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Conserved domains on  [gi|767904408|ref|XP_011539795|]
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metal regulatory transcription factor 1 isoform X2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.09e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767904408 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 4.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767904408 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 360-494 1.36e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  360 QDLSTISPAIIF-ESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSAS-------LSLPLVLQPGLSEPP 431
Cdd:pfam03154 139 QDNRSTSPSIPSpQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATagptpsaPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  432 QPLLPASAPSA-------------------PPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHqefLPHPQAP 492
Cdd:pfam03154 219 NQTQSTAAPHTliqqtptlhpqrlpsphppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH---MQHPVPP 295


                  ..
gi 767904408  493 QP 494
Cdd:pfam03154 296 QP 297
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.09e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767904408 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 1.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.52e-05
                          10        20
                  ....*....|....*....|....*..
gi 767904408  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 4.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767904408 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 360-494 1.36e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  360 QDLSTISPAIIF-ESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSAS-------LSLPLVLQPGLSEPP 431
Cdd:pfam03154 139 QDNRSTSPSIPSpQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATagptpsaPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  432 QPLLPASAPSA-------------------PPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHqefLPHPQAP 492
Cdd:pfam03154 219 NQTQSTAAPHTliqqtptlhpqrlpsphppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH---MQHPVPP 295


                  ..
gi 767904408  493 QP 494
Cdd:pfam03154 296 QP 297
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
93-291 1.09e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.86  E-value: 1.09e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  93 YVQHIISPDQIHLTINPGSTPMPRNIEGATLTLQSeCPETKRKEVKRYQCTfeGCPRTYSTAGNLRTHQKT--HRGEY-- 168
Cdd:COG5048  244 SPSSLSSSDSSSSASESPRSSLPTASSQSSSPNES-DSSSEKGFSLPIKSK--QCNISFSRSSPLTRHLRSvnHSGESlk 320

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 169 TFVCNQEGCGKAFLTSYSLRIHVRVHTKEKPFECDVQGCEKAFNTL------YRLKAHQRLHTGKTFNCESEGCSKYFTT 242
Cdd:COG5048  321 PFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLlnneppQSLQQYKDLKNDKKSETLSNSCIRNFKR 400

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767904408 243 LSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFC 291
Cdd:COG5048  401 DSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLC 449
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-316 5.84e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.84e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 172 CNQEGCGKAFLTSYSLRIHVR--VHTKE--KPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCE-SEGCSKYFTTLSDL 246
Cdd:COG5048  290 IKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYSLCGKLFSRNDALKRHILLHTSISPAKEkLLNSSSKFSPLLNN 369

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767904408 247 RKH-----IRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCEKTFSTQYSLKSHMKGHDNK 316
Cdd:COG5048  370 EPPqslqqYKDLKNDKKSETLSNSCIRNFKRDSNLSLHIITHLSFRPYNCKNPPCSKSFNRHYNLIPHKKIHTNH 444
zf-H2C2_2 pfam13465
Zinc-finger double domain;
245-271 1.52e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.97  E-value: 1.52e-05
                          10        20
                  ....*....|....*....|....*..
gi 767904408  245 DLRKHIRTHTGEKPFRCDHdgCGKAFA 271
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFK 25
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 231-310 4.35e-05

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 42.79  E-value: 4.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  231 CESEGCSKYFTTLSDLRKHIRTHTGE------KPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNgCEKTFSTQY 304
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCPPtqslegKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCEN-CLLRFRTHR 80


                  ....*.
gi 767904408  305 SLKSHM 310
Cdd:pfam15909  81 SLFKHL 86
zf-H2C2_2 pfam13465
Zinc-finger double domain;
275-302 1.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.48e-04
                          10        20
                  ....*....|....*....|....*...
gi 767904408  275 HLKTHVRTHTGERPFFCPSngCEKTFST 302
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 197-284 1.72e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.72e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 197 EKPFECDVQGCEKAFNTLYRLKAHqRLHTgktfnceseGCSKYFTTLSDLRKHIRTHTGEKPFRCDHdgCGKAFAASHHL 276
Cdd:COG5189  347 GKPYKCPVEGCNKKYKNQNGLKYH-MLHG---------HQNQKLHENPSPEKMNIFSAKDKPYRCEV--CDKRYKNLNGL 414


                 ....*...
gi 767904408 277 KTHvRTHT 284
Cdd:COG5189  415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
186-213 3.71e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.71e-04
                          10        20
                  ....*....|....*....|....*...
gi 767904408  186 SLRIHVRVHTKEKPFECDVqgCEKAFNT 213
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-328 4.91e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.78  E-value: 4.91e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 767904408 285 GERPFFCPSNGCEKTFSTQYSLKSHMK-GHDNKGHSYNALPQ-HNG 328
Cdd:COG5189  346 DGKPYKCPVEGCNKKYKNQNGLKYHMLhGHQNQKLHENPSPEkMNI 391
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 172-250 1.15e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 38.55  E-value: 1.15e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  172 CNQEGCGKAFLTSYSLRIHVRVHT------KEKPFECDVQGCEKAFNTLYRLKAHQRLHTGKTFNCESEGCSKYFTTLSD 245
Cdd:pfam15909   2 CSSPGCCLSFPSVRDLAQHLRTHCpptqslEGKLFRCSALSCTETFPSMQELVAHSKLHYKPNRYFKCENCLLRFRTHRS 81


                  ....*
gi 767904408  246 LRKHI 250
Cdd:pfam15909  82 LFKHL 86
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 360-494 1.36e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 41.68  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  360 QDLSTISPAIIF-ESMFQNSDDTAIQEDPQQTASLTESFNGDAESVSDVPPSTGNSAS-------LSLPLVLQPGLSEPP 431
Cdd:pfam03154 139 QDNRSTSPSIPSpQDNESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATagptpsaPSVPPQGSPATSQPP 218

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408  432 QPLLPASAPSA-------------------PPPAPSLGPGSQQAAFGNPPALLQPPEVPVPHSTQFAANHqefLPHPQAP 492
Cdd:pfam03154 219 NQTQSTAAPHTliqqtptlhpqrlpsphppLQPMTQPPPPSQVSPQPLPQPSLHGQMPPMPHSLQTGPSH---MQHPVPP 295


                  ..
gi 767904408  493 QP 494
Cdd:pfam03154 296 QP 297
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
225-334 4.35e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 4.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767904408 225 TGKTFNCESEGCSKYFTTLSDLRKHIRTHTGEKPFRCDHDGCGKAFAASHHLKTHVRTHTGERPFFCPSNGCektfSTQY 304
Cdd:COG5048   28 SNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLP----LSNS 103

                         90       100       110
                 ....*....|....*....|....*....|
gi 767904408 305 SLKSHMKGHDNKGHSYNALPQHNGSEDTNH 334
Cdd:COG5048  104 KASSSSLSSSSSNSNDNNLLSSHSLPPSSR 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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