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Conserved domains on  [gi|767932652|ref|XP_011530555|]
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microtubule-associated protein 9 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK12704 super family cl36166
phosphodiesterase; Provisional
507-592 3.81e-06

phosphodiesterase; Provisional


The actual alignment was detected with superfamily member PRK12704:

Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652 507 ARKGEA-LQAFEKWKEKKMEYLKEKNRKEREYERAKK---QKEE-----ETVAEKKKDNLTAVEKWNEKKEAFFKQKEKE 577
Cdd:PRK12704  53 AIKKEAlLEAKEEIHKLRNEFEKELRERRNELQKLEKrllQKEEnldrkLELLEKREEELEKKEKELEQKQQELEKKEEE 132
                         90
                 ....*....|....*
gi 767932652 578 kINEKRKEELKRAEK 592
Cdd:PRK12704 133 -LEELIEEQLQELER 146
PTZ00121 super family cl31754
MAEBL; Provisional
281-621 3.88e-05

MAEBL; Provisional


The actual alignment was detected with superfamily member PTZ00121:

Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  281 KSDENKENSFSADHVTTAVEKSKEsqvtADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKN 360
Cdd:PTZ00121 1445 KADEAKKKAEEAKKAEEAKKKAEE----AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  361 KKSTNNRASSASARlmTSEFLKKSSSKRRTPSTTTSSHYLGTLKVldQKPSQKQSIEPDRADNIRAAVYQEWLEKKNV-- 438
Cdd:PTZ00121 1521 AKKADEAKKAEEAK--KADEAKKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKAEEARIee 1596
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  439 YLHEMHRIKRIESENLRIQNEQKKAA----------KREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAaR 508
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeelkkaeeekKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK-K 1675
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  509 KGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEET-----VAEKKKDNLTAVEKWNEK--------KEAFFKQKE 575
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeeLKKAEEENKIKAEEAKKEaeedkkkaEEAKKDEEE 1755
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767932652  576 KEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQK 621
Cdd:PTZ00121 1756 KKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
507-592 3.81e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652 507 ARKGEA-LQAFEKWKEKKMEYLKEKNRKEREYERAKK---QKEE-----ETVAEKKKDNLTAVEKWNEKKEAFFKQKEKE 577
Cdd:PRK12704  53 AIKKEAlLEAKEEIHKLRNEFEKELRERRNELQKLEKrllQKEEnldrkLELLEKREEELEKKEKELEQKQQELEKKEEE 132
                         90
                 ....*....|....*
gi 767932652 578 kINEKRKEELKRAEK 592
Cdd:PRK12704 133 -LEELIEEQLQELER 146
PTZ00121 PTZ00121
MAEBL; Provisional
281-621 3.88e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  281 KSDENKENSFSADHVTTAVEKSKEsqvtADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKN 360
Cdd:PTZ00121 1445 KADEAKKKAEEAKKAEEAKKKAEE----AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  361 KKSTNNRASSASARlmTSEFLKKSSSKRRTPSTTTSSHYLGTLKVldQKPSQKQSIEPDRADNIRAAVYQEWLEKKNV-- 438
Cdd:PTZ00121 1521 AKKADEAKKAEEAK--KADEAKKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKAEEARIee 1596
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  439 YLHEMHRIKRIESENLRIQNEQKKAA----------KREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAaR 508
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeelkkaeeekKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK-K 1675
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  509 KGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEET-----VAEKKKDNLTAVEKWNEK--------KEAFFKQKE 575
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeeLKKAEEENKIKAEEAKKEaeedkkkaEEAKKDEEE 1755
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767932652  576 KEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQK 621
Cdd:PTZ00121 1756 KKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
511-624 6.76e-05

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 44.70  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  511 EALQAFEKWKEKKMEYLKEKNRKEREyERAKKQKEEetvAEKKKDNLTAVEKWNEKKEAFFKQKEKEKIN----EKRKEE 586
Cdd:pfam13904  52 QPLEAYENWLAAKQRQRQKELQAQKE-EREKEEQEA---ELRKRLAKEKYQEWLQRKARQQTKKREESHKqkaaESASKS 127
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767932652  587 LKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRH 624
Cdd:pfam13904 128 LAKPERKVSQEEAKEVLQEWERKKLEQQQRKREEEQRE 165
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
557-638 6.97e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.61  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  557 LTAVEKWNEKKEaffKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWS 636
Cdd:pfam13904  54 LEAYENWLAAKQ---RQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLAK 130

