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Conserved domains on  [gi|1034613644|ref|XP_016859476|]
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leucine-rich repeat transmembrane neuronal protein 1 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1034613644 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886   358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1034613644 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886   358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.20e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 112 LRRVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDL---VKVNFAhfPRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGN 266
Cdd:cd21340    73 LYLGGNRISVV--EGLENLTNLEELHIENQRLppgEKLTFD--PRSLAALSNSLRV------------------LNISGN 130

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034613644 267 EIEYMEPhvFETVPHLQSLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340   131 NIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.38e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034613644 113 RRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 7.71e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 7.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113  307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLV-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113  387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034613644 247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113  466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
LRR smart00370
Leucine-rich repeats, outliers;
136-159 5.26e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 1034613644  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-406 5.20e-31

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 124.66  E-value: 5.20e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  49 LLYCEALNLTEAPHNLSGLLGLSLRYNSLSELRAGQFTGLMQLTWLYLDHNhicsvqgDAFQKLRRVKELTLSSNQITQL 128
Cdd:COG4886    56 LLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDL 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 129 PNTtFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQFVPvRIFQDCRSLKFLDIGYNQLKSLArNSFAGL 208
Cdd:COG4886   129 PEE-LANLTNLKELDLSNNQLTDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDLP-EPLGNL 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 209 FKLTELHLEHNDLVKVNFAhFPRLISLHSLCLRRNKVaivvSSLDWVW---NLEKMDLSGNEIEYMEPhvFETVPHLQSL 285
Cdd:COG4886   205 TNLEELDLSGNQLTDLPEP-LANLTNLETLDLSNNQL----TDLPELGnltNLEELDLSNNQLTDLPP--LANLTNLKTL 277

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 286 QLDSNRLTYIEPRILNSWKSLTSITLAGNLWDCGRNVCALASWLNNFQGRYDGNLQCASPEYAQGEDVLDAVYAFHLCED 365
Cdd:COG4886   278 DLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLN 357

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1034613644 366 GAEPTSGHLLSAVTNRSDLGPPASSATTLADGGEGQHDGTF 406
Cdd:COG4886   358 LLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTA 398
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 112-314 1.20e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 70.20  E-value: 1.20e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 112 LRRVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRANAIQfvpvRI--FQDCRSLKF 189
Cdd:cd21340     1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIE----KIenLENLVNLKK 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 190 LDIGYNQLKSLarNSFAGLFKLTELHLEHNDL---VKVNFAhfPRLISLHSLCLRRnkvaivvssldwvwnlekMDLSGN 266
Cdd:cd21340    73 LYLGGNRISVV--EGLENLTNLEELHIENQRLppgEKLTFD--PRSLAALSNSLRV------------------LNISGN 130

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034613644 267 EIEYMEPhvFETVPHLQSLQLDSNRLTYIEP--RILNSWKSLTSITLAGN 314
Cdd:cd21340   131 NIDSLEP--LAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
113-173 1.38e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 65.24  E-value: 1.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034613644 113 RRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
90-149 6.35e-13

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 63.31  E-value: 6.35e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  90 QLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKL 149
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
161-221 2.22e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.77  E-value: 2.22e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034613644 161 RKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 88-314 7.71e-11

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.87  E-value: 7.71e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  88 LMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLH 167
Cdd:PLN00113  307 LQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEGLCSSGNLFKLI 386

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 168 MRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLV-KVNFAHFpRLISLHSLCLRRNKVA 246
Cdd:PLN00113  387 LFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYFLDISNNNLQgRINSRKW-DMPSLQMLSLARNKFF 465

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1034613644 247 IVVSSLDWVWNLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGN 314
Cdd:PLN00113  466 GGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHN 533
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
90-293 3.38e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 56.24  E-value: 3.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  90 QLTWLYLDHNHICSV----QGDafqklrrVKELTLSSNQITQLPNTtfrpMPN-LRSVDLSYNKLQALAPDLFHGLRKLT 164
Cdd:PRK15370  200 QITTLILDNNELKSLpenlQGN-------IKTLYANSNQLTSIPAT----LPDtIQEMELSINRITELPERLPSALQSLD 268

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 165 TLHmraNAIQFVPVRIFQDcrsLKFLDIGYNQLKSLARNSFAGlfkLTELHLEHNDLVKVNfAHFPrlISLHSLCLRRNK 244
Cdd:PRK15370  269 LFH---NKISCLPENLPEE---LRYLSVYDNSIRTLPAHLPSG---ITHLNVQSNSLTALP-ETLP--PGLKTLEAGENA 336

