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Conserved domains on  [gi|767901878|ref|XP_011538793|]
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aldo-keto reductase family 1 member A1 isoform X1 [Homo sapiens]

Protein Classification

aldo-keto reductase family protein( domain architecture ID 305)

aldo-keto reductase family protein may be an NAD(P)(H) oxidoreductase that reduces aldehydes and ketones to primary and secondary alcohols

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AKR_SF super family cl00470
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 1-201 1.27e-154

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


The actual alignment was detected with superfamily member cd19106:

Pssm-ID: 444925 [Multi-domain]  Cd Length: 305  Bit Score: 430.27  E-value: 1.27e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19106  105 IHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19106  185 AQNELIAHCKARGLVVTAYSPLGSPDRPWAKPDEPVLLEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIK 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPR 201
Cdd:cd19106  265 QNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVPR 305
 
Name Accession Description Interval E-value
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 1-201 1.27e-154

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 430.27  E-value: 1.27e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19106  105 IHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19106  185 AQNELIAHCKARGLVVTAYSPLGSPDRPWAKPDEPVLLEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIK 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPR 201
Cdd:cd19106  265 QNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVPR 305
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 2-190 1.36e-72

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 220.70  E-value: 1.36e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYafergdnpfpknadgticydSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:COG0656   99 HWPG--------------------PGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDrawrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQ 161
Cdd:COG0656  159 QRELLAFCREHGIVVEAYSPLGRGK----------LLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRE 228

                        170       180
                 ....*....|....*....|....*....
gi 767901878 162 NIKVFDFTFSPEEMKQLNALNKNWRYIVP 190
Cdd:COG0656  229 NLDAFDFELSDEDMAAIDALDRGERLGPD 257
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
1-186 7.00e-37

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 129.81  E-value: 7.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPyafergdnpfpknadgtiCYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:PRK11565 106 MHWP------------------VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLM 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:PRK11565 168 QQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIA 239

                        170       180
                 ....*....|....*....|....*.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALNKNWR 186
Cdd:PRK11565 240 ENFDVFDFRLDKDELGEIAKLDQGKR 265
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 26-182 5.54e-36

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 127.81  E-value: 5.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   26 STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY--LAQNELIAHCQARGLEVTAYSPLG 103
Cdd:pfam00248 113 DTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLG 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  104 S--------SDRAWRDPDEPVLLEE---------PVVLALAEKYGRSPAQILLRW--QVQRKVICIPKSITPSRILQNIK 164
Cdd:pfam00248 193 GglltgkytRDPDKGPGERRRLLKKgtplnlealEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLG 272

                         170
                  ....*....|....*...
gi 767901878  165 VFDFTFSPEEMKQLNALN 182
Cdd:pfam00248 273 ALEFPLSDEEVARIDELL 290
 
Name Accession Description Interval E-value
AKR_AKR1A1-4 cd19106
AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol ...
 1-201 1.27e-154

AKR1A family of aldo-keto reductase (AKR); The AKR1A family of AKR includes alcohol dehydrogenase [NADP(+)] (ALR, EC 1.1.1.2) from Homo sapiens (AKR1A1), Sus scrofa (AKR1A2), Rattus norvegicus (liver, AKR1A3), and Mus musculus (AKR1A4). ALR, also known as aldehyde reductase, or ALDR1, catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid.


Pssm-ID: 381332 [Multi-domain]  Cd Length: 305  Bit Score: 430.27  E-value: 1.27e-154
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19106  105 IHWPYAFERGDNPFPKNPDGTIRYDSTHYKETWKAMEKLVDKGLVKAIGLSNFNSRQIDDILSVARIKPAVLQVECHPYL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19106  185 AQNELIAHCKARGLVVTAYSPLGSPDRPWAKPDEPVLLEEPKVKALAKKYNKSPAQILLRWQVQRGVVVIPKSVTPSRIK 264

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDGKRVPR 201
Cdd:cd19106  265 QNIQVFDFTLSPEEMKQLDALNRNWRYIVPMITVDGKRVPR 305
AKR_AKR1B1-19 cd19107
AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase ...
 1-214 4.02e-83

AKR1B family of aldo-keto reductase (AKR); The AKR1B family of AKR includes aldose reductase (AR, EC 1.1.1.21) from Homo sapiens (AKR1B1), Oryctolagus cuniculus (kidney, AKR1B2), Mus musculus (AKR1B3), Rattus norvegicus (lens, AKR1B4), Bos taurus (lens/testis, AKR1B5), and Sus scrofa (lens, AKR1B6), aldose reductase-related protein 1 (ALD1, EC1.1.1.21) from Mus musculus (AKR1B7), Rattus norvegicus (AKR1B14), and Homo sapiens (AKR1B15), Mus musculus fibroblast growth factor induced protein (FR-1 or AKR1B8, EC 1.1.1.21), Cricetulus griseus aldose reductase-related protein 2 (ALD2 or AKR1B9, EC 1.1.1.21), aldose reductase-like from Homo sapiens (ARL-1 or AKR1B10) and Rattus norvegicus (AKR1B13), aldo-keto reductase from Gallus domesticus (eye, tongue, esophagus, AKR1B12), and Oryctolagus cuniculus AR-like protein (3beta-HSD, AKR1B19). AR, also called aldehyde reductase, catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies. ALD1 reduces a broad range of aliphatic and aromatic aldehydes to the corresponding alcohols. It may play a role in the metabolism of xenobiotic aromatic aldehydes. FR-1, also called aldose reductase-related protein 2, or fibroblast growth factor-regulated protein (FGFRP), is induced by fibroblast growth factor-1. It may play a role in the regulation of the cell cycle. FR-1 belongs to the NADPH-dependent aldo-keto reductase family. ALD2 is an inducible aldo-keto reductase with a preference for aliphatic substrates. It can also act on small aromatic aldehydes, steroid aldehydes and some ketone substrates. ARL-1, also called aldose reductase-like, or aldose reductase-related protein (ARP), or small intestine reductase, or SI reductase, acts as all-trans-retinaldehyde reductase that can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). It may be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs. AKR1B15, also called estradiol 17-beta-dehydrogenase AKR1B15, is a mitochondrial aldo-keto reductase that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. It has a strong selectivity towards NADP(H). AKR1B19 is aldose reductase-like that may show 3-beta-hydroxysteroid dehydrogenase (3beta-HSD) activity.


Pssm-ID: 381333 [Multi-domain]  Cd Length: 307  Bit Score: 249.26  E-value: 4.02e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR--PAVLQVECHP 78
Cdd:cd19107  101 IHWPTGFKPGKELFPLDESGNVIPSDTTFLDTWEAMEELVDEGLVKAIGVSNFNHLQIERILNKPGLKykPAVNQIECHP 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  79 YLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSR 158
Cdd:cd19107  181 YLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHNKTTAQVLIRFPIQRNLVVIPKSVTPER 260

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767901878 159 ILQNIKVFDFTFSPEEMKQLNALNKNWRYIVpmltvdgkrVPRDAGHPLYPFNDPY 214
Cdd:cd19107  261 IAENFKVFDFELSSEDMATILSFNRNWRACA---------LLSCSSHKDYPFHAEY 307
AKR_AKR1-5-like cd19071
AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases ...
 1-179 2.37e-78

AKR1/2/3/4/5 family of aldo-keto reductase (AKR) and similar proteins; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. The family includes AKR1A/B/C/D/E/G/I, AKR2A/B/C/D/E, AKR3A/B/C/D/E/G, AKR4A/B/C, AKR5A/B/C/D/E/F/G/H, and similar proteins.


Pssm-ID: 381297 [Multi-domain]  Cd Length: 251  Bit Score: 235.07  E-value: 2.37e-78
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPknadgticydsthYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19071   94 IHWPVPGKEGGSKEA-------------RLETWRALEELVDEGLVRSIGVSNFNVEHLEELLAAARIKPAVNQIELHPYL 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRawrdpdepVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19071  161 QQKELVEFCKEHGIVVQAYSPLGRGRR--------PLLDDPVLKEIAKKYGKTPAQVLLRWALQRGVVVIPKSSNPERIK 232

                        170
                 ....*....|....*....
gi 767901878 161 QNIKVFDFTFSPEEMKQLN 179
Cdd:cd19071  233 ENLDVFDFELSEEDMAAID 251
AKR_AKR2E1-5 cd19116
AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a ...
 1-188 8.50e-74

AKR2E family of aldo-keto reductase (AKR); Bombyx mori 3-dehydroecdysone reductase is a founding member of aldo-keto reductase family 2 member E4 (AKR2E4). It is a NADP-dependent oxidoreductase with high 3-dehydroecdysone reductase activity. It may play a role in the regulation of molting and has lower activity with phenylglyoxal and isatin (in vitro). This family also includes 3-dehydroecdysone 3b-reductase from Spodoptera littoralis and Trichoplusia ni, DL-glyceraldehyde reductase from Drosophila melanogaster, aldo-keto reductase from Bombyx mori, which correspond to aldo-keto reductase family 2 member E1, E2, E3 and E5 (AKR2E1/2/3/5), respectively.


Pssm-ID: 381342 [Multi-domain]  Cd Length: 292  Bit Score: 224.85  E-value: 8.50e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAF-ERGDNPFPKNADgticYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY 79
Cdd:cd19116  109 IHWPVAFkENNDSESNGDGS----LSDIDYLETWRGMEDLVKLGLTRSIGVSNFNSEQINRLLSNCNIKPAVNQIEVHPT 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  80 LAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEPVlLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRI 159
Cdd:cd19116  185 LTQEKLVAYCQSNGIVVMAYSPFGRLVPRGQTNPPPR-LDDPTLVAIAKKYGKTTAQIVLRYLIDRGVVPIPKSSNKKRI 263

                        170       180
                 ....*....|....*....|....*....
gi 767901878 160 LQNIKVFDFTFSPEEMKQLNALNKNWRYI 188
Cdd:cd19116  264 KENIDIFDFQLTPEEVAALNSFNTNQRVY 292
ARA1 COG0656
Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, ...
 2-190 1.36e-72

Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440421 [Multi-domain]  Cd Length: 259  Bit Score: 220.70  E-value: 1.36e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYafergdnpfpknadgticydSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:COG0656   99 HWPG--------------------PGPYVETWRALEELYEEGLIRAIGVSNFDPEHLEELLAETGVKPAVNQVELHPYLQ 158

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDrawrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQ 161
Cdd:COG0656  159 QRELLAFCREHGIVVEAYSPLGRGK----------LLDDPVLAEIAEKHGKTPAQVVLRWHLQRGVVVIPKSVTPERIRE 228

                        170       180
                 ....*....|....*....|....*....
gi 767901878 162 NIKVFDFTFSPEEMKQLNALNKNWRYIVP 190
Cdd:COG0656  229 NLDAFDFELSDEDMAAIDALDRGERLGPD 257
AKR_AKR3G1 cd19123
AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a ...
 1-188 9.73e-72

AKR3G family of aldo-keto reductase (AKR); Synechocystis sp. aldo/keto reductase slr0942 is a founding member of aldo-keto reductase family 3 member G1 (AKR3G1). It is an aldo/keto reductase that catalyzes the NADPH-dependent reduction of aldehyde- and ketone-groups of different classes of carbonyl compounds to the corresponding alcohols.


Pssm-ID: 381349 [Multi-domain]  Cd Length: 297  Bit Score: 219.98  E-value: 9.73e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGdNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19123  109 MHWPVALKKG-VGFPESGEDLLSLSPIPLEDTWRAMEELVDKGLCRHIGVSNFSVKKLEDLLATARIKPAVNQVELHPYL 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDR--AWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSR 158
Cdd:cd19123  188 QQPELLAFCRDNGIHLTAYSPLGSGDRpaAMKAEGEPVLLEDPVINKIAEKHGASPAQVLIAWAIQRGTVVIPKSVNPER 267

                        170       180       190
                 ....*....|....*....|....*....|
gi 767901878 159 ILQNIKVFDFTFSPEEMKQLNALNKNWRYI 188
Cdd:cd19123  268 IQQNLEAAEVELDASDMATIAALDRHHRYV 297
AKR_AKR1C1-35 cd19108
AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) ...
 1-188 1.14e-70

AKR1C family of aldo-keto reductase (AKR); The AKR1C family of aldo-keto reductase (AKR) includes AKR1C1 (20-alpha-hydroxysteroid dehydrogenase, also known as 20alpha-HSD), AKR1C2 (3alpha-HSD type 3), AKR1C3 (17beta-HSD type 5), and AKR1C4 (3alpha-HSD type 1) from Homo sapiens; AKR1C5 (20alpha-HSD, also known as prostaglandin-E(2) 9-reductase) from Rattus norvegicus (ovary); AKR1C6 (estradiol 17beta-HSD type 5) from Mus musculus; AKR1C7 (prostaglandin F synthase 1 or PGF1) from Bos taurus (lung); AKR1C8 (20alpha-HSD) from Rattus norvegicus (ovary); AKR1C9 (3alpha-HSD) from Rattus norvegicus (liver); AKR1C10a (Rho crystallin) from Rana temporaria and AKR1C10b (Rho crystallin) from Rana catesbeina; AKR1C11 (prostaglandin F synthase 2 or PGF2) from Bos taurus (liver); AKR1C12 (aldo-keto reductase or AKR), AKR1C13 (interleukin-3-regulated AKR), and AKR1C14 (3alpha-HSD) from Mus musculus; AKR1C15 (NADPH-dependent reductase), AKR1C16 (NAD+-preferring 3alpha/17beta/20alpha-HSD), and AKR1C17 (NAD+-dependent 3alpha-HSD) from Rattus norvegicus; AKR1C18 (20alpha-HSD), AKR1C19 (3-hydroxybutyrate dehydrogenase or 3HB dehydrogenase), AKR1C20 (3alpha(17beta)-HSD), AKR1C21 (3(17)alpha-HSD), AKR1C22 (dihydrodiol dehydrogenase or DD) from Mus musculus; AKR1C23 (20alpha-HSD) from Equus caballus; AKR1C24 (NAD+-dependent 17beta-HSD) from Rattus norvegicus; AKR1C25 (3(20)alpha-HSD) from Macaca fuscata; AKR1C26 (identical to morphine 6-dehydrogenase or M6DH, acts as NAD(+)-dependent 3alpha/17beta-HSD), AKR1C27/AKR1C28 (NAD(+)-dependent 3alpha/17beta-HSDs), AKR1C29 (identical to 3-hydroxyhexobarbital dehydrogenase or 3HBD, acts as NADPH-preferring reductase with 3alpha/3beta/17beta/20alpha-HSD activity), AKR1C30 (identical to naloxone reductase type 1 and acts as 17beta-HSD), AKR1C31 (3alpha/17beta/20alpha-HSD), AKR1C32 (identical to loxoprofen reductase and acts as 3alpha/20alpha-HSD), and AKR1C33 (identical to naloxone reductase type 2 and mainly acts as 3alpha-HSD) from Oryctolagus cuniculus; AKR1C34 (NAD+-dependent morphine 6-dehydrogenase or M6DH with 3beta/17beta/20alpha-HSD activity) and AKR1C35 (NAD+-dependent dehydrogenase with 3(17)beta-HSD activity) from Mesocricetus auratus.


Pssm-ID: 381334 [Multi-domain]  Cd Length: 303  Bit Score: 217.48  E-value: 1.14e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RPAVLQVECHP 78
Cdd:cd19108  111 IHFPVALKPGEELFPKDENGKLIFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNRRQLEMILNKPGLkyKPVCNQVECHP 190

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  79 YLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPS 157
Cdd:cd19108  191 YLNQSKLLDFCKSKDIVLVAYSALGSQrDKEWVDQNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSFNEK 270

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767901878 158 RILQNIKVFDFTFSPEEMKQLNALNKNWRYI 188
Cdd:cd19108  271 RIKENLQVFEFQLTSEDMKALDGLNRNLRYL 301
AKR_AKR1G1_CeAKR cd19154
Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding ...
 2-186 3.07e-70

Caenorhabditis elegans aldo-keto reductase (CeAKR) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381380 [Multi-domain]  Cd Length: 303  Bit Score: 216.12  E-value: 3.07e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:cd19154  110 HAPAAFKDDEGESGTMENGMSIHDAVDVEDVWRGMEKVYDEGLTKAIGVSNFNNDQIQRILDNARVKPHNNQVECHLYFP 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDRAWRDPD-----EPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITP 156
Cdd:cd19154  190 QKELVEFCKKHNISVTSYATLGSPGRANFTKStgvspAPNLLQDPIVKAIAEKHGKTPAQVLLRYLLQRGIAVIPKSATP 269

                        170       180       190
                 ....*....|....*....|....*....|
gi 767901878 157 SRILQNIKVFDFTFSPEEMKQLNALNKNWR 186
Cdd:cd19154  270 SRIKENFNIFDFSLSEEDMATLEEIEKSLR 299
AKR_AKR1D1-3 cd19109
AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes ...
 1-210 5.03e-68

AKR1D family of aldo-keto reductase (AKR); The AKR1D family of aldo-keto reductase includes 3-oxo-5-beta-steroid 4-dehydrogenase (EC 1.3.1.3) from Homo sapiens (AKR1D1), Rattus norvegicus (liver, AKR1D2), and Oryctolagus cuniculus (AKR1D3). 3-oxo-5-beta-steroid 4-dehydrogenase, also called delta(4)-3-ketosteroid 5-beta-reductase (EC 1.3.99.6), or delta(4)-3-oxosteroid 5-beta-reductase, or 5-beta-reductase, efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites.


Pssm-ID: 381335 [Multi-domain]  Cd Length: 308  Bit Score: 210.81  E-value: 5.03e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV--RPAVLQVECHP 78
Cdd:cd19109  105 IEMPMAFKPGDEIYPRDENGKWLYHKTNLCATWEALEACKDAGLVKSIGVSNFNRRQLELILNKPGLkhKPVSNQVECHP 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  79 YLAQNELIAHCQARGLEVTAYSPLGSS-DRAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPS 157
Cdd:cd19109  185 YFTQPKLLEFCQQHDIVIVAYSPLGTCrDPIWVNVSSPPLLEDPLLNSIGKKYNKTAAQVVLRFNIQRGVVVIPKSFNPE 264

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767901878 158 RILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPMLTVDgkrvprdagHPLYPF 210
Cdd:cd19109  265 RIKENFQIFDFSLTEEEMKDIEALNKNVRYVELLMWRD---------HPEYPF 308
AKR_AKR1E1-2 cd19110
AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1, ...
 1-214 3.54e-66

AKR1E family of aldo-keto reductase (AKR); The AKR1E family of AKR includes 1,5-anhydro-D-fructose reductase (EC 1.1.1.263) from Mus musculus (liver, AKR1E1) and Homo sapiens (AKR1E2). 1,5-anhydro-D-fructose reductase), also called AF reductase, or aldo-keto reductase family 1 member C-like protein 2 (AKR1CL2), catalyzes the NADPH-dependent reduction of 1,5-anhydro-D-fructose (AF) to 1,5-anhydro-D-glucitol. AKR1E2 is a testis aldo-keto reductase (tAKR), which is also known as testis-specific protein (TSP), or LoopADR.


Pssm-ID: 381336 [Multi-domain]  Cd Length: 301  Bit Score: 205.96  E-value: 3.54e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS--VRPAVLQVECHP 78
Cdd:cd19110  101 IHWPMGFKPGEPDLPLDRSGMVIPSDTDFLDTWEAMEDLVIEGLVKNIGVSNFNHEQLERLLNKPGlrVKPVTNQIECHP 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  79 YLAQNELIAHCQARGLEVTAYSPLGSSDRAWRdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSR 158
Cdd:cd19110  181 YLTQKKLISFCQSRNVSVTAYRPLGGSCEGVD------LIDDPVIQRIAKKHGKSPAQILIRFQIQRNVIVIPKSVTPSR 254

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767901878 159 ILQNIKVFDFTFSPEEMKQLNALNKNWRYIVpmltvdgkrVPRDAGHPLYPFNDPY 214
Cdd:cd19110  255 IKENIQVFDFELTEHDMDNLLSLDRNLRLAT---------FPITENHKDYPFHIEY 301
AKR_AKR4C1-15 cd19125
AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase ...
 1-179 4.37e-66

AKR4C family of aldo-keto reductase (AKR); The AKR4C family of AKR includes aldose reductase (ALR) from Hordeum vulgare (AKR4C1), Bromus inermis (AKR4C2), Avena fatua (AKR4C3), and Xerophyta viscosa (AKR4C4), two aldose reductases, DpAR1 (AKR4C5) and DpAR2(AKR4C6), from Digitalis purpurea, aldehyde reductase from Zea mays (AKR4C7), four aldo-keto reductases from Arabidopsis thaliana (AKR4C8-11), and another three aldo-keto reductases from Aloe arborescens (AKR4C12) and Oryza sativa (AKR4C14/15). ALR (EC 1.1.1.21), also called AR, aldehyde reductase, or polyol dehydrogenase (NADP(+)), is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides. Both DpAR1 and DpAR2 reduce the ketone group of steroid structures. They may be involved in plant steroid metabolism in general and in cardenolide biosynthesis in particular. Plant aldo-keto reductases of the AKR4C subfamily play key roles during stress and are attractive targets for developing stress-tolerant crops.


Pssm-ID: 381351 [Multi-domain]  Cd Length: 287  Bit Score: 205.27  E-value: 4.37e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDnPFPKNADgticYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19125  108 IHWPVRLKKGA-HMPEPEE----VLPPDIPSTWKAMEKLVDSGKVRAIGVSNFSVKKLEDLLAVARVPPAVNQVECHPGW 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19125  183 QQDKLHEFCKSKGIHLSAYSPLGSPGTTWVKKN---VLKDPIVTKVAEKLGKTPAQVALRWGLQRGTSVLPKSTNEERIK 259

                        170
                 ....*....|....*....
gi 767901878 161 QNIKVFDFTFSPEEMKQLN 179
Cdd:cd19125  260 ENIDVFDWSIPEEDFAKFS 278
AKR_AKR1G1_1I cd19111
Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase ...
 2-189 3.07e-64

Caenorhabditis elegans aldo-keto reductase (CeAKR), Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; CeAKR is a founding member of aldo-keto reductase family 1 member G1 (AKR1G1). It may catalyze the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381337 [Multi-domain]  Cd Length: 286  Bit Score: 200.42  E-value: 3.07e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYAFE-RGDNPFPKNAdgticydSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19111  102 HHPCGFVnKKDKGERELA-------SSDVTSVWRAMEALVSEGKVKSIGLSNFNPRQINKILAYAKVKPSNLQLECHAYL 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRA--WRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSR 158
Cdd:cd19111  175 QQRELRKFCNKKNIVVTAYAPLGSPGRAnqSLWPDQPDLLEDPTVLAIAKELDKTPAQVLLRFVLQRGTGVLPKSTNKER 254

                        170       180       190
                 ....*....|....*....|....*....|.
gi 767901878 159 ILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 189
Cdd:cd19111  255 IEENFEVFDFELTEEHFKKLKTLDRNMKYFD 285
AKR_AKR1I_CgAKR1 cd19155
Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi ...
 1-186 3.14e-63

Coptotermes gestroi aldo-keto reductase (CgAKR-1) and similar proteins; Coptotermes gestroi aldo-keto reductase (CgAKR-1) is a founding member of aldo-keto reductase family 1 member I (AKR1I). It is a multipurpose enzyme with potential biotechnological applications.


Pssm-ID: 381381 [Multi-domain]  Cd Length: 307  Bit Score: 198.52  E-value: 3.14e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFE-RGDNPFPKNADGTICYD-STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHP 78
Cdd:cd19155  109 IHFPVGSLsKEDDSGKLDPTGEHKQDyTTDLLDIWKAMEAQVDQGLTRSIGLSNFNREQMARILKNARIKPANLQVELHV 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  79 YLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDP-------DEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIP 151
Cdd:cd19155  189 YLQQKDLVDFCSTHSITVTAYAPLGSPGAAHFSPgtgspsgSSPDLLQDPVVKAIAERHGKSPAQVLLRWLMQRGVVVIP 268

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 767901878 152 KSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWR 186
Cdd:cd19155  269 KSTNAARIKENFQVFDFELTEADMAKLSSLDKNIR 303
AKR_DrGR-like cd19136
Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like ...
 1-181 6.30e-63

Danio rerio glyoxal reductase-like (GR-like) protein and similar proteins; Danio rerio GR-like protein is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase similar to Bacillus subtilis glyoxal reductase (YvgN) that reduces glyoxal and methylglyoxal (2-oxopropanal).


Pssm-ID: 381362 [Multi-domain]  Cd Length: 262  Bit Score: 196.31  E-value: 6.30e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWP-YAFERGDNPfpKNADgticydstHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY 79
Cdd:cd19136   99 IHWPgVQGLKPSDP--RNAE--------LRRESWRALEDLYKEGKLRAIGVSNYTVRHLEELLKYCEVPPAVNQVEFHPH 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  80 LAQNELIAHCQARGLEVTAYSPLGSSDrawrdpdePVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRI 159
Cdd:cd19136  169 LVQKELLKFCKDHGIHLQAYSSLGSGD--------LRLLEDPTVLAIAKKYGRTPAQVLLRWALQQGIGVIPKSTNPERI 240

                        170       180
                 ....*....|....*....|..
gi 767901878 160 LQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19136  241 AENIKVFDFELSEEDMAELNAL 262
AKR_AKR5G1-3 cd19157
AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), ...
 29-187 3.55e-61

AKR5G family of aldo-keto reductase (AKR); Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase are founding members of aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381383 [Multi-domain]  Cd Length: 265  Bit Score: 191.84  E-value: 3.55e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  29 YKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDra 108
Cdd:cd19157  112 YKETWKALEKLYKDGRVRAIGVSNFQVHHLEDLLADAEIVPMVNQVEFHPRLTQKELRDYCKKQGIQLEAWSPLMQGQ-- 189

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767901878 109 wrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 187
Cdd:cd19157  190 --------LLDNPVLKEIAEKYNKSVAQVILRWDLQNGVVTIPKSIKEHRIIENADVFDFELSQEDMDKIDALNENLRV 260
AKR_AKR5F1 cd19133
the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid ...
 2-182 5.49e-57

the AKR5F family of aldo-keto reductase (AKR); Klebsiella sp. 2,5-diketo-D-gluconic acid reductase (2,5-DKG reductase) is a founding member of aldo-keto reductase family 5 member F1 (AKR5F1). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381359 [Multi-domain]  Cd Length: 255  Bit Score: 180.85  E-value: 5.49e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYaferGDnpfpknadgticydsthYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:cd19133  104 HQPF----GD-----------------VYGAWRAMEELYKEGKIRAIGVSNFYPDRLVDLILHNEVKPAVNQIETHPFNQ 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQ 161
Cdd:cd19133  163 QIEAVEFLKKYGVQIEAWGPFAEGRNN--------LFENPVLTEIAEKYGKSVAQVILRWLIQRGIVVIPKSVRPERIAE 234

                        170       180
                 ....*....|....*....|.
gi 767901878 162 NIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19133  235 NFDIFDFELSDEDMEAIAALD 255
AKR_AKR2D1 cd19115
AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose ...
 1-187 2.31e-56

AKR2D family of aldo-keto reductase (AKR); Aspergillus niger NAD(P)H-dependent D-xylose reductase xyl1 (XR, EC 1.1.1.307) is a founding member of aldo-keto reductase family 2 member D1 (AKR2D1). It catalyzes the initial reaction in the xylose utilization pathway by reducing D-xylose into xylitol in a NAD(P)H dependent manner.


