NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1034557755|ref|XP_016856532|]
View 

gap junction alpha-4 protein isoform X1 [Homo sapiens]

Protein Classification

gap junction protein( domain architecture ID 11981343)

gap junction protein form gap-junctions between cells and contains four transmembrane (TM) regions; one gap junction consists of a cluster of closely packed pairs of TM channels, the connexons, through which materials of low molecular weight diffuse from one cell to a neighboring cell

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-220 4.72e-128

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


:

Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 364.90  E-value: 4.72e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755   3 DWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQF 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755  83 LFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPqveralaaverqmaKISVAEDGRLRIRGALMGTYVASVLCK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEE--------------EGKKEAEPKVHIRGGLLWTYVLSLLFR 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034557755 163 SVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLC 204
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-220 4.72e-128

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 364.90  E-value: 4.72e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755   3 DWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQF 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755  83 LFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPqveralaaverqmaKISVAEDGRLRIRGALMGTYVASVLCK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEE--------------EGKKEAEPKVHIRGGLLWTYVLSLLFR 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034557755 163 SVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLC 204
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
165-220 2.21e-31

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 112.58  E-value: 2.21e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034557755  165 LEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAIC 56
 
Name Accession Description Interval E-value
Connexin pfam00029
Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane ...
 3-220 4.72e-128

Connexin; Connexin proteins form gap-junctions between cells. They carry four transmembrane regions, hence why this family now includes Connexin_CCC, which represented the second pair of TMs.


Pssm-ID: 459638 [Multi-domain]  Cd Length: 217  Bit Score: 364.90  E-value: 4.72e-128
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755   3 DWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQF 82
Cdd:pfam00029   1 DWSFLGRLLEEVNKHSTVVGKIWLTVLFIFRILVLGVAAESVWGDEQSDFVCNTLQPGCENVCYDAFFPISHIRFWVLQI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1034557755  83 LFVSTPTLVYLGHVIYLSRREERLRQKEGELRALPAKDPqveralaaverqmaKISVAEDGRLRIRGALMGTYVASVLCK 162
Cdd:pfam00029  81 IFVSTPSLLYLGHVAHRIAREEKRREKEEEEMEEELYEE--------------EGKKEAEPKVHIRGGLLWTYVLSLLFR 146

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1034557755 163 SVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Cdd:pfam00029 147 IVLEVGFLVGQYYLYGFEVPPLFKCSRSPCPNTVDCFVSRPTEKTIFLLFMFVVSGLC 204
Connexin_CCC smart01089
Gap junction channel protein cysteine-rich domain;
165-220 2.21e-31

Gap junction channel protein cysteine-rich domain;


Pssm-ID: 198157  Cd Length: 67  Bit Score: 112.58  E-value: 2.21e-31
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1034557755  165 LEAGFLYGQWRLYGWTMEPVFVCQRAPCPYLVDCFVSRPTEKTIFIIFMLVVGLIS 220
Cdd:smart01089   1 LEVGFLYGQYYLYGFQVPPLYKCSRSPCPNTVDCFVSRPTEKTIFLIFMLVVSAIC 56
CNX smart00037
Connexin homologues; Connexin channels participate in the regulation of signaling between ...
 43-76 4.50e-23

Connexin homologues; Connexin channels participate in the regulation of signaling between developing and differentiated cell types.


Pssm-ID: 128352  Cd Length: 34  Bit Score: 89.82  E-value: 4.50e-23
                           10        20        30
                   ....*....|....*....|....*....|....
gi 1034557755   43 SVWGDEQSDFECNTAQPGCTNVCYDQAFPISHIR 76
Cdd:smart00037   1 SVWGDEQSDFVCNTQQPGCENVCYDQAFPISHVR 34
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH