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Conserved domains on  [gi|767931339|ref|XP_011530018|]
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transmembrane protein 154 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMEM154 super family cl20971
TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, ...
 28-122 8.92e-25

TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection. This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.


The actual alignment was detected with superfamily member pfam15102:

Pssm-ID: 434459  Cd Length: 153  Bit Score: 91.93  E-value: 8.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931339   28 ENSGDTTVESERPNKVTIPSTFAAVTIKETLN-----ANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYK 102
Cdd:pfam15102  10 ENSGDTALETYTLETETTTATFAAVTTTESFNqttanANLSSTDFDNDSNQLEFILMIIIPLVLLIILLLSVAILITYYR 89

                          90       100
                  ....*....|....*....|
gi 767931339  103 RKRTKQEPSSQGSQSALQTY 122
Cdd:pfam15102  90 RKRRKDDPTSEGSQDALQTY 109
 
Name Accession Description Interval E-value
TMEM154 pfam15102
TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, ...
 28-122 8.92e-25

TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection. This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.


Pssm-ID: 434459  Cd Length: 153  Bit Score: 91.93  E-value: 8.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931339   28 ENSGDTTVESERPNKVTIPSTFAAVTIKETLN-----ANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYK 102
Cdd:pfam15102  10 ENSGDTALETYTLETETTTATFAAVTTTESFNqttanANLSSTDFDNDSNQLEFILMIIIPLVLLIILLLSVAILITYYR 89

                          90       100
                  ....*....|....*....|
gi 767931339  103 RKRTKQEPSSQGSQSALQTY 122
Cdd:pfam15102  90 RKRRKDDPTSEGSQDALQTY 109
 
Name Accession Description Interval E-value
TMEM154 pfam15102
TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, ...
 28-122 8.92e-25

TMEM154 protein family; The function of this family of transmembrane proteins has not, as yet, been determined. However, it is thought to be a therapeutic target for ovine lentivirus infection. This family of proteins is found in eukaryotes and members are typically between 138 and 320 amino acids in length.


Pssm-ID: 434459  Cd Length: 153  Bit Score: 91.93  E-value: 8.92e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767931339   28 ENSGDTTVESERPNKVTIPSTFAAVTIKETLN-----ANINSTNFAPDENQLEFILMVLIPLILLVLLLLSVVFLATYYK 102
Cdd:pfam15102  10 ENSGDTALETYTLETETTTATFAAVTTTESFNqttanANLSSTDFDNDSNQLEFILMIIIPLVLLIILLLSVAILITYYR 89

                          90       100
                  ....*....|....*....|
gi 767931339  103 RKRTKQEPSSQGSQSALQTY 122
Cdd:pfam15102  90 RKRRKDDPTSEGSQDALQTY 109
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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