NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767902267|ref|XP_011538940|]
View 

ataxin-7-like protein 2 isoform X1 [Homo sapiens]

Protein Classification

SCA7 domain-containing protein( domain architecture ID 10550843)

SCA7 domain-containing protein similar to protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 239-300 1.03e-22

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


:

Pssm-ID: 462422  Cd Length: 61  Bit Score: 91.89  E-value: 1.03e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767902267  239 HRKMARKECDLNRQCGVINPeTKKICTRLLTCKIHSVHQRREVQGRAKDFDVLVAELKANSR 300
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVILP-NGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 239-300 1.03e-22

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 91.89  E-value: 1.03e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767902267  239 HRKMARKECDLNRQCGVINPeTKKICTRLLTCKIHSVHQRREVQGRAKDFDVLVAELKANSR 300
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVILP-NGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
 
Name Accession Description Interval E-value
SCA7 pfam08313
SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component ...
 239-300 1.03e-22

SCA7, zinc-binding domain; This domain is found in the protein Sgf73/Sca7 which is a component of the multihistone acetyltransferase complexes SAGA and SILK. This domain is also found in Ataxin-7, a human protein which in its polyglutamine expanded pathological form, is responsible for the neurodegenerative disease spinocerebellar ataxia 7 (SCA7). Ataxin-7 is an integral component of the mammalian SAGA-like complexes, the TATA-binding protein-free TAF-containing complex (TFTC) and the SPT3/TAF9/GCN5 acetyltransferase complex (STAGA). This domain is a minimal domain in ataxin-7-like proteins that is required for interaction with TFTC/STAGA subunits and is conserved highly through evolution. The domain contains a conserved Cys(3)His motif that binds zinc, thus indicating this to be a new zinc-binding domain.


Pssm-ID: 462422  Cd Length: 61  Bit Score: 91.89  E-value: 1.03e-22
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767902267  239 HRKMARKECDLNRQCGVINPeTKKICTRLLTCKIHSVHQRREVQGRAKDFDVLVAELKANSR 300
Cdd:pfam08313   1 KKPKAKRPVDVDKQCGVILP-NGGPCTRSLTCKTHSMGAKRAVPGRSKPFDVLLAEYQKKNQ 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH