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Conserved domains on  [gi|768008826|ref|XP_011525205|]
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V-set and transmembrane domain-containing protein 2B isoform X2 [Homo sapiens]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208729)

immunoglobulin (Ig) domain-containing protein adopts a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition

CATH:  2.60.40.10
PubMed:  7932691|8176743|23842991|10436082|3289571|9541533
SCOP:  3000071

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-129 1.20e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 59.44  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHelalsvpgarSKTVRVQGNDISHRLRLSAVRLQDEG 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAE----------SGRFSVSRSGSTSTLTISNVTPEDSG 64

                           90
                   ....*....|....*.
gi 768008826   114 VYECRVSDYSDDDTQE 129
Cdd:smart00410  65 TYTCAATNSSGSASSG 80
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-129 1.20e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 59.44  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHelalsvpgarSKTVRVQGNDISHRLRLSAVRLQDEG 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAE----------SGRFSVSRSGSTSTLTISNVTPEDSG 64

                           90
                   ....*....|....*.
gi 768008826   114 VYECRVSDYSDDDTQE 129
Cdd:smart00410  65 TYTCAATNSSGSASSG 80
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 32-139 2.51e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 2.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826   32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELAL----SVPGARSKTVRVQGNDISHR--LR 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYysngSEEGVKKGRFSGRGDPSNGDgsLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768008826  104 LSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 139
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 28-124 1.84e-06

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 45.72  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATsyslEIQWWYLKEPPRELLHELalsVPGARSKTVRVQGNDISH---RLRL 104
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYHQHatsTISI 73

                         90       100
                 ....*....|....*....|
gi 768008826 105 SAVRLQDEGVYECRVSDYSD 124
Cdd:cd20940   74 DNLTEEDTGTYECRASNDPD 93
 
Name Accession Description Interval E-value
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 34-129 1.20e-11

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 59.44  E-value: 1.20e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826    34 PKDVTVREGDDIEMPCafRASGATSYSLeiqWWYlKEPPRELLHelalsvpgarSKTVRVQGNDISHRLRLSAVRLQDEG 113
Cdd:smart00410   1 PPSVTVKEGESVTLSC--EASGSPPPEV---TWY-KQGGKLLAE----------SGRFSVSRSGSTSTLTISNVTPEDSG 64

                           90
                   ....*....|....*.
gi 768008826   114 VYECRVSDYSDDDTQE 129
Cdd:smart00410  65 TYTCAATNSSGSASSG 80
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 32-139 2.51e-09

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 53.62  E-value: 2.51e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826   32 EVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQW--WYLKEPPRELLHELAL----SVPGARSKTVRVQGNDISHR--LR 103
Cdd:pfam07686   1 QTPREVTVALGGSVTLPCTYS----SSMSEASTSvyWYRQPPGKGPTFLIAYysngSEEGVKKGRFSGRGDPSNGDgsLT 76

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 768008826  104 LSAVRLQDEGVYECRVsDYSDDDTQEHKAQamLRVL 139
Cdd:pfam07686  77 IQNLTLSDSGTYTCAV-IPSGEGVFGKGTR--LTVL 109
I-set pfam07679
Immunoglobulin I-set domain;
30-120 1.06e-08

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 51.49  E-value: 1.06e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826   30 FTEVPKDVTVREGDDIEMPCafRASGATSysLEIQWWYLKEPPREllhelalsvpgarSKTVRVQGNDISHRLRLSAVRL 109
Cdd:pfam07679   3 FTQKPKDVEVQEGESARFTC--TVTGTPD--PEVSWFKDGQPLRS-------------SDRFKVTYEGGTYTLTISNVQP 65

                          90
                  ....*....|.
gi 768008826  110 QDEGVYECRVS 120
Cdd:pfam07679  66 DDSGKYTCVAT 76
Ig0_BSG1 cd20940
Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are ...
 28-124 1.84e-06

Immunoglobulin-like Ig0 domain of basigin-1 (BSG1) and similar proteins; The members here are composed of the immunoglobulin (Ig) domain of the collagenase stimulatory factor, basigin-1 (BSG1; also known as Cluster of Differentiation 147 (CD147) and Extracellular Matrix Metalloproteinase Inducer (EMMPRIN)) and similar proteins. CD147 is a transmembrane glycoprotein that belongs to the immunoglobulin superfamily. It is expressed in nearly all cells including platelets and fibroblasts and is involved in inflammatory diseases, and cancer progression. CD147 is highly expressed in several cancers and used as a prognostic marker. The two primary isoforms of CD147 that are related to cancer progression have been identified: CD147 Ig1-Ig2 (also called Basigin-2) that is ubiquitously expressed in most tissues and CD147 Ig0-Ig1-Ig2 (also called Basigin-1) that is retinal specific and implicated in retinoblastoma. Studies showed that CD147 Ig0 domain is a potent stimulator of interleukin-6 and suggest that the CD147 Ig0 dimer is the functional unit required for activity.


Pssm-ID: 409534  Cd Length: 116  Bit Score: 45.72  E-value: 1.84e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATsyslEIQWWYLKEPPRELLHELalsVPGARSKTVRVQGNDISH---RLRL 104
Cdd:cd20940    1 AGFIKSPLSQQRLVGDSVELHCEAVGSPIP----EIQWWFEGQEPNEICSQL---WDGARLDRVHINATYHQHatsTISI 73

                         90       100
                 ....*....|....*....|
gi 768008826 105 SAVRLQDEGVYECRVSDYSD 124
Cdd:cd20940   74 DNLTEEDTGTYECRASNDPD 93
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 34-120 7.56e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 43.32  E-value: 7.56e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826   34 PKDVTVREGDDIEMPCafRASGATSYslEIQWWYLKEPPRELLHElalsvpgarsktvRVQGNDISHRLRLSAVRLQDEG 113
Cdd:pfam13927   8 PSSVTVREGETVTLTC--EATGSPPP--TITWYKNGEPISSGSTR-------------SRSLSGSNSTLTISNVTRSDAG 70


                  ....*..
gi 768008826  114 VYECRVS 120
Cdd:pfam13927  71 TYTCVAS 77
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 33-121 4.83e-04

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 38.33  E-value: 4.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826   33 VPKDVTVREGDDIEMPCafRASGATSYsLEIQWWYLKEPPRELLHelalsvpgarskTVRVQGNDISHRLRLSAVRLQDE 112
Cdd:pfam00047   2 APPTVTVLEGDSATLTC--SASTGSPG-PDVTWSKEGGTLIESLK------------VKHDNGRTTQSSLLISNVTKEDA 66


                  ....*....
gi 768008826  113 GVYECRVSD 121
Cdd:pfam00047  67 GTYTCVVNN 75
IgV_TCR_delta cd07706
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here ...
 31-126 9.71e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) delta chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the delta chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens; they recognize protein antigens directly and without antigen processing, and MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409503  Cd Length: 112  Bit Score: 37.88  E-value: 9.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  31 TEVPKDVTVREGDDIEMPCAFRasgaTSYSLEIQWWYlKEPPRE----LLHELAlSVPGARSK--TVRVQGNDISHRLRL 104
Cdd:cd07706    3 TQAQPDVSVQVGEEVTLNCRYE----TSWTNYYLFWY-KQLPSGemtfLIRQDS-SEQNAKSGrySVNFQKAQKSISLTI 76

                         90       100
                 ....*....|....*....|..
gi 768008826 105 SAVRLQDEGVYECRVSDYSDDD 126
Cdd:cd07706   77 SALQLEDSAKYFCALSLPYDTD 98
IgV_1_Nectin-4_like cd05888
First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are ...
 35-139 1.58e-03

First immunoglobulin (Ig) domain of nectin-4, and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of nectin-4 (also known as poliovirus receptor related protein 4 or LNIR receptor). Nectin-4 belongs to the nectin family, which is comprised of four transmembrane glycoproteins (nectins-1 through -4). Nectins are synaptic cell adhesion molecules (CAMs) which participate in adhesion and signaling at various intracellular junctions. Nectins form homophilic cis-dimers, followed by homophilic and heterophilic trans-dimers involved in cell-cell adhesion. For example nectin-4 trans-interacts with nectin-1. Nectin-4 has also been shown to interact with the actin filament-binding protein, afadin. Unlike the other nectins, which are widely expressed in adult tissues, nectin-4 is mainly expressed during embryogenesis, and is not detected in normal adult tissue or in serum. Nectin-4 is re-expressed in breast carcinoma, and patients having metastatic breast cancer have a circulating form of nectin-4 formed from the ectodomain


Pssm-ID: 409471  Cd Length: 108  Bit Score: 37.19  E-value: 1.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  35 KDVTVREGDDIEMPCAFRASGATSYsleIQWWYLKEPPRELLHELAL-------SVPGARSKTVRVQGN----DISHRLR 103
Cdd:cd05888    1 DVVTVVLGQDAKLPCFYRGDSGEQV---GQVAWARVDAGEGAQEIALlhskyglHVFPAYEGRVEQPPPprpaDGSVLLR 77

                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 768008826 104 lSAVRlQDEGVYECRVSDYSDDDTQehkAQAMLRVL 139
Cdd:cd05888   78 -NAVQ-ADEGEYECRVSTFPAGNFQ---AELRLRVL 108
Ig_LP_like cd05877
Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The ...
 32-127 2.08e-03

Immunoglobulin (Ig)-like domain of human cartilage link protein (LP), and similar domains; The members here are composed of the immunoglobulin (Ig)-like domain similar to that found in human cartilage link protein (LP; also called hyaluronan and proteoglycan link protein). In cartilage, chondroitin-keratan sulfate proteoglycan (CSPG), aggrecan, forms cartilage link protein stabilized aggregates with hyaluronan (HA). These aggregates contribute to the tissue's load bearing properties. Aggregates having other CSPGs substituting for aggrecan may contribute to the structural integrity of many different tissues. Members of the vertebrate HPLN (hyaluronan/HA and proteoglycan binding link) protein family are physically linked adjacent to CSPG genes.


Pssm-ID: 409461  Cd Length: 117  Bit Score: 37.30  E-value: 2.08e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  32 EVPKDVTVREGDDIEMPCAFR--ASGATSYSLEIQWWylKEPPRELLHELALSVPGARSKT-------VRVQG---NDIS 99
Cdd:cd05877    2 TVQAKVFSHRGGNVTLPCRYHyePELSAPRKIRVKWT--KLEVDYAKEEDVLVAIGTRHKSygsyqgrVFLRRaddLDAS 79

                         90       100
                 ....*....|....*....|....*...
gi 768008826 100 hrLRLSAVRLQDEGVYECRVSDYSDDDT 127
Cdd:cd05877   80 --LVITDLRLEDYGRYRCEVIDGLEDES 105
IgV_1_PVR_like cd05718
First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 ...
 33-122 2.23e-03

First immunoglobulin variable (IgV) domain of poliovirus receptor (PVR, also known as CD155 and necl-5), and similar domains; The members here are composed of the first immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155 and nectin-like protein 5 (necl-5)). Poliovirus (PV) binds to its cellular receptor (PVR/CD155) to initiate infection. CD155 is a membrane-anchored, single-span glycoprotein; its extracellular region has three Ig-like domains. There are four different isotypes of CD155 (referred to as alpha, beta, gamma, and delta), that result from alternate splicing of the CD155 mRNA, and have identical extracellular domains. CD155-beta and CD155-gamma are secreted; CD155-alpha and CD155-delta are membrane-bound and function as PV receptors. The virus recognition site is contained in the amino-terminal domain, D1. Having the virus attachment site on the receptor distal from the plasma membrane may be important for successful initiation of infection of cells by the virus. CD155 binds in the poliovirus "canyon" with a footprint similar to that of the intercellular adhesion molecule-1 receptor on human rhinoviruses. This group also includes the first Ig-like domain of nectin-1 (also known as poliovirus receptor related protein(PVRL)1; CD111), nectin-3 (also known as PVRL 3), nectin-4 (also known as PVRL4; LNIR receptor)and DNAX accessory molecule 1 (DNAM-1; CD226).


Pssm-ID: 409383  Cd Length: 113  Bit Score: 37.04  E-value: 2.23e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  33 VPKDVTVREGDDIEMPCAFRASGATSYSlEIQWWYLKEPPRELL---H-ELALSVPGARSKTV-----RVQGNDIShrLR 103
Cdd:cd05718    5 VPTEVTGFLGGSVTLPCSLTSPGTTKIT-QVTWMKIGAGSSQNVavfHpQYGPSVPNPYAERVeflaaRLGLRNAT--LR 81

                         90
                 ....*....|....*....
gi 768008826 104 LSAVRLQDEGVYECRVSDY 122
Cdd:cd05718   82 IRNLRVEDEGNYICEFATF 100
IgV_NKp30 cd20926
Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and ...
 28-119 4.74e-03

Immunoglobulin variable (IgV) domain of Natural Killer cell activating receptor NKp30 and similar domains; The members here are composed of the immunoglobulin variable region (IgV) of Natural Killer cell activating receptor NKp30 (also known as Natural Cytotoxicity triggering Receptor 3 (NCR3)) and similar domains. NKp30 Recognizes the N-Terminal IgV Domain of B7-H6. In humans, the activating natural cytotoxicity receptor NKp30 plays a major role in NK cell-mediated tumor cell lysis. NKp30 recognizes the cell-surface protein B7-H6, which is expressed on tumor, but not healthy, cells.


Pssm-ID: 409520  Cd Length: 112  Bit Score: 36.11  E-value: 4.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  28 AAFTEVPKDVTVREGDDIEMPCAFRASGATSYSLEIQWWYLKEPPREllhELALSVPGARSKTVRVQGNDISH----RLR 103
Cdd:cd20926    1 ALWVSQPPEIRTLEGSSAFLPCSFNASQGRLAIGSVTWFRDEVAPGK---EVRNGTPEFRGRLAPLASSRFLRdhqaELH 77

                         90
                 ....*....|....*.
gi 768008826 104 LSAVRLQDEGVYECRV 119
Cdd:cd20926   78 IWDVRGHDAGIYVCRV 93
IGv smart00406
Immunoglobulin V-Type;
44-117 7.46e-03

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 34.67  E-value: 7.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826    44 DIEMPCafRASGATSYSLEIQWwyLKEPPR---ELLHELALSVPGARSKTV--RVQGNDISHR----LRLSAVRLQDEGV 114
Cdd:smart00406   1 SVTLSC--KFSGSTFSSYYVSW--VRQPPGkglEWLGYIGSNGSSYYQESYkgRFTISKDTSKndvsLTISNLRVEDTGT 76


                   ...
gi 768008826   115 YEC 117
Cdd:smart00406  77 YYC 79
Ig cd00096
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 45-120 8.09e-03

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409353 [Multi-domain]  Cd Length: 70  Bit Score: 34.23  E-value: 8.09e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 768008826  45 IEMPCafRASGATSysLEIQWWYLKEPPREllhelalsvpgarSKTVRVQGNDISHRLRLSAVRLQDEGVYECRVS 120
Cdd:cd00096    1 VTLTC--SASGNPP--PTITWYKNGKPLPP-------------SSRDSRRSELGNGTLTISNVTLEDSGTYTCVAS 59
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 32-123 9.48e-03

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 35.27  E-value: 9.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 768008826  32 EVPKD-VTVREGDDIEMPCAFRASGATSYSLEIQWWYLKEPPReLLHELALSVPGARSKTVR------------VQGNdi 98
Cdd:cd20934    1 RVPEDpVVALVGTDATLRCSFSPEPGFSLAQLSVFWQLTDTKQ-LVHSFTESQDQGRDQGSAyanrtalfpdllAQGN-- 77

                         90       100
                 ....*....|....*....|....*..
gi 768008826  99 sHRLRLSAVRLQDEGVYEC--RVSDYS 123
Cdd:cd20934   78 -ASLRLQRVRVADEGSYTCfvSVQDFG 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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