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Conserved domains on  [gi|767997892|ref|XP_011524045|]
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nucleoporin SEH1 isoform X2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-299 1.66e-18

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---------LATGKLLR-TLTGHSGAVTSVAFSPD--GKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSriSKLI--------------EKMNRAHLYNFHIPSSR--AHSP-- 151
Cdd:COG2319  187 RLW------DLATGKLLRTLTGhTGAVRSVAFSPD--GKLLasgsadgtvrlwdlATGKLLRTLTGHSGSVRsvAFSPdg 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 152 -MIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLkpvrkel 228
Cdd:COG2319  259 rLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLWDL------- 317

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767997892 229 tSSGgptkfeiHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 299
Cdd:COG2319  318 -ATG-------KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-299 1.66e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---------LATGKLLR-TLTGHSGAVTSVAFSPD--GKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSriSKLI--------------EKMNRAHLYNFHIPSSR--AHSP-- 151
Cdd:COG2319  187 RLW------DLATGKLLRTLTGhTGAVRSVAFSPD--GKLLasgsadgtvrlwdlATGKLLRTLTGHSGSVRsvAFSPdg 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 152 -MIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLkpvrkel 228
Cdd:COG2319  259 rLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLWDL------- 317

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767997892 229 tSSGgptkfeiHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 299
Cdd:COG2319  318 -ATG-------KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-299 1.70e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSEsgdwhctaswKVKRTTLVDSRTSVTDVKFAPKHMglMLATCSADGIV 90
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----------GELLRTLKGHTGPVRDVAASADGT--YLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSRiskliekmnrahlynfhipssrahsPMIAVGSDDSSpnamakVQ 169
Cdd:cd00200   76 RLW------DLETGECVRTLTGhTSYVSSVAFSPDG-------------------------RILSSSSRDKT------IK 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 170 IFEYNENTRKYakaeTLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRIFTLKpvrkeltssggptkfEIHIVAQFDN 247
Cdd:cd00200  119 VWDVETGKCLT----TLRGHTDWVNSVAFSPDG----TFVASSSQDgtIKLWDLR---------------TGKCVATLTG 175

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767997892 248 HNSQVWRVSWNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVNG 299
Cdd:cd00200  176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---LSTGKCLGTLRGHENGVNS 224
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-277 1.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767997892   242 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 277
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
242-276 7.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767997892  242 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
11-299 1.66e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 86.50  E-value: 1.66e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRtTLVDSRTSVTDVKFAPKhmGLMLATCSADGIV 90
Cdd:COG2319  119 HTGAVRSVAFSPDGKTLASGSADGTVRLWD---------LATGKLLR-TLTGHSGAVTSVAFSPD--GKLLASGSDDGTV 186

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSriSKLI--------------EKMNRAHLYNFHIPSSR--AHSP-- 151
Cdd:COG2319  187 RLW------DLATGKLLRTLTGhTGAVRSVAFSPD--GKLLasgsadgtvrlwdlATGKLLRTLTGHSGSVRsvAFSPdg 258

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 152 -MIAVGSDDSSpnamakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLkpvrkel 228
Cdd:COG2319  259 rLLASGSADGT------VRLW----DLATGELLRTLTGHSGGVNSVAFSPD-GK---LLASGSDDgtVRLWDL------- 317

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767997892 229 tSSGgptkfeiHIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 299
Cdd:COG2319  318 -ATG-------KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---ATGELLRTLTGHTGAVTS 377
WD40 COG2319
WD40 repeat [General function prediction only];
11-279 1.18e-17

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 83.81  E-value: 1.18e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVkRTTLVDSRTSVTDVKFAPKhmGLMLATCSADGIV 90
Cdd:COG2319  203 HTGAVRSVAFSPDGKLLASGSADGTVRLWD---------LATGKL-LRTLTGHSGSVRSVAFSPD--GRLLASGSADGTV 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEiscklscscISWNPSRISKLiekmnrahlynfhipssrAHSP---MIAVGSDDSSpnamak 167
Cdd:COG2319  271 RLW------DLATGELLRT---------LTGHSGGVNSV------------------AFSPdgkLLASGSDDGT------ 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 168 VQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeihIVAQF 245
Cdd:COG2319  312 VRLW----DLATGKLLRTLTGHTGAVRSVAFSPD-GK---TLASGSDDgtVRLWDLATGE---------------LLRTL 368

                        250       260       270
                 ....*....|....*....|....*....|....
gi 767997892 246 DNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAN 279
Cdd:COG2319  369 TGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
4-299 9.01e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.41  E-value: 9.01e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892   4 ARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSESGDwhctaswkvkRTTLVDSRTSVTDVKFAPKhmGLMLAT 83
Cdd:COG2319   70 LLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLL----------LRTLTGHTGAVRSVAFSPD--GKTLAS 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  84 CSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSp 162
Cdd:COG2319  138 GSADGTVRLW------DLATGKLLRTLTGhSGAVTSVAFSPD-------------------------GKLLASGSDDGT- 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 163 namakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLKPVRkeltssggptkfeih 240
Cdd:COG2319  186 -----VRLW----DLATGKLLRTLTGHTGAVRSVAFSPD-GK---LLASGSADgtVRLWDLATGK--------------- 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767997892 241 IVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 299
Cdd:COG2319  238 LLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDL---ATGELLRTLTGHSGGVNS 293
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-299 1.70e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 73.14  E-value: 1.70e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDKSEsgdwhctaswKVKRTTLVDSRTSVTDVKFAPKHMglMLATCSADGIV 90
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGDGTIKVWDLET----------GELLRTLKGHTGPVRDVAASADGT--YLASGSSDKTI 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  91 RIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSRiskliekmnrahlynfhipssrahsPMIAVGSDDSSpnamakVQ 169
Cdd:cd00200   76 RLW------DLETGECVRTLTGhTSYVSSVAFSPDG-------------------------RILSSSSRDKT------IK 118

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 170 IFEYNENTRKYakaeTLMTVTDPVHDIAFAPNLgrsfHILAIATKD--VRIFTLKpvrkeltssggptkfEIHIVAQFDN 247
Cdd:cd00200  119 VWDVETGKCLT----TLRGHTDWVNSVAFSPDG----TFVASSSQDgtIKLWDLR---------------TGKCVATLTG 175

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767997892 248 HNSQVWRVSWNITGTVLASSGDDGCVRLWKanyMDNWKCTGILKGNGSPVNG 299
Cdd:cd00200  176 HTGEVNSVAFSPDGEKLLSSSSDGTIKLWD---LSTGKCLGTLRGHENGVNS 224
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 11-277 1.16e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 67.75  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDK---------------------SESGDWHCTAS-------WKVK----RT 58
Cdd:cd00200   50 HTGPVRDVAASADGTYLASGSSDKTIRLWDLetgecvrtltghtsyvssvafSPDGRILSSSSrdktikvWDVEtgkcLT 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  59 TLVDSRTSVTDVKFAPKHMglMLATCSADGIVRIYeapdvmNLSQWSLQHEISC-KLSCSCISWNPSriskliekmnrah 137
Cdd:cd00200  130 TLRGHTDWVNSVAFSPDGT--FVASSSQDGTIKLW------DLRTGKCVATLTGhTGEVNSVAFSPD------------- 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 138 lynfhipssrahSPMIAVGSDDSSpnamakVQIFEynenTRKYAKAETLMTVTDPVHDIAFAPNLgrsfHILAIATKD-- 215
Cdd:cd00200  189 ------------GEKLLSSSSDGT------IKLWD----LSTGKCLGTLRGHENGVNSVAFSPDG----YLLASGSEDgt 242

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767997892 216 VRIFTLKPVRkeltssggptkfeihIVAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 277
Cdd:cd00200  243 IRVWDLRTGE---------------CVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
4-299 5.50e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 60.70  E-value: 5.50e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892   4 ARSIAADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhctASWKVKRTTLVDSRTSVTDVKFAPKhmGLMLAT 83
Cdd:COG2319   28 LLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLD----------AAAGALLATLLGHTAAVLSVAFSPD--GRLLAS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  84 CSADGIVRIYEAPDVMNLSQWSLQHEiscklSCSCISWNPSriskliekmnrahlynfhipssrahSPMIAVGSDDSSpn 163
Cdd:COG2319   96 ASADGTVRLWDLATGLLLRTLTGHTG-----AVRSVAFSPD-------------------------GKTLASGSADGT-- 143

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892 164 amakVQIFeyneNTRKYAKAETLMTVTDPVHDIAFAPNlGRsfhILAIATKD--VRIFTLKpvrkeltsSGGPtkfeihi 241
Cdd:COG2319  144 ----VRLW----DLATGKLLRTLTGHSGAVTSVAFSPD-GK---LLASGSDDgtVRLWDLA--------TGKL------- 196

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 767997892 242 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWKAnymDNWKCTGILKGNGSPVNG 299
Cdd:COG2319  197 LRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDL---ATGKLLRTLTGHSGSVRS 251
WD40 COG2319
WD40 repeat [General function prediction only];
11-97 3.28e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.92  E-value: 3.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRTtLVDSRTSVTDVKFAPKhmGLMLATCSADGIV 90
Cdd:COG2319  329 HTGAVRSVAFSPDGKTLASGSDDGTVRLWD---------LATGELLRT-LTGHTGAVTSVAFSPD--GRTLASGSADGTV 396


                 ....*..
gi 767997892  91 RIYEAPD 97
Cdd:COG2319  397 RLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
9-97 7.17e-08

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 54.15  E-value: 7.17e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892   9 ADHKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRtTLVDSRTSVTDVKFAPKhmGLMLATCSADG 88
Cdd:COG2319  285 TGHSGGVNSVAFSPDGKLLASGSDDGTVRLWD---------LATGKLLR-TLTGHTGAVRSVAFSPD--GKTLASGSDDG 352


                 ....*....
gi 767997892  89 IVRIYEAPD 97
Cdd:COG2319  353 TVRLWDLAT 361
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 10-125 4.24e-07

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 51.18  E-value: 4.24e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767997892  10 DHKDLIHDVSFDFHGRRMATCSSDQSVKVWDksesgdwhcTASWKVKRtTLVDSRTSVTDVKFAPKhmGLMLATCSADGI 89
Cdd:cd00200  133 GHTDWVNSVAFSPDGTFVASSSQDGTIKLWD---------LRTGKCVA-TLTGHTGEVNSVAFSPD--GEKLLSSSSDGT 200

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 767997892  90 VRIYeapdvmNLSQWSLQHEISCKL-SCSCISWNPSR 125
Cdd:cd00200  201 IKLW------DLSTGKCLGTLRGHEnGVNSVAFSPDG 231
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 242-277 1.90e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.90e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 767997892   242 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLWK 277
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 11-40 6.69e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.69e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 767997892    11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
242-276 7.65e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 7.65e-05
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 767997892  242 VAQFDNHNSQVWRVSWNITGTVLASSGDDGCVRLW 276
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
11-40 1.91e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.91e-04
                          10        20        30
                  ....*....|....*....|....*....|
gi 767997892   11 HKDLIHDVSFDFHGRRMATCSSDQSVKVWD 40
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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