11 TNDFLGFSRSDTLVHEVEKRYRLYcrqfphaQLGYGGSRAILGPSSLLDDLEHKIAHFHGAPEAFIVPSGYMANLGLCAH 90

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1034631760 323 LAKMMPgcEIYSDSGNHASMIQGIRNSRVPKYIFRHNDVSHLRELLQ 369
Cdd:PRK05937   91 LSSVTD--YVLWDEQVHISVVYSLSVISGWHQSFRHNDLDHLESLLE 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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