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Conserved domains on  [gi|767998153|ref|XP_011524099|]
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DNA polymerase iota isoform X2 [Homo sapiens]

Protein Classification

DNA polymerase Y subunit UmuC family protein( domain architecture ID 1000143)

DNA polymerase Y subunit UmuC family protein similar to plasmid-encoded MucB protein, which is a DNA polymerase (pol RI) specialized for lesion bypass in the presence of MucA', RecA, and single strand-binding protein (SSB)

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PolY super family cl28996
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 56-423 1.35e-170

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


The actual alignment was detected with superfamily member cd01703:

Pssm-ID: 452909 [Multi-domain]  Cd Length: 379  Bit Score: 483.13  E-value: 1.35e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVT 135
Cdd:cd01703    1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 136 ELLEEFSP--VVERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMY 213
Cdd:cd01703   81 RLLRSYSWndRVERLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIE 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 214 NQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP 291
Cdd:cd01703  125 NELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSN 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 292 ---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASL 353
Cdd:cd01703  205 rnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASL 284

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998153 354 LNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGTGlqspdfcaSSLMQRRLEDKLVKL 423
Cdd:cd01703  285 LERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTGG--------NEIAARPIEKILMRL 355
 
Name Accession Description Interval E-value
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 56-423 1.35e-170

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 483.13  E-value: 1.35e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVT 135
Cdd:cd01703    1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 136 ELLEEFSP--VVERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMY 213
Cdd:cd01703   81 RLLRSYSWndRVERLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIE 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 214 NQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP 291
Cdd:cd01703  125 NELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSN 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 292 ---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASL 353
Cdd:cd01703  205 rnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASL 284

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998153 354 LNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGTGlqspdfcaSSLMQRRLEDKLVKL 423
Cdd:cd01703  285 LERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTGG--------NEIAARPIEKILMRL 355
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 53-373 4.26e-81

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 253.14  E-value: 4.26e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYRE 129
Cdd:COG0389    1 RRILHVDMDAFYASVEQRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGS--QIAAE 207
Cdd:COG0389   80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGS------------------------------------ARLFGSaeAIARR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 208 MREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQ 287
Cdd:COG0389  124 IRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLA 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 288 TFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRK 363
Cdd:COG0389  203 ALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLG 278

                        330
                 ....*....|
gi 767998153 364 PHTVRLIIRR 373
Cdd:COG0389  279 ARTVTVKLRT 288
PRK02406 PRK02406
DNA polymerase IV; Validated
 61-426 2.52e-58

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 194.57  E-value: 2.52e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  61 DCFYAQVEMISNPELKDKPLGV----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTE 136
Cdd:PRK02406   2 DCFYAAVEMRDNPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 137 LLEEFSPVVERLGFDENFVDLTEmvEKRLQQlqsdelSAVTvsghvynnqsinlldvlhirllvgsqIAAEMREAMYNQL 216
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTD--NKLCIG------SATL--------------------------IAQEIRQDIFEEL 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 217 GLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK 296
Cdd:PRK02406 127 GLTASAGVAPNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIR 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 297 ELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEEL---LASLLNRVcQDGRKPHTVRLIIR 372
Cdd:PRK02406 206 HFG-KFGRRLYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTVGVKLK 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767998153 373 RYSSEKhygresrqcpipsHVIQKLGTGLQSPDFC--ASSLMQRRLEDKLVKLEGV 426
Cdd:PRK02406 284 FADFQQ-------------TTKEHTADPLDKADLIelLAQALLRRLGGRGVRLLGV 326
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 58-235 1.22e-47

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 160.05  E-value: 1.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153   58 VDLDCFYAQVEMISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKV 134
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  135 TELLEEFSPV-VERLGFDENFVDLTEMVEkrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMY 213
Cdd:pfam00817  80 FEILRRFSTPkVEQASIDEAFLDLTGLEK----------------------------------LFGAEEALAKRLRREIA 125

                         170       180
                  ....*....|....*....|..
gi 767998153  214 NQLGLTGCAGVASNKLLAKLVS 235
Cdd:pfam00817 126 EETGLTCSIGIAPNKLLAKLAS 147
TIGR03491 TIGR03491
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ...
 260-325 1.26e-04

RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.


Pssm-ID: 274603 [Multi-domain]  Cd Length: 457  Bit Score: 44.24  E-value: 1.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  260 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 325
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
 
Name Accession Description Interval E-value
PolY_Pol_iota cd01703
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ...
 56-423 1.35e-170

DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.