Pssm-ID: 381341 [Multi-domain]  Cd Length: 311  Bit Score: 181.08  E-value: 2.31e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDnP---FP---KNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 74
Cdd:cd19115  110 IHFPIALKYVD-PavrYPpgwFYDGKKVEFSNAPIQETWTAMEKLVDKGLARSIGVSNFSAQLLMDLLRYARIRPATLQI 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  75 ECHPYLAQNELIAHCQARGLEVTAYSPLG-------SSDRAwrdPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKV 147
Cdd:cd19115  189 EHHPYLTQPRLVKYAQKEGIAVTAYSSFGpqsflelDLPGA---KDTPPLFEHDVIKSIAEKHGKTPAQVLLRWATQRGI 265

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 767901878 148 ICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 187
Cdd:cd19115  266 AVIPKSNNPKRLAQNLDVTGFDLEAEEIKAISALDIGLRF 305
AKR_CeZK1290-like cd19135
Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the ...
 1-181 7.50e-56

Caenorhabditis elegans ZK1290.5 and similar proteins; Caenorhabditis elegans ZK1290.5 is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381361 [Multi-domain]  Cd Length: 265  Bit Score: 178.29  E-value: 7.50e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNAdgticydsthykETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19135  106 LHWPDCPSSGKNVKETRA------------ETWRALEELYDEGLCRAIGVSNFLIEHLEQLLEDCSVVPHVNQVEFHPFQ 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSsdraWRdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19135  174 NPVELIEYCRDNNIVFEGYCPLAK----GK------ALEEPTVTELAKKYQKTPAQILIRWSIQNGVVTIPKSTKEERIK 243

                        170       180
                 ....*....|....*....|.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19135  244 ENCQVFDFSLSEEDMATLDSL 264
AKR_AKR5A_5G cd19126
AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes ...
 28-182 2.33e-55

AKR5A and AKR5G families of aldo-keto reductase (AKR); The AKR5A family of AKR includes prostaglandin F2-alpha synthase (PGFS) from Leishmania major (AKR5A1) and Trypanosoma brucei (AKR5A2). PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity for synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde. The AKR5G family of AKR includes Bacillus subtilis glyoxal reductase (GR), uncharacterized oxidoreductase YtbE, and Bacillus aryabhattai aldo-keto reductase, which corresponds to aldo-keto reductase family 5 member G1-3 (AKR5G1-3), respectively. GR (YvgN, EC 1.1.1.283), also called methylglyoxal reductase, reduces glyoxal and methylglyoxal (2-oxopropanal). It is not involved in vitamin B6 biosynthesis.


Pssm-ID: 381352 [Multi-domain]  Cd Length: 254  Bit Score: 176.86  E-value: 2.33e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  28 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSdr 107
Cdd:cd19126  110 KFIDTWKALEKLYASGKVKAIGVSNFQEHHLEELLAHADVVPAVNQVEFHPYLTQKELRGYCKSKGIVVEAWSPLGQG-- 187

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901878 108 awrdpdepVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19126  188 --------GLLSNPVLAAIGEKYGKSAAQVVLRWDIQHGVVTIPKSVHASRIKENADIFDFELSEDDMTAIDALN 254
AKR_AKR5B1 cd19127
AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) ...
 1-182 7.19e-55

AKR5B family of aldo-keto reductase (AKR); Pseudomonas putida morphine 6-dehydrogenase (M6DH) is a founding member of the aldo-keto reductase family 5 member B1 (AKR5B1). M6DH (EC 1.1.1.218), also called naloxone reductase, oxidizes the C-6 hydroxy group of morphine and codeine.


Pssm-ID: 381353 [Multi-domain]  Cd Length: 268  Bit Score: 176.06  E-value: 7.19e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPyafergdnpFPKNADGTIcydsthykETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19127  102 LHWP---------VPNDFDRTI--------QAYKALEKLLAEGRVRAIGVSNFTPEHLERLIDATTVVPAVNQVELHPYF 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAWR-DPDEPV-LLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSR 158
Cdd:cd19127  165 SQKDLRAFHRRLGIVTQAWSPIGGVMRYGAsGPTGPGdVLQDPTITGLAEKYGKTPAQIVLRWHLQNGVSAIPKSVHPER 244

                        170       180
                 ....*....|....*....|....
gi 767901878 159 ILQNIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19127  245 IAENIDIFDFALSAEDMAAIDALD 268
AKR_AKR3B1-3 cd19118
AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde ...
 2-181 1.63e-54

AKR3B family of aldo-keto reductase (AKR); Sporidiobolus salmonicolor NADPH-dependent aldehyde reductase 1 (ARI, EC 1.1.1.2), Trichosporonoides megachilieni NADPH-dependent erthyrose reductase (ER) 1/2 and 3, are founding members of aldo-keto reductase family 3 member B1 (AKR3B1), B2 (AKR3B2), and B3 (AKR3B3), respectively. Sporidiobolus salmonicolor NADPH-ARI, also called alcohol dehydrogenase [NADP(+)], or aldehyde reductase I, or ALR 1, catalyzes the asymmetric reduction of aliphatic and aromatic aldehydes and ketones to an R-enantiomer. It reduces ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate. Trichosporonoides megachilieni NADPH-ERs catalyze the reduction of D-erythrose.


Pssm-ID: 381344 [Multi-domain]  Cd Length: 283  Bit Score: 175.29  E-value: 1.63e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYAFERGDNPFPKNADGT----ICYD-STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVEC 76
Cdd:cd19118  106 HWPVAFKPTGDLNPLTAVPTnggeVDLDlSVSLVDTWKAMVELKKTGKVKSIGVSNFSIDHLQAIIEETGVVPAVNQIEA 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  77 HPYLAQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITP 156
Cdd:cd19118  186 HPLLLQDELVDYCKSKNIHITAYSPLGNNLAG-----LPLLVQHPEVKAIAAKLGKTPAQVLIAWGIQRGHSVIPKSVTP 260

                        170       180
                 ....*....|....*....|....*
gi 767901878 157 SRILQNIKvfDFTFSPEEMKQLNAL 181
Cdd:cd19118  261 SRIRSNFE--QVELSDDEFNAVTAL 283
AKR_AKR2B1-10 cd19113
AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent ...
 1-187 1.99e-52

AKR2B family of aldo-keto reductase (AKR); The AKR2B family of AKR includes NAD(P)H-dependent D-xylose reductase (XR) from Pichia stipites, Kluyveromyces lactis, Pachysolen tannophilus, Candida tropicalis, and Candida tenuis, Gre3p from Saccharomyces cerevisiae, XR from Candida tropicalis, Pichia guilliermondii, Debaryomyces hansenli, and Debaryomyces nepalensis, which correspond to aldo-keto reductase family 2 member B1-B10 (AKR2B1-10), respectively. XR (EC1.1.1.307) catalyzes the NAD(P)H dependent reduction of xylose to xylitol.


Pssm-ID: 381339 [Multi-domain]  Cd Length: 310  Bit Score: 171.09  E-value: 1.99e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAF------ERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 74
Cdd:cd19113  108 IHFPIAFkfvpieEKYPPGFYCGDGDNFVYEDVPILDTWKALEKLVDAGKIKSIGVSNFPGALILDLLRGATIKPAVLQI 187

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  75 ECHPYLAQNELIAHCQARGLEVTAYSPLGSSD----RAWRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICI 150
Cdd:cd19113  188 EHHPYLQQPKLIEYAQKAGITITAYSSFGPQSfvelNQGRALNTPTLFEHDTIKSIAAKHNKTPAQVLLRWATQRGIAVI 267

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 767901878 151 PKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 187
Cdd:cd19113  268 PKSNLPERLLQNLSVNDFDLTKEDFEEIAKLDIGLRF 304
AKR_AKR3A1-2 cd19117
AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are ...
 1-183 3.52e-52

AKR3A family of aldo-keto reductase (AKR); Saccharomyces cerevisiae Gcy1p and Ypr1p are founding members of aldo-keto reductase family 3 member A1 (AKR3A1) and A2 (AKR3A2), respectively. Gcy1p, also called galactose-inducible crystallin-like protein 1, is a glycerol dehydrogenase involved in glycerol catabolism under microaerobic conditions. It has mRNA binding activity. Ypr1p acts as a 2-methylbutyraldehyde reductase that displays high specific activity towards 2-methylbutyraldehyde, as well as other aldehydes such as hexanal.


Pssm-ID: 381343 [Multi-domain]  Cd Length: 284  Bit Score: 169.60  E-value: 3.52e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPF-PKNADGT-ICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILS--VASVRPAVLQVEC 76
Cdd:cd19117  105 MHWPVPLDPDGNDFlFKKDDGTkDHEPDWDFIKTWELMQKLPATGKVKAIGVSNFSIKNLEKLLAspSAKIVPAVNQIEL 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  77 HPYLAQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITP 156
Cdd:cd19117  185 HPLLPQPKLVDFCKSKGIHATAYSPLGSTNAP--------LLKEPVIIKIAKKHGKTPAQVIISWGLQRGYSVLPKSVTP 256

                        170       180
                 ....*....|....*....|....*..
gi 767901878 157 SRILQNIKVfdFTFSPEEMKQLNALNK 183
Cdd:cd19117  257 SRIESNFKL--FTLSDEEFKEIDELHK 281
AKR_AKR2A1-2 cd19112
AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 ...
 19-190 2.19e-51

AKR2A family of aldo-keto reductase (AKR); The AKR2A family of AKR includes AKR2A1 (NADP-dependent D-sorbitol-6-phosphate dehydrogenase or NADP-S6PDH) from Malus domestica, and AKR2A2 (NADPH-dependent mannose-6-phosphate reductase or NADPH-M6PR) from Apium graveolens. NADP-S6PDH (EC 1.1.1.200), also called aldose-6-phosphate reductase [NADPH], synthesizes sorbitol-6-phosphate, a key intermediate in the synthesis of sorbitol which is a major photosynthetic product in many members of the Rosaceae family. NADPH-M6PR (EC 1.1.1.224), also called NADPH-dependent M6P reductase, is a key enzyme involved in mannitol biosynthesis.


Pssm-ID: 381338 [Multi-domain]  Cd Length: 308  Bit Score: 168.05  E-value: 2.19e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  19 DGTICYDSThyketWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTA 98
Cdd:cd19112  133 DVTISLETT-----WHAMEKLVSAGLVRSIGISNYDIFLTRDCLAYSKIKPAVNQIETHPYFQRDSLVKFCQKHGISVTA 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  99 YSPLG--SSDRAWRDPDEPvlLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMK 176
Cdd:cd19112  208 HTPLGgaAANAEWFGSVSP--LDDPVLKDLAKKYGKSAAQIVLRWGIQRNTAVIPKSSKPERLKENIDVFDFQLSKEDMK 285

                        170
                 ....*....|....
gi 767901878 177 QLNALNKNWRYIVP 190
Cdd:cd19112  286 LIKSLDRKYRTNQP 299
AKR_AKR5A1_2 cd19156
AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from ...
 29-187 2.73e-51

AKR5A family of aldo-keto reductase (AKR); Prostaglandin F2-alpha synthase (PGFS) from Leishmania major and Trypanosoma brucei are founding members of aldo-keto reductase family 5 member A1 (AKR5A1) and A2 (AKR5A2), respectively. PGFS, also called 9,11-endoperoxide prostaglandin H2 reductase, catalyzes the NADP-dependent formation of prostaglandin F2-alpha from prostaglandin H2. It has also aldo/ketoreductase activity toward the synthetic substrates 9,10-phenanthrenequinone and p-nitrobenzaldehyde.


Pssm-ID: 381382 [Multi-domain]  Cd Length: 266  Bit Score: 166.54  E-value: 2.73e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  29 YKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDra 108
Cdd:cd19156  111 FKDTWKAFEKLYKEKKVRAIGVSNFHEHHLEELLKSCKVAPMVNQIELHPLLTQEPLRKFCKEKNIAVEAWSPLGQGK-- 188

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767901878 109 wrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 187
Cdd:cd19156  189 --------LLSNPVLKAIGKKYGKSAAQVIIRWDIQHGIITIPKSVHEERIQENFDVFDFELTAEEIRQIDGLNTDHRY 259
AKR_AKR5C2 cd19131
Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; ...
 28-182 7.67e-51

Escherichia coli 2,5-diketo-D-gluconic acid reductase A (DkgA/YqhE) and similar proteins; Escherichia coli DkgA/YqhE is a founding member of aldo-keto reductase family 5 member C2 (AKR5C2). DkgA/YqhE (EC 1.1.1.274), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). It is also capable of stereoselective -keto ester reductions on ethyl acetoacetate and other 2-substituted derivatives.