                  ..
gi 767932652  637 PP 638
Cdd:pfam13904 131 PE 132
 
Name Accession Description Interval E-value
PRK12704 PRK12704
phosphodiesterase; Provisional
507-592 3.81e-06

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 49.78  E-value: 3.81e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652 507 ARKGEA-LQAFEKWKEKKMEYLKEKNRKEREYERAKK---QKEE-----ETVAEKKKDNLTAVEKWNEKKEAFFKQKEKE 577
Cdd:PRK12704  53 AIKKEAlLEAKEEIHKLRNEFEKELRERRNELQKLEKrllQKEEnldrkLELLEKREEELEKKEKELEQKQQELEKKEEE 132
                         90
                 ....*....|....*
gi 767932652 578 kINEKRKEELKRAEK 592
Cdd:PRK12704 133 -LEELIEEQLQELER 146
PTZ00121 PTZ00121
MAEBL; Provisional
281-621 3.88e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.06  E-value: 3.88e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  281 KSDENKENSFSADHVTTAVEKSKEsqvtADDLEEEKAKAELIMDDDRTVDPLLSKSQSILISTSATASSKKTIEDRNIKN 360
Cdd:PTZ00121 1445 KADEAKKKAEEAKKAEEAKKKAEE----AKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEE 1520
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  361 KKSTNNRASSASARlmTSEFLKKSSSKRRTPSTTTSSHYLGTLKVldQKPSQKQSIEPDRADNIRAAVYQEWLEKKNV-- 438
Cdd:PTZ00121 1521 AKKADEAKKAEEAK--KADEAKKAEEKKKADELKKAEELKKAEEK--KKAEEAKKAEEDKNMALRKAEEAKKAEEARIee 1596
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  439 YLHEMHRIKRIESENLRIQNEQKKAA----------KREEALASFEAWKAMKEKEAKKIAAKKRLEEKNKKKTEEENAaR 508
Cdd:PTZ00121 1597 VMKLYEEEKKMKAEEAKKAEEAKIKAeelkkaeeekKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAKKAEEDK-K 1675
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  509 KGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEEET-----VAEKKKDNLTAVEKWNEK--------KEAFFKQKE 575
Cdd:PTZ00121 1676 KAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKkkaeeLKKAEEENKIKAEEAKKEaeedkkkaEEAKKDEEE 1755
                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*.
gi 767932652  576 KEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQK 621
Cdd:PTZ00121 1756 KKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIK 1801
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
511-624 6.76e-05

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 44.70  E-value: 6.76e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  511 EALQAFEKWKEKKMEYLKEKNRKEREyERAKKQKEEetvAEKKKDNLTAVEKWNEKKEAFFKQKEKEKIN----EKRKEE 586
Cdd:pfam13904  52 QPLEAYENWLAAKQRQRQKELQAQKE-EREKEEQEA---ELRKRLAKEKYQEWLQRKARQQTKKREESHKqkaaESASKS 127
                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 767932652  587 LKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRH 624
Cdd:pfam13904 128 LAKPERKVSQEEAKEVLQEWERKKLEQQQRKREEEQRE 165
PRK12705 PRK12705
hypothetical protein; Provisional
492-633 3.87e-04

hypothetical protein; Provisional


Pssm-ID: 237178 [Multi-domain]  Cd Length: 508  Bit Score: 43.54  E-value: 3.87e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652 492 RLEEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLKEKNRKEREYERAKKQKEeetVAEKKKDNLTAVEKWNEKKEAFF 571
Cdd:PRK12705  38 ILQEAQKEAEEKLEAALLEAKELLLRERNQQRQEARREREELQREEERLVQKEE---QLDARAEKLDNLENQLEEREKAL 114
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767932652 572 KQKEKEKINEKRK--EELKRAEKKDKD---KQAINEYEKWLEnKEKQERIERKQKKRHSFLESEALP 633
Cdd:PRK12705 115 SARELELEELEKQldNELYRVAGLTPEqarKLLLKLLDAELE-EEKAQRVKKIEEEADLEAERKAQN 180
CCDC34 pfam13904
Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several ...
557-638 6.97e-04

Coiled-coil domain-containing protein 3; This family is found in eukaryotes; it has several conserved tryptophan residues. The function is not known.


