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Conserved domains on  [gi|767936385|ref|XP_011541892|]
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organic cation/carnitine transporter 2 isoform X4 [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 1000272)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates; similar to Drosophila melanogaster organic cation transporter protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
2A0119 super family cl36765
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-314 1.24e-144

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


The actual alignment was detected with superfamily member TIGR00898:

Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 418.27  E-value: 1.24e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   12 GTEILGKSVRIIFSTLGvCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 91
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKIL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   92 RKAAKANGIVVPSTIFDPSELQDLSSKKQQsHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:TIGR00898 284 QRIAKINGKKLPAEVLSLSLEKDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLF 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:TIGR00898 363 ISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTV 442

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936385  252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDT 314
Cdd:TIGR00898 443 VRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-314 1.24e-144

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 418.27  E-value: 1.24e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   12 GTEILGKSVRIIFSTLGvCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 91
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKIL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   92 RKAAKANGIVVPSTIFDPSELQDLSSKKQQsHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:TIGR00898 284 QRIAKINGKKLPAEVLSLSLEKDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLF 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:TIGR00898 363 ISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTV 442

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936385  252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDT 314
Cdd:TIGR00898 443 VRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 12-304 3.64e-131

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 378.35  E-value: 3.64e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  12 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPesprwlisqgrfeeaevii 91
Cdd:cd17376  113 GTEILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP------------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  92 rkaakangivvpstifdpselqdlsskkqqshnildllrtwnirMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:cd17376  174 --------------------------------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:cd17376  210 LSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTV 289

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936385 252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17376  290 VRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
Sugar_tr pfam00083
Sugar (and other) transporter;
26-319 5.26e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 5.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   26 TLGVC--IFYAFGYMVLPLFAYFIRD------WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEviiRKAAKA 97
Cdd:pfam00083 138 ALGSLyqLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   98 NGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLW-MTISVGYFGLSLDTPNlhgdIFVNCFLSAMV 176
Cdd:pfam00083 215 RGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQiFQQLTGINAIFYYSTT----IFENLGLSDSF 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  177 EVPAYVLAWLLLQ-----YLPRRYSMATALFLGGSVLLFMQLVP-------PDLYYLATVLVMVGKFGVTAAFSM----- 239
Cdd:pfam00083 291 LVTIIVGVVNFVFtfiaiFLVDRFGRRPLLLLGAAGMAICFVILgivallgVSKSDWAGIVAIVFIALFIAFFAMgwgpv 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  240 VYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRFLPYILMGSLTILTAILT-LFLPESFGTPLpDTID 316
Cdd:pfam00083 371 PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVfFFVPETKGRTL-EEID 449


                  ...
gi 767936385  317 QML 319
Cdd:pfam00083 450 ELF 452
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
193-304 9.93e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 9.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 193 RRYSMATALFLGGSVLLFMQLVPPdlYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 272
Cdd:COG2271  247 RKLVLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767936385 273 YFV--YLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:COG2271  325 LLVgyLLDATGYQAAFLLLAALALLAALLALLLL 358
xylE PRK10077
D-xylose transporter XylE; Provisional
 35-93 9.95e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 46.99  E-value: 9.95e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  35 FGYMVLPLFAYFIRD-----------WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 93
Cdd:PRK10077 167 FGQLVVYFVNYFIARsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRK 236
 
Name Accession Description Interval E-value
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 12-314 1.24e-144

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 418.27  E-value: 1.24e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   12 GTEILGKSVRIIFSTLGvCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVII 91
Cdd:TIGR00898 205 NTEFLPKKQRAIVGTLI-QVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPRWLISQGRIEEALKIL 283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   92 RKAAKANGIVVPSTIFDPSELQDLSSKKQQsHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:TIGR00898 284 QRIAKINGKKLPAEVLSLSLEKDLSSSKKQ-YSFLDLFRTPNLRKTTLCLMMLWFTTAFSYYGLVLDLGNLGGNIYLDLF 362

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:TIGR00898 363 ISGLVELPAKLITLLLIDRLGRRYTMAASLLLAGVALLLLLFVPVDLYFLRTALAVLGKFGITSAFQMVYLYTAELYPTV 442

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767936385  252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLPESFGTPLPDT 314
Cdd:TIGR00898 443 VRNLGVGVCSTMARVGSIISPFLVYLGEKWLFLPLVLFGGLALLAGILTLFLPETKGVPLPET 505
MFS_SLC22A4_5_OCTN1_2 cd17376
Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 ...
 12-304 3.64e-131

Solute carrier family 22 members 4 and 5 (also called Organic cation/carnitine transporters 1 and 2) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 22 members 4 (SLC22A4) and 5 (SLC22A5), and similar proteins. SLC22A4 is also called ergothioneine transporter (ETT) or organic cation/carnitine transporter 1 (OCTN1). It is a sodium-ion dependent, low affinity carnitine transporter, and a highly specific transporter for the uptake of ergothioneine (ET), a thiolated derivative of histidine with antioxidant properties. ET is a natural compound produced only by certain fungi and bacteria and must be absorbed from the diet by humans and other vetebrates. SLC22A5, also called organic cation/carnitine transporter 2 (OCTN2), is a sodium-ion dependent, high affinity carnitine transporter involved in the active cellular uptake of carnitine. SLC22A4/5 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340934 [Multi-domain]  Cd Length: 342  Bit Score: 378.35  E-value: 3.64e-131
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  12 GTEILGKSVRIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPesprwlisqgrfeeaevii 91
Cdd:cd17376  113 GTEILGKSVRILFSTLGVCIFYAIGYMLLPLFAYFIRDWRMLLLALTLPGVLCVPLWWFIP------------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  92 rkaakangivvpstifdpselqdlsskkqqshnildllrtwnirMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:cd17376  174 --------------------------------------------ITTIMSLLLWMAISVGYFGLSLNTPNLHGDPYLNCF 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:cd17376  210 LSAVIEVPAYIIAWLLLRSLPRRYSIAATLVLGGGVLLFIQLVPTDLQVLATALVMLGKFGITAAFSMVYVYTAELYPTV 289