Pssm-ID: 381357 [Multi-domain]  Cd Length: 256  Bit Score: 165.24  E-value: 7.67e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  28 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDr 107
Cdd:cd19131  112 KYVETWKALIELKKEGRVKSIGVSNFTIEHLQRLIDETGVVPVVNQIELHPRFQQRELRAFHAKHGIQTESWSPLGQGG- 190

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901878 108 awrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19131  191 ---------LLSDPVIGEIAEKHGKTPAQVVIRWHLQNGLVVIPKSVTPSRIAENFDVFDFELDADDMQAIAGLD 256
AKR_AKR3C2-3 cd19120
Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis ...
 13-187 2.47e-48

Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase, Candida parapsilosis NADPH-dependent conjugated polyketone reductase C2 (CPR), and similar proteins; Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase (EC 1.1.1.190/EC 1.1.1.191) and Candida parapsilosis NADPH-dependent CPR (EC 1.1.1.358/EC 1.1.1.168) are founding members of aldo-keto reductase family 3 member C2 (AKR3C2) and C3 (AKR3C3), respectively. Saccharomyces pombe NAD/NADP-dependent indole-3-acetaldehyde reductase catalyzes the conversion from (Indol-3-yl)ethanol to (indol-3-yl)acetaldehyde in a NAD/NADP-dependent manner. CPR, also called 2-dehydropantolactone reductase, or 2-dehydropantolactone reductase (A-specific), or ketopantoyl-lactone reductase, acts as a NADPH-dependent conjugated polyketone reductase with broad substrate specificity and strict stereospecificity. It reduces ketopantoyl lactone and isatin.


Pssm-ID: 381346 [Multi-domain]  Cd Length: 269  Bit Score: 158.93  E-value: 2.47e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  13 PFPKNADGTIcydsthyKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA--QNELIAHCQ 90
Cdd:cd19120  106 FFAKEGGPTL-------AEAWAELEALKDAGLVRSIGVSNFRIEDLEELLDTAKIKPAVNQIEFHPYLYpqQPALLEYCR 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  91 ARGLEVTAYSPLGSsdrAWRDPDEPVlleEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTF 170
Cdd:cd19120  179 EHGIVVSAYSPLSP---LTRDAGGPL---DPVLEKIAEKYGVTPAQVLLRWALQKGIVVVTTSSKEERMKEYLEAFDFEL 252

                        170
                 ....*....|....*..
gi 767901878 171 SPEEMKQLNALNKNWRY 187
Cdd:cd19120  253 TEEEVEEIDKAGKQKHF 269
AKR_AKR5D1_E1 cd19132
AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B ...
 29-182 2.84e-48

AKR5D and AKR5E families of aldo-keto reductase (AKR); 2,5-diketo-D-gluconic acid reductase B (DkgB) from Corynebacterium sp. and 2,5-diketo-D-gluconic acid reductase Zymomonas mobilis are founding members of aldo-keto reductase family 5 member D1 (AKR5D1) and E1 (AKR5E1), respectively. DkgB (EC 1.1.1.274), also called 2,5-didehydrogluconate reductase (2-dehydro-D-gluconate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381358 [Multi-domain]  Cd Length: 255  Bit Score: 158.59  E-value: 2.84e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  29 YKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGssdra 108
Cdd:cd19132  110 YVEAWQALIEAREEGLVRSIGVSNFLPEHLDRLIDETGVTPAVNQIELHPYFPQAEQRAYHREHGIVTQSWSPLG----- 184

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767901878 109 wRDPDepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19132  185 -RGSG---LLDEPVIKAIAEKHGKTPAQVVLRWHVQLGVVPIPKSANPERQRENLAIFDFELSDEDMAAIAALD 254
AKR_AKR3D1 cd19121
AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, ...
 1-181 6.03e-48

AKR3D family of aldo-keto reductase (AKR); Trichoderma reesei D-galacturonate reductase (GAR1, EC 1.1.1.365), also called D-galacturonic acid reductase, or GalUR, is a founding member of aldo-keto reductase family 3 member D1 (AKR3D1). It mediates the reduction of D-galacturonate to L-galactonate, the first step in D-galacturonate catabolic process. It also has activity with D-glucuronate and DL-glyceraldehyde. Its activity is seen only with NADPH and not with NADH.


Pssm-ID: 381347 [Multi-domain]  Cd Length: 279  Bit Score: 158.46  E-value: 6.03e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAF--ERGDNPFPKNADGTICYDST-HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECH 77
Cdd:cd19121  106 VHWPVLLnpNGNHDLFPTLPDGSRDLDWDwNHVDTWKQMEKVLKTGKTKAIGVSNYSIPYLEELLKHATVVPAVNQVENH 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  78 PYLAQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPS 157
Cdd:cd19121  186 PYLPQQELVDFCKEKGILIEAYSPLGSTGSP--------LISDEPVVEIAKKHNVGPGTVLISYQVARGAVVLPKSVTPD 257

                        170       180
                 ....*....|....*....|....
gi 767901878 158 RILQNIKVFDFTfsPEEMKQLNAL 181
Cdd:cd19121  258 RIKSNLEIIDLD--DEDMNKLNDI 279
AKR_AKR3F2_3 cd19073
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti ...
 31-179 2.19e-47

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB), Sinorhizobium meliloti isatin reductase and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381299 [Multi-domain]  Cd Length: 243  Bit Score: 155.89  E-value: 2.19e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDrawr 110
Cdd:cd19073  105 ETLGALKELKEAGKVKSIGVSNFTIELLEEALDISPLPIAVNQVEFHPFLYQAELLEYCRENDIVITAYSPLARGE---- 180

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767901878 111 dpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19073  181 ------VLRDPVIQEIAEKYDKTPAQVALRWLVQKGIVVIPKASSEDHLKENLAIFDWELTSEDVAKID 243
AKR_BaDH-like cd19129
Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium ...
 1-179 1.41e-46

Bradyrhizobium diazoefficiens dehydrogenase (DH) and similar proteins; Bradyrhizobium diazoefficiens DH is the prototype of this family. It belongs to aldo/keto reductase family.


Pssm-ID: 381355 [Multi-domain]  Cd Length: 295  Bit Score: 155.31  E-value: 1.41e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDS-THYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY 79
Cdd:cd19129  103 IHTPFAFQPGDEQDPRDANGNVIYDDgVTLLDTWRAMERLVDEGRCKAIGLSDVSLEKLREIFEAARIKPAVVQVESHPY 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  80 LAQNELIAHCQARGLEVTAYSPLGSSdrawrdpDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRI 159
Cdd:cd19129  183 LPEWELLDFCKNHGIVLQAFAPLGHG-------MEPKLLEDPVITAIARRVNKTPAQVLLAWAIQRGTALLTTSKTPSRI 255

                        170       180
                 ....*....|....*....|.
gi 767901878 160 LQNikvFDFTFSPEE-MKQLN 179
Cdd:cd19129  256 REN---FDISTLPEDaMREIN 273
AKR_AKR4A_4B cd19124
AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes ...
 2-181 1.85e-46

AKR4A and AKR4B families of aldo-keto reductase (AKR); The AKR4A family of AKR includes Glycine max NAD(P)H-dependent 6'-deoxychalcone synthase (6DCS, EC 3.1.170), chalcone reductase (CHR, EC 2.3.1.74) from Medicago sativa, Glycyrrhiza echinate, and Glycyrrhiza glabra, which are founding members of aldo-keto reductase family 4 member A1 (AKR4A1), A2 (AKR4A2), A3 (AKR4A3), and A4 (AKR4A4), respectively. NAD(P)H-6DCS co-acts with chalcone synthase in formation of 4,2',4'-trihydroxychalcone, involved in the biosynthesis of glyceollin type phytoalexins. CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. The AKR4B family of AKR includes Sesbania rostrate chalcone reductase (CHR, AKR4B1), Papaver somniferum codeinone reductase (COR, AKR4B2/ AKR4B3), Fragaria x ananassa D-galacturonate reductase (GalUR, AKR4B4), deoxymugineic acid synthase 1 (DMAS1) from Zea mays (AKR4B5), Oryza sativa (AKR4B6), Hordeum vulgare (AKR4B7), Triticum aestivum (AKR4B8), and Erythroxylum coca methylecgonone reductase (MecgoR, AKR4B10). CHR, also called chalcone polyketide reductase, is a key enzyme of the flavonoid/isoflavonoid biosynthesis pathway. NADPH-dependent COR and non-functional NADPH-dependent COR from Papaver somniferum are founding members of aldo-keto reductase family 4 member B2 (AKR4B2) and B3 (AKR4B3), respectively. NADPH-dependent COR (EC 1.1.1.247) reduces codeinone to codeine in the penultimate step in morphine biosynthesis. It can use morphinone, hydrocodone, and hydromorphone as substrates during reductive reaction with NADPH as cofactor, and morphine and dihydrocodeine as substrates during oxidative reaction with NADP as cofactor. GalUR (EC 1.1.1.365), also called aldo-keto reductase 2 (AKR2), is involved in ascorbic acid (vitamin C) biosynthesis by catalyzing the conversion from L-galactonate and NADP(+) to D-galacturonate and NADPH. DMAS1 (EC 1.1.1.285) catalyzes the reduction of a 3''-keto intermediate during the biosynthesis of 2'-deoxymugineic acid (DMA) from L-Met. It is involved in the formation of phytosiderophores (MAs) belonging to the mugineic acid family and required to acquire iron. MecgoR catalyzes the stereospecific reduction of methylecgonone to methylecgonine, the penultimate step in cocaine biosynthesis.


Pssm-ID: 381350 [Multi-domain]  Cd Length: 281  Bit Score: 154.73  E-value: 1.85e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYAFERGDNPFPKNADGTICYDsthYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:cd19124  106 HWPVSLKPGKFSFPIEEEDFLPFD---IKGVWEAMEECQRLGLTKAIGVSNFSCKKLQELLSFATIPPAVNQVEMNPAWQ 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDRAWRDpdePVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQ 161
Cdd:cd19124  183 QKKLREFCKANGIHVTAYSPLGAPGTKWGS---NAVMESDVLKEIAAAKGKTVAQVSLRWVYEQGVSLVVKSFNKERMKQ 259

                        170       180
                 ....*....|....*....|
gi 767901878 162 NIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19124  260 NLDIFDWELTEEDLEKISEI 279
AKR_AKR2C1 cd19114
AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent ...
 1-192 8.74e-46

AKR2C family of aldo-keto reductase (AKR); Mucor mucedo NADP-dependent 4-dihydromethyl-trisporate dehydrogenase (TDH), also called 4-dihydromethyltrisporate dehydrogenase, or 4-dihydromethyl-TA dehydrogenase, is a founding member of aldo-keto reductase family 2 member C1 (AKR2C1). It is involved in the biosynthesis of trisporic acid, the sexual hormone of zygomycetes, which induces the first steps of zygophore development. TDH catalyzes the NADP-dependent oxidation of (+) mating-type specific precursor 4-dihydromethyl-trisporate to methyl-trisporate.


Pssm-ID: 381340 [Multi-domain]  Cd Length: 302  Bit Score: 153.48  E-value: 8.74e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGD---NPFPKNADG---TICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQV 74
Cdd:cd19114  101 IHFPIPAAYVDpaeNYPFLWKDKelkKFPLEQSPMQECWREMEKLVDAGLVRNIGIANFNVQLILDLLTYAKIKPAVLQI 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  75 ECHPYLAQNELIAHCQARGLEVTAYSPLGSSdrAWRDPDEPV-----LLEEPVVLALAEKYGRSPAQILLRWQVQRKVIC 149
Cdd:cd19114  181 EHHPYLQQKRLIDWAKKQGIQITAYSSFGNA--VYTKVTKHLkhftnLLEHPVVKKLADKHKRDTGQVLLRWAVQRNITV 258

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 767901878 150 IPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIVPML 192
Cdd:cd19114  259 IPKSVNVERMKTNLDITSYKLDEEDMEALYELEANARFNDPVV 301
AKR_AKR3F3 cd19140
Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin ...
 2-181 7.65e-45

Sinorhizobium meliloti isatin reductase and similar proteins; Sinorhizobium meliloti isatin reductase is a founding member of aldo-keto reductase family 3 member F3 (AKR3F3). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381366 [Multi-domain]  Cd Length: 253  Bit Score: 149.72  E-value: 7.65e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPyafergdnpfpkNADGTIcydsthyKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLA 81
Cdd:cd19140  102 HWP------------NKDVPL-------AETLGALNEAQEAGLARHIGVSNFTVALLREAVELSEAPLFTNQVEYHPYLD 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  82 QNELIAHCQARGLEVTAYSPLGSSDrawrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQR-KVICIPKSITPSRIL 160
Cdd:cd19140  163 QRKLLDAAREHGIALTAYSPLARGE----------VLKDPVLQEIGRKHGKTPAQVALRWLLQQeGVAAIPKATNPERLE 232

                        170       180
                 ....*....|....*....|.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19140  233 ENLDIFDFTLSDEEMARIAAL 253
AKR_GlAR-like cd19128
Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), ...
 1-181 1.85e-44

Giardia lamblia aldose reductase (AR) and similar proteins; Giardia lamblia AR (EC 1.1.1.21), also called aldehyde reductase, is the prototype of this family. It catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.