Pssm-ID: 464032 [Multi-domain]  Cd Length: 221  Bit Score: 41.61  E-value: 6.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  557 LTAVEKWNEKKEaffKQKEKEKINEKRKEELKRAEKKDKDKQAINEYEKWLENKEKQERIERKQKKRHSFLESEALPPWS 636
Cdd:pfam13904  54 LEAYENWLAAKQ---RQRQKELQAQKEEREKEEQEAELRKRLAKEKYQEWLQRKARQQTKKREESHKQKAAESASKSLAK 130

                  ..
gi 767932652  637 PP 638
Cdd:pfam13904 131 PE 132
CCDC47 pfam07946
PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of ...
528-599 2.33e-03

PAT complex subunit CCDC47; This family represents CCDC47 proteins which are a component of the PAT complex, an endoplasmic reticulum (ER)-resident membrane multiprotein complex that facilitates multi-pass membrane proteins insertion into membranes. The PAT complex, formed by CCDC47 and Asterix proteins, acts as an intramembrane chaperone by directly interacting with nascent transmembrane domains (TMDs), releasing its substrates upon correct folding, and is needed for optimal biogenesis of multi-pass membrane proteins. CCDC47 is required to maintain the stability of Asterix. CCDC47 is associated with various membrane-associated processes and is component of a ribosome-associated ER translocon complex involved in multi-pass membrane protein transport into the ER membrane and biogenesis. It is also involved in the regulation of calcium ion homeostasis in the ER, being also required for proper protein degradation via the ERAD (ER-associated degradation) pathway.


Pssm-ID: 462322  Cd Length: 323  Bit Score: 40.63  E-value: 2.33e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767932652  528 KEKNRKEREYERAKKQKEEEtvAEKKkdnltavEKWNEKKEAFFKQKEKEKINEKRKEELKRAEKKDKDKQA 599
Cdd:pfam07946 259 LKKAKKTREEEIEKIKKAAE--EERA-------EEAQEKKEEAKKKEREEKLAKLSPEEQRKYEEKERKKEQ 321
PTZ00121 PTZ00121
MAEBL; Provisional
412-623 3.00e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 3.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  412 QKQSIEPDRADNIRAAVYQEWLEKKNVyLHEMHRIKRIESENLRIQNEQKKAAKREEALASFEAWKAMKEKEAKKIAAKK 491
Cdd:PTZ00121 1236 KKDAEEAKKAEEERNNEEIRKFEEARM-AHFARRQAAIKAEEARKADELKKAEEKKKADEAKKAEEKKKADEAKKKAEEA 1314
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652  492 RleEKNKKKTEEENAARKGEALQAFEKWKEKKMEYLK---EKNRKEREYERAKKQKEEETVAEKKKDNLTAVEKWNEKKE 568
Cdd:PTZ00121 1315 K--KADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKaeaEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKK 1392
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 767932652  569 AFFKQKEKEKiNEKRKEELKraeKKDKDKQAINEYEKWLENKEKQERIERKQKKR 623
Cdd:PTZ00121 1393 ADEAKKKAEE-DKKKADELK---KAAAAKKKADEAKKKAEEKKKADEAKKKAEEA 1443
PRK12704 PRK12704
phosphodiesterase; Provisional
524-628 4.62e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 40.15  E-value: 4.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767932652 524 MEYLKEKNRKEREYERAKKQKEEETVAEKKKDnltavEKWNEKKEAFFKQKEK-EKINEKRKEELKRAEKK--------D 594
Cdd:PRK12704  25 RKKIAEAKIKEAEEEAKRILEEAKKEAEAIKK-----EALLEAKEEIHKLRNEfEKELRERRNELQKLEKRllqkeenlD 99
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 767932652 595 KDKQAINEYEKWLENKEKQ-ERIERKQKKRHSFLE 628
Cdd:PRK12704 100 RKLELLEKREEELEKKEKElEQKQQELEKKEEELE 134
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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