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936385 252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17376  290 VRNMGVGVCSTASRIGSIISPYFVYLGAYDRYLPYILMGSLTVLIGILTLFLP 342
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 12-304 2.44e-74

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 232.86  E-value: 2.44e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  12 GTEILGKSVRIIFSTLGvCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPesprwlisqgrfeeaevii 91
Cdd:cd17317  103 GMEIVGPKYRSFVGILF-GLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLLLWWLP------------------- 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  92 rkaakangivvpstifdpselqdlsskkqqshnildllrtwnirMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:cd17317  163 --------------------------------------------RRTIIVGLIWFVTSLVYYGLSLNSSNLGGNLYLNFF 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:cd17317  199 LSGLVEIPAYFLALLLLDRLGRRWTLSGSLLLAGLACLVTALLPDDENTLALTLALVGKFAISAAFSVIYLYTAELYPTV 278

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936385 252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17317  279 VRNTGVGLCSTVARVGAILAPFIVLLGKIGPLLPLIIFGVLALLGGLLTLLLP 331
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 12-304 7.39e-48

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 164.77  E-value: 7.39e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  12 GTEILGKSVRIIFSTLGVCiFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPesprwlisqgrfeeaevii 91
Cdd:cd17374  113 GTEWTTPRHRALAITLTSC-FFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP------------------- 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  92 rkaakangivvpstifdpselqdlsskkqqshnildllrtwniRMVTIMSIMlWMTISVGYFGLSLDTPNLHGDIFVNCF 171
Cdd:cd17374  173 -------------------------------------------KRTLILSFV-WFANSFSYYGLSLDLQHLGLNVFLLQF 208

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 172 LSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:cd17374  209 LFGAVEVPARCLALFLLNHMGRRISQAVLLLLAGLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAELFPTV 288

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936385 252 VRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17374  289 LRQTGMGLNSMFARIGGILAPLIMLLGVYSPLLPMIIYGVLPILAGLLALLLP 341
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 128-304 1.99e-38

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 139.89  E-value: 1.99e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 128 LLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSV 207
Cdd:cd17375  165 ILCCWMLPKRTITVWLIWFTGSLGYYVFSLGSVNLGGNEYLNLFLVGAVEIPSYIIACIGMDKLGRRNTLAPFLLLSALA 244

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 208 LLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYI 287
Cdd:cd17375  245 CMLIMVIPQDYEVLTIVLSMTGKFAIAIAFGLIYLYTAELYPTIVRSLAVGSGSMMCRVGSVVAPFCVYLSDVWIFLPQL 324

                        170
                 ....*....|....*..
gi 767936385 288 LMGSLTILTAILTLFLP 304
Cdd:cd17375  325 LVGIMAFLSGILTLMLP 341
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 14-304 2.08e-37

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 137.60  E-value: 2.08e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  14 EILGKSVRIIFSTLGvCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPesprwlisqGRfeeaeviirk 93
Cdd:cd17377  119 ECVGKSYWALAGSLG-GLFFAVGIAQYALLGYFIRSWRTLAVVVNLQGTLVFLLSLFIP---------GR---------- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  94 aakangivvpstifdpselqdlsskkqqshnildllrtwnirmvTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLS 173
Cdd:cd17377  179 --------------------------------------------TLILMYVWFVCSLVYYGLTLNAGDLGGNIYLNLALS 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 174 AMVEVPAYVLAWLLL--QYLPRRYSMATALFLGGSVLLFMQLVP------PDLYYLATVLVMVGKFGVTAAFSMVYVYTA 245
Cdd:cd17377  215 GLVELPAYPLCIYLInqKWSGRRRTLAGFLFLGGIACLLVMFVPekkdsgVFAVVNSTSLSLLGKLTISAAFNIVYIYTS 294

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767936385 246 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17377  295 ELYPTVVRNAGLGVCSMFSRVGGIIAPFIPSLKSVQWSLPFIVFGASGLSAGLLSLLLP 353
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 13-304 4.22e-35

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 130.93  E-value: 4.22e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  13 TEILGKSVRIIFSTLgVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESprwlisqgrfeeaeviir 92
Cdd:cd17379  112 TEFVGSKYRRTVGIV-YQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLFLLYYWFIPKH------------------ 172

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  93 kaakangivvpstifdpselqdlsskkqqshnildllrtwnirmvTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFL 172
Cdd:cd17379  173 ---------------------------------------------TFILMYAWFTSAVVYQGLIMRLGITGGNLYLDFFI 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 173 SAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVV 252
Cdd:cd17379  208 SALVELPAAFIILLTIDRIGRRLPFAASNIVAGAACLITAFIPPDLHWLKTTIACVGRLGITMAFEIVCLVNTELYPTFL 287

