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Conserved domains on  [gi|768024686|ref|XP_011528457|]
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radial spoke head 14 homolog isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 88-123 1.64e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


:

Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.90  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024686   88 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
HEAT super family cl34257
HEAT repeat [General function prediction only];
40-123 8.14e-03

HEAT repeat [General function prediction only];


The actual alignment was detected with superfamily member COG1413:

Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 35.76  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024686  40 LDTLVLCLQED-------ATEALG----SNVVLVLKQKLLSANQNIRSKAARALLNVSISRegkkqvchfdVIPILVHLL 108
Cdd:COG1413   18 VPALIAALADEdpdvraaAARALGrlgdPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE----------AVPALIAAL 87

                         90
                 ....*....|....*
gi 768024686 109 KDPVEHVKSNAAGAL 123
Cdd:COG1413   88 KDEDPEVRRAAAEAL 102
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 88-123 1.64e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.90  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024686   88 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 88-123 2.47e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.79  E-value: 2.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024686    88 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
HEAT COG1413
HEAT repeat [General function prediction only];
40-123 8.14e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 35.76  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024686  40 LDTLVLCLQED-------ATEALG----SNVVLVLKQKLLSANQNIRSKAARALLNVSISRegkkqvchfdVIPILVHLL 108
Cdd:COG1413   18 VPALIAALADEdpdvraaAARALGrlgdPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE----------AVPALIAAL 87

                         90
                 ....*....|....*
gi 768024686 109 KDPVEHVKSNAAGAL 123
Cdd:COG1413   88 KDEDPEVRRAAAEAL 102
 
Name Accession Description Interval E-value
Arm pfam00514
Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form ...
 88-123 1.64e-05

Armadillo/beta-catenin-like repeat; Approx. 40 amino acid repeat. Tandem repeats form super-helix of helices that is proposed to mediate interaction of beta-catenin with its ligands. CAUTION: This family does not contain all known armadillo repeats.


Pssm-ID: 425727 [Multi-domain]  Cd Length: 41  Bit Score: 40.90  E-value: 1.64e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 768024686   88 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:pfam00514   1 SPENKQAVIEAGAVPPLVRLLSSPDEEVQEEAAWAL 36
ARM smart00185
Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form ...
 88-123 2.47e-04

Armadillo/beta-catenin-like repeats; Approx. 40 amino acid repeat. Tandem repeats form superhelix of helices that is proposed to mediate interaction of beta-catenin with its ligands. Involved in transducing the Wingless/Wnt signal. In plakoglobin arm repeats bind alpha-catenin and N-cadherin.


Pssm-ID: 214547 [Multi-domain]  Cd Length: 41  Bit Score: 37.79  E-value: 2.47e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 768024686    88 SREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:smart00185   1 DDENKQAVVDAGGLPALVELLKSEDEEVVKEAAWAL 36
HEAT_2 pfam13646
HEAT repeats; This family includes multiple HEAT repeats.
 60-124 9.99e-04

HEAT repeats; This family includes multiple HEAT repeats.


Pssm-ID: 433376 [Multi-domain]  Cd Length: 88  Bit Score: 37.32  E-value: 9.99e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768024686   60 VLVLKQKLL-SANQNIRSKAARALlnvsisregkKQVCHFDVIPILVHLLKDPVEHVKSNAAGALM 124
Cdd:pfam13646   1 LPALLQALLrDPDPEVRAAAIRAL----------GRIGDPEAVPALLELLKDEDPAVRRAAAEALG 56
HEAT COG1413
HEAT repeat [General function prediction only];
40-123 8.14e-03

HEAT repeat [General function prediction only];


Pssm-ID: 441023 [Multi-domain]  Cd Length: 137  Bit Score: 35.76  E-value: 8.14e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768024686  40 LDTLVLCLQED-------ATEALG----SNVVLVLKQKLLSANQNIRSKAARALLNVSISRegkkqvchfdVIPILVHLL 108
Cdd:COG1413   18 VPALIAALADEdpdvraaAARALGrlgdPRAVPALLEALKDPDPEVRAAAAEALGRIGDPE----------AVPALIAAL 87

                         90
                 ....*....|....*
gi 768024686 109 KDPVEHVKSNAAGAL 123
Cdd:COG1413   88 KDEDPEVRRAAAEAL 102
HEAT_EZ pfam13513
HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats ...
 73-123 9.66e-03

HEAT-like repeat; The HEAT repeat family is related to armadillo/beta-catenin-like repeats (see pfam00514). These EZ repeats are found in subunits of cyanobacterial phycocyanin lyase and other proteins and probably carry out a scaffolding role.


Pssm-ID: 463906 [Multi-domain]  Cd Length: 55  Bit Score: 33.88  E-value: 9.66e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 768024686   73 NIRSKAARALLNVSISREGKKQVCHFDVIPILVHLLKDPVEHVKSNAAGAL 123
Cdd:pfam13513   2 RVREAAALALGSLAEGGPDLLAPAVPELLPALLPLLNDDSDLVREAAAWAL 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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