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Conserved domains on  [gi|767963898|ref|XP_011538511|]
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leucine-rich repeat-containing protein 27 isoform X2 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 3.02e-18

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 767963898 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
PTZ00121 super family cl31754
MAEBL; Provisional
 225-472 2.83e-04

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  225 MKEKASflppvEKPDLSELRKSADS---SENWPSE-EEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEEakkAEEAKKKaEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRfHGQAP 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEA-EEKKK 1648

                         250
                  ....*....|...
gi 767963898  460 LEEMRKAAEDLEI 472
Cdd:PTZ00121 1649 AEELKKAEEENKI 1661
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 3.02e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 767963898 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR_8 pfam13855
Leucine rich repeat;
67-126 5.35e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.35e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767963898   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 6.81e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 767963898 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
PTZ00121 PTZ00121
MAEBL; Provisional
 225-472 2.83e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  225 MKEKASflppvEKPDLSELRKSADS---SENWPSE-EEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEEakkAEEAKKKaEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRfHGQAP 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEA-EEKKK 1648

                         250
                  ....*....|...
gi 767963898  460 LEEMRKAAEDLEI 472
Cdd:PTZ00121 1649 AEELKKAEEENKI 1661
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 330-469 4.23e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.19  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  330 IRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKipsatDLIDNRKVPL 409
Cdd:pfam17380 435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEK-----ELEERKQAMI 509

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  410 NPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHgqaplEEMRKAAED 469
Cdd:pfam17380 510 EEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQ-----EQMRKATEE 564
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 7.88e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
LRR smart00370
Leucine-rich repeats, outliers;
90-113 1.93e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.93e-03
                           10        20
                   ....*....|....*....|....
gi 767963898    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-155 3.02e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.91  E-value: 3.02e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  49 ILDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIK 127
Cdd:COG4886  140 ELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLPEELGNL-TNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLT 218

                         90       100
                 ....*....|....*....|....*...
gi 767963898 128 MLPVELGSVTTLKALNLRHCPLEFPPQL 155
Cdd:COG4886  219 DLPEPLANLTNLETLDLSNNQLTDLPEL 246
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
52-155 6.43e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.06  E-value: 6.43e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  52 LSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKMLPV 131
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLPEELANL-TNLKELDLSNNQLTDLPEPLGNLTNLKSLDLSNNQLTDLPE 176

                         90       100
                 ....*....|....*....|....*
gi 767963898 132 ELGSVTTLKALNLRHCPL-EFPPQL 155
Cdd:COG4886  177 ELGNLTNLKELDLSNNQItDLPEPL 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 4.71e-14

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 74.20  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLCRLEEVF-RIPSLQQLHLQRNALCVIPQDFFQLlPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  187 LDLSNNQITDLPEPLgNLTNLEELDLSGNQLTDLPEPLANL-TNLETLDLSNNQLTDLPE-LGNLTNLEELDLSNNQLTD 264

                         90       100
                 ....*....|....*....|..
gi 767963898 129 LPvELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  265 LP-PLANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-150 4.46e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 4.46e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNalcvipqDFFQLLPNLTWLDLRYNRIKALPSGIGAHQHLKTLLLERNPIKML 129
Cdd:COG4886   79 LLLLSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDL 151

                         90       100
                 ....*....|....*....|.
gi 767963898 130 PVELGSVTTLKALNLRHCPLE 150
Cdd:COG4886  152 PEPLGNLTNLKSLDLSNNQLT 172
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
50-132 1.26e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 60.33  E-value: 1.26e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLCRL-EEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPSgIGAHQHLKTLLLERNPIKM 128
Cdd:COG4886  210 LDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTDLPP-LANLTNLKTLDLSNNQLTD 286


                 ....
gi 767963898 129 LPVE 132
Cdd:COG4886  287 LKLK 290
LRR_8 pfam13855
Leucine rich repeat;
67-126 5.35e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 5.35e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767963898   67 PSLQQLHLQRNALCVIPQDFFQLLPNLTWLDLRYNRIKALPSGIGAH-QHLKTLLLERNPI 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGlPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 50-146 6.81e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 45.61  E-value: 6.81e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLC-RLE-EVFRIPSLQQLHLQRNAlcvipqdFFQLLP------NLTWLDLRYNRIK-ALPSGIGAHQHLKTLL 120
Cdd:PLN00113 433 LDISNNNLQgRINsRKWDMPSLQMLSLARNK-------FFGGLPdsfgskRLENLDLSRNQFSgAVPRKLGSLSELMQLK 505

                         90       100
                 ....*....|....*....|....*..
gi 767963898 121 LERNPIK-MLPVELGSVTTLKALNLRH 146
Cdd:PLN00113 506 LSENKLSgEIPDELSSCKKLVSLDLSH 532
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
49-106 7.68e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.31  E-value: 7.68e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767963898  49 ILDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQDFFqlLPNLTWLDLRYNRIKAL 106
Cdd:COG4886  232 TLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLAN--LTNLKTLDLSNNQLTDL 287
PTZ00121 PTZ00121
MAEBL; Provisional
 225-472 2.83e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  225 MKEKASflppvEKPDLSELRKSADS---SENWPSE-EEIRRFWKLRQEIVEHVKADvlgdQLLTRELPPNLKAALNIEKE 300
Cdd:PTZ00121 1436 AKKKAE-----EAKKADEAKKKAEEakkAEEAKKKaEEAKKADEAKKKAEEAKKAD----EAKKKAEEAKKKADEAKKAA 1506

