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Conserved domains on  [gi|767906065|ref|XP_011540463|]
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dynein axonemal intermediate chain 4 isoform X1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 509-746 2.62e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 2.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 509 GVTAVDFSiGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWIEQDRgttgdgkreILVSISADGR 588
Cdd:cd00200   95 YVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HTDWVNSVAFSPDGT---------FVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 589 ISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIhKCSCSYNEQYL 668
Cdd:cd00200  159 IKLWDLRTG-------KCVAT-----------------LTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLWDLSTGKCL 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767906065 669 DTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 746
Cdd:cd00200  213 GTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 509-746 2.62e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 2.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 509 GVTAVDFSiGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWIEQDRgttgdgkreILVSISADGR 588
Cdd:cd00200   95 YVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HTDWVNSVAFSPDGT---------FVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 589 ISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIhKCSCSYNEQYL 668
Cdd:cd00200  159 IKLWDLRTG-------KCVAT-----------------LTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLWDLSTGKCL 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767906065 669 DTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 746
Cdd:cd00200  213 GTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
493-794 3.32e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 3.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 493 WNKTNPWPERIYQSPYG-VTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 569
Cdd:COG2319  105 WDLATGLLLRTLTGHTGaVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAF----- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 570 gtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLA 649
Cdd:COG2319  171 --SPDGKL--LASGSDDGTVRLWDLATG-------KLLRT-----------------LTGHTGAVRSVAFSP-DGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 650 GTEEGHIHKCSCSyNEQYLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS 727
Cdd:COG2319  222 GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767906065 728 PKSSYIFAAANENRVEIWDLhiSTLDPLIVNTANPGiKFTTILFAKQTDCLLVGDSDGQVSVYELRN 794
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 1.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767906065   664 NEQYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
666-703 1.69e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767906065  666 QYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 703
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 509-746 2.62e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 77.38  E-value: 2.62e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 509 GVTAVDFSiGAPNLLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWIEQDRgttgdgkreILVSISADGR 588
Cdd:cd00200   95 YVSSVAFS-PDGRILSSSSRDKTIKVWDVETGKCLTTLRG------HTDWVNSVAFSPDGT---------FVASSSQDGT 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 589 ISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIhKCSCSYNEQYL 668
Cdd:cd00200  159 IKLWDLRTG-------KCVAT-----------------LTGHTGEVNSVAFSP-DGEKLLSSSSDGTI-KLWDLSTGKCL 212

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767906065 669 DTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWD 746
Cdd:cd00200  213 GTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
493-794 3.32e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 3.32e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 493 WNKTNPWPERIYQSPYG-VTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 569
Cdd:COG2319  105 WDLATGLLLRTLTGHTGaVRSVAFS---PDgkTLASGSADGTVRLWDLATGKLLRTL------TGHSGAVTSVAF----- 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 570 gtTGDGKReiLVSISADGRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLA 649
Cdd:COG2319  171 --SPDGKL--LASGSDDGTVRLWDLATG-------KLLRT-----------------LTGHTGAVRSVAFSP-DGKLLAS 221

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 650 GTEEGHIHKCSCSyNEQYLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWS 727
Cdd:COG2319  222 GSADGTVRLWDLA-TGKLLRTLTGHSGSVRSVAFSP---DgrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS 297

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767906065 728 PKSSYIFAAANENRVEIWDLhiSTLDPLIVNTANPGiKFTTILFAKQTDCLLVGDSDGQVSVYELRN 794
Cdd:COG2319  298 PDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTG-AVRSVAFSPDGKTLASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
509-747 3.28e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 75.33  E-value: 3.28e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 509 GVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgtTGDGKReiLVSISAD 586
Cdd:COG2319  206 AVRSVAFS---PDgkLLASGSADGTVRLWDLATGKLLRTLTG------HSGSVRSVAF-------SPDGRL--LASGSAD 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 587 GRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIH-------KC 659
Cdd:COG2319  268 GTVRLWDLATG-------ELLRT-----------------LTGHSGGVNSVAFSP-DGKLLASGSDDGTVRlwdlatgKL 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 660 scsyneqyLDTYRGHKGPVYKVTWNPFcHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANE 739
Cdd:COG2319  323 --------LRTLTGHTGAVRSVAFSPD-GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSAD 393


                 ....*...
gi 767906065 740 NRVEIWDL 747
Cdd:COG2319  394 GTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
509-794 6.89e-14

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 74.56  E-value: 6.89e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 509 GVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgtTGDGKReiLVSISAD 586
Cdd:COG2319  164 AVTSVAFS---PDgkLLASGSDDGTVRLWDLATGKLLRTLTG------HTGAVRSVAF-------SPDGKL--LASGSAD 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 587 GRISKWVIRKGldcydlmRLKRTtaasnkkggekekkdeaLISRQAPGMCFAFHPkDTNIYLAGTEEGHIHKCSCSyNEQ 666
Cdd:COG2319  226 GTVRLWDLATG-------KLLRT-----------------LTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLA-TGE 279

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 667 YLDTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEI 744
Cdd:COG2319  280 LLRTLTGHSGGVNSVAFSP---DgkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|
gi 767906065 745 WDLHISTLDPLIVNTANPgikFTTILFAKQTDCLLVGDSDGQVSVYELRN 794
Cdd:COG2319  357 WDLATGELLRTLTGHTGA---VTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 493-791 1.96e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 1.96e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 493 WNKTNPWPERIYQSPYG-VTAVDFSIGAPNLLAVGYhNGTIAIYNVRSNSNVPVLDSsespqkHLGPVWQLQWieqdrgt 571
Cdd:cd00200   36 WDLETGELLRTLKGHTGpVRDVAASADGTYLASGSS-DKTIRLWDLETGECVRTLTG------HTSYVSSVAF------- 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 572 tgDGKREILVSISADGRISKWVIRKGLDCYdlmrlkrttaasnkkggekekkdeALISRQAPGMCFAFHPkDTNIYLAGT 651
Cdd:cd00200  102 --SPDGRILSSSSRDKTIKVWDVETGKCLT------------------------TLRGHTDWVNSVAFSP-DGTFVASSS 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 652 EEGHIH-----KCSCSYneqyldTYRGHKGPVYKVTWNPfchD--VFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDV 724
Cdd:cd00200  155 QDGTIKlwdlrTGKCVA------TLTGHTGEVNSVAFSP---DgeKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSV 225

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767906065 725 AWSPKSSYIFAAANENRVEIWDLHISTLDPLIVNTANPgikFTTILFAKQTDCLLVGDSDGQVSVYE 791
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNS---VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 555-804 7.12e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 63.89  E-value: 7.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 555 HLGPVWQLQWieqdrgttgDGKREILVSISADGRISKWvirkgldCYDLMRLKRTtaasnkkggekekkdeaLISRQAPG 634
Cdd:cd00200    8 HTGGVTCVAF---------SPDGKLLATGSGDGTIKVW-------DLETGELLRT-----------------LKGHTGPV 54

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 635 MCFAFHPKDTNIYLAGTEeghiHKCSCsYN---EQYLDTYRGHKGPVYKVTWNPFCHdVFLSCSADWGVIIWQQENVKPS 711
Cdd:cd00200   55 RDVAASADGTYLASGSSD----KTIRL-WDletGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCL 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 712 LSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDLhistldplivNTANPGIKFT-------TILFAKQTDCLLVGDSD 784
Cdd:cd00200  129 TTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL----------RTGKCVATLTghtgevnSVAFSPDGEKLLSSSSD 198

                        250       260
                 ....*....|....*....|
gi 767906065 785 GQVSVYELRnMPTVLETGRG 804
Cdd:cd00200  199 GTIKLWDLS-TGKCLGTLRG 217
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 670-798 1.81e-09

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 1.81e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 670 TYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL-- 747
Cdd:cd00200    4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLet 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 748 -----------------HISTLDPLIV-----------NTANPGIKFT---------TILFAKQTDCLLVGDSDGQVSVY 790
Cdd:cd00200   83 gecvrtltghtsyvssvAFSPDGRILSsssrdktikvwDVETGKCLTTlrghtdwvnSVAFSPDGTFVASSSQDGTIKLW 162


                 ....*...
gi 767906065 791 ELRNMPTV 798
Cdd:cd00200  163 DLRTGKCV 170
WD40 COG2319
WD40 repeat [General function prediction only];
668-794 1.40e-05

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 48.37  E-value: 1.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 668 LDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIWQQENVKPSLSFYPATSVVYDVAWSPKSSYIFAAANENRVEIWDL 747
Cdd:COG2319   71 LATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL 149

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767906065 748 H----ISTLDPlivntanPGIKFTTILFAKQTDCLLVGDSDGQVSVYELRN 794
Cdd:COG2319  150 AtgklLRTLTG-------HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLAT 193
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 664-703 1.80e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.80e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767906065   664 NEQYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 703
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLW 39
WD40 COG2319
WD40 repeat [General function prediction only];
493-592 2.31e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 44.52  E-value: 2.31e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767906065 493 WNKTNPWPERIYQSP-YGVTAVDFSigaPN--LLAVGYHNGTIAIYNVRSNSNVPVLdssespQKHLGPVWQLQWieqdr 569
Cdd:COG2319  315 WDLATGKLLRTLTGHtGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTL------TGHTGAVTSVAF----- 380

                         90       100
                 ....*....|....*....|...
gi 767906065 570 gtTGDGKReiLVSISADGRISKW 592
Cdd:COG2319  381 --SPDGRT--LASGSADGTVRLW 399
WD40 pfam00400
WD domain, G-beta repeat;
666-703 1.69e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.94  E-value: 1.69e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767906065  666 QYLDTYRGHKGPVYKVTWNPfCHDVFLSCSADWGVIIW 703
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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