Pssm-ID: 381354 [Multi-domain]  Cd Length: 277  Bit Score: 149.60  E-value: 1.85e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19128   98 IHWPLAFDMDTDGDPRDDNQIQSLSKKPLEDTWRAMEQCVDEKLTKNIGVSNYSTKLLTDLLNYCKIKPFMNQIECHPYF 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSdrawRDPDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQR---KVICIPKSITPS 157
Cdd:cd19128  178 QNDKLIKFCIENNIHVTAYRPLGGS----YGDGNLTFLNDSELKALATKYNTTPPQVIIAWHLQKwpkNYSVIPKSANKS 253

                        170       180
                 ....*....|....*....|....
gi 767901878 158 RILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19128  254 RCQQNFDINDLALTKEDMDAINTL 277
AKR_AKR3C1 cd19119
Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar ...
 2-181 7.90e-41

Saccharomyces cerevisiae D-arabinose dehydrogenase [NAD(P)+] heavy chain (Ara1p) and similar proteins; Saccharomyces cerevisiae Ara1p (EC 1.1.1.117), also called D-arabinose 1-dehydrogenase (NAD(P)(+)), is a founding members of aldo-keto reductase family 3 member C1 (AKR3C1). It catalyzes the oxidation of D-arabinose, L-xylose, L-fucose, and L-galactose in the presence of NADP(+).


Pssm-ID: 381345 [Multi-domain]  Cd Length: 294  Bit Score: 140.71  E-value: 7.90e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPYAFERGDNP-----FPKNADGTICY-DSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVE 75
Cdd:cd19119  110 HWPVCFEKDSDDsgkpfTPVNDDGKTRYaASGDHITTYKQLEKIYLDGRAKAIGVSNYSIVYLERLIKECKVVPAVNQVE 189

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  76 CHPYLAQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSIT 155
Cdd:cd19119  190 LHPHLPQMDLRDFCFKHGILVTAYSPLGSHGAP--------NLKNPLVKKIAEKYNVSTGDILISYHVRQGVIVLPKSLK 261

                        170       180
                 ....*....|....*....|....*.
gi 767901878 156 PSRILQNIKVFDFTfsPEEMKQLNAL 181
Cdd:cd19119  262 PVRIVSNGKIVSLT--KEDLQKLDDI 285
AKR_AKR5H1 cd19134
AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding ...
 29-187 3.83e-40

AKR5H family of aldo-keto reductase (AKR); Mycobacterium smegmatis MSMEG_2407 is a founding member of aldo-keto reductase family 5 member H1 (AKR5H1). It is a NADPH-dependent aldo-keto reductase that reduces methylglyoxal and phenylglyoxal.


Pssm-ID: 381360 [Multi-domain]  Cd Length: 263  Bit Score: 138.07  E-value: 3.83e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  29 YKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDra 108
Cdd:cd19134  114 YVDSWGGLMKLREEGLARSIGVSNFTAEHLENLIDLTFFTPAVNQIELHPLLNQAELRKVNAQHGIVTQAYSPLGVGR-- 191

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767901878 109 wrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRY 187
Cdd:cd19134  192 --------LLDNPAVTAIAAAHGRTPAQVLLRWSLQLGNVVISRSSNPERIASNLDVFDFELTADHMDALDGLDDGTRF 262
AKR_AKR5C1 cd19130
Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; ...
 1-182 4.39e-38

Corynebacterium sp. 2,5-diketo-D-gluconic acid reductase A (DkgA) and similar proteins; Corynebacterium sp. DkgA is a founding member of aldo-keto reductase family 5 member C1 (AKR5C1). DkgA (EC 1.1.1.346), also called 2,5-DKG reductase A, or 2,5-DKGR A, or 25DKGR-A, or AKR5C, catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 5-keto-D-fructose and dihydroxyacetone can also serve as substrates.


Pssm-ID: 381356 [Multi-domain]  Cd Length: 256  Bit Score: 132.34  E-value: 4.39e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPyAFERGDnpfpknadgticydsthYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:cd19130  103 VHWP-TPAAGN-----------------YVHTWEAMIELRAAGRTRSIGVSNFLPPHLERIVAATGVVPAVNQIELHPAY 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDrawrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:cd19130  165 QQRTIRDWAQAHDVKIEAWSPLGQGK----------LLGDPPVGAIAAAHGKTPAQIVLRWHLQKGHVVFPKSVRRERME 234

                        170       180
                 ....*....|....*....|..
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALN 182
Cdd:cd19130  235 DNLDVFDFDLTDTEIAAIDALD 256
dkgA PRK11565
2,5-didehydrogluconate reductase DkgA;
1-186 7.00e-37

2,5-didehydrogluconate reductase DkgA;


Pssm-ID: 183203 [Multi-domain]  Cd Length: 275  Bit Score: 129.81  E-value: 7.00e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPyafergdnpfpknadgtiCYDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPYL 80
Cdd:PRK11565 106 MHWP------------------VPAIDHYVEAWKGMIELQKEGLIKSIGVCNFQIHHLQRLIDETGVTPVINQIELHPLM 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 AQNELIAHCQARGLEVTAYSPLGSSDRAwrdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRIL 160
Cdd:PRK11565 168 QQRQLHAWNATHKIQTESWSPLAQGGKG--------VFDQKVIRDLADKYGKTPAQIVIRWHLDSGLVVIPKSVTPSRIA 239

                        170       180
                 ....*....|....*....|....*.
gi 767901878 161 QNIKVFDFTFSPEEMKQLNALNKNWR 186
Cdd:PRK11565 240 ENFDVFDFRLDKDELGEIAKLDQGKR 265
AKR_AKR3E1 cd19122
AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol ...
 1-183 3.01e-36

AKR3E family of aldo-keto reductase (AKR); Trichoderma reesei NADP(+)-dependent glycerol 2-dehydrogenase (GLD2, EC 1.1.1.156), also called dihydroxyacetone reductase, is a founding member of aldo-keto reductase family 3 member E1 (AKR3E1). It acts as a glycerol oxidoreductase probably involved in glycerol synthesis.


Pssm-ID: 381348 [Multi-domain]  Cd Length: 291  Bit Score: 128.51  E-value: 3.01e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFPK-NADG--TICYDSTHYKE-TWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVEC 76
Cdd:cd19122  109 VHWPIAAEKNDQRSPKlGPDGkyVILKDLTENPEpTWRAMEEIYESGKAKAIGVSNWTIPGLKKLLSFAKVKPHVNQIEI 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  77 HPYLAQNELIAHCQARGLEVTAYSPLGSSDRAWRDPDEpvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITP 156
Cdd:cd19122  189 HPFLPNEELVDYCFSNDILPEAYSPLGSQNQVPSTGER--VSENPTLNEVAEKGGYSLAQVLIAWGLRRGYVVLPKSSTP 266

                        170       180
                 ....*....|....*....|....*..
gi 767901878 157 SRILQNIKVFDftFSPEEMKQLNALNK 183
Cdd:cd19122  267 SRIESNFKSIE--LSDEDFEAINQVAK 291
Aldo_ket_red pfam00248
Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain ...
 26-182 5.54e-36

Aldo/keto reductase family; This family includes a number of K+ ion channel beta chain regulatory domains - these are reported to have oxidoreductase activity.


Pssm-ID: 425554 [Multi-domain]  Cd Length: 290  Bit Score: 127.81  E-value: 5.54e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   26 STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY--LAQNELIAHCQARGLEVTAYSPLG 103
Cdd:pfam00248 113 DTPIEETWDALEELKKEGKIRAIGVSNFDAEQIEKALTKGKIPIVAVQVEYNLLrrRQEEELLEYCKKNGIPLIAYSPLG 192

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  104 S--------SDRAWRDPDEPVLLEE---------PVVLALAEKYGRSPAQILLRW--QVQRKVICIPKSITPSRILQNIK 164
Cdd:pfam00248 193 GglltgkytRDPDKGPGERRRLLKKgtplnlealEALEEIAKEHGVSPAQVALRWalSKPGVTIPIPGASNPEQLEDNLG 272

                         170
                  ....*....|....*...
gi 767901878  165 VFDFTFSPEEMKQLNALN 182
Cdd:pfam00248 273 ALEFPLSDEEVARIDELL 290
AKR_AKR3F1-like cd19072
Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime ...
 30-179 1.34e-30

Thermotoga maritime Tm1743, Escherichia coli YeaE and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase. Escherichia coli YeaE may act as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381298 [Multi-domain]  Cd Length: 263  Bit Score: 113.09  E-value: 1.34e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  30 KETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP-AVLQVECHPYL--AQNELIAHCQARGLEVTAYSPLGSSD 106
Cdd:cd19072  117 EETLRAMEELVEEGKIRYIGVSNFSLEELEEAQSYLKKGPiVANQVEYNLFDreEESGLLPYCQKNGIAIIAYSPLEKGK 196

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767901878 107 RAwRDPDEPVLLEepvvlaLAEKYGRSPAQILLRWQVQRK-VICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19072  197 LS-NAKGSPLLDE------IAKKYGKTPAQIALNWLISKPnVIAIPKASNIEHLEENAGALGWELSEEDLQRLD 263
AKR_AKR3F2 cd19139
Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; ...
 31-181 4.07e-30

Escherichia coli 2,5-diketo-D-gluconic acid reductase B (DkgB/YafB) and similar proteins; Escherichia coli DkgB/YafB (EC 1.1.1.346), also called 2,5-didehydrogluconate reductase (2-dehydro-L-gulonate-forming), or 2,5-DKG reductase B, or 2,5-DKGR B, or 25DKGR-B, is a founding member of aldo-keto reductase family 3 member F2 (AKR3F2). It catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG).


Pssm-ID: 381365 [Multi-domain]  Cd Length: 248  Bit Score: 111.29  E-value: 4.07e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP-AVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGssdraw 109
Cdd:cd19139  107 EYIGALAEAKEQGLTRHIGVSNFTIALLDEAIAVVGAGAiATNQIELSPYLQNRKLVAHCKQHGIHVTSYMTLA------ 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767901878 110 rdpdEPVLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19139  181 ----YGKVLDDPVLAAIAERHGATPAQIALAWAMARGYAVIPSSTKREHLRSNLLALDLTLDADDMAAIAAL 248
AKR_YeaE cd19138
Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this ...
 26-179 1.24e-27

Escherichia coli YeaE and similar proteins; Escherichia coli YeaE is the prototype of this family. It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381364 [Multi-domain]  Cd Length: 266  Bit Score: 105.41  E-value: 1.24e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  26 STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP-AVLQVECHpyLAQ----NELIAHCQARGLEVTAYS 100
Cdd:cd19138  114 GVPLAETVAAMEELKKEGKIRAWGVSNFDTDDMEELWAVPGGGNcAANQVLYN--LGSrgieYDLLPWCREHGVPVMAYS 191

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 101 PLGSSDRAWRDpdepvLLEEPVVLALAEKYGRSPAQILLRWQV-QRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19138  192 PLAQGGLLRRG-----LLENPTLKEIAARHGATPAQVALAWVLrDGNVIAIPKSGSPEHARENAAAADLELTEEDLAELD 266
PdxI COG0667
Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme ...
 25-181 1.35e-27

Pyridoxal reductase PdxI or related oxidoreductase, aldo/keto reductase family [Coenzyme transport and metabolism, General function prediction only];


Pssm-ID: 440431 [Multi-domain]  Cd Length: 316  Bit Score: 106.42  E-value: 1.35e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  25 DSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS--VRPAVLQVEchpY-----LAQNELIAHCQARGLEVT 97
Cdd:COG0667  127 PDTPIEETLGALDELVREGKIRYIGVSNYSAEQLRRALAIAEglPPIVAVQNE---YslldrSAEEELLPAARELGVGVL 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  98 AYSPLGS---------------SDRAWRDPDEPVLLEE-----PVVLALAEKYGRSPAQILLRWQVQRKVICIPksI--- 154
Cdd:COG0667  204 AYSPLAGglltgkyrrgatfpeGDRAATNFVQGYLTERnlalvDALRAIAAEHGVTPAQLALAWLLAQPGVTSV--Ipga 281

                        170       180
                 ....*....|....*....|....*...
gi 767901878 155 -TPSRILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:COG0667  282 rSPEQLEENLAAADLELSAEDLAALDAA 309
AKR_AKR3F1 cd19137
Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding ...
 29-179 2.19e-24

Thermotoga maritime Tm1743 and similar proteins; Thermotoga maritime Tm1743 is a founding member of aldo-keto reductase family 3 member F1 (AKR3F1). It is a aldo/keto reductase family oxidoreductase.


Pssm-ID: 381363 [Multi-domain]  Cd Length: 260  Bit Score: 96.87  E-value: 2.19e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  29 YKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVECHPY---LAQNELIAHCQARGLEVTAYSPLgss 105
Cdd:cd19137  116 LEETLSAMAEGVRQGLIRYIGVSNFNRRLLEEAISKSQTPIVCNQVKYNLEdrdPERDGLLEYCQKNGITVVAYSPL--- 192

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901878 106 drawrdpDEPVLLEEPVVLALAEKYGRSPAQILLRWQVQR-KVICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19137  193 -------RRGLEKTNRTLEEIAKNYGKTIAQIALAWLIQKpNVVAIPKAGRVEHLKENLKATEIKLSEEEMKLLD 260
AKR_AtPLR-like cd19093
Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR ...
 1-179 6.01e-24

Arabidopsis thaliana pyridoxal reductase (PLR) and similar proteins; Arabidopsis thaliana PLR (EC 1.1.1.65) is the prototype of this family. It catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+), and is involved in the PLP salvage pathway.