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1034613644 245 VAIVVSSLDwvWNLEKMDLSGNEIEYMEphvfETV-PHLQSLQLDSNRLT 293
Cdd:PRK15370  337 LTSLPASLP--PELQVLDVSKNQITVLP----ETLpPTITTLDVSRNALT 380
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 75-192 5.95e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.25  E-value: 5.95e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  75 NSLSELRagQFTGLMQLTWLYLDHNHICSVQGdaFQKLRRVKELTLsSNQitQLPNT---TFRPM------PNLRSVDLS 145
Cdd:cd21340    56 NQIEKIE--NLENLVNLKKLYLGGNRISVVEG--LENLTNLEELHI-ENQ--RLPPGeklTFDPRslaalsNSLRVLNIS 128

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*....
gi 1034613644 146 YNKLQALAPdlFHGLRKLTTLHMRANAIQ-FVPV-RIFQDCRSLKFLDI 192
Cdd:cd21340   129 GNNIDSLEP--LAPLRNLEQLDASNNQISdLEELlDLLSSWPSLRELDL 175
LRR_8 pfam13855
Leucine rich repeat;
73-125 7.63e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 7.63e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1034613644  73 RYNSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQI 125
Cdd:pfam13855   9 SNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
257-315 1.75e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 1.75e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1034613644 257 NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-235 1.40e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 51.00  E-value: 1.40e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  96 LDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFhGLRKLTTLHMRANAIQF 175
Cdd:PLN00113  411 LQDNSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSF-GSKRLENLDLSRNQFSG 489

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1034613644 176 VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL---VKVNFAHFPRLISL 235
Cdd:PLN00113  490 AVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLsgqIPASFSEMPVLSQL 552
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 86-285 3.85e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.40  E-value: 3.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  86 TGLMQLTWLYLDHNHI----CSVQGDAFQKLRRVKELTLSSNQIT----QLPNTTFRPMPNLRSVDLSYNKL-----QAL 152
Cdd:COG5238   233 KGNKSLTTLDLSNNQIgdegVIALAEALKNNTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIgdegaIAL 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 153 APdlfhGLRKLTTLHMranaiqfvpvrifqdcrslkfLDIGYNQL-----KSLARNsFAGLFKLTELHLEHN---DLVKV 224
Cdd:COG5238   313 AE----GLQGNKTLHT---------------------LNLAYNGIgaqgaIALAKA-LQENTTLHSLDLSDNqigDEGAI 366

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1034613644 225 NFAHFPRLI-SLHSLCLRRNKV----AIVVSSLDWVWNLEKMDLSGNEIEY-MEPHVFETVPHLQSL 285
Cdd:COG5238   367 ALAKYLEGNtTLRELNLGKNNIgkqgAEALIDALQTNRLHTLILDGNLIGAeAQQRLEQLLERIKSV 433
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 75-228 6.29e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 49.08  E-value: 6.29e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  75 NSLSELRAGQFTGLMQLTWLYLDHNHICSVQGDAFQKLRRVKELTLSSNQIT-QLPNTtFRPmPNLRSVDLSYNKLQALA 153
Cdd:PLN00113  414 NSFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKFFgGLPDS-FGS-KRLENLDLSRNQFSGAV 491

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 154 PDLFHGLRKLTTLHMRANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHND------------- 220
Cdd:PLN00113  492 PRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQlsgeipknlgnve 571


                  ....*....
gi 1034613644 221 -LVKVNFAH 228
Cdd:PLN00113  572 sLVQVNISH 580
LRR_8 pfam13855
Leucine rich repeat;
234-292 6.67e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 43.67  E-value: 6.67e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1034613644 234 SLHSLCLRRNKVaivvSSLDWVW-----NLEKMDLSGNEIEYMEPHVFETVPHLQSLQLDSNRL 292
Cdd:pfam13855   2 NLRSLDLSNNRL----TSLDDGAfkglsNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 90-221 9.50e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 48.69  E-value: 9.50e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  90 QLTWLYLDHNHICSVQGDAFQKlRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMR 169
Cdd:PLN00113  453 SLQMLSLARNKFFGGLPDSFGS-KRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLS 531

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1034613644 170 ANAIQFVPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDL 221
Cdd:PLN00113  532 HNQLSGQIPASFSEMPVLSQLDLSQNQLSGEIPKNLGNVESLVQVNISHNHL 583
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 99-314 2.26e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  99 NHICSVQGDAFQKLRRVKELTLSSNQIT-QLPNTTFRpMPNLRSVDLSYNKLQALAP-DLFHGLRKLTTLHMRANAIQ-- 174
Cdd:PLN00113   55 ADVCLWQGITCNNSSRVVSIDLSGKNISgKISSAIFR-LPYIQTINLSNNQLSGPIPdDIFTTSSSLRYLNLSNNNFTgs 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 175 ----FVPV-------------RIFQDC---RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLIS 234
Cdd:PLN00113  134 iprgSIPNletldlsnnmlsgEIPNDIgsfSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKS 213

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 235 LHSLCLRRNKVA----------IVVSSLDWVWNlekmDLSGnEIeymePHVFETVPHLQSLQLDSNRLTYIEPRILNSWK 304
Cdd:PLN00113  214 LKWIYLGYNNLSgeipyeigglTSLNHLDLVYN----NLTG-PI----PSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQ 284

                         250
                  ....*....|
gi 1034613644 305 SLTSITLAGN 314
Cdd:PLN00113  285 KLISLDLSDN 294
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 85-268 1.26e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 44.27  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  85 FTGLMQLTWLYLDHNHICSVQGDAFQKLRR---VKELTLSSN----QITQLPNTTFR-PMPNLRSVDLSYNKL-----QA 151
Cdd:cd00116    77 LTKGCGLQELDLSDNALGPDGCGVLESLLRsssLQELKLNNNglgdRGLRLLAKGLKdLPPALEKLVLGRNRLegascEA 156

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 152 LApDLFHGLRKLTTLHMRANAIQF----VPVRIFQDCRSLKFLDIGYNQLKSLARNSFAGLFK----LTELHLEHNDLVK 223
Cdd:cd00116   157 LA-KALRANRDLKELNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTD 235

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1034613644 224 VNFAHF-----PRLISLHSLCLRRNKVAI-----VVSSLDWVWNLEKMDLSGNEI 268
Cdd:cd00116   236 AGAAALasallSPNISLLTLSLSCNDITDdgakdLAEVLAEKESLLELDLRGNKF 290
LRR_8 pfam13855
Leucine rich repeat;
185-245 2.99e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 2.99e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1034613644 185 RSLKFLDIGYNQLKSLARNSFAGLFKLTELHLEHNDLVKVNFAHFPRLISLHSLCLRRNKV 245
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_9 pfam14580
Leucine-rich repeat;
107-210 3.78e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 41.29  E-value: 3.78e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644 107 DAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAP-DLFHGLRKLTTLHMRANAIQFVP---VRIFQ 182
Cdd:pfam14580  58 DGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDlDPLASLKKLTFLSLLRNPVTNKPhyrLYVIY 137

                          90       100
                  ....*....|....*....|....*...
gi 1034613644 183 DCRSLKFLDigYNQLKSLARNSFAGLFK 210
Cdd:pfam14580 138 KVPQLRLLD--FRKVKQKERQAAEKMFR 163
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 114-149 2.22e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 2.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034613644 114 RVKELTLSSNQITQLPNttFRPMPNLRSVDLSYNKL 149
Cdd:pfam12799   2 NLEVLDLSNNQITDIPP--LAKLPNLETLDLSGNNK 35
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 137-171 2.53e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 35.68  E-value: 2.53e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1034613644 137 PNLRSVDLSYNKLQALapDLFHGLRKLTTLHMRAN 171
Cdd:pfam12799   1 PNLEVLDLSNNQITDI--PPLAKLPNLETLDLSGN 33
PLN03150 PLN03150
hypothetical protein; Provisional
 94-173 2.78e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.57  E-value: 2.78e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034613644  94 LYLDHNHICSVQGDAFQKLRRVKELTLSSNQITQLPNTTFRPMPNLRSVDLSYNKLQALAPDLFHGLRKLTTLHMRANAI 173
Cdd:PLN03150  423 LGLDNQGLRGFIPNDISKLRHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSL 502
LRR_8 pfam13855
Leucine rich repeat;
280-315 2.99e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 2.99e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1034613644 280 PHLQSLQLDSNRLTYIEPRILNSWKSLTSITLAGNL 315
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNL 36
LRR smart00370
Leucine-rich repeats, outliers;
136-159 5.26e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 1034613644  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
136-159 5.26e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 34.25  E-value: 5.26e-03
                           10        20
                   ....*....|....*....|....
gi 1034613644  136 MPNLRSVDLSYNKLQALAPDLFHG 159
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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