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Conserved domains on  [gi|767912185|ref|XP_011542388|]
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WD repeat-containing protein 64 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-377 9.82e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 9.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 123 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 196
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 197 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 276
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 277 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 353
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912185 354 SAAVDESGFLFATGAYNGTVRIWD 377
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-743 1.81e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 347 GFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLpegkdwKEDEHCLRRLIFLKaqekHQQLVLALERNGTIK 426
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL------KGHTGPVRDVAASA----DGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 427 miqgkeddiylmvIWELpdvvpflQDGKHAVHLRMSTRDrnmaipfpdvelivernfsqptdnptmdllrVNCIDLLQVE 506
Cdd:cd00200   77 -------------LWDL-------ETGECVRTLTGHTSY-------------------------------VSSVAFSPDG 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 507 gyNLIAAGTLNGVIILWNFVTSTVKKVYR----PEDCFTVNPDlhpKHF----KINDILFLF--RTPECARRSsqdsics 576
Cdd:cd00200  106 --RILSSSSRDKTIKVWDVETGKCLTTLRghtdWVNSVAFSPD---GTFvassSQDGTIKLWdlRTGKCVATL------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 577 ssqcesskgpqsskgskqSIHDSEVKGeqtdvmvgkqqpmdkkhpgIANLPEAQPpiLVTAHEDGHLRLWTL-EGRLLKD 655
Cdd:cd00200  174 ------------------TGHTGEVNS-------------------VAFSPDGEK--LLSSSSDGTIKLWDLsTGKCLGT 214

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 656 mlpFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILcnissfldppHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTAS 735
Cdd:cd00200  215 ---LRGHEN-GVNSVAFSPDGYLLASGSEDGTIRV----------WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*...
gi 767912185 736 IDGSVRLW 743
Cdd:cd00200  281 ADGTIRIW 288
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-377 9.82e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 9.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 123 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 196
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 197 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 276
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 277 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 353
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912185 354 SAAVDESGFLFATGAYNGTVRIWD 377
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
187-393 2.66e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.66e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 187 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 266
Cdd:COG2319  135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 267 SMIYDANHGMLITGSSvmDmypltRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQV 339
Cdd:COG2319  209 SVAFSPDGKLLASGSA--D-----GTVRlwdlATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912185 340 yQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:COG2319  282 -RTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-743 1.81e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 347 GFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLpegkdwKEDEHCLRRLIFLKaqekHQQLVLALERNGTIK 426
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL------KGHTGPVRDVAASA----DGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 427 miqgkeddiylmvIWELpdvvpflQDGKHAVHLRMSTRDrnmaipfpdvelivernfsqptdnptmdllrVNCIDLLQVE 506
Cdd:cd00200   77 -------------LWDL-------ETGECVRTLTGHTSY-------------------------------VSSVAFSPDG 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 507 gyNLIAAGTLNGVIILWNFVTSTVKKVYR----PEDCFTVNPDlhpKHF----KINDILFLF--RTPECARRSsqdsics 576
Cdd:cd00200  106 --RILSSSSRDKTIKVWDVETGKCLTTLRghtdWVNSVAFSPD---GTFvassSQDGTIKLWdlRTGKCVATL------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 577 ssqcesskgpqsskgskqSIHDSEVKGeqtdvmvgkqqpmdkkhpgIANLPEAQPpiLVTAHEDGHLRLWTL-EGRLLKD 655
Cdd:cd00200  174 ------------------TGHTGEVNS-------------------VAFSPDGEK--LLSSSSDGTIKLWDLsTGKCLGT 214

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 656 mlpFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILcnissfldppHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTAS 735
Cdd:cd00200  215 ---LRGHEN-GVNSVAFSPDGYLLASGSEDGTIRV----------WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*...
gi 767912185 736 IDGSVRLW 743
Cdd:cd00200  281 ADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 346-377 8.78e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.78e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767912185   346 HGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 377
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
633-748 1.06e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 633 ILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSFldpphdekkfKQLLS 711
Cdd:COG2319  176 LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG----------KLLRT 241

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767912185 712 WRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNG 748
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 123-377 9.82e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 99.33  E-value: 9.82e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 123 KLHNDWVMKIRYISALNCFGSCSLDSnhslvleSLK--RLEDNLPVREFsmpRGANTFCYCVKAN----VIVTGGDDKVI 196
Cdd:cd00200   48 KGHTGPVRDVAASADGTYLASGSSDK-------TIRlwDLETGECVRTL---TGHTSYVSSVAFSpdgrILSSSSRDKTI 117

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 197 RLWHpNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGM 276
Cdd:cd00200  118 KVWD-VETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG-----EVNSVAFSPDGEK 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 277 LITGSSVMDMYPLTRMIQDTKQVPHTHEREINVMLY--NKYFhqvLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVT 353
Cdd:cd00200  192 LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFspDGYL---LASGSEdGTIRVWDLRTGECVQTL---SGHTNSVT 265