Pssm-ID: 381319 [Multi-domain]  Cd Length: 293  Bit Score: 96.14  E-value: 6.01e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYAFERGDNPFpknadgticydsthyketWKALEALVAKGLVQALGLSNFNSRQI---DDILSVASVRPAVLQVE-- 75
Cdd:cd19093  110 LHWPGPWYSQIEAL------------------MDGLADAVEEGLVRAVGVSNYSADQLrraHKALKERGVPLASNQVEys 171

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  76 -CHPYLAQNELIAHCQARGLEVTAYSPLG--------SSDRAWRDPDEPVLLEE------PVVLAL---AEKYGRSPAQI 137
Cdd:cd19093  172 lLYRDPEQNGLLPACDELGITLIAYSPLAqglltgkySPENPPPGGRRRLFGRKnlekvqPLLDALeeiAEKYGKTPAQV 251

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 767901878 138 LLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19093  252 ALNWLIAKGVVPIPGAKNAEQAEENAGALGWRLSEEEVAELD 293
dkgB PRK11172
2,5-didehydrogluconate reductase DkgB;
36-190 9.21e-23

2,5-didehydrogluconate reductase DkgB;


Pssm-ID: 183012 [Multi-domain]  Cd Length: 267  Bit Score: 92.39  E-value: 9.21e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  36 LEALV---AKGLVQALGLSNFN---SRQIDDILSVASVrpAVLQVECHPYLAQNELIAHCQARGLEVTAYSPLGSSDraw 109
Cdd:PRK11172 111 MQALLeakKQGLTREIGISNFTialMKQAIAAVGAENI--ATNQIELSPYLQNRKVVAFAKEHGIHVTSYMTLAYGK--- 185

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 110 rdpdepvLLEEPVVLALAEKYGRSPAQILLRWQVQRKVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKNWRYIV 189
Cdd:PRK11172 186 -------VLKDPVIARIAAKHNATPAQVILAWAMQLGYSVIPSSTKRENLASNLLAQDLQLDAEDMAAIAALDRNGRLVS 258


                 .
gi 767901878 190 P 190
Cdd:PRK11172 259 P 259
AKR_AKR11B1-like cd19084
AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called ...
 31-179 1.84e-21

AKR11B1/AKR11B2 subfamily of aldo-keto reductase (AKR); Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor. Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381310 [Multi-domain]  Cd Length: 296  Bit Score: 89.51  E-value: 1.84e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVechPY--LAQN---ELIAHCQARGLEVTAYSPLG-- 103
Cdd:cd19084  125 ETAEALEKLKKEGKIRYIGVSNFSVEQLEEARKYGPI--VSLQP---PYsmLEREieeELLPYCRENGIGVLPYGPLAqg 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 104 -------------SSDRAWRDPD--EPVLLEEPVVLA----LAEKYGRSPAQILLRWQVQRK----VICIPKsiTPSRIL 160
Cdd:cd19084  200 lltgkykkeptfpPDDRRSRFPFfrGENFEKNLEIVDklkeIAEKYGKSLAQLAIAWTLAQPgvtsAIVGAK--NPEQLE 277

                        170
                 ....*....|....*....
gi 767901878 161 QNIKVFDFTFSPEEMKQLN 179
Cdd:cd19084  278 ENAGALDWELTEEELKEID 296
AKR_AKR8A1-2 cd19077
AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding ...
 31-179 9.75e-19

AKR8A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe PLR and PLR2 are founding members of aldo-keto reductase family 8 member A1-2 (AKR8A1-2), respectively. PLR (EC 1.1.1.65), also called PL reductase (PL-red), catalyzes the reduction of pyridoxal (PL) with NADPH and oxidation of pyridoxine (PN) with NADP(+).


Pssm-ID: 381303 [Multi-domain]  Cd Length: 302  Bit Score: 82.29  E-value: 9.75e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVECHPY---LAQNELIAHCQARGLEVTAYSPLGSS-- 105
Cdd:cd19077  129 ETIKALKELVKEGKIRGIGLSEVSAETIRRAHAVHPI--AAVEVEYSLFsreIEENGVLETCAELGIPIIAYSPLGRGll 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 106 DRAWRDPDE--------------PVLLEEPVVLA-----LAEKYGRSPAQILLRW---QVQRKVICIPKSITPSRILQNI 163
Cdd:cd19077  207 TGRIKSLADipegdfrrhldrfnGENFEKNLKLVdalqeLAEKKGCTPAQLALAWilaQSGPKIIPIPGSTTLERVEENL 286

                        170
                 ....*....|....*.
gi 767901878 164 KVFDFTFSPEEMKQLN 179
Cdd:cd19077  287 KAANVELTDEELKEIN 302
AKR_AKR11B3 cd19085
Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is ...
 2-184 5.50e-18

Synechococcus sp. aldo-keto reductase (SakR1) and similar proteins; Synechococcus sp. SakR1 is a founding member of aldo-keto reductase family 11 member B3(AKR11B3). It is responsible for methylglyoxal detoxification.


Pssm-ID: 381311 [Multi-domain]  Cd Length: 292  Bit Score: 79.94  E-value: 5.50e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPyafeRGDNPFpknadgticydsthyKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAsvRPAVLQVechPY-L 80
Cdd:cd19085  104 HWP----SSDVPL---------------EETMEALEKLKEEGKIRAIGVSNFGPAQLEEALDAG--RIDSNQL---PYnL 159

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 ----AQNELIAHCQARGLEVTAYSPL------GSSDRAWRDPDE------PVLLEEPV----------VLALAEKYGRSP 134
Cdd:cd19085  160 lwraIEYEILPFCREHGIGVLAYSPLaqglltGKFSSAEDFPPGdartrlFRHFEPGAeeetfealekLKEIADELGVTM 239

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767901878 135 AQILLRWQVQRKVI--CIPKSITPSRILQNIKVFDFTFSPEEMKQLNALNKN 184
Cdd:cd19085  240 AQLALAWVLQQPGVtsVIVGARNPEQLEENAAAVDLELSPSVLERLDEISDP 291
AKR_unchar cd19102
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 1-181 4.59e-17

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381328 [Multi-domain]  Cd Length: 302  Bit Score: 77.71  E-value: 4.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPYaferGDNPFpknadgticydsthyKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVechPYL 80
Cdd:cd19102  115 IHWPD----PDEPI---------------EEAWGALAELKEEGKVRAIGVSNFSVDQMKRCQAIHPI--ASLQP---PYS 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  81 A-----QNELIAHCQARGLEVTAYSPLGS--------SDRAWRDPD------EPVLLEE---------PVVLALAEKYGR 132
Cdd:cd19102  171 LlrrgiEAEILPFCAEHGIGVIVYSPMQSglltgkmtPERVASLPAddwrrrSPFFQEPnlarnlalvDALRPIAERHGR 250

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767901878 133 SPAQILLRWQVQRKVI--CIPKSITPSRILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19102  251 TVAQLAIAWVLRRPEVtsAIVGARRPDQIDETVGAADLRLTPEELAEIEAL 301
AKR_AKR9C1 cd19081
AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a ...
 25-179 5.35e-17

AKR9C family of aldo-keto reductase (AKR); Haloferax volcanii aldo-keto reductase is a founding member of aldo-keto reductase family 9 member C1 (AKR9C1).


Pssm-ID: 381307 [Multi-domain]  Cd Length: 308  Bit Score: 77.64  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  25 DSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVECHPY---LAQNELIAHCQARGLEVT 97
Cdd:cd19081  126 PATPLEETLGALNDLIRQGKVRYIGASNYSAWRLQEALELSRqhglPRYVSLQPEYNLVdreSFEGELLPLCREEGIGVI 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  98 AYSPLGS-------------SDRAWRDPDEPVLLEEP------VVLALAEKYGRSPAQILLRWQVQRKVICIPksI---- 154
Cdd:cd19081  206 PYSPLAGgfltgkyrseadlPGSTRRGEAAKRYLNERglrildALDEVAAEHGATPAQVALAWLLARPGVTAP--Iagar 283

                        170       180
                 ....*....|....*....|....*
gi 767901878 155 TPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19081  284 TVEQLEDLLAAAGLRLTDEEVARLD 308
AKR_EcYajO-like cd19079
Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this ...
 25-179 5.91e-17

Escherichia coli YajO and similar proteins; Escherichia coli YajO is the prototype of this family. It is an uncharacterized aldo/keto reductase family oxidoreductase.


Pssm-ID: 381305 [Multi-domain]  Cd Length: 312  Bit Score: 77.62  E-value: 5.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  25 DSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV----RPAVLQvechPYL------AQNELIAHCQARGL 94
Cdd:cd19079  130 YETPIEETLEALHDVVKSGKVRYIGASSMYAWQFAKALHLAEKngwtKFVSMQ----NHYnllyreEEREMIPLCEEEGI 205

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  95 EVTAYSPL----------GSSDRAWRDPDEPVLLE-------EPV---VLALAEKYGRSPAQILLRWQVQRKVICIPksI 154
Cdd:cd19079  206 GVIPWSPLargrlarpwgDTTERRRSTTDTAKLKYdyfteadKEIvdrVEEVAKERGVSMAQVALAWLLSKPGVTAP--I 283

                        170       180
                 ....*....|....*....|....*....
gi 767901878 155 ----TPSRILQNIKVFDFTFSPEEMKQLN 179
Cdd:cd19079  284 vgatKLEHLEDAVAALDIKLSEEEIKYLE 312
AKR_AKR9A_9B cd19080
AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus ...
 31-179 5.65e-16

AKR9A and AKR9B families of aldo-keto reductase (AKR); The AKR9A family includes Aspergillus nidulans sterigmatocystin biosynthesis dehydrogenase StcV, Aspergillus flavus norsolorinic acid reductase (NOR), and Phanerochaete chrysosporium aryl-alcohol dehydrogenase [NADP(+)] (AAD), are founding members of aldo-keto reductase family 9 member A1-3 (AKR9A1-3), respectively. StcV may be involved in the dehydration of 5'-hydroxyaverantin to form averufin. NOR is involved in aflatoxin biosynthesis. AAD (EC1.1.1.91) is involved in lignin degradation and reduces aromatic benzaldehydes to their respective alcohols in the presence of NADP(H). The AKR9B family includes Saccharomyces cerevisiae aryl-alcohol dehydrogenases AAD14p, AAD3p, AAD4p, and AAD10p, which are founding members of aldo-keto reductase family 9 member B1-4 (AKR9B1-4), respectively.


Pssm-ID: 381306 [Multi-domain]  Cd Length: 307  Bit Score: 74.56  E-value: 5.65e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR----PAVLQVECHpyLAQ----NELIAHCQARGLEVTAYSPL 102
Cdd:cd19080  131 EVMRALDDLVRAGKVLYVGISDTPAWVVARANTLAELRgwspFVALQIEYS--LLErtpeRELLPMARALGLGVTPWSPL 208

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 103 GS--------------SDRAWRDPDEPVLLEE------PVVLALAEKYGRSPAQILLRWQVQRKVICIPkSITPSRILQ- 161
Cdd:cd19080  209 GGglltgkyqrgeegrAGEAKGVTVGFGKLTErnwaivDVVAAVAEELGRSAAQVALAWVRQKPGVVIP-IIGARTLEQl 287

                        170       180
                 ....*....|....*....|
gi 767901878 162 --NIKVFDFTFSPEEMKQLN 179
Cdd:cd19080  288 kdNLGALDLTLSPEQLARLD 307
AKR_AKR13B1 cd19088
AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde ...
 35-171 2.91e-14

AKR13B family of aldo-keto reductase (AKR); Xylella fastidiosa phenylacetaldehyde dehydrogenase is a founding member of aldo-keto reductase family 13 member B1 (AKR13B1). phenylacetaldehyde dehydrogenase (EC 1.2.1.39) catalyzes the NAD+-dependent oxidation of phenylactealdehyde to phenylacetic acid.


Pssm-ID: 381314 [Multi-domain]  Cd Length: 256  Bit Score: 69.17  E-value: 2.91e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  35 ALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVECHPYLAQNE-LIAHCQARGLEVTAYSPLGSsdrawrdpd 113
Cdd:cd19088  128 ALAELQDEGLIRHIGLSNVTVAQIEEARAIVRI--VSVQNRYNLANRDDEgVLDYCEAAGIAFIPWFPLGG--------- 196

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 114 EPVLLEEPVVLALAEKYGRSPAQILLRWQVQRK--VICIPKSITPSRILQNIKVFDFTFS 171
Cdd:cd19088  197 GDLAQPGGLLAEVAARLGATPAQVALAWLLARSpvMLPIPGTSSVEHLEENLAAAGLRLS 256
AKR_SF cd06660
Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of ...
 31-164 8.86e-14

Aldo-keto reductase (AKR) superfamily; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications. Members have very distinct functions and include the prokaryotic 2,5-diketo-D-gluconic acid reductases and beta-keto ester reductases, the eukaryotic aldose reductases, aldehyde reductases, hydroxysteroid dehydrogenases, steroid 5beta-reductases, potassium channel beta-subunits, and aflatoxin aldehyde reductases, among others.


Pssm-ID: 381296 [Multi-domain]  Cd Length: 232  Bit Score: 67.54  E-value: 8.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVE---CHPYLAQNELIAHCQARGLEVTAYSPLG 103
Cdd:cd06660  118 ETLEALNELVREGKIRYIGVSNWSAERLAEALAYAKahglPGFAAVQPQyslLDRSPMEEELLDWAEENGLPLLAYSPLA 197

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767901878 104 ssdrawrdpdepvlleepvvlalaekygRSPAQILLRWQVQRK--VICIPKSITPSRILQNIK 164
Cdd:cd06660  198 ----------------------------RGPAQLALAWLLSQPfvTVPIVGARSPEQLEENLA 232
AKR_AKR12A1_B1_C1 cd19087
AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, ...
 26-181 4.45e-13

AKR12A, AKR12B, AKR12C families of aldo-keto reductase (AKR); Streptomyces fradiae TylCII, Saccharopolyspora erythraea EryBII, and Streptomyces avermitilis aveBVIII are founding members of aldo-keto reductase family 12 member A1 (AKR12A1), B1 (AKR12B1), and C1(AKR12C1), respectively. TylCII acts as a NDP-hexose 2,3-enoyl reductase. EryBII is a mycarose/desosamine reductase involved in L-mycarose and D-desosamine production. aveBVIII functions as a dTDP-4-keto-6-deoxy-L-hexose-2,3-reductase.


Pssm-ID: 381313 [Multi-domain]  Cd Length: 310  Bit Score: 66.44  E-value: 4.45e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  26 STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRP-AVLQVECHPY-----LAQNELIAHCQARGLEVTAY 99
Cdd:cd19087  124 DTPLEETLRALDDLVRQGKIRYIGVSNFAAWQIAKAQGIAARRGlLRFVSEQPMYnllkrQAELEILPAARAYGLGVIPY 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 100 SPLG--------------SSDRAWRDPDEPVLLEEPVVLALAEKY-------GRSPAQILLRWQVQRKVICIPkSITPSR 158
Cdd:cd19087  204 SPLAgglltgkygkgkrpESGRLVERARYQARYGLEEYRDIAERFealaaeaGLTPASLALAWVLSHPAVTSP-IIGPRT 282

                        170       180
                 ....*....|....*....|....*.
gi 767901878 159 ILQ---NIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19087  283 LEQledSLAALEITLTPELLAEIDEL 308
AKR_BsYcsN_EcYdhF-like cd19092
Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and ...
 31-174 8.88e-13

Bacillus subtilis YcsN, Escherichia coli YdhF and similar proteins; Bacillus subtilis YcsN and Escherichia coli YdhF are prototypes of this family. They are uncharacterized aldo/keto reductase family oxidoreductases.


Pssm-ID: 381318 [Multi-domain]  Cd Length: 287  Bit Score: 65.66  E-value: 8.88e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRPAVLQVEC---HPYLAQNELIAHCQARGLEVTAYSPLG---- 103
Cdd:cd19092  131 EVAEAFDELVKSGKVRYFGVSNFTPSQIELLQSYLDQPLVTNQIELsllHTEAIDDGTLDYCQLLDITPMAWSPLGggrl 210

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767901878 104 SSDRAWRDPDEPVLLEEpvvlaLAEKYGRSPAQILLRWqVQR---KVICIPKSITPSRILQNIKVFDFTFSPEE 174
Cdd:cd19092  211 FGGFDERFQRLRAALEE-----LAEEYGVTIEAIALAW-LLRhpaRIQPILGTTNPERIRSAVKALDIELTREE 278
AKR_PsAKR cd19091
Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an ...
 31-181 1.02e-12

Polaromonas Sp. aldo-keto reductase and similar proteins; The prototype of this family is an uncharacterized aldo-keto reductase from Polaromonas sp.


Pssm-ID: 381317 [Multi-domain]  Cd Length: 319  Bit Score: 65.71  E-value: 1.02e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQVecHPYLA----QNELIAHCQARGLEVTAYSPL 102
Cdd:cd19091  138 ETLRALDDLVRQGKVRYIGVSNFSAWQIMKALGISErrglARFVALQA--YYSLLgrdlEHELMPLALDQGVGLLVWSPL 215

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 103 G--------------SSDRAWRD--PDEPVLLEE---PVVLAL---AEKYGRSPAQILLRWQVQRKVIcipKSI-----T 155
Cdd:cd19091  216 AggllsgkyrrgqpaPEGSRLRRtgFDFPPVDRErgyDVVDALreiAKETGATPAQVALAWLLSRPTV---SSViigarN 292

                        170       180
                 ....*....|....*....|....*.
gi 767901878 156 PSRILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19091  293 EEQLEDNLGAAGLSLTPEEIARLDKV 318
AKR_unchar cd19101
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 24-180 1.10e-11

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381327 [Multi-domain]  Cd Length: 304  Bit Score: 62.61  E-value: 1.10e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  24 YDSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSvASVRPAVLQVEcHPYL---AQNELIAHCQARGLEVTAYS 100
Cdd:cd19101  116 YSDPGYLDAAKHLAELQEEGKIRHLGLTNFDTERLREILD-AGVPIVSNQVQ-YSLLdrrPENGMAALCEDHGIKLLAYG 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 101 PLGS---SDRaWRDPDEPV---------------------------LLEepVVLALAEKYGRSPAQILLRWQVQRKviCI 150
Cdd:cd19101  194 TLAGgllSEK-YLGVPEPTgpaletrslqkyklmidewggwdlfqeLLR--TLKAIADKHGVSIANVAVRWVLDQP--GV 268

                        170       180       190
                 ....*....|....*....|....*....|....
gi 767901878 151 PKSITPSR----ILQNIKVFDFTFSPEEMKQLNA 180
Cdd:cd19101  269 AGVIVGARnsehIDDNVRAFSFRLDDEDRAAIDA 302
AKR_AKR13A_13D cd19076
AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto ...
 31-178 1.79e-11

AKR13A and AKR13D families of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor. Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381302 [Multi-domain]  Cd Length: 303  Bit Score: 61.85  E-value: 1.79e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSrqiDDILSVASVRP-AVLQVECHPYL--AQNELIAHCQARGLEVTAYSPLGssdR 107
Cdd:cd19076  133 ETVGAMAELVEEGKVRYIGLSEASA---DTIRRAHAVHPiTAVQSEYSLWTrdIEDEVLPTCRELGIGFVAYSPLG---R 206

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 108 -----AWRDPDEP---------------------VLLEEpvVLALAEKYGRSPAQILLRWQVQRK--VICIPKSITPSRI 159
Cdd:cd19076  207 gfltgAIKSPEDLpeddfrrnnprfqgenfdknlKLVEK--LEAIAAEKGCTPAQLALAWVLAQGddIVPIPGTKRIKYL 284

                        170
                 ....*....|....*....
gi 767901878 160 LQNIKVFDFTFSPEEMKQL 178
Cdd:cd19076  285 EENVGALDVVLTPEELAEI 303
AKR_AKR11B2 cd19149
Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; ...
 2-178 7.67e-11

Escherichia coli NADH-specific methylglyoxal reductase (YdjG) and similar proteins; Escherichia coli YdjG is a founding member of aldo-keto reductase family 11 member B2 (AKR11B2). It catalyzes the NADH-dependent reduction of methylglyoxal (2-oxopropanal) in vitro. It may play some role in intestinal colonization.


Pssm-ID: 381375 [Multi-domain]  Cd Length: 315  Bit Score: 60.36  E-value: 7.67e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   2 HWPyafergDNPFPknadgticydsthYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVechPY-- 79
Cdd:cd19149  133 HWQ------DVETP-------------IEETMEALEELKRQGKIRAIGASNVSVEQIKEYVKAGQL--DIIQE---KYsm 188

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  80 ---LAQNELIAHCQARGLEVTAYSPLGS-------------------SDRAWRDPD--EPV--LLEEpvVLALAEKYGRS 133
Cdd:cd19149  189 ldrGIEKELLPYCKKNNIAFQAYSPLEQglltgkitpdrefdagdarSGIPWFSPEnrEKVlaLLEK--WKPLCEKYGCT 266

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 767901878 134 PAQILLRWQVQR----KVICipKSITPSRILQNIKVFDFTFSPEEMKQL 178
Cdd:cd19149  267 LAQLVIAWTLAQpgitSALC--GARKPEQAEENAKAGDIRLSAEDIATM 313
AKR_AKR13C1_2 cd19078
AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli ...
 34-179 1.57e-09

AKR13C family of aldo-keto reductase (AKR); The AKR13C family includes Helicobacter pyroli aldehyde reductase (AKR13C1) and Thermotoga maritima aldo-keto reductase (AKR13C2). Aldehyde reductase (EC 1.1.1.21), also called aldose reductase, is a cytosolic NADPH-dependent oxidoreductase that catalyzes the reduction of a variety of aldehydes and carbonyls, including monosaccharides.


Pssm-ID: 381304 [Multi-domain]  Cd Length: 301  Bit Score: 56.47  E-value: 1.57e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  34 KALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVECH-----PylaQNELIAHCQARGLEVTAYSPLG----- 103
Cdd:cd19078  130 GTMKELIKEGKIRHWGLSEAGVETIRRAHAVCPV--TAVQSEYSmmwreP---EKEVLPTLEELGIGFVPFSPLGkgflt 204

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 104 -----------SSDRAW--RDPDEPV-----LLEepVVLALAEKYGRSPAQILLRWQVQRK--VICIPKSITPSRILQNI 163
Cdd:cd19078  205 gkidentkfdeGDDRASlpRFTPEALeanqaLVD--LLKEFAEEKGATPAQIALAWLLAKKpwIVPIPGTTKLSRLEENI 282

                        170
                 ....*....|....*.
gi 767901878 164 KVFDFTFSPEEMKQLN 179
Cdd:cd19078  283 GAADIELTPEELREIE 298
AKR_AKR13A1 cd19144
AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC ...
 26-178 2.56e-09

AKR13A family of aldo-keto reductase (AKR); Schizosaccharomyces pombe aldo-keto reductase YakC is a founding member of aldo-keto reductase family 13 member A1 (AKR13A1). It catalyzes the reversible reduction of ketones to the respective alcohols using NADP(+) as a hydride donor.


Pssm-ID: 381370 [Multi-domain]  Cd Length: 323  Bit Score: 55.91  E-value: 2.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  26 STHYKETWKALEALVAKGLVQALGLSNFNSrqiDDILSVASVRP-AVLQVECHPYL-----AQNELIAHCQARGLEVTAY 99
Cdd:cd19144  131 KTPIEKTVAAMAELVQEGKIKHIGLSECSA---ETLRRAHAVHPiAAVQIEYSPFSldierPEIGVLDTCRELGVAIVAY 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 100 SPLGSS--DRAWRDPDE----------PVLLEE--PVVL-------ALAEKYGRSPAQILLRWQVQRK--VICIPKSITP 156
Cdd:cd19144  208 SPLGRGflTGAIRSPDDfeegdfrrmaPRFQAEnfPKNLelvdkikAIAKKKNVTAGQLTLAWLLAQGddIIPIPGTTKL 287

                        170       180
                 ....*....|....*....|..
gi 767901878 157 SRILQNIKVFDFTFSPEEMKQL 178
Cdd:cd19144  288 KRLEENLGALKVKLTEEEEKEI 309
AKR_unchar cd19752
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 31-164 5.51e-09

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381391 [Multi-domain]  Cd Length: 291  Bit Score: 54.65  E-value: 5.51e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVR----PAVLQVEcHPYL-------------AQNELIAHCQARG 93
Cdd:cd19752  129 ETLEAFNELVKAGKVRAIGASNFAAWRLERARQIARQQgwaeFSAIQQR-HSYLrprpgadfgvqriVTDELLDYASSRP 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  94 -LEVTAYSPL--GSSDRAWR-------DPDEPVLLEepVVLALAEKYGRSPAQILLRWQVQRKVICIP--KSITPSRILQ 161
Cdd:cd19752  208 dLTLLAYSPLlsGAYTRPDRplpeqydGPDSDARLA--VLEEVAGELGATPNQVVLAWLLHRTPAIIPllGASTVEQLEE 285


                 ...
gi 767901878 162 NIK 164
Cdd:cd19752  286 NLA 288
AKR_Tas-like cd19094
Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the ...
 1-181 4.71e-08

Escherichia coli Tas protein and similar proteins; Escherichia coli Tas protein is the prototype of this family. It is an NADP(H)-dependent aldo-keto reductase that catalyzes the reversible reduction of ketones to the respective alcohols using NADP(H) as a hydride donor.


Pssm-ID: 381320 [Multi-domain]  Cd Length: 328  Bit Score: 52.18  E-value: 4.71e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878   1 MHWPyafERGDNPFPKNADGTICY--DSTHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASV----RPAVLQv 74
Cdd:cd19094  119 LHWP---DRYTPLFGGGYYTEPSEeeDSVSFEEQLEALGELVKAGKIRHIGLSNETPWGVMKFLELAEQlglpRIVSIQ- 194

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  75 ecHPY--LAQNELIAH---CQARGLEVTAYSPLGS-------SDRAWRDPD-------------EPVLLEEPV--VLALA 127
Cdd:cd19094  195 --NPYslLNRNFEEGLaeaCHRENVGLLAYSPLAGgvltgkyLDGAARPEGgrlnlfpgymaryRSPQALEAVaeYVKLA 272

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767901878 128 EKYGRSPAQILLRWQVQRKVIC--IpksITPSRILQ---NIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19094  273 RKHGLSPAQLALAWVRSRPFVTstI---IGATTLEQlkeNIDAFDVPLSDELLAEIDAV 328
AKR_AKR13D1 cd19145
AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of ...
 31-178 5.05e-08

AKR13D family of aldo-keto reductase (AKR); Rauvolfia serpentina PR is a founding member of aldo-keto reductase family 13 member D1 (AKR13D1). It catalyzes the NADPH-dependent reduction of the aldehyde perakine to yield the alcohol raucaffrinoline in the biosynthetic pathway of ajmaline in Rauvolfia, a key step in indole alkaloid biosynthesis. This family also includes Arabidopsis thaliana aldo-keto reductases, ALKR1-6.