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767936385 253 RNMGVGVSSTASRLGSILSPYFVY-LGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17379  288 RNLGVSVCSSLCDIGGIIAPFLLYrLAEIWLELPLIVFGVLALVAGGLVLLLP 340
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 20-304 4.00e-33

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 125.61  E-value: 4.00e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  20 VRIIFSTL-GVCifYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPEsprwlisqgrfeeaeviirkaakan 98
Cdd:cd17446  119 VRAVVGTLlGYC--YTLGQLILAGVAYAIRDWRWLQLAVSLPFFIFFLYSWWFPR------------------------- 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  99 givvpstifdpselqdlsskkqqshnildllrtwnirmVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEV 178
Cdd:cd17446  172 --------------------------------------ITFCLSLVWFSTSFAYYGLAMDLQKFGVSIYLIQIIFGAVDI 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 179 PAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVG 258
Cdd:cd17446  214 PAKFISTLTMSYLGRRPTQAAALILAGIMILANIFVPQDLQTVRTALAVFGKGCLAASFNCVYLYTGELYPTVIRQTGMG 293

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*.
gi 767936385 259 VSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17446  294 LGSTMARLGGIVAPLVKMLGEYYPFLPLIIYGAAPILSGIAACFLP 339
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 24-304 6.92e-33

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 124.84  E-value: 6.92e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  24 FSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPEsprwlisqgrfeeaeviirkaakangivvp 103
Cdd:cd17447  124 VAGVLISLFWTVGNMLLALVAYLIRDWRWLILAVTLPCAPGIITWWWVPK------------------------------ 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 104 stifdpselqdlsskkqqshnildllrtwnirmVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYVL 183
Cdd:cd17447  174 ---------------------------------ISLCTGIVWFGVAFTYYGISFNISGFGLNVYLTQFIYGAIELPAKLL 220

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 184 AWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTA 263
Cdd:cd17447  221 AYLLLDRIGRRLTQAGSLILTGLSIGINILIPSEFTVVRTVIAVLGKGFSEAAFTTVFLYTSELYPTVLRQNGMGYTSFI 300

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 767936385 264 SRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17447  301 ARLGGSLAPLVILLDDVWLSLPQVIFCGVALLAGGVAFLLP 341
MFS_OCT_plant cd17378
Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of ...
 13-304 4.36e-28

Plant organic cation/carnitine transporters of the Major Facilitator Superfamily of transporters; Plant organic cation/carnitine transporters (OCTs) are sequence-similar to their animal counterparts, which are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. Little is know about plant OCTs. In Arabidopsis, there are six genes belonging to this family that show distinct, organ-specific expression pattern of the individual genes. AtOCT1 has been found to affect root development and carnitine-related responses in Arabidopsis. AtOCT4, 5 and 6 are up-regulated during drought stress, AtOCT3 and 5 during cold stress and AtOCT5 and 6 during salt stress treatments. Plant OCTs belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340936 [Multi-domain]  Cd Length: 342  Bit Score: 112.07  E-value: 4.36e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  13 TEILGKSVRiifSTLGVCIFYAF--GYMVLPLFAYFI-RDWRMLLVALTMPGVLCVALWWFIPEsprwlisqgrfeeaev 89
Cdd:cd17378  113 TEPVGPKWR---GQVGMSTFFFFvlGFMSLPGIAYLNgSSWRVLYFWTSIPALIYCILVYLFAR---------------- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  90 iirkaakangivvpstifdpselqdlsskkqqshnildllrtwniRMVTIMsiMLWMTISVGYFGLSLDTPNLHGDIFVN 169
Cdd:cd17378  174 ---------------------------------------------RLLAVM--VIGFGIGMVYYGIPLAVGNLKFNIYLS 206

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 170 CFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDL-YYLATVLVMVGKFGVTAAFSMVYVYTAELY 248
Cdd:cd17378  207 VALNALSELPAFVITAFLLDRFGRRPSLLGFTLLSGASCLLCFVLSIGGtTSLQIALELVGFFGAAGAFNLLYIYTVELF 286

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767936385 249 PTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17378  287 PTCVRNAALGMLRQALVVGGIFAPFIVSLGRKNAALSFGVFGVAILLLGLFALGLP 342
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 19-311 6.80e-16

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 78.53  E-value: 6.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   19 SVRIIFSTLGvcIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK----A 94
Cdd:TIGR00879 166 SLYQLAITFG--ILVAYGFGSGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGKGRVEEARKSLARlrgtS 243

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   95 AKANGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRT--WNIRMVTIMSIMLWMT-ISV-----GYFGLSLDTPNLHGdi 166
Cdd:TIGR00879 244 GEDKELLDELELIDIKRSIEKRSVQPSWGSLFSSTRRirRRLFLGVVLQWFQQFTgINAimyysPTIFENAGVSTDHA-- 321

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  167 FVNCFLSAMVEVPAYVLAWLLLQYLPRR-------YSMATALFLGGSvlLFMQLVPPDLY---YLATVLVMVgkfgVTAA 236
Cdd:TIGR00879 322 FLVSIIVGAVNFAFTFVAIFLVDRFGRRpllligaAGMAICLFVLGI--LGASFVTGSSKssgNVAIVFILL----FIAF 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  237 FSM-----VYVYTAELYPTVVRNMGVGVSSTASRLGSIL-SPYFVY-LGAYDRFLPYILMGSLTILTAILTLF-LPESFG 308
Cdd:TIGR00879 396 FAMgwgpvPWVIVSEIFPLSLRPKGISIAVAANWLANFIvGFLFPTmLESIGVGGVFIFFGGLNVLGLIFVYFfLPETKG 475


