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Conserved domains on  [gi|767995962|ref|XP_011523576|]
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ATPase family AAA domain-containing protein 5 isoform X8 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK04195 super family cl35251
replication factor C large subunit; Provisional
 214-330 8.14e-15

replication factor C large subunit; Provisional


The actual alignment was detected with superfamily member PRK04195:

Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 78.42  E-value: 8.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962  214 DMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRraeleerqnlkgkrdekhedfsgGIDFKgssddeeesrlcnTVLI 293
Cdd:PRK04195    1 MMPWVEKYRPKTLSDVVGNEKAKEQLREWIESWLK-----------------------GKPKK-------------ALLL 44

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767995962  294 TGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI 330
Cdd:PRK04195   45 YGPPGVGKTSLAHALANDYGWEVIELNASDQRTADVI 81
 
Name Accession Description Interval E-value
PRK04195 PRK04195
replication factor C large subunit; Provisional
 214-330 8.14e-15

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 78.42  E-value: 8.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962  214 DMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRraeleerqnlkgkrdekhedfsgGIDFKgssddeeesrlcnTVLI 293
Cdd:PRK04195    1 MMPWVEKYRPKTLSDVVGNEKAKEQLREWIESWLK-----------------------GKPKK-------------ALLL 44

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767995962  294 TGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI 330
Cdd:PRK04195   45 YGPPGVGKTSLAHALANDYGWEVIELNASDQRTADVI 81
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 291-336 1.06e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 48.74  E-value: 1.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767995962   291 VLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSG---------RQILSQLKE 336
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgesekrlRELFEAAKK 55
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 168-326 1.94e-05

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 48.41  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962   168 NSKSKRKKpneYSKNLEKTNRKSEELSKRNNSsGIKLDSSKDSGTEdmLWTEKYQPQTASELIGNELAIKKLHSWLKdwk 247
Cdd:TIGR00602   31 PTSSHRRK---NSPSTDIHARKRGFLSLEQDT-GLELSSENLDGNE--PWVEKYKPETQHELAVHKKKIEEVETWLK--- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962   248 rrAELEERQNLKgkrdekhedfsggidfkgssddeeesrlcnTVLITGPTGVGKTAAVYACAQELGFKIFE-VNASSQRS 326
Cdd:TIGR00602  102 --AQVLENAPKR------------------------------ILLITGPSGCGKSTTIKILSKELGIQVQEwSNPTLPDF 149
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 289-323 4.74e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 44.44  E-value: 4.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767995962  289 NTVLITGPTGVGKTAAVYACAQEL---GFKIFEVNASS 323
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASD 57
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
289-348 1.24e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.53  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962  289 NTVLITGPTGVGKTAAV---------YACAQELGFKIFEVNASSQRSGRQILSQL-KEATQSHQVDKQGV 348
Cdd:COG1474    52 SNVLIYGPTGTGKTAVAkyvleeleeEAEERGVDVRVVYVNCRQASTRYRVLSRIlEELGSGEDIPSTGL 121
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 289-327 1.73e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 1.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767995962    289 NTVLITGPTGVGKTAAVYACAQEL---GFKIFEVNASSQRSG 327
Cdd:smart00382    3 EVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEE 44
 
Name Accession Description Interval E-value
PRK04195 PRK04195
replication factor C large subunit; Provisional
 214-330 8.14e-15

replication factor C large subunit; Provisional


Pssm-ID: 235250 [Multi-domain]  Cd Length: 482  Bit Score: 78.42  E-value: 8.14e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962  214 DMLWTEKYQPQTASELIGNELAIKKLHSWLKDWKRraeleerqnlkgkrdekhedfsgGIDFKgssddeeesrlcnTVLI 293
Cdd:PRK04195    1 MMPWVEKYRPKTLSDVVGNEKAKEQLREWIESWLK-----------------------GKPKK-------------ALLL 44

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767995962  294 TGPTGVGKTAAVYACAQELGFKIFEVNASSQRSGRQI 330
Cdd:PRK04195   45 YGPPGVGKTSLAHALANDYGWEVIELNASDQRTADVI 81
AAA pfam00004
ATPase family associated with various cellular activities (AAA); AAA family proteins often ...
 291-336 1.06e-06

ATPase family associated with various cellular activities (AAA); AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes.


Pssm-ID: 459627 [Multi-domain]  Cd Length: 130  Bit Score: 48.74  E-value: 1.06e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 767995962   291 VLITGPTGVGKTAAVYACAQELGFKIFEVNASSQRSG---------RQILSQLKE 336
Cdd:pfam00004    1 LLLYGPPGTGKTTLAKAVAKELGAPFIEISGSELVSKyvgesekrlRELFEAAKK 55
rad24 TIGR00602
checkpoint protein rad24; All proteins in this family for which functions are known are ...
 168-326 1.94e-05

checkpoint protein rad24; All proteins in this family for which functions are known are involved in DNA damage tolerance (likely cell cycle checkpoints).This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129690 [Multi-domain]  Cd Length: 637  Bit Score: 48.41  E-value: 1.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962   168 NSKSKRKKpneYSKNLEKTNRKSEELSKRNNSsGIKLDSSKDSGTEdmLWTEKYQPQTASELIGNELAIKKLHSWLKdwk 247
Cdd:TIGR00602   31 PTSSHRRK---NSPSTDIHARKRGFLSLEQDT-GLELSSENLDGNE--PWVEKYKPETQHELAVHKKKIEEVETWLK--- 101

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962   248 rrAELEERQNLKgkrdekhedfsggidfkgssddeeesrlcnTVLITGPTGVGKTAAVYACAQELGFKIFE-VNASSQRS 326
Cdd:TIGR00602  102 --AQVLENAPKR------------------------------ILLITGPSGCGKSTTIKILSKELGIQVQEwSNPTLPDF 149
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
 289-323 4.74e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 44.44  E-value: 4.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767995962  289 NTVLITGPTGVGKTAAVYACAQEL---GFKIFEVNASS 323
Cdd:cd00009    20 KNLLLYGPPGTGKTTLARAIANELfrpGAPFLYLNASD 57
CDC6 COG1474
Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];
289-348 1.24e-03

Cdc6-related protein, AAA superfamily ATPase [Replication, recombination and repair];


Pssm-ID: 441083 [Multi-domain]  Cd Length: 389  Bit Score: 42.53  E-value: 1.24e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767995962  289 NTVLITGPTGVGKTAAV---------YACAQELGFKIFEVNASSQRSGRQILSQL-KEATQSHQVDKQGV 348
Cdd:COG1474    52 SNVLIYGPTGTGKTAVAkyvleeleeEAEERGVDVRVVYVNCRQASTRYRVLSRIlEELGSGEDIPSTGL 121
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
 289-327 1.73e-03

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.05  E-value: 1.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|..
gi 767995962    289 NTVLITGPTGVGKTAAVYACAQEL---GFKIFEVNASSQRSG 327
Cdd:smart00382    3 EVILIVGPPGSGKTTLARALARELgppGGGVIYIDGEDILEE 44
SpoVK COG0464
AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle ...
 291-323 5.66e-03

AAA+-type ATPase, SpoVK/Ycf46/Vps4 family [Cell wall/membrane/envelope biogenesis, Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];


Pssm-ID: 440232 [Multi-domain]  Cd Length: 397  Bit Score: 40.28  E-value: 5.66e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767995962  291 VLITGPTGVGKTAAVYACAQELGFKIFEVNASS 323
Cdd:COG0464   194 LLLYGPPGTGKTLLARALAGELGLPLIEVDLSD 226
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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