Pssm-ID: 381371 [Multi-domain]  Cd Length: 304  Bit Score: 52.05  E-value: 5.05e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSrqiDDILSVASVRP-AVLQVECHPYL--AQNELIAHCQARGLEVTAYSPLG---- 103
Cdd:cd19145  134 ITMGELKKLVEEGKIKYIGLSEASA---DTIRRAHAVHPiTAVQLEWSLWTrdIEEEIIPTCRELGIGIVPYSPLGrgff 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 104 -SSDRAWRDPDE-------PVLLEEPV---------VLALAEKYGRSPAQILLRWQVQR--KVICIPKSITPSRILQNIK 164
Cdd:cd19145  211 aGKAKLEELLENsdvrkshPRFQGENLeknkvlyerVEALAKKKGCTPAQLALAWVLHQgeDVVPIPGTTKIKNLNQNIG 290

                        170
                 ....*....|....
gi 767901878 165 VFDFTFSPEEMKQL 178
Cdd:cd19145  291 ALSVKLTKEDLKEI 304
AKR_AKR14A1_2 cd19089
AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate ...
 23-176 1.07e-07

AKR14A family of aldo-keto reductase (AKR); Escherichia coli L-glyceraldehyde 3-phosphate reductase (GPR/YghZ), also called GAP reductase, is a founding member of aldo-keto reductase family 14 member A1 (AKR14A1). It catalyzes the stereospecific, NADPH-dependent reduction of L-glyceraldehyde 3-phosphate (L-GAP). It is also involved in the stress response as a methylglyoxal reductase which converts the toxic metabolite methylglyoxal to acetol in vitro and in vivo. Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2). It catalyzes the conversion of 3-hydroxybutanal (3-HB) to 1,3-butanediol (1,3-BDO) by using NADPH as a cofactor.


Pssm-ID: 381315 [Multi-domain]  Cd Length: 308  Bit Score: 51.10  E-value: 1.07e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  23 CYD-STHYKETWKALEALVAKGLVQALGLSNFNS---RQIDDILSVASVRPAVLQVechPY-----LAQNELIAHCQARG 93
Cdd:cd19089  125 RYDpDTPLEETMTALADAVRSGKALYVGISNYPGakaRRAIALLRELGVPLIIHQP---RYslldrWAEDGLLEVLEEAG 201

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  94 LEVTAYSPLGS---SDRAWRDPDE------------PVLLEEPVVLAL------AEKYGRSPAQILLRWQVQRKVIC--- 149
Cdd:cd19089  202 IGFIAFSPLAQgllTDKYLNGIPPdsrraaeskfltEEALTPEKLEQLrklnkiAAKRGQSLAQLALSWVLRDPRVTsvl 281

                        170       180
                 ....*....|....*....|....*...
gi 767901878 150 IPKSiTPSRILQNIKVFDFT-FSPEEMK 176
Cdd:cd19089  282 IGAS-SPSQLEDNVAALKNLdFSEEELA 308
AKR_AKR11A1_11D1 cd19083
AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto ...
 31-181 1.77e-06

AKR11A and AKR11D families of aldo-keto reductase (AKR); Bacillus subtilis aldo-keto reductase IolS, also called vegetative protein 147 (VEG147), is a founding member of aldo-keto reductase family 11 member A1 (AKR11A1). It is able to reduce the standard aldo-keto reductase (AKR) substrates DL-glyceraldehyde, D-erythrose, and methylglyoxal in the presence of NADPH, albeit with poor efficiency in vitro. Bacillus aryabhattai aldo keto reductase is a founding member of aldo-keto reductase family 11 member D1 (AKR11D1).


Pssm-ID: 381309 [Multi-domain]  Cd Length: 307  Bit Score: 47.41  E-value: 1.77e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQI-----DDILSVASVRPAVLQVEchpylAQNELIAHCQARGLEVTAYSPLGS- 104
Cdd:cd19083  133 EAVGALQELKDEGKIRAIGVSNFSLEQLkeankDGYVDVLQGEYNLLQRE-----AEEDILPYCVENNISFIPYFPLASg 207

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 105 ------------SDRAWRDpDEPVLLEEPV---------VLALAEKYGRSPAQILLRWQVQRKVI--CIPKSITPSRILQ 161
Cdd:cd19083  208 llagkytkdtkfPDNDLRN-DKPLFKGERFsenldkvdkLKSIADEKGVTVAHLALAWYLTRPAIdvVIPGAKRAEQVID 286

                        170       180
                 ....*....|....*....|
gi 767901878 162 NIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19083  287 NLKALDVTLTEEEIAFIDAL 306
AKR_unchar cd19103
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 31-181 6.42e-06

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381329 [Multi-domain]  Cd Length: 299  Bit Score: 45.79  E-value: 6.42e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETW-KALEALVAKGLVQALGLSNFNSRQI---DDILSVASVRpaVLQVECHPYL-----AQNELIAHCQARGLEVTAYSP 101
Cdd:cd19103  122 ERWtPELIPLLKSGKVKHVGVSNHNLAEIkraNEILAKAGVS--LSAVQNHYSLlyrssEEAGILDYCKENGITFFAYMV 199

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878 102 L------GSSDRAWRDPDE--------PVL--LEE--PVVLALAEKYGRSPAQILLRWqvqrkviCIPKSITP------- 156
Cdd:cd19103  200 LeqgalsGKYDTKHPLPEGsgraetynPLLpqLEEltAVMAEIGAKHGASIAQVAIAW-------AIAKGTTPiigvtkp 272

                        170       180
                 ....*....|....*....|....*
gi 767901878 157 SRILQNIKVFDFTFSPEEMKQLNAL 181
Cdd:cd19103  273 HHVEDAARAASITLTDDEIKELEQL 297
PRK10376 PRK10376
putative oxidoreductase; Provisional
 34-182 7.65e-06

putative oxidoreductase; Provisional


Pssm-ID: 236676 [Multi-domain]  Cd Length: 290  Bit Score: 45.35  E-value: 7.65e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  34 KALEALVA---KGLVQALGLSNFNSRQIDDILSVASvrpaVLQVECHPYLAQ---NELIAHCQARGLEVTAYSPLGSSdr 107
Cdd:PRK10376 145 EPLTVLAElqrQGLVRHIGLSNVTPTQVAEARKIAE----IVCVQNHYNLAHradDALIDALARDGIAYVPFFPLGGF-- 218

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767901878 108 awrDPdepvlLEEPVVLALAEKYGRSPAQILLRWQVQR--KVICIPKSITPSRILQNIKVFDFTFSPEEMKQLNALN 182
Cdd:PRK10376 219 ---TP-----LQSSTLSDVAASLGATPMQVALAWLLQRspNILLIPGTSSVAHLRENLAAAELVLSEEVLAELDGIA 287
AKR_AKR7A1-5 cd19075
AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1 ...
 26-141 7.55e-05

AKR7A family of aldo-keto reductase (AKR); Aflatoxin B1 aldehyde reductase member 1/3 (AKR7A1/AKR7A3/AFAR) from Rattus norvegicus, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR1/AFAR) and aflatoxin B1 aldehyde reductase member 3 (AKR7A3/AFAR2) from Homo sapiens, aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AFAR2) from Rattus norvegicus, and aflatoxin B1 aldehyde reductase member 2 (AKR7A2/AKR7A5/AFAR) from Mus musculus, are founding members of aldo-keto reductase family 7 member A1-5 (AKR7A1-5), respectively. AKR7A2 (EC 1.1.1.n11), also called AFB1 aldehyde reductase 1, or AFB1-AR 1, or aldoketoreductase 7, or succinic semialdehyde reductase, or SSA reductase, catalyzes the NADPH-dependent reduction of succinic semialdehyde to gamma-hydroxybutyrate (GHB). It has NADPH-dependent aldehyde reductase activity towards 2-carboxybenzaldehyde, 2-nitrobenzaldehyde and pyridine-2-aldehyde (in vitro). AKR7A2, AKR7A3 (also called AFB1 aldehyde reductase 2 or AFB1-AR 2), and AKR7A4 (also called AFB1 aldehyde reductase 3, or AFB1-AR 3, or aldoketoreductase 7-like), may be involved in protection of liver against the toxic and carcinogenic effects of aflatoxin B1 (AFB1), a potent hepatocarcinogen. They can reduce the dialdehyde protein-binding form of AFB1 to the non-binding AFB1 dialcohol.


Pssm-ID: 381301 [Multi-domain]  Cd Length: 304  Bit Score: 42.54  E-value: 7.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  26 STHYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSVAS----VRPAVLQ---------VEchpylaqNELIAHCQAR 92
Cdd:cd19075  108 STPLEETLAAIDELYKEGKFKEFGLSNYSAWEVAEIVEICKengwVLPTVYQgmynaitrqVE-------TELFPCLRKL 180

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 767901878  93 GLEVTAYSPLG--------------------SSDRAWRDP-----DEPVLLEE-PVVLALAEKYGRSPAQILLRW 141
Cdd:cd19075  181 GIRFYAYSPLAggfltgkykysedkagggrfDPNNALGKLyrdryWKPSYFEAlEKVEEAAEKEGISLAEAALRW 255
AKR_AKR11B1 cd19148
Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also ...
 31-102 8.08e-05

Bacillus subtilis aldo-keto reductase YhdN and similar proteins; Bacillus subtilis YhdN, also called general stress protein 69 (GSP69), is a founding member of aldo-keto reductase family 11 member B1 (AKR11B1). It acts as an aldo-keto reductase (AKR) that catalyzes the reversible reduction of ketones to the respective alcohols using NAD(P)H as a hydride donor.


Pssm-ID: 381374 [Multi-domain]  Cd Length: 302  Bit Score: 42.29  E-value: 8.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVrpAVLQVechPY-----LAQNELIAHCQARGLEVTAYSPL 102
Cdd:cd19148  127 ETAEALKELLDEGKIRAIGVSNFSPEQMETFRKVAPL--HTVQP---PYnlferEIEKDVLPYARKHNIVTLAYGAL 198
AKR_Fe-S_oxidoreductase cd19096
Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S ...
 33-167 9.04e-04

Fe-S oxidoreductase and similar proteins; The family includes a group of uncharacterized Fe-S oxidoreductase that belongs to aldo-keto reductase (AKR) superfamily. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381322 [Multi-domain]  Cd Length: 255  Bit Score: 39.08  E-value: 9.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  33 WKALEALVAKGLVQALGLSnF--NSRQIDDILSVASVRPAVLQvecHPYLAQN-----ELIAHCQARGLEVTAYSPLGSS 105
Cdd:cd19096  121 LEFLEKAKKEGLIRHIGFS-FhdSPELLKEILDSYDFDFVQLQ---YNYLDQEnqagrPGIEYAAKKGMGVIIMEPLKGG 196

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767901878 106 DRAWRdpdepvlleEPVVLALAEKYGRSPAQILLRWQV-QRKVICIpkSI---TPSRILQNIKVFD 167
Cdd:cd19096  197 GLANN---------PPEALAILCGAPLSPAEWALRFLLsHPEVTTV--LSgmsTPEQLDENIAAAD 251
AKR_FDH cd19162
D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S, ...
 31-113 2.51e-03

D-threo-aldose 1-dehydrogenase (FDH) and similar proteins; FDH (EC1.1.1.122), also called (2S,3R)-aldose dehydrogenase, or L-fucose dehydrogenase, catalyzes the oxidation of L-fucose to L-fuconolactone in the presence of NADP(+). It is also active against L-galactose, and to a much lesser degree, D-arabinose.


Pssm-ID: 381388 [Multi-domain]  Cd Length: 290  Bit Score: 38.11  E-value: 2.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  31 ETWKALEALVAKGLVQALGLSNFNSRQIDDILSVASVRpAVLQVECHPYL---AQNELIAHCQARGLEVTAYSPLGSSDR 107
Cdd:cd19162  129 DAFPALEELRAEGVVGAIGVGVTDWAALLRAARRADVD-VVMVAGRYTLLdrrAATELLPLCAAKGVAVVAAGVFNSGIL 207


                 ....*.
gi 767901878 108 AWRDPD 113
Cdd:cd19162  208 ATDDPA 213
AKR_unchar cd19097
uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of ...
 28-140 9.58e-03

uncharacterized aldo-keto reductase (AKR) superfamily protein; This family includes a group of uncharacterized AKR superfamily proteins. Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance in both health and industrial applications.


Pssm-ID: 381323 [Multi-domain]  Cd Length: 267  Bit Score: 35.97  E-value: 9.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767901878  28 HYKETWKALEALVAKGLVQALGLSNFNSRQIDDILSvaSVRPAVLQVechPY------LAQNELIAHCQARGLEVTAYSP 101
Cdd:cd19097  116 HGGKLVEALLELKKEGLIRKIGVSVYSPEELEKALE--SFKIDIIQL---PFnildqrFLKSGLLAKLKKKGIEIHARSV 190

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767901878 102 L--GssdrawrdpdepVLLEEPVVL---------------ALAEKYGRSPAQILLR 140
Cdd:cd19097  191 FlqG------------LLLMEPDKLpakfapakpllkklhELAKKLGLSPLELALG 234
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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