                  ...
gi 767936385  309 TPL 311
Cdd:TIGR00879 476 RTL 478
Sugar_tr pfam00083
Sugar (and other) transporter;
26-319 5.26e-15

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 75.77  E-value: 5.26e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   26 TLGVC--IFYAFGYMVLPLFAYFIRD------WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEviiRKAAKA 97
Cdd:pfam00083 138 ALGSLyqLAITFGILLAYIFGLGLNKtsnsdgWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAR---EVLAKL 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   98 NGIVVPSTIFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLW-MTISVGYFGLSLDTPNlhgdIFVNCFLSAMV 176
Cdd:pfam00083 215 RGVPDVDRELDEIKDSLEAGQEAEKASWKELFSTKTRRQRLLIGVMLQiFQQLTGINAIFYYSTT----IFENLGLSDSF 290

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  177 EVPAYVLAWLLLQ-----YLPRRYSMATALFLGGSVLLFMQLVP-------PDLYYLATVLVMVGKFGVTAAFSM----- 239
Cdd:pfam00083 291 LVTIIVGVVNFVFtfiaiFLVDRFGRRPLLLLGAAGMAICFVILgivallgVSKSDWAGIVAIVFIALFIAFFAMgwgpv 370

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  240 VYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF--VYLGAYDRFLPYILMGSLTILTAILT-LFLPESFGTPLpDTID 316
Cdd:pfam00083 371 PWVIVSELFPLSVRSKAMALATAANWLANFLIGFLfpIITDAIGLGYTFFIFAGLLVLFIIFVfFFVPETKGRTL-EEID 449


                  ...
gi 767936385  317 QML 319
Cdd:pfam00083 450 ELF 452
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 134-302 6.37e-14

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 71.86  E-value: 6.37e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 134 IRMVTIMSIMLWMTISVGYFGLSLDTPNL--------HGDIFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGG 205
Cdd:cd17316  175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlqtvlglsPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 206 -SVLLFMQLVPPDLYYLATVLVMVGkFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFV--YLGAYDR 282
Cdd:cd17316  255 iLALPLFYLLSGSPTLLLLLLFILS-FFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIalLLASTGG 333

                        170       180
                 ....*....|....*....|
gi 767936385 283 FLPYILMGSLTILTAILTLF 302
Cdd:cd17316  334 TGVPALILALLAIVALIVAL 353
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 33-272 7.30e-12

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 65.84  E-value: 7.30e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   33 YAFGYMVLPLFAYFI---RDWR-MLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIirkaakaNGIVVPSTIFD 108
Cdd:TIGR00895 150 YPIGAAVGGFLAGWLipvFGWRsLFYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVRRIV-------NAIAPQMQAEA 222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  109 PSELQDLSSKKQQSHNILDLLRTWniRMVTIMsIMLWMTIS---VGYFGLSLDTPNLHGDIFVNCFLSAMVEVPAYV--- 182
Cdd:TIGR00895 223 QSALPEQKSTQGTKRSVFKALFQG--KTARIT-VLLWLLYFmllVGVYFLTNWLPKLMVELGFSLSLAATGGALFNFggv 299

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  183 -----LAWLLLQYLPRRYsmaTALFLGGSVLLFM---QLVPPDLyyLATVLVMVGKFgVTAAFSMVYVYTAELYPTVVRN 254
Cdd:TIGR00895 300 igsiiFGWLADRLGPRVT---ALLLLLGAVFAVLvgsTLFSPTL--LLLLGAIAGFF-VNGGQSGLYALMALFYPTAIRA 373

                         250
                  ....*....|....*...
gi 767936385  255 MGVGVSSTASRLGSILSP 272
Cdd:TIGR00895 374 TGVGWAIGIGRLGAIIGP 391
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 171-273 6.51e-11

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 62.94  E-value: 6.51e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 171 FLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLggSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPT 250
Cdd:cd17372  236 FIATFAEFPGLLISAAMIDRLGRKASMASMLFT--CCIFLLLLLICQSPFILTVLLFGGRACISAAFTVVYIYTPEVYPT 313

                         90       100
                 ....*....|....*....|...
gi 767936385 251 VVRNMGVGVSSTASRLGSILSPY 273
Cdd:cd17372  314 AVRALGVGTGSSVGRIGAILCPF 336
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 172-304 1.02e-09

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 59.44  E-value: 1.02e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 172 LSAMVEVPAYVLAWLLLQYLPRRYSMAtaLFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTV 251
Cdd:cd17442  244 ISTLGEIALNPLNILGINFLGRRLSLV--ITMGLTAIFFLLLNICTSSAGLTIFLFMLRALVSANFNTVYIYTAEVYPTT 321

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 767936385 252 VRNMGVGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17442  322 MRALGMGTSGSLCRIGAMVAPFISqVLMSASVLGALCLFSSVCIVCAISAFTLP 375
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 13-305 3.15e-09

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 58.04  E-value: 3.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  13 TEILGKSVRIIFSTLgVCIFYAFGYMVLPLFAY-----FIRDWRMLLVALTMPGVLCVALWWFIPESPRWL-ISQGRFEE 86
Cdd:cd17357  131 QEISPSELRGALGSL-TQIGVTLGILLGQVFGLpsvlgTETLWPYLLFFPGIPALLQLAALPFFPESPKFLlISKGDEEE 209

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  87 AEVIIRKAAKANGIVVPStiFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIML---------WMTISVGYF---- 153
Cdd:cd17357  210 AEKSLKFLRGIEDDVDQE--LEEIKKESEQMGDQKQVSLMQLLRDPSLRLPLLLVLVVsasqqfsgiNAIFFYSTFifen 287

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 154 -GLSLDTPnlhgdIFVNCFLSaMVEVPAYVLAWLLLQYLPRR-------YSMATALFLGGSVLLFMQLVPPDLYYLATVL 225
Cdd:cd17357  288 aGFSPQLA-----EWANLGIG-IVNVLSTIVGPFLIEKVGRRplllislSVCAVALLLMSVFLFLSEQNSWMSYGCIVAI 361

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 226 vmvgkFGVTAAFSMV-----YVYTAELYPTVVRNMGVGVSSTASRLGSILSPYFVY----LGAYDRFLPYILmgsLTILT 296
Cdd:cd17357  362 -----FLFIFFFAIGlgpipWFIGAELFPQAPRSAAQSLGSSVNWTSNFIVGMAFPplqsIGGGFVFIIFAI---PCALF 433

                        330
                 ....*....|
gi 767936385 297 AILTLF-LPE 305
Cdd:cd17357  434 LLYLYRyLPE 443
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 3-162 5.18e-09

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 57.68  E-value: 5.18e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385    3 QHLSWV---WPSGTeilgksvrIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 79
Cdd:TIGR01299 291 EHLSWLcmfWMIGG--------IYAAAMAWAIIPHYGWSFQMGSAYQFHSWRVFVIVCAFPCVFAIGALTFMPESPRFFL 362

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   80 SQGRFEEAEVIIR--------------KAAKANGIVVPSTIFDPSELQDLSSKKQQSHNI----------LDLLRTWN-- 133
Cdd:TIGR01299 363 ENGKHDEAWMILKlihdtnmrakghpeKVFSVNHIKTIHQEDELIEIESDTGTWYQRCFVralsegggiwGNFLRCFNpe 442

                         170       180
                  ....*....|....*....|....*....
gi 767936385  134 IRMVTIMSIMLWMTISVGYFGLSLDTPNL 162
Cdd:TIGR01299 443 VREITIKLMGVWFTLSFGYYGLSVWFPDM 471
MFS_SVOP cd17441
Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic ...
 31-304 1.84e-08

Synaptic vesicle 2-related protein (SVOP) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein (SVOP) is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. This SVOP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340999 [Multi-domain]  Cd Length: 372  Bit Score: 55.20  E-value: 1.84e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  31 IFYAFGYMVLPLFAYFIRD---WRMLLVALTMPGVLCVALWWFIPESPR----------WLISQGRFEEAEVIIRKAAKA 97
Cdd:cd17441  129 VFWALGTVFEVLLAVFVMPtlgWRWLLILSALPLLIFAVLCFWLPESARywttillwfiWFSNAFSYYGLVLLTTELFQA 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  98 NGIVVPSTIFDPSELQDLSSKKQQSHNILDLLrtwnirmvtimsimlWMTISvgyfglsldtpnlhgdifvncflsamvE 177
Cdd:cd17441  209 GDVCSGSSGKKVEGKCSLECEYLTTSDYMDLL---------------WTTLS---------------------------E 246

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 178 VPAYVLAWLLLQYLPRRYSMATALF-LGGSVLLFMQLVPpdlYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMG 256
Cdd:cd17441  247 FPGLLVTLWIIDRFGRKKTMALCFFvFSFCTLLLFSCVG---RFSLTVLLFIARAFISGGFQAAYVYTPEVYPTATRALG 323

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*....
gi 767936385 257 VGVSSTASRLGSILSPYFV-YLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17441  324 LGTCSGMARVGALITPFIAqVMLESSVYLTLSVYSGCCLLAAIASCFLP 372
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 44-306 3.00e-08

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 55.19  E-value: 3.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  44 AYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRKAAKAN--GIVVPSTIFDPSELQdlsskkqq 121
Cdd:cd17363  159 AYQFHSWRVFVIVCALPSVASVVALTFMPESPRFLLEVGKHDEAWMILKQVHDTNmrAKGHPERVFTVSHIK-------- 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 122 shnildllrtwniRMVTIMSIMLWMTISVGYFGLSLDTP----------------------------------------- 160
Cdd:cd17363  231 -------------RMNTLFLAIVWFTMSFSYYGLTVWFPdmikylqfedslfeecyfedvtstntffenctfintvfynt 297

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 161 NLHGDIFVNC-------------------------------FLSAMVEVPAYVLAWLLLQYLPRRYSMATALFLGGSVLL 209
Cdd:cd17363  298 DLFEYKFIDSrflnstfflkekcgchlnddeenayliylvsFLGSLSVLPGNIVSALLMDKIGRLKMIGGSMLLSAVCCF 377

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 210 FMQLVPPDlyyLATVLVMVGKFGVT-AAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY-FVYLGAYDRFLPYI 287
Cdd:cd17363  378 FLFFGNSE---SAMIGLQCLFCGVSiAAWNALDVVTVELYPTDKRATAFGFLNGLCKLAAILGNSiFGSFVGITKVIPIL 454

                        330
                 ....*....|....*....
gi 767936385 288 LMGSLTILTAILTLFLPES 306
Cdd:cd17363  455 LASAALVCGGLLALKLPET 473
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 13-305 8.06e-08

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 53.73  E-value: 8.06e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  13 TEILGKSVRIIFSTLgVCIFYAFGYMVLPLFAYFIRdWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIR 92
Cdd:cd17358  120 AEIAPKNVRGALGSL-NQLLVNIGILLGYVLGSFLP-WRTLALIGAIPPVVFLILLFFIPESPRWLAKKGREEEAEKSLQ 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  93 KAAKANGIVVPSTIFDPSELQDlsSKKQQSHNILDLLRTWNIRMVTIMSIMLWM------TISVGYFGLS-LDTPNLHGD 165
Cdd:cd17358  198 FLRGKDADISKEAAEIQEELAE--LEKEAKESSFSDLFQRKYLKPLVIGLGLMLfqqlsgINAVIFYASSiFDEAGSGLD 275

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 166 IFVNCFLSAMVEVPAYVLAWLLLQYLPRRYSM--------ATALFLGGSVLLFMQLVPPDLY-YLATVLVMVGKFGVTAA 236
Cdd:cd17358  276 PNTATIIIGVVQVVGTLVATLLVDRLGRRPLLlvsaigmgIGLLALGLYFYLQEHGALLSSVsWLPLVGLVIYIISFSIG 355

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767936385 237 F-SMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPYF-----VYLGAYDRFLPYILMGSLTILtaILTLFLPE 305
Cdd:cd17358  356 LgPLPWVIMSEIFPAKIKGLAGSLVTLVNWLFAFIVTKTfpfltLAWGASGTFWIFAGICGLALV--FVLLFVPE 428
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 180-272 1.75e-07

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 52.20  E-value: 1.75e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 180 AYVLAWLLLQYLPRRYSMATalFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGV 259
Cdd:cd17365  223 SLLLGWLADRFGPKRVLALF--FALGAVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGW 300

                         90
                 ....*....|...
gi 767936385 260 SSTASRLGSILSP 272
Cdd:cd17365  301 ALGVGRLGAILGP 313
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 3-181 2.72e-07

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 52.22  E-value: 2.72e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   3 QHLSWV---WPSGTeilgksvrIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 79
Cdd:cd17440  123 EHLSWLcmfWMIGG--------IYASAMAWAIIPHYGWSFSMGSAYQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  80 SQGRFEEAEVIIRKAAKANGIV--VPSTIFDPSELQdlsskkqqshnildllrtwniRMVTIMSIMLWMTISVGYFGLSL 157
Cdd:cd17440  195 EVGKHDEAWMILKQIHDTNMRArgQPEKVFTVNRIK---------------------KDNTIKLTIVWLTLSFGYYGLSV 253

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767936385 158 DTPNL-----------HGDIFVNCFLSAMVEVPAY 181
Cdd:cd17440  254 WFPDVikhlqfksvtfEDSLFKSCFFEDVTSVNTY 288
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
193-304 9.93e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 9.93e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 193 RRYSMATALFLGGSVLLFMQLVPPdlYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSP 272
Cdd:COG2271  247 RKLVLAIGLLLAALALLLLALLPS--PALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGP 324

                         90       100       110
                 ....*....|....*....|....*....|....
gi 767936385 273 YFV--YLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:COG2271  325 LLVgyLLDATGYQAAFLLLAALALLAALLALLLL 358
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 3-162 2.93e-06

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 48.77  E-value: 2.93e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   3 QHLSWVwpsgteilgksvrIIFSTLGVCIFYAFGYMVLPLFA--------YFIRDWRMLLVALTMPGVLCVALWWFIPES 74
Cdd:cd17438  123 EHLSWL-------------CMFWMIGGLYASAMAWSIIPHYGwgfsmgtnYHFHSWRVFVIICALPCIASIIALKFMPES 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  75 PRWLISQGRFEEAEVIIRKAAKAN--GIVVPSTIFDPSELQdlsskkqqshnildllrtwniRMVTIMSIMLWMTISVGY 152
Cdd:cd17438  190 PRFLLEMGKHDEAWMILKNIHDTNmrAKGTPEKVFTVSNIK---------------------RKNTLFLAVVWFTMAFSY 248

                        170
                 ....*....|
gi 767936385 153 FGLSLDTPNL 162
Cdd:cd17438  249 YGLTVWFPDM 258
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 3-162 3.33e-06

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 48.49  E-value: 3.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   3 QHLSWV---WPSGTeilgksvrIIFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLI 79
Cdd:cd17439  123 EHLSWLcmfWMIGG--------IYASAMAWAIIPHYGWSFQMGSAYQFHSWRVFVLVCAFPSVFAIGALTTMPESPRFFL 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  80 SQGRFEEAEVIIRKAAKANGIVV--PSTIFDPSELQdlsskkqqshnildllrtwniRMVTIMSIMLWMTISVGYFGLSL 157
Cdd:cd17439  195 ENGKHDEAWMVLKQVHDTNMRAKghPERVFSVTHIK---------------------RRITLMMMAVWFTMSFSYYGLTV 253


                 ....*
gi 767936385 158 DTPNL 162
Cdd:cd17439  254 WFPDM 258
xylE PRK10077
D-xylose transporter XylE; Provisional
 35-93 9.95e-06

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 46.99  E-value: 9.95e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  35 FGYMVLPLFAYFIRD-----------WRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIRK 93
Cdd:PRK10077 167 FGQLVVYFVNYFIARsgdaswlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQAEGILRK 236
MFS_SLC22A17 cd17445
Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier ...
 171-304 3.56e-05

Solute carrier family 22, member 17 of the Major Facilitator Superfamily; Solute carrier family 22, member 17 (SLC22A17) is also called 24p3 receptor (24p3R), lipocalin-2 receptor, or neutrophil gelatinase-associated lipocalin (NGAL) receptor (NGALR). It functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. LCN2 is a secreted protein of the lipocalin family that induces apoptosis in some types of cells and inhibits bacterial growth by sequestration of the iron-laden bacterial siderophore. Over-expressions of NGAL and NGALR have been found to be correlated with unfavorable clinicopathologic features and poor prognosis of patients with hepatocellular carcinoma. SLC22A17 is a member of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341003 [Multi-domain]  Cd Length: 346  Bit Score: 45.15  E-value: 3.56e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 171 FLSAMVEVPAYVLAWLLLQYLPRRYSMATALFL-----GGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTA 245
Cdd:cd17445  208 YLSYLLSTGTAGLACLFLCATVDRFGRRGILLLamtltGIASLILLGLMDYLNDAAIKTFSILGLFSSQAAASLSILFAA 287

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767936385 246 ELYPTVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17445  288 EVIPTVIRGSGLGLIMALGSLGGLSSPLMRLRNQHGYFLHHVVLASLALLAILSIMLLP 346
MFS_SLC22A31 cd17443
Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier ...
 171-304 4.19e-05

Solute carrier family 22, member 31 of the Major Facilitator Superfamily; Solute carrier family 22, member 31 (SLC22A31) is an uncharacterized member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A31 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341001 [Multi-domain]  Cd Length: 343  Bit Score: 44.77  E-value: 4.19e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 171 FLSAMVEVPAYVLAWLLLQYLPRR-YSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYP 249
Cdd:cd17443  209 FLQAGLEALACIFLCLTVDRCGRRgVLLLGTIVTGLSSLLLLALTQYLHGGLVLVLSVVGLLASHAVSMLSMFFAAEVLP 288

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767936385 250 TVVRNMGVGVSSTASRLGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17443  289 TVIRGAGLGLIMGAGFLGRAAGPLMELQNKQGYFLHHVVFASFAVLSVLCILLLP 343
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 37-305 1.47e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 43.44  E-value: 1.47e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  37 YMVLPLFAYFIrDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRfeeaeviiRKAAKAngIVVPSTIFDPselqdls 116
Cdd:cd17371  144 ALLFPLLPPEI-AWRVLFLLGALPALLVLFIRRFVKEPPQWQAARAA--------RRHFAD--RPSLRELFSP------- 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 117 skkqqshnilDLLRTwnirmvTIMSIMLWMTISVGYFGLSLDTPNL----HGDIFVNCFLSAMVEVPA----YVLAWLLL 188
Cdd:cd17371  206 ----------PLLRT------TLLASLLATGALGGYYGITTWLPSYltgeRGLSFEGSAGYLVVTILGgflgYLAGGFLA 269

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 189 QYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGkFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGS 268
Cdd:cd17371  270 DRIGRRNNFALFALGSAISILLYFFLPLSPTLILILGFPLG-FFASGPFSGMGAYLTELFPTAVRATAQGFCYNVGRIIG 348

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 767936385 269 ILSPYFV-YLGAYDRFLPYILMGSLT--ILTAILTLFLPE 305
Cdd:cd17371  349 ALFPFLVgFLATSGSLGTAIAVFAAVyyIAGLVLALLLPE 388
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 26-83 2.08e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 42.94  E-value: 2.08e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767936385  26 TLGVCIFYAFGYMVLPLFAYFIRD---WRMLLVALTMPGVLCVALWWFIPESPRWLISQGR 83
Cdd:cd17359  135 VFGQLLAYIVNYLIANAGGADWLGaegWRWMLGLEAIPAILFLLGMLFIPESPRWLVSKGK 195
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 26-92 2.31e-04

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 42.94  E-value: 2.31e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767936385  26 TLGVCI--FYAFGYMVLPLFAYFIrDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEAEVIIR 92
Cdd:cd17433  130 TLGSCVqlMVVIGIMGAYLAGLVL-DWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEAMAALR 197
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-301 4.07e-04

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 42.03  E-value: 4.07e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  23 IFSTLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQgrfeeaeviirkaakangivv 102
Cdd:cd06174  124 LLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARA--------------------- 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 103 pstifdPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTPNLHGDIFVNC-FLSAMVEVPAY 181
Cdd:cd06174  183 ------KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLlSLFGLAGALGS 256

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 182 VLAWLLLQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGkFGVTAAFSMVYVYTAELYPTVVRNMGVGVSS 261
Cdd:cd06174  257 LLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLG-FGLGGLLPLSFALIAELFPPEIRGTAFGLLN 335

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767936385 262 TASRLGSILSPY---FVYLGAYDRFLPYILMGSLTILTAILTL 301
Cdd:cd06174  336 TFGFLGGAIGPLlagFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 13-87 7.65e-04

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 40.97  E-value: 7.65e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767936385  13 TEILGKSVRiifSTLGVC--IFYAFGYMVLPLFAyFIRDWRMLLVALTMPGVLCVALWWFIPESPRWLISQGRFEEA 87
Cdd:cd17434  120 SEISHPGVR---GALGACpqIMAVFGSLALYALG-LLLPWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKA 192
MFS_SLC22A17_like cd17373
Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; ...
 26-304 1.19e-03

Solute carrier family 22, member 17 and similar proteins of the Major Facilitator Superfamily; This group is composed of Solute carrier family 22, members 17, 23, and 31. They are members of the SLC22 family of organic cation/anion/zwitterion transporters, which includes organic cation transporters (OCTs/OCTNs) and organic anion transporters (OATs). SLC22A17 functions as a cell surface receptor for lipocalin-2 (LCN2), also called NGAL or 24p3, which plays a key role in iron homeostasis and transport. SLC22A23 and SLC22A31 are orphan members of the SLC22 family. SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22A17-like group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340931 [Multi-domain]  Cd Length: 348  Bit Score: 40.19  E-value: 1.19e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  26 TLGVCIFYAFGYMVLPLFAYFIRDWRMLLVALTMPGVLCVALWWFIPEsprwlisqgrfeeaeviirkaakaNGIVVPST 105
Cdd:cd17373  116 TMVASLVAVAGQFLMPGLAALCRDWRVLQALIICPFLLMLLYWSIFPK------------------------NILILGFN 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 106 IFDPSELQDLSSKKQQSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGlslDTPNLhgdifvncFLSAMVEVPAYVLAW 185
Cdd:cd17373  172 SLTGYGIRHCFARSMMGHEPENFYLDYYLTAGIAAVACVFLCVTVDFLG---RRGGL--------LLFMILTGLASLLLL 240

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 186 LLLQYLPRRYSMATAlflggsvllfmQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASR 265
Cdd:cd17373  241 GLLNLIGKYSQHPDS-----------GMSDSVKDKFSIAFSVLGLFASHAVGSLSVLFAAEVTPTVIRGGGLGLVLASGG 309

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 767936385 266 LGSILSPYFVYLGAYDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17373  310 LGMLTGPIIELHNQKGYFLQHVVFACCALLCILCILLLP 348
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 126-304 4.43e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 38.71  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 126 LDLLRTWNIRMVTIMSIMLWMTISVgYFGLSLDTPNLHGDIFVNCFLSAM---VEVPAYVLAWLLlQYLPRRYSMATALF 202
Cdd:cd17473  194 LPWKRVLPIYFLAFLAMLLFYVIPI-QLPFLLQERGGGSAALIGLALAIAslaGAIGALLFGRLK-RRLGKRRLLAIGFA 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 203 LGGSVLLFMQLVPPdlYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLGSILSPY---FVYLGA 279
Cdd:cd17473  272 LMALGFLLLALASG--LWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLvlgPLVNLT 349

                        170       180
                 ....*....|....*....|....*
gi 767936385 280 YDRFLPYILMGSLTILTAILTLFLP 304
Cdd:cd17473  350 GGLSGAFLILGVLALVLAIVLLLLR 374
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 178-306 5.30e-03

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 38.41  E-value: 5.30e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 178 VPAYVLAWLLLQYLPRRYsMATALFLGGSVLLFMQLVPPDLYYLATVLVMVgKFGVTAAFS------MVYVYTAELYPTV 251
Cdd:cd17364  254 VPGYWFTVFLIDRIGRKK-IQMMGFFGMTIFLLILAGPYDHWKISTIGFFV-LYGLTFFFSnfgpntTTFIVPAEVFPAR 331

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 767936385 252 VRNMGVGVSSTASRLGSILSPY-FVYLGAYDRFLPY-ILMGSLTILTAILTLFLPES 306
Cdd:cd17364  332 VRSTCHGISAASGKIGAIVGSFlFLSLTQNIGVRNVlIILAGVALLGIILTLLFPEE 388
MFS_1 pfam07690
Major Facilitator Superfamily;
31-272 5.37e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 38.17  E-value: 5.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385   31 IFYAFGYMVLPLFAYFI---RDWRMLLVALTMPGVLCVALWWFIPESPRwlisQGRFEEAEVIIRKAAKANGIVVpstif 107
Cdd:pfam07690 128 AGFGLGAALGPLLGGLLaslFGWRAAFLILAILSLLAAVLLLLPRPPPE----SKRPKPAEEARLSLIVAWKALL----- 198

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  108 dpselqdlsskkqqSHNILDLLRTWNIRMVTIMSIMLWMTISVGYFGLSLDTpnlhgDIFVNCFLSAMVEVPAYVLAWLL 187
Cdd:pfam07690 199 --------------RDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALL-----AGLLLGLGGLLGAIGRLLLGRLS 259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385  188 LQYLPRRYSMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFGVTAAFSMVYVYTAELYPTVVRNMGVGVSSTASRLG 267
Cdd:pfam07690 260 DRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339


                  ....*
gi 767936385  268 SILSP 272
Cdd:pfam07690 340 GALGP 344
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 180-272 8.91e-03

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 37.63  E-value: 8.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767936385 180 AYVLAWLLLQYLPRRysMATALFLGGSVLLFMQLVPPDLYYLATVLVMVGKFgVTAAFSMVYVYTAELYPTVVRNMGVGV 259
Cdd:PRK11551 272 SLLIGALMDRLRPRR--VVLLIYAGILASLAALAAAPSFAGMLLAGFAAGLF-VVGGQSVLYALAPLFYPTQVRGTGVGA 348

                         90
                 ....*....|...
gi 767936385 260 SSTASRLGSILSP 272
Cdd:PRK11551 349 AVAVGRLGSMAGP 361
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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