NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767989822|ref|XP_011521346|]
View 

FH1/FH2 domain-containing protein 1 isoform X3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 647-1031 1.67e-80

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


:

Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 268.83  E-value: 1.67e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    647 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 718
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    719 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 797
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    798 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQVD-FeqlteNLG 872
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYgF-----KLS 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    873 QLER----RSRAAEESL-------------RSLAKHELAP-ALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLG 934
Cdd:smart00498  229 SLLKlsdvKSADNKTTLlhflvkiirkkylGGLSDPENLDdKFIEVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYG 308

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    935 YTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRERNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgp 1014
Cdd:smart00498  309 EDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEERRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE--- 377

                           410
                    ....*....|....*..
gi 767989822   1015 grgdADSHASMKSLLTS 1031
Cdd:smart00498  378 ----RDFLGVLDSLLEE 390
Formin_GBD_N super family cl39720
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 6.39e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


The actual alignment was detected with superfamily member pfam18382:

Pssm-ID: 465735  Cd Length: 119  Bit Score: 189.10  E-value: 6.39e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767989822    93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 super family cl33186
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.10e-07

104 kDa microneme/rhoptry antigen; Provisional


The actual alignment was detected with superfamily member PTZ00449:

Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449  530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449  605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767989822  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449  683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 647-1031 1.67e-80

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 268.83  E-value: 1.67e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    647 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 718
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    719 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 797
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    798 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQVD-FeqlteNLG 872
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYgF-----KLS 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    873 QLER----RSRAAEESL-------------RSLAKHELAP-ALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLG 934
Cdd:smart00498  229 SLLKlsdvKSADNKTTLlhflvkiirkkylGGLSDPENLDdKFIEVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYG 308

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    935 YTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRERNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgp 1014
Cdd:smart00498  309 EDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEERRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE--- 377

                           410
                    ....*....|....*..
gi 767989822   1015 grgdADSHASMKSLLTS 1031
Cdd:smart00498  378 ----RDFLGVLDSLLEE 390
FH2 pfam02181
Formin Homology 2 Domain;
642-960 4.10e-77

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 258.74  E-value: 4.10e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   642 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 713
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   714 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 792
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   793 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG------------- 859
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDgtrrgqakgfkls 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   860 ---------------------------------------------SQVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 893
Cdd:pfam02181  229 sllklsdtkstdnkttllhylvkiirekfpevldfsselshvkkaAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767989822   894 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 960
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 6.39e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 189.10  E-value: 6.39e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767989822    93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.10e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449  530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449  605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767989822  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449  683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
 
Name Accession Description Interval E-value
FH2 smart00498
Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, ...
 647-1031 1.67e-80

Formin Homology 2 Domain; FH proteins control rearrangements of the actin cytoskeleton, especially in the context of cytokinesis and cell polarisation. Members of this family have been found to interact with Rho-GTPases, profilin and other actin-assoziated proteins. These interactions are mediated by the proline-rich FH1 domain, usually located in front of FH2 (but not listed in SMART). Despite this cytosolic function, vertebrate formins have been assigned functions within the nucleus. A set of Formin-Binding Proteins (FBPs) has been shown to bind FH1 with their WW domain.


Pssm-ID: 214697 [Multi-domain]  Cd Length: 392  Bit Score: 268.83  E-value: 1.67e-80
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    647 PTKRKTVKLFWRELKLAGghgvsasrfgPCATLWASLDPVS-VDTARLEHLFESRAKEVLPSKKAGEGR-------RTMT 718
Cdd:smart00498    5 KPKKKLKPLHWDKLNPSD----------LSGTVWDKIDEESeGDLDELEELFSAKEKTKSASKDVSEKKsilkkkaSQEF 74

                            90       100       110       120       130       140       150       160
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    719 TVLDPKRSNAINIGLTTLP-PVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPdIPLGPAENFLMTL 797
Cdd:smart00498   75 KILDPKRSQNLAILLRKLHmSYEEIKEAILEGDEDVLSVDLLEQLLKYAPTKEELKKLREYKEEDP-EELARAEQFLLLI 153

                           170       180       190       200       210       220       230       240
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    798 ASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG----SQVD-FeqlteNLG 872
Cdd:smart00498  154 SNIPYLEERLNALLFKANFEEEVEDLKPQIEKVEAACEELRESKKFRKLLELILAIGNYMNGgsrrGQAYgF-----KLS 228

                           250       260       270       280       290       300       310       320
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    873 QLER----RSRAAEESL-------------RSLAKHELAP-ALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLG 934
Cdd:smart00498  229 SLLKlsdvKSADNKTTLlhflvkiirkkylGGLSDPENLDdKFIEVMKPFLKAAKEKYDKLQKDLSDLKTRFEKLVEYYG 308

                           330       340       350       360       370       380       390       400
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    935 YTPQaarEVRIMQFCHTLREFALEYRTCRErvlQQQQKQATYRERNKTRGRMITETEKFSGVAGEapSNPSVPVAVSsgp 1014
Cdd:smart00498  309 EDPK---DTSPEEFFKDFNEFLKEFSKAAE---ENIKKEEEEEERRKKLVKETTEYEQSSSRQKE--RNPSMDFEVE--- 377

                           410
                    ....*....|....*..
gi 767989822   1015 grgdADSHASMKSLLTS 1031
Cdd:smart00498  378 ----RDFLGVLDSLLEE 390
FH2 pfam02181
Formin Homology 2 Domain;
642-960 4.10e-77

Formin Homology 2 Domain;


Pssm-ID: 396655  Cd Length: 372  Bit Score: 258.74  E-value: 4.10e-77
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   642 DSSALPTKRKTVKLFWRELKLAGGHGvsasrfgpcaTLWASLDPVS----VDTARLEHLFESRAKEVLPSK----KAGEG 713
Cdd:pfam02181    1 PKKTPKPKKKLKPLHWDKVRPSQDRG----------TVWDKLDDESfeldGDLSELEELFSAKAKTKKNKKsedkSSSKK 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   714 RRTMTTVLDPKRSNAINIGLTTL-PPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIeeAQLANPDIPLGPAEN 792
Cdd:pfam02181   71 KPKEVSLLDPKRAQNIAILLRKLkLPPEEIIQAILEGDEDALDLELLENLLKMAPTKEELKKL--KEYKGDPSELGRAEQ 148

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   793 FLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNG------------- 859
Cdd:pfam02181  149 FLLELSKIPRLEARLRALLFKSTFEEEIEELKPSLEALEAASEELRNSRKFKKLLELILALGNYMNDgtrrgqakgfkls 228

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822   860 ---------------------------------------------SQVDFEQLTENLGQLERRSRAAEESLRSLAK-HEL 893
Cdd:pfam02181  229 sllklsdtkstdnkttllhylvkiirekfpevldfsselshvkkaAKVNLEQLEKDVKQLERGLKKLERELELSALdEHP 308

                          330       340       350       360       370       380
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767989822   894 APALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPqaaREVRIMQFCHTLREFALEYR 960
Cdd:pfam02181  309 DDKFREVLKEFLKSAEEKLDKLESLLREALELFKELVEYFGEDP---KETSPEEFFKILRDFLKEFK 372
Formin_GBD_N pfam18382
Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of ...
 17-135 6.39e-56

Formin N-terminal GTPase-binding domain; This is the N-terminal GTPase-binding domain (GBD) of formins also known as formin homology domain-containing proteins (FHOD) pfam02181. This GBD is recruited by Rac and Ras GTPases in cells and plays an essential role for FHOD1-mediated actin remodelling and transcriptional activation, localizes to specific GTPases in cells, and binds to GTPases in vitro. It exhibits structural similarity to the ubiquitin superfold as found, for example, in the Ras-binding domains of c-Raf1 or PI3 kinase, but contains an unusual loop that inserts into the first FH3 repeat.


Pssm-ID: 465735  Cd Length: 119  Bit Score: 189.10  E-value: 6.39e-56
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822    17 TVRVQYLEDTDPFAC-ANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQV---SPSGYYLDTELSLEEQR 92
Cdd:pfam18382    1 TCRVQYLNDTDPFACtSNFPEPTRPPTFTFNEDLPLSEQLAGVHRLLQAPHKLEDCALQVyrdGDYGNYLDLDSSLAEQR 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 767989822    93 EMLEGFYEEiskgRKPTLILRTQLSVRVNAILEKLYSSSGPEL 135
Cdd:pfam18382   81 EELEGFQED----RKNSLVLRTQLSVRVHAIIEKLLNSSGREL 119
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 337-553 9.10e-07

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 53.15  E-value: 9.10e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  337 EDGDIEEAPGAGGRRERRKP-SSEEGKRSRRSlegggCPARAPEPG--------PTGPASPVGPTSSTGPALLTGP--AS 405
Cdd:PTZ00449  530 EEGEHEDSKESDEPKEGGKPgETKEGEVGKKP-----GPAKEHKPSkiptlskkPEFPKDPKHPKDPEEPKKPKRPrsAQ 604

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  406 SPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKlHQTASVWAPESPPVPQSP--PGQAR--LEARFLENVAAAETEKq 481
Cdd:PTZ00449  605 RPTRPKSPKLPELLDIPKSPKRPESPKSPKRPPPP-QRPSSPERPEGPKIIKSPkpPKSPKppFDPKFKEKFYDDYLDA- 682

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767989822  482 valAQGRAETLAGAMPNEAGGHPDARQLwdsPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE 553
Cdd:PTZ00449  683 ---AAKSKETKTTVVLDESFESILKETL---PETPGTPFTTPRPLPPKLPRDEEFPFEPIGDPDAEQPDDIE 748
PHA03247 PHA03247
large tegument protein UL36; Provisional
 347-564 4.51e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 51.09  E-value: 4.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  347 AGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPAlltgPASSPVGPPSGLQASVNLFPTISV 426
Cdd:PHA03247 2581 AVTSRARRPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPS----PAANEPDPHPPPTVPPPERPRDDP 2656

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  427 APSADTSSERsiyklhqtasVWAPESPPVPQSPPGQARLEArflenvaaaetekqvalaqgrAETLAGAMPNEAGGHPDA 506
Cdd:PHA03247 2657 APGRVSRPRR----------ARRLGRAAQASSPPQRPRRRA---------------------ARPTVGSLTSLADPPPPP 2705

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 767989822  507 RqlwdSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPR 564
Cdd:PHA03247 2706 P----TPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPAR 2759
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
377-554 9.64e-06

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 49.85  E-value: 9.64e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  377 APEPGPTGPASPVGPTSSTGPALLtgPASSPVGPPSGLQASVNLFPTISVAPSAdTSSERSIYKLHQTASVWAPESPPVP 456
Cdd:PRK07003  357 AFEPAVTGGGAPGGGVPARVAGAV--PAPGARAAAAVGASAVPAVTAVTGAAGA-ALAPKAAAAAAATRAEAPPAAPAPP 433

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  457 QS-----------PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSP 525
Cdd:PRK07003  434 ATadrgddaadgdAPVPAKANARASADSRCDERDAQPPADSGSASAPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAP 513

                         170       180
                  ....*....|....*....|....*....
gi 767989822  526 APcvllrAQRSLAPEPKEPLIPASPKAEP 554
Cdd:PRK07003  514 AA-----ASREDAPAAAAPPAPEARPPTP 537
PRK07003 PRK07003
DNA polymerase III subunit gamma/tau;
342-526 5.05e-05

DNA polymerase III subunit gamma/tau;


Pssm-ID: 235906 [Multi-domain]  Cd Length: 830  Bit Score: 47.54  E-value: 5.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  342 EEAPGAGGRRERRKPSSEEGKRSR---RSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASV 418
Cdd:PRK07003  359 EPAVTGGGAPGGGVPARVAGAVPApgaRAAAAVGASAVPAVTAVTGAAGAALAPKAAAAAAATRAEAPPAAPAPPATADR 438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  419 NLFPTISVAPSADTSSERSIYKLHQTASVWAPESPPVPQS-PPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMP 497
Cdd:PRK07003  439 GDDAADGDAPVPAKANARASADSRCDERDAQPPADSGSASaPASDAPPDAAFEPAPRAAAPSAATPAAVPDARAPAAASR 518

                         170       180
                  ....*....|....*....|....*....
gi 767989822  498 NEAGGHPDARQLWDSPEtAPAARTPQSPA 526
Cdd:PRK07003  519 EDAPAAAAPPAPEARPP-TPAAAAPAARA 546
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 370-583 1.67e-04

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 45.75  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  370 GGGCPARAPEPGPTG-------PASPVGPTSSTGPAllTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLH 442
Cdd:PRK07764  593 GAAGGEGPPAPASSGppeeaarPAAPAAPAAPAAPA--PAGAAAAPAEASAAPAPGVAAPEHHPKHVAVPDASDGGDGWP 670

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  443 QTASVWAPESPPVPQSPPGQArlearflenvAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTP 522
Cdd:PRK07764  671 AKAGGAAPAAPPPAPAPAAPA----------APAGAAPAQPAPAPAATPPAGQADDPAAQPPQAAQGASAPSPAADDPVP 740

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 767989822  523 QSPAP---CVLLRAQRSLAPE--PKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDM 583
Cdd:PRK07764  741 LPPEPddpPDPAGAPAQPPPPpaPAPAAAPAAAPPPSPPSEEEEMAEDDAPSMDDEDRRDAEEVAM 806
PHA03378 PHA03378
EBNA-3B; Provisional
 344-561 2.50e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 45.44  E-value: 2.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  344 APGAGGRRE-RRKPSSEEGKRSRRSL-EGGGCPARAPEPGPTGPASPVGPTSST-GPALLTGPASSPVGPPSGLQASVNL 420
Cdd:PHA03378  589 APSYAQTPWpVPHPSQTPEPPTTQSHiPETSAPRQWPMPLRPIPMRPLRMQPITfNVLVFPTPHQPPQVEITPYKPTWTQ 668

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  421 FPTISVAPS-ADTSSERSIYKLHQTASVWA--------PESPPVPQSPPGQARLEARflENVAAAETEKQVALAQGRAET 491
Cdd:PHA03378  669 IGHIPYQPSpTGANTMLPIQWAPGTMQPPPraptpmrpPAAPPGRAQRPAAATGRAR--PPAAAPGRARPPAAAPGRARP 746

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 767989822  492 LAGAmPNEAGGHPDARQLWDSPETAPAARTPQSP---APCVLLRAQRSLAPEPKEPLIPAS----PKAEPIWELPTR 561
Cdd:PHA03378  747 PAAA-PGRARPPAAAPGRARPPAAAPGAPTPQPPpqaPPAPQQRPRGAPTPQPPPQAGPTSmqlmPRAAPGQQGPTK 822
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
398-571 2.76e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 45.25  E-value: 2.76e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  398 ALLTGPASSPVGPPSGLQASVNLFPTISVAPSAdtssersiyklhqtasvwAPESPPVPQSPPGQARLEARFLENVAAAE 477
Cdd:PRK12323  362 AFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAA------------------AAPAPAAPPAAPAAAPAAAAAARAVAAAP 423

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  478 TEKQVALaqgraETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAE--PI 555
Cdd:PRK12323  424 ARRSPAP-----EALAAARQASARGPGGAPAPAPAPAAAPAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDdpPP 498

                         170
                  ....*....|....*..
gi 767989822  556 WE-LPTRAPRLSIGDLD 571
Cdd:PRK12323  499 WEeLPPEFASPAPAQPD 515
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 386-563 1.09e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 43.15  E-value: 1.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  386 ASPVGPTSSTGPALLTGPASS-PV---GPPSGLQAsvnlfPTISVAPSADTSSERSIYKLHQTASVwAPESPPVPQSPPG 461
Cdd:PRK10263  334 AAPVEPVTQTPPVASVDVPPAqPTvawQPVPGPQT-----GEPVIAPAPEGYPQQSQYAQPAVQYN-EPLQQPVQPQQPY 407

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  462 QARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPcvllRAQRSLAPEP 541
Cdd:PRK10263  408 YAPAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQTEQTYQQPAA----QEPLYQQPQP 483

                         170       180
                  ....*....|....*....|....
gi 767989822  542 KEPliPASPKAEPIWE--LPTRAP 563
Cdd:PRK10263  484 VEQ--QPVVEPEPVVEetKPARPP 