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  301 LPKPRHVFRRKTASSRSilpdllspyqmAIRAKRLEESRAA-ALRELQEKQALMEQQRREKraLQEWRERAQRMRKRKEE 379
Cdd:PTZ00121 1507 EAKKKADEAKKAEEAKK-----------ADEAKKAEEAKKAdEAKKAEEKKKADELKKAEE--LKKAEEKKKAEEAKKAE 1573

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  380 LSKLLPPRRSMVASKIPSATdlIDNRKVPLNPPGKMKpsKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRfHGQAP 459
Cdd:PTZ00121 1574 EDKNMALRKAEEAKKAEEAR--IEEVMKLYEEEKKMK--AEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEA-EEKKK 1648

                         250
                  ....*....|...
gi 767963898  460 LEEMRKAAEDLEI 472
Cdd:PTZ00121 1649 AEELKKAEEENKI 1661
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 330-469 4.23e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 43.19  E-value: 4.23e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  330 IRAKRLEESRAAALRELQEKQALMEQQRREKRALQEWRERAQRMRKRKEELSKLLPPRRSMVASKipsatDLIDNRKVPL 409
Cdd:pfam17380 435 REVRRLEEERAREMERVRLEEQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEK-----ELEERKQAMI 509

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  410 NPPGKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHgqaplEEMRKAAED 469
Cdd:pfam17380 510 EEERKRKLLEKEMEERQKAIYEEERRREAEEERRKQQEMEERRRIQ-----EQMRKATEE 564
PTZ00121 PTZ00121
MAEBL; Provisional
 332-468 5.89e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.82  E-value: 5.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  332 AKRLEESRAAALRELQEKQALMEQQRR--EKRALQEWRE-----RAQRMRKrKEELSKLLPPRRSMVASKIPSATDLIDN 404
Cdd:PTZ00121 1145 ARKAEDAKRVEIARKAEDARKAEEARKaeDAKKAEAARKaeevrKAEELRK-AEDARKAEAARKAEEERKAEEARKAEDA 1223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767963898  405 RKVPlnppgKMKPSKEKSPQASKEMSALQERNLEEKIKQHVLQMREQRRFHGQAPLEEMRKAAE 468
Cdd:PTZ00121 1224 KKAE-----AVKKAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKAEEARKADE 1282
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 50-129 7.88e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 7.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLCRLEEVFRIPSLQQLHLQRNALCVIPQdfFQLLPNLTWLDLRYNRIKALPsGIGAHQHLKTLLLERNPIKML 129
Cdd:cd21340    7 LYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIE-NLENLVNLKKLYLGGNRISVV 83
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 57-123 8.87e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.92  E-value: 8.87e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767963898  57 LCRLEEVFRIPSLQQLHLQRNALCVIpqDFFQLLPNLTWLDLRYNRIKALpSGIGAHQHLKTLLLER 123
Cdd:cd21340   36 ITKIENLEFLTNLTHLYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVV-EGLENLTNLEELHIEN 99
LRR smart00370
Leucine-rich repeats, outliers;
90-113 1.93e-03

Leucine-rich repeats, outliers;


Pssm-ID: 197688 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.93e-03
                           10        20
                   ....*....|....*....|....
gi 767963898    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00370   1 LPNLRELDLSNNQLSSLPPGAFQG 24
LRR_TYP smart00369
Leucine-rich repeats, typical (most populated) subfamily;
90-113 1.93e-03

Leucine-rich repeats, typical (most populated) subfamily;


Pssm-ID: 197687 [Multi-domain]  Cd Length: 24  Bit Score: 35.79  E-value: 1.93e-03
                           10        20
                   ....*....|....*....|....
gi 767963898    90 LPNLTWLDLRYNRIKALPSGIGAH 113
Cdd:smart00369   1 LPNLRELDLSNNQLSSLPPGAFQG 24
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 63-144 2.09e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.99  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  63 VFRIPSLQQLHLQRNALC-VIPQDFFQLLPNLTWLDLRYNRIK-ALPSgiGAHQHLKTLLLERNPIK-MLPVELGSVTTL 139
Cdd:PLN00113  89 IFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTgSIPR--GSIPNLETLDLSNNMLSgEIPNDIGSFSSL 166


                 ....*
gi 767963898 140 KALNL 144
Cdd:PLN00113 167 KVLDL 171
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 50-150 6.03e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 38.88  E-value: 6.03e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767963898  50 LDLSESGLC-----RLEEVFRIPSLQQLHLQRNALCVIPQDFFQ-----LLPNLTWLDLRYNRI-----KALPSGIGAHQ 114
Cdd:cd00116   86 LDLSDNALGpdgcgVLESLLRSSSLQELKLNNNGLGDRGLRLLAkglkdLPPALEKLVLGRNRLegascEALAKALRANR 165

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 767963898 115 HLKTLLLERNP-----IKMLPVELGSVTTLKALNLRHCPLE 150
Cdd:cd00116  166 DLKELNLANNGigdagIRALAEGLKANCNLEVLDLNNNGLT 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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