                        250       260
                 ....*....|....*....|....
gi 767912185 354 SAAVDESGFLFATGAYNGTVRIWD 377
Cdd:cd00200  266 SLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
187-393 2.66e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 2.66e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 187 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 266
Cdd:COG2319  135 LASGSADGTVRLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA-----VR 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 267 SMIYDANHGMLITGSSvmDmypltRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQV 339
Cdd:COG2319  209 SVAFSPDGKLLASGSA--D-----GTVRlwdlATGKLLRTltgHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELL 281

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912185 340 yQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:COG2319  282 -RTLTGHSG--GVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 332
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 173-393 7.93e-19

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 87.78  E-value: 7.93e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 173 RGANTFCYCVKA----NVIVTGGDDKVIRLWhpNIST-KPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTL 247
Cdd:cd00200    6 KGHTGGVTCVAFspdgKLLATGSGDGTIKVW--DLETgELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 248 SLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSSvmDMyplTRMIQDT-----KQVPHTHEREINVMLYNKYFHQVLTI 322
Cdd:cd00200   84 ECVRTLTGHTSY-----VSSVAFSPDGRILSSSSR--DK---TIKVWDVetgkcLTTLRGHTDWVNSVAFSPDGTFVASS 153

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767912185 323 CSESIIRVWELETGLQVYQIlepHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:cd00200  154 SQDGTIKLWDLRTGKCVATL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENG 221
WD40 COG2319
WD40 repeat [General function prediction only];
187-393 1.92e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 88.81  E-value: 1.92e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 187 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIY 266
Cdd:COG2319  177 LASGSDDGTVRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGS-----VR 250

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 267 SMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGlQV 339
Cdd:COG2319  251 SVAFSPDGRLLASGSA-------DGTVRlwdlATGELLRTltgHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATG-KL 322

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767912185 340 YQILEPHgfNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:COG2319  323 LRTLTGH--TGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGA 374
WD40 COG2319
WD40 repeat [General function prediction only];
185-377 1.53e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.12  E-value: 1.53e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 185 NVIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmq 264
Cdd:COG2319  217 KLLASGSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG----- 290

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 265 IYSMIYDANHGMLITGSS-----VMDMypltrmiqDTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETG 336
Cdd:COG2319  291 VNSVAFSPDGKLLASGSDdgtvrLWDL--------ATGKLLRTltgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATG 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767912185 337 LQVyQILEPHGfnTEVTSAAVDESGFLFATGAYNGTVRIWD 377
Cdd:COG2319  363 ELL-RTLTGHT--GAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
186-393 8.43e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.73  E-value: 8.43e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 186 VIVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqI 265
Cdd:COG2319   92 LLASASADGTVRLWDLA-TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGA-----V 165

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 266 YSMIYDANHGMLITGSSvmdmyplTRMIQ----DTKQVPHT---HEREINVMLYNKYFHQVLTICSESIIRVWELETGLQ 338
Cdd:COG2319  166 TSVAFSPDGKLLASGSD-------DGTVRlwdlATGKLLRTltgHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKL 238

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767912185 339 VyQILEPHGFntEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:COG2319  239 L-RTLTGHSG--SVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGG 290
WD40 COG2319
WD40 repeat [General function prediction only];
184-393 3.24e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 3.24e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 184 ANVIVTGGDDKVIRLWhPNISTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdm 263
Cdd:COG2319   48 GARLAAGAGDLTLLLL-DAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGA---- 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 264 qIYSMIYDANHGMLITGSSvmdmypltrmiqdtkqvPHThereinvmlynkyfhqvlticsesiIRVWELETGlQVYQIL 343
Cdd:COG2319  123 -VRSVAFSPDGKTLASGSA-----------------DGT-------------------------VRLWDLATG-KLLRTL 158

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 767912185 344 EPHgfNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:COG2319  159 TGH--SGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGA 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 207-393 6.66e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 58.12  E-value: 6.66e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 207 PVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGGpgdmqIYSMIYDANHGMLITGSsvMDm 286
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGP-----VRDVAASADGTYLASGS--SD- 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 287 ypltRMIQ----DTKQVPHT---HEREINVMLYNKYfHQVLTICSE-SIIRVWELETGLQVYQIlepHGFNTEVTSAAVD 358
Cdd:cd00200   73 ----KTIRlwdlETGECVRTltgHTSYVSSVAFSPD-GRILSSSSRdKTIKVWDVETGKCLTTL---RGHTDWVNSVAFS 144