Pssm-ID: 176457 [Multi-domain]  Cd Length: 379  Bit Score: 483.13  E-value: 1.35e-170
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVT 135
Cdd:cd01703    1 IHLDLDCFYAQVEEIRDPSLKSKPLGIQQKYIVVTCNYEARRLGVKKLMSIKDAKEICPDLVLVNGEDLTPFRDMSKKVY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 136 ELLEEFSP--VVERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMY 213
Cdd:cd01703   81 RLLRSYSWndRVERLGFDENFMDVTEM------------------------------------RLLVASHIAYEMRERIE 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 214 NQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLI--HSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSP 291
Cdd:cd01703  125 NELGLTCCAGIASNKLLAKLVGSVNKPNQQTTLLPPSCADLMdfMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQEFSN 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 292 ---------------KILEKELGISVAQRIQKLSFGEDNSPVI-LSGPPQSFSEEDSFKKCSSEV--EAKNKIEELLASL 353
Cdd:cd01703  205 rnrqtvgaapsllelLLMVKEFGEGIGQRIWKLLFGRDTSPVKpASDFPQQISIEDSYKKCSLEEirEARNKIEELLASL 284

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767998153 354 LNRVCQ--------DGRKPHTVRLIIRRYSSEKH-YGRESRQCPIPSHVIQKLGTGlqspdfcaSSLMQRRLEDKLVKL 423
Cdd:cd01703  285 LERMKQdlqevkagDGRRPHTLRLTLRRYTSTKKhYNRESKQAPIPSHVFQKLTGG--------NEIAARPIEKILMRL 355
PolY cd00424
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ...
 56-393 2.35e-115

Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176453 [Multi-domain]  Cd Length: 343  Bit Score: 341.26  E-value: 2.35e-115
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKY----LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMS 131
Cdd:cd00424    1 LHIDFDNFFASVEQLARPELKGRPVVVVPFNsdstCVIACSYEARKYGVKRGMPVREARKMCPNLILVP-ARLDLYRRLS 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 132 YKVTELLEEFSPVVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsghvynnqsinlldvlhirLLVGSQIAAEMREA 211
Cdd:cd00424   80 ERLLSELEEVAPLVEVASIDELFLDLTGSARL----------------------------------LGLGSEVALRIKRH 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 212 MYNQLG-LTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIhSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFS 290
Cdd:cd00424  126 IAEQLGgITASIGIASNKLLAKLAAKYAKPDGLTILDPEDLPGFL-SKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAAS 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 291 PKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVE-AKNKIEELLASLLNRVCQDGRKPHTVRL 369
Cdd:cd00424  205 PDALLALWGGVSGERLWYALRGIDDEPLSPPRPRKSFSHERVLPRDSRNAEdARPLLRLLLEKLARRLRRDGRGATRLRL 284

                        330       340
                 ....*....|....*....|....*.
gi 767998153 370 IIRRYSSE--KHYGRESRQCPIPSHV 393
Cdd:cd00424  285 WLRTVDGRwsGHADIPSRSAPRPIST 310
PolY_Pol_IV_kappa cd03586
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ...
 56-426 7.80e-83

DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.


Pssm-ID: 176459 [Multi-domain]  Cd Length: 334  Bit Score: 257.45  E-value: 7.80e-83
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSY 132
Cdd:cd03586    1 IHIDMDAFYASVEQRDNPELKGKPVAVggsSDRGVVSTASYEARKFGVRSAMPIFQAKKLCPNLIFVPP-RFDKYREVSR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 133 KVTELLEEFSPVVERLGFDENFVDltemvekrlqqlqsdelsavtVSGHVYNNQSInlldvlhirllvgSQIAAEMREAM 212
Cdd:cd03586   80 QIMEILREYTPLVEPLSIDEAYLD---------------------VTDYVRLFGSA-------------TEIAKEIRARI 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 213 YNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPK 292
Cdd:cd03586  126 REETGLTASAGIAPNKFLAKIASDLNKPNGLTVIPPEDVEEFLAPL-PVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVE 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 293 ILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLII 371
Cdd:cd03586  205 LLKKLFG-KSGRRLYELARGIDNRPVEPDRERKSIGVERTFsEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKL 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 767998153 372 RRYSSEKHygreSRQCPIPSHViqklgTGLQSPDFCASSLMQRRLEDKLVKLEGV 426
Cdd:cd03586  284 KYADFSTR----TRSRTLPEPT-----DDAEDIYELALELLEELLDGRPIRLLGV 329
DinP COG0389
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ...
 53-373 4.26e-81

Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];


Pssm-ID: 440158 [Multi-domain]  Cd Length: 336  Bit Score: 253.14  E-value: 4.26e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV---QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYRE 129
Cdd:COG0389    1 RRILHVDMDAFYASVEQRDRPELRGKPVAVggdNNRGVVAAASYEARAFGVRSGMPLFQARRLCPDLVVLPP-DFELYRD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMvekrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGS--QIAAE 207
Cdd:COG0389   80 VSRRVMAILERYTPLVEPLSIDEAFLDVTGS------------------------------------ARLFGSaeAIARR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 208 MREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDLQ 287
Cdd:COG0389  124 IRRRIRRETGLTVSVGIAPNKFLAKIASDLAKPDGLTVIPPGEVAAFLAPL-PVEKLWGVGPKTAEKLARLGIRTIGDLA 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 288 TFSPKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDGRK 363
Cdd:COG0389  203 ALPRAELRRRFG-KVGERLYRLARGIDPRPVEPRRPRKSIGVERTFGE---DLTDLEELEAALRRLAERLAerlrRQGLG 278

                        330
                 ....*....|
gi 767998153 364 PHTVRLIIRR 373
Cdd:COG0389  279 ARTVTVKLRT 288
PRK02406 PRK02406
DNA polymerase IV; Validated
 61-426 2.52e-58

DNA polymerase IV; Validated


Pssm-ID: 235035 [Multi-domain]  Cd Length: 343  Bit Score: 194.57  E-value: 2.52e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  61 DCFYAQVEMISNPELKDKPLGV----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSYKVTE 136
Cdd:PRK02406   2 DCFYAAVEMRDNPELRGKPVAVggspGRRGVISTCNYEARKFGVRSAMPTAQALKLCPDLIFVPG-RFDVYKEVSRQIRE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 137 LLEEFSPVVERLGFDENFVDLTEmvEKRLQQlqsdelSAVTvsghvynnqsinlldvlhirllvgsqIAAEMREAMYNQL 216
Cdd:PRK02406  81 IFRRYTDLIEPLSLDEAYLDVTD--NKLCIG------SATL--------------------------IAQEIRQDIFEEL 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 217 GLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK 296
Cdd:PRK02406 127 GLTASAGVAPNKFLAKIASDWNKPNGLFVITPEEVDAFLATLP-VEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIR 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 297 ELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEEL---LASLLNRVcQDGRKPHTVRLIIR 372
Cdd:PRK02406 206 HFG-KFGRRLYERARGIDERPVKPDRERKSVGVERTFAEdLYDLEACLAELPRLaekLERRLERA-KPDKRIKTVGVKLK 283

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 767998153 373 RYSSEKhygresrqcpipsHVIQKLGTGLQSPDFC--ASSLMQRRLEDKLVKLEGV 426
Cdd:PRK02406 284 FADFQQ-------------TTKEHTADPLDKADLIelLAQALLRRLGGRGVRLLGV 326
PolY_Pol_eta cd01702
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ...
 56-397 5.26e-56

DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.


Pssm-ID: 176456 [Multi-domain]  Cd Length: 359  Bit Score: 189.06  E-value: 5.26e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLV------NGED------ 123
Cdd:cd01702    1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNSIIAVSYAARAFGVTRFMTIDEAKKKCPDLILAhvatykKGEDeadyhe 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 124 ----------LTRYREMSYKVTELLEEFSPVVERLGFDENFVDLtemvekrlqqlqsdelsavtvsghvynnqsinlldv 193
Cdd:cd01702   81 npsparhkvsLDPYRRASRKILNILKRFGDVVEKASIDEAYLDL------------------------------------ 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 194 lhirllvGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAK 273
Cdd:cd01702  125 -------GSRIVEEIRQQVYDELGYTCSAGIAHNKMLAKLASGMNKPNAQTILRNDAVASFLSSLP-ITSIRGLGGKLGE 196

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 274 CL-EALGINSVRDLQTF--SPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF--KKCSSEVEAKNKIEE 348
Cdd:cd01702  197 EIiDLLGLPTEGDVAGFrsSESDLQEHFGEKLGEWLYNLLRGIDHEPVKPRPLPKSMGSSKNFpgKTALSTEDVQHWLLV 276

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|...
gi 767998153 349 LLASLLNRVCQD----GRKPHTVRLiirRYSSEKHYGRESRQCPIPSHVIQKL 397
Cdd:cd01702  277 LASELNSRLEDDryenNRRPKTLVL---SLRQRGDGVRRSRSCALPRYDAQKI 326
PRK01810 PRK01810
DNA polymerase IV; Validated
 52-426 2.59e-55

DNA polymerase IV; Validated


Pssm-ID: 179337 [Multi-domain]  Cd Length: 407  Bit Score: 188.31  E-value: 2.59e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  52 SRVIVHVDLDCFYAQVEMISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTR 126
Cdd:PRK01810   4 GRVIFHVDMNSFFASVEIAYDPSLQGKPLAVagnekERKGIIVTCSYEARAYGIRTTMPLWEAKRLCPQLIVRR-PNFDR 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsGHVYnnqsinlldvlhirllvgsQIAA 206
Cdd:PRK01810  83 YREASRQMFQILSEFTPLVQPVSIDEGYLDITDCYAL----------------GSPL-------------------EIAK 127

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 207 EMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLnHIKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:PRK01810 128 MIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPLGITVLRKRDVPEMLWPL-PVGEMHGIGEKTAEKLKDIGIQTIGDL 206

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 287 QTFSPKILEKELGISvAQRIQKLSFGEDNSPVilsgPPQSFSEEDS------FKKCSSEV-EAKNKIEELLASLLNRVCQ 359
Cdd:PRK01810 207 AKADEHILRAKLGIN-GVRLQRRANGIDDRPV----DPEAIYQFKSvgnsttLSHDMDEEkELLDVLRRLSKSVSKRLQK 281

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 360 DGRKPHTVRLIIrRYSSEKHYGREsrqcpipshviQKLGTGLQSPD---FCASSLMQRRLEDKLVKLEGV 426
Cdd:PRK01810 282 KTVVSYNVQIMI-RYHDRRTITRS-----------KTLKNPIWEKRdifQAASRLFKQHWNGDPVRLLGV 339
IMS pfam00817
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
 58-235 1.22e-47

impB/mucB/samB family; These proteins are involved in UV protection (Swiss).


Pssm-ID: 425885 [Multi-domain]  Cd Length: 148  Bit Score: 160.05  E-value: 1.22e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153   58 VDLDCFYAQVEMISNPELKDKPLGVQQKY---LVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKV 134
Cdd:pfam00817   1 IDMDAFFASVELLRDPELKGKPVAVGGGNgrgIVAAASYEARKYGVRSGMPVFEAKKLCPNLIVV-PPDLELYRRASRKI 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  135 TELLEEFSPV-VERLGFDENFVDLTEMVEkrlqqlqsdelsavtvsghvynnqsinlldvlhiRLLVGSQIAAEMREAMY 213
Cdd:pfam00817  80 FEILRRFSTPkVEQASIDEAFLDLTGLEK----------------------------------LFGAEEALAKRLRREIA 125

                         170       180
                  ....*....|....*....|..
gi 767998153  214 NQLGLTGCAGVASNKLLAKLVS 235
Cdd:pfam00817 126 EETGLTCSIGIAPNKLLAKLAS 147
PolY_Rev1 cd01701
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ...
 23-373 1.17e-43

DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.


Pssm-ID: 176455 [Multi-domain]  Cd Length: 404  Bit Score: 157.48  E-value: 1.17e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  23 AWAMELADVGAAASSQ-GVHDQVLPTPNASSRVIVHVDLDCFYAQVEMISNPELKDKPLGV-QQKYL---VVTCNYEARK 97
Cdd:cd01701   16 TWKARLKDFFRELSNGsKEADPSNSIHPDLQRIIMHVDFDCFFVSVSIRNRPDLKGKPVAVcHGKGPnseIASCNYEARS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  98 LGVKKLMNVRDAKEKCPQLVLVnGEDLTRYREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEkrlqqlqsdelsavt 177
Cdd:cd01701   96 YGIKNGMWVGQAKKLCPQLVTL-PYDFEAYEEVSLTFYEILASYTDNIEAVSCDEALIDITSLLE--------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 178 vsghvynnQSINLLDVLhirllvGSQIAAEMREAmynqlglTGC---AGVASNKLLAKLVSGVFKPNQQTVLLPESCQHL 254
Cdd:cd01701  160 --------ETYELPEEL------AEAIRNEIRET-------TGCsasVGIGPNILLARLATRKAKPDGQYHLSAEKVEEF 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 255 IHSLNhIKEIPGIGYKTA-KCLEALG-INSVRDLQTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDS 332
Cdd:cd01701  219 LSQLK-VGDLPGVGSSLAeKLVKLFGdTCGGLELRSKTKEKLQKVLGPKTGEKLYDYCRGIDDRPVTGEKERKSVSAEIN 297

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*.
gi 767998153 333 ----FKKcssEVEAKNKIEELLASLLNRVCQDGRKPHTVRL-IIRR 373
Cdd:cd01701  298 ygirFTN---VDDVEQFLQRLSEELSKRLEESNVTGRQITLkLMKR 340
PRK03348 PRK03348
DNA polymerase IV; Provisional
 50-374 1.97e-42

DNA polymerase IV; Provisional


Pssm-ID: 235118 [Multi-domain]  Cd Length: 454  Bit Score: 155.09  E-value: 1.97e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  50 ASSRVIVHVDLDCFYAQVEMISNPELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTR 126
Cdd:PRK03348   2 RAQRWVLHLDMDAFFASVEQLTRPTLRGRPVlvgGLGGRGVVAGASYEARVFGARSAMPMHQARRLVGNGAVVLPPRFVV 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLTEmvekrlqqLQSDELSAVTvsghvynnqsinlldvlhirllvgsQIAA 206
Cdd:PRK03348  82 YRAASRRVFDTLRELSPVVEQLSFDEAFVEPAE--------LAGASAEEVE-------------------------AFAE 128

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 207 EMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:PRK03348 129 RLRARVREETGLPASVGAGSGKQIAKIASGLAKPDGIRVVPPGEERELLAPLP-VRRLWGIGPVTEEKLHRLGIETIGDL 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 287 QTFSPKILEKELGISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKK-CSSEVEAKNKIEELLASLLNRVCQDGRKPH 365
Cdd:PRK03348 208 AALSEAEVANLLGATVGPALHRLARGIDDRPVAERAEAKQISAESTFAVdLTTRAQLREAIERIAEHAHRRLLKDGRGAR 287


                 ....*....
gi 767998153 366 TVRLIIRRY 374
Cdd:PRK03348 288 TVTVKLRKS 296
PRK14133 PRK14133
DNA polymerase IV; Provisional
 53-379 3.25e-40

DNA polymerase IV; Provisional


Pssm-ID: 184529 [Multi-domain]  Cd Length: 347  Bit Score: 146.79  E-value: 3.25e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  53 RVIVHVDLDCFYAQVEMISNPELKDKPL---GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYRE 129
Cdd:PRK14133   3 RVIIHVDMDAFFASVEQMDNPKLKGKPVivgGISERGVVSTCSYEARKYGVHSAMPVFMAKKRCPHGIFLPVR-HERYKE 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 130 MSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsghvynnqsinlldvlhirllvGSQIAAEMR 209
Cdd:PRK14133  82 VSKNIFKILYEVTPIVEPVSIDEAYLDITNIKEE-------------------------------------PIKIAKYIK 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 210 EAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQTF 289
Cdd:PRK14133 125 KKVKKETGLTLSVGISYNKFLAKLASDWNKPDGIKIITEDMIPDILKPLP-ISKVHGIGKKSVEKLNNIGIYTIEDLLKL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 290 SPKILEK---ELGISVAQRIQklsfGEDNSPVILSGPPQSFSEEDSFKKcssEVEAKNKIEELLASLLNRVCQDGRKPH- 365
Cdd:PRK14133 204 SREFLIEyfgKFGVEIYERIR----GIDYREVEVSRERKSIGKETTLKK---DTKDKEELKKYLKDFSNIISEELKKRNl 276

                        330
                 ....*....|....*..
gi 767998153 366 ---TVRLIIRRYSSEKH 379
Cdd:PRK14133 277 ygkTVTVKIKTSDFQTH 293
PRK02794 PRK02794
DNA polymerase IV; Provisional
 55-333 6.63e-36

DNA polymerase IV; Provisional


Pssm-ID: 179473 [Multi-domain]  Cd Length: 419  Bit Score: 136.60  E-value: 6.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  55 IVHVDLDCFYAQVEMISNPELKDKPL--GVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGeDLTRYREMSY 132
Cdd:PRK02794  38 IAHIDCDAFYASVEKRDNPELRDKPViiGGGKRGVVSTACYIARIHGVRSAMPMFKALKLCPDAVVIKP-DMEKYVRVGR 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 133 KVTELLEEFSPVVERLGFDENFVDL--TEmvekRLQqlqsDELSAVTVSghvynnqsinlldvlhiRLlvgsqiAAEMRE 210
Cdd:PRK02794 117 EVRAMMQALTPLVEPLSIDEAFLDLsgTE----RLH----GAPPAVVLA-----------------RF------ARRVER 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 211 amynQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSlNHIKEIPGIGYKTAKCLEALGINSVRDLQTFS 290
Cdd:PRK02794 166 ----EIGITVSVGLSYNKFLAKIASDLDKPRGFSVIGRAEALAFLAP-KPVGIIWGVGPATAARLARDGIRTIGDLQRAD 240

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|...
gi 767998153 291 PKILEKELGiSVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSF 333
Cdd:PRK02794 241 EADLMRRFG-SMGLRLWRLARGIDDRKVSPDREAKSVSAETTF 282
PolY_Pol_V_umuC cd01700
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ...
 58-397 1.12e-35

umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.


Pssm-ID: 176454 [Multi-domain]  Cd Length: 344  Bit Score: 134.21  E-value: 1.12e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  58 VDLDCFYAQVEMISNPELKDKPLGVqqkyL------VVTCNYEARKLGVKKLMNVRDAKEKCPQL-VLVNGEDLTRYREM 130
Cdd:cd01700    3 VDCNSFYASCERVFRPLLLGRPLVV----LsnndgcVIARSPEAKALGIKMGSPYFKVPDLLERHgVAVFSSNYALYGDM 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 131 SYKVTELLEEFSPVVERLGFDENFVDLTemvekrlqqlqsdelsavtvsgHVYNNQSINlldvlhirllvgsQIAAEMRE 210
Cdd:cd01700   79 SRRIMSILERFSPDVEVYSIDESFLDLT----------------------GSLRFGDLE-------------ELARKIRR 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 211 AMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQT----VLLPESCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:cd01700  124 RILQETGIPVTVGIGPTKTLAKLANDLAKKKNPYggvvDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDL 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 287 QTFSPKILEKELGIsVAQRIQKLSFGEDNSPVILSGPP-QSFSEEDSFKKcssEVEAKNKIEELLASLLNRVC----QDG 361
Cdd:cd01700  204 AQADPDLLRKKFGV-VGERLVRELNGIDCLPLEEYPPPkKSIGSSRSFGR---DVTDLDELKQALAEYAERAAeklrRQK 279

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 767998153 362 RKPHTVRLIIR--RYSSEKHYGRESRQCPIPSHVIQKL 397
Cdd:cd01700  280 SVARTISVFIGtsGFSRQPKYYSATNTLPYPTNDTREI 317
PRK03103 PRK03103
DNA polymerase IV; Reviewed
 53-427 4.49e-35

DNA polymerase IV; Reviewed


Pssm-ID: 235104 [Multi-domain]  Cd Length: 409  Bit Score: 134.36  E-value: 4.49e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV-----QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRY 127
Cdd:PRK03103   3 RVILLVDMQSFYASVEKAANPELKGRPVIVsgdpeRRSGVVLAACPLAKAYGVKTAERLWEAQQKCPDLVVVKPR-MQRY 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 128 REMSYKVTELLEEFSPVVERLGFDENFVDLTemvekrlqqlqsdelsavtvsghvynnqsinlldvlHIRLLVGS--QIA 205
Cdd:PRK03103  82 IDVSLQITRILEDFTDLVEPFSIDEQFLDVT------------------------------------GSQKLFGSplEIA 125

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 206 AEMREAMYNQLGLTGCAGVASNKLLAKLVSGVF---KPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINS 282
Cdd:PRK03103 126 QKIQQRIMRETGVYARVGIGPNKLLAKMACDNFakkNPDGLFTLDKEDVPADLWPLP-VRKLFGVGSRMEKHLRRMGIRT 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 283 VRDLQTFSPKILEKELGIsVAQRIQKLSFGEDNSPVilsgPPQSFSEEDSFKKCSS---EVEAKNKIEELLASLLNRVCQ 359
Cdd:PRK03103 205 IGQLANTPLERLKKRWGI-NGEVLWRTANGIDYSPV----TPHSLDRQKAIGHQMTlprDYRGFEEIKVVLLELCEEVCR 279

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 360 DGRKPH----TVRLIIRrySSEKHYGRE-SRQCPIPSHV----------------------IQKLG---TGLQSPDFCAS 409
Cdd:PRK03103 280 RARAKGymgrTVSVSLR--GADFDWPTGfSRQMTLPEPTnlamevyeaacklfhrhwdgkpVRRVGvtlSNLVSDDVWQL 357

                        410
                 ....*....|....*...
gi 767998153 410 SLMQRRleDKLVKLEGVF 427
Cdd:PRK03103 358 SLFGDR--ERKRSLGYVM 373
PRK03858 PRK03858
DNA polymerase IV; Validated
 55-318 5.08e-35

DNA polymerase IV; Validated


Pssm-ID: 179663 [Multi-domain]  Cd Length: 396  Bit Score: 133.96  E-value: 5.08e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  55 IVHVDLDCFYAQVEMISNPELKDKPL----GVqqkylVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEdLTRYREM 130
Cdd:PRK03858   6 ILHADLDSFYASVEQRDDPALRGRPVivggGV-----VLAASYEAKAYGVRTAMGGRQARRLCPQAVVVPPR-MSAYSRA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 131 SYKVTELLEEFSPVVERLGFDENFVDltemvekrlqqlqsdelsavtVSGhvynnqsinlldvlhIRLLVG--SQIAAEM 208
Cdd:PRK03858  80 SKAVFEVFRDTTPLVEGLSIDEAFLD---------------------VGG---------------LRRISGtpVQIAARL 123

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 209 REAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQT 288
Cdd:PRK03858 124 RRRVREEVGLPITVGVARTKFLAKVASQVAKPDGLLVVPPDRELAFLHPLP-VRRLWGVGPVTAAKLRAHGITTVGDVAE 202

                        250       260       270
                 ....*....|....*....|....*....|
gi 767998153 289 FSPKILEKELGISVAQRIQKLSFGEDNSPV 318
Cdd:PRK03858 203 LPESALVSLLGPAAGRHLHALAHNRDPRRV 232
PRK01216 PRK01216
DNA polymerase IV; Validated
 54-318 1.05e-34

DNA polymerase IV; Validated


Pssm-ID: 179251 [Multi-domain]  Cd Length: 351  Bit Score: 131.84  E-value: 1.05e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  54 VIVHVDLDCFYAQVEMISNPELKDKPLGV-------QQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNGEDLTr 126
Cdd:PRK01216   2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVcvysgrfEDSGAVATANYEARKLGIKAGMPIVEAKKILPNAVYLPMRKEV- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 127 YREMSYKVTELLEEFSPVVERLGFDENFVDLTEMVEKrlqqlqsdelsavtvsghvyNNQSINLldvlhirllvgsqiAA 206
Cdd:PRK01216  81 YQQVSNRIMKLLREYSEKIEIASIDEAYLDISDKVKN--------------------YQDAYNL--------------GL 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 207 EMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:PRK01216 127 EIKNKILEKEKITVTVGISKNKVFAKIAADMAKPNGIKVIDDEEVKRFINELD-IADIPGIGDITAEKLKKLGVNKLVDT 205

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767998153 287 QTFSPKILEKELGISVAQRIQKLSFGEDNSPV 318
Cdd:PRK01216 206 LRIEFDELKGIIGEAKAKYLFSLARNEYNEPV 237
PRK03352 PRK03352
DNA polymerase IV; Validated
 53-372 4.77e-33

DNA polymerase IV; Validated


Pssm-ID: 179564 [Multi-domain]  Cd Length: 346  Bit Score: 127.45  E-value: 4.77e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  53 RVIVHVDLDCFYAQVEMISNPELKDKPLGV------QQKYLVVTC-NYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLT 125
Cdd:PRK03352   5 RWVLHVDLDQFIAAVELLRRPELAGLPVIVggngdpTEPRKVVTCaSYEARAFGVRAGMPLRTAARRCPDAVFLP-SDPA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 126 RYREMSYKVTELLEEFSPVVERLGFDENFVdltemvekrlqqlqsdelsAVTVSGHVynnqsinlldvlhirllvgsQIA 205
Cdd:PRK03352  84 AYDAASEEVMATLRDLGVPVEVWGWDEAFL-------------------GVDTDDPE--------------------ALA 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 206 AEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRD 285
Cdd:PRK03352 125 EEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKPAGVFRLTDANWMAVMGDRP-TDALWGVGPKTAKRLAALGITTVAD 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 286 LQTFSPKILEKELGISVAQRIQKLSFGEDNSPVIlSGP--PQSFSEEDSFKK---CSSEVEAknKIEELLASLLNRVCQD 360
Cdd:PRK03352 204 LAAADPAELAATFGPTTGPWLLLLARGGGDTEVS-AEPwvPRSRSREVTFPQdltDRAEVES--AVRELARRVLDEVVAE 280

                        330
                 ....*....|..
gi 767998153 361 GRKPHTVRLIIR 372
Cdd:PRK03352 281 GRPVTRVAVKVR 292
PTZ00205 PTZ00205
DNA polymerase kappa; Provisional
 56-379 8.92e-21

DNA polymerase kappa; Provisional


Pssm-ID: 140232 [Multi-domain]  Cd Length: 571  Bit Score: 94.70  E-value: 8.92e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  56 VHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVT 135
Cdd:PTZ00205 136 IHLDMDMFYAAVEIKKHPEYAAIPLAIGTMTMLQTANYVARGRGIRQGMPGFLALKICPNLLILP-PDFDAYNEESNTVR 214

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 136 ELLEEFSPVVERLGFDENFVDLTEMVEkRLQQLQSDElsavtvsghvynnqsinlldvlhirllvgsQIAAEMREAMYNQ 215
Cdd:PTZ00205 215 RIVAEYDPNYISFGLDELTLEVSAYIE-RFEGTKTAE------------------------------DVASELRVRVFGE 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 216 LGLTGCAGVASNKLLAKLVSGVFKPNQQTVL---LPESCQHLIHSLNhIKEIPGIGYKTAKCLEALGINSVRDLQT---- 288
Cdd:PTZ00205 264 TKLTASAGIGPTAALAKIASNINKPNGQHDLnlhTRGDVMTYVRDLG-LRSVPGVGKVTEALLKGLGITTLSDIYNrrve 342

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 289 ----FSPKILEKELGISVAqrIQKL-----SFGEDNSPVILSGPPQSFSEEDSFKKcsseVEAKNKIEELLASLLNRVCQ 359
Cdd:PTZ00205 343 lcyiLHNNLFRFLLGASIG--IMQWpdaatAANTENCEGATGGQRKAISSERSFTT----PRTKEGLQEMVDTVFNGAYE 416

                        330       340
                 ....*....|....*....|....
gi 767998153 360 DGRKPH----TVRLIIrRYSSEKH 379
Cdd:PTZ00205 417 EMRKSElmcrQISLTI-RWASYRY 439
umuC PRK03609
translesion error-prone DNA polymerase V subunit UmuC;
57-313 6.44e-17

translesion error-prone DNA polymerase V subunit UmuC;


Pssm-ID: 179607 [Multi-domain]  Cd Length: 422  Bit Score: 82.12  E-value: 6.44e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  57 HVDLDCFYAQVEMISNPELKDKPLGV--QQKYLVVTCNYEARKLGVK---KLMNVRDAKEKCPQLVLVNGEDLtrYREMS 131
Cdd:PRK03609   4 LCDVNSFYASCETVFRPDLRGKPVVVlsNNDGCVIARSAEAKALGIKmgdPWFKQKDLFRRCGVVCFSSNYEL--YADMS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 132 YKVTELLEEFSPVVERLGFDENFVDLTemvekrlqqlqsdelsavtvsghvynnqsinllDVLHIRLLvgSQIAAEMREA 211
Cdd:PRK03609  82 NRVMSTLEELSPRVEIYSIDEAFCDLT---------------------------------GVRNCRDL--TDFGREIRAT 126

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 212 MYNQLGLTGCAGVASNKLLAKLVSGVFKP-NQQT---VLL--PESCQHLIhSLNHIKEIPGIGYKTAKCLEALGINSVRD 285
Cdd:PRK03609 127 VLQRTHLTVGVGIAQTKTLAKLANHAAKKwQRQTggvVDLsnLERQRKLL-SLQPVEEVWGVGRRISKKLNAMGIKTALD 205

                        250       260
                 ....*....|....*....|....*...
gi 767998153 286 LQTFSPKILEKELGISVAQRIQKLSfGE 313
Cdd:PRK03609 206 LADTNIRFIRKHFNVVLERTVRELR-GE 232
PolY_like cd03468
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ...
 73-328 1.23e-07

DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.


Pssm-ID: 176458 [Multi-domain]  Cd Length: 335  Bit Score: 53.15  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  73 PELKDKPLGV--QQKYLVVT-CNYEARKLGVKKLMNVRDAKEKCPQLVLVNgEDLTRYREMSYKVTELLEEFSPVVERLG 149
Cdd:cd03468   18 PADDEAPLAVveRKKAGRILaCNAAARAAGVRPGMPLAEALALCPNLQVVE-YDPEADARALQELALWLLRFTPLVALDG 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 150 FDENFVDltemvekrlqqlqsdelsaVTVSGHVYNNQsINLLDVLHIRLLVgsqiaaemreamynqLGLTGCAGVASNKL 229
Cdd:cd03468   97 PDGLLLD-------------------VTGCLHLFGGE-DALAASLRAALAT---------------LGLSARAGIADTPG 141

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153 230 LAKLVSgvFKPNQQTVLLPESCQHLIHSLNH-IKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGISVAQRIQK 308
Cdd:cd03468  142 AAWLLA--RAGGGRGVLRREALAAALVLLAPlPVAALRLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQ 219

                        250       260
                 ....*....|....*....|
gi 767998153 309 LsFGEDNSPVILSGPPQSFS 328
Cdd:cd03468  220 A-YGRDPEPLLFSPPPPAFD 238
TIGR03491 TIGR03491
RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family ...
 260-325 1.26e-04

RecB family nuclease, putative, TM0106 family; Members of this uncharacterized protein family are found broadly but sporadically among bacteria. The N-terminal region is homologous to the Cas4 protein of CRISPR systems, although this protein family shows no signs of association with CRISPR repeats.


Pssm-ID: 274603 [Multi-domain]  Cd Length: 457  Bit Score: 44.24  E-value: 1.26e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767998153  260 HIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRIQK--LSFGEdNSPVILSGPPQ 325
Cdd:TIGR03491 208 HLSLVPGIGPSRYRLLQELGIHTLEDLAAADPNDLEDfgEQGLGVAEQLVQqaRAQLE-GRPILLAPPKA 276
IMS_HHH pfam11798
IMS family HHH motif; These proteins are involved in UV protection, eg.
 248-280 1.87e-04

IMS family HHH motif; These proteins are involved in UV protection, eg.


Pssm-ID: 432081 [Multi-domain]  Cd Length: 32  Bit Score: 38.53  E-value: 1.87e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767998153  248 PESCQHLIHSLNhIKEIPGIGYKTAKCLEALGI 280
Cdd:pfam11798   1 PDDVPEFLWPLP-ISKIPGIGKKLAEKLKALGI 32
IMS_C pfam11799
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
 324-393 2.86e-04

impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).


Pssm-ID: 463354 [Multi-domain]  Cd Length: 104  Bit Score: 39.85  E-value: 2.86e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767998153  324 PQSFSEEDSF-KKCSSEVEAKNKIEELLASLLNRVCQDGRKPHTVRLIIRRYssekHYGRESRQCPIPSHV 393
Cdd:pfam11799   1 RKSIGAERTFgRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYS----DFRTITRSVTLPSPT 67
radA PRK04301
DNA repair and recombination protein RadA; Validated
 261-308 2.52e-03

DNA repair and recombination protein RadA; Validated


Pssm-ID: 235273 [Multi-domain]  Cd Length: 317  Bit Score: 39.86  E-value: 2.52e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 767998153 261 IKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELGIS--VAQRIQK 308
Cdd:PRK04301   8 LEDLPGVGPATAEKLREAGYDTVEAIAVASPKELSEAAGIGesTAAKIIE 57
HHH_5 pfam14520
Helix-hairpin-helix domain;
263-306 2.67e-03

Helix-hairpin-helix domain;


Pssm-ID: 434010 [Multi-domain]  Cd Length: 57  Bit Score: 35.93  E-value: 2.67e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767998153  263 EIPGIGYKTAKCLEALGINSVRDLQTFSPKILEK--ELGISVAQRI 306
Cdd:pfam14520   6 SISGIGPKTALALLSAGIGTVEDLAEADVDELAEipGIGEKTAQRI 51
RecG COG1200
RecG-like helicase [Replication, recombination and repair];
261-286 5.43e-03

RecG-like helicase [Replication, recombination and repair];


Pssm-ID: 440813 [Multi-domain]  Cd Length: 684  Bit Score: 39.26  E-value: 5.43e-03
                         10        20
                 ....*....|....*....|....*.
gi 767998153 261 IKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:COG1200    8 LTYLKGVGPKRAKLLAKLGIRTVGDL 33
PRK10917 PRK10917
ATP-dependent DNA helicase RecG; Provisional
 261-286 6.07e-03

ATP-dependent DNA helicase RecG; Provisional


Pssm-ID: 236794 [Multi-domain]  Cd Length: 681  Bit Score: 38.98  E-value: 6.07e-03
                         10        20
                 ....*....|....*....|....*.
gi 767998153 261 IKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:PRK10917  11 LTSLKGVGPKTAEKLAKLGIHTVQDL 36
Cdd1 pfam11731
Pathogenicity locus; Cdd1 is expressed as part of the pathogenicity locus operon in several ...
 255-286 6.44e-03

Pathogenicity locus; Cdd1 is expressed as part of the pathogenicity locus operon in several different orders of bacteria. Many members of the family are annotated as being putative mitomycin resistance proteins but this could not be confirmed.


Pssm-ID: 463333 [Multi-domain]  Cd Length: 82  Bit Score: 35.66  E-value: 6.44e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 767998153  255 IHSLNHIKEIPGIGYKTAKCLEALGINSVRDL 286
Cdd:pfam11731   2 RDGLKELQDIPNIGPAIAEDLRLLGIRSPEEL 33
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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