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767912185 359 ESGFLFATGAYNGTVRIWDFGSGQEMKVLPEGKDW 393
Cdd:cd00200  145 PDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGE 179
WD40 COG2319
WD40 repeat [General function prediction only];
227-393 1.07e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 58.38  E-value: 1.07e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 227 DQHVVSLSSAKVFRVWDIQTLSLLQVFHDSQGgpgdmQIYSMIYDANHGMLITGSSVMDMYPLTRMIQDTKQVPHTHERE 306
Cdd:COG2319    6 GAALAAASADLALALLAAALGALLLLLLGLAA-----AVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 307 INVMLYNKYFHQVLTICSESIIRVWELETGLQvyqILEPHGFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKV 386
Cdd:COG2319   81 VLSVAFSPDGRLLASASADGTVRLWDLATGLL---LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRT 157


                 ....*..
gi 767912185 387 LPEGKDW 393
Cdd:COG2319  158 LTGHSGA 164
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 347-743 1.81e-05

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 47.71  E-value: 1.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 347 GFNTEVTSAAVDESGFLFATGAYNGTVRIWDFGSGQEMKVLpegkdwKEDEHCLRRLIFLKaqekHQQLVLALERNGTIK 426
Cdd:cd00200    7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTL------KGHTGPVRDVAASA----DGTYLASGSSDKTIR 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 427 miqgkeddiylmvIWELpdvvpflQDGKHAVHLRMSTRDrnmaipfpdvelivernfsqptdnptmdllrVNCIDLLQVE 506
Cdd:cd00200   77 -------------LWDL-------ETGECVRTLTGHTSY-------------------------------VSSVAFSPDG 105

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 507 gyNLIAAGTLNGVIILWNFVTSTVKKVYR----PEDCFTVNPDlhpKHF----KINDILFLF--RTPECARRSsqdsics 576
Cdd:cd00200  106 --RILSSSSRDKTIKVWDVETGKCLTTLRghtdWVNSVAFSPD---GTFvassSQDGTIKLWdlRTGKCVATL------- 173

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 577 ssqcesskgpqsskgskqSIHDSEVKGeqtdvmvgkqqpmdkkhpgIANLPEAQPpiLVTAHEDGHLRLWTL-EGRLLKD 655
Cdd:cd00200  174 ------------------TGHTGEVNS-------------------VAFSPDGEK--LLSSSSDGTIKLWDLsTGKCLGT 214

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 656 mlpFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILcnissfldppHDEKKFKQLLSWRAHSLEIIQVIYVEEKQVVLTAS 735
Cdd:cd00200  215 ---LRGHEN-GVNSVAFSPDGYLLASGSEDGTIRV----------WDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGS 280


                 ....*...
gi 767912185 736 IDGSVRLW 743
Cdd:cd00200  281 ADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
187-246 8.74e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 46.06  E-value: 8.74e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 187 IVTGGDDKVIRLWHPNiSTKPVGKLVGHMFSIAEIVTNEKDQHVVSLSSAKVFRVWDIQT 246
Cdd:COG2319  345 LASGSDDGTVRLWDLA-TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 346-377 8.78e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.78e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 767912185   346 HGFNTEVTSAAVDESGFLFATGAYNGTVRIWD 377
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
633-748 1.06e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 42.59  E-value: 1.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 633 ILVTAHEDGHLRLWTLE-GRLLKdmlPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSFldpphdekkfKQLLS 711
Cdd:COG2319  176 LLASGSDDGTVRLWDLAtGKLLR---TLTGHTG-AVRSVAFSPDGKLLASGSADGTVRLWDLATG----------KLLRT 241

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767912185 712 WRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNG 748
Cdd:COG2319  242 LTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG 278
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 629-749 1.56e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 41.55  E-value: 1.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 629 AQPPILVTAHEDGHLRLWTLEGRLLKDMLpfTKHSAISLTSLYTDSCTRILLAGNveGHVILCnissfldppHDEKKFKQ 708
Cdd:cd00200   19 PDGKLLATGSGDGTIKVWDLETGELLRTL--KGHTGPVRDVAASADGTYLASGSS--DKTIRL---------WDLETGEC 85

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767912185 709 LLSWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLW--------HALNGH 749
Cdd:cd00200   86 VRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWdvetgkclTTLRGH 134
WD40 COG2319
WD40 repeat [General function prediction only];
631-748 2.70e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.05  E-value: 2.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767912185 631 PPILVTAHEDGHLRLWTLEGRLLKdmLPFTKHSAiSLTSLYTDSCTRILLAGNVEGHVILCNISSFldpphdekkfKQLL 710
Cdd:COG2319   90 GRLLASASADGTVRLWDLATGLLL--RTLTGHTG-AVRSVAFSPDGKTLASGSADGTVRLWDLATG----------KLLR 156

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 767912185 711 SWRAHSLEIIQVIYVEEKQVVLTASIDGSVRLWHALNG 748
Cdd:COG2319  157 TLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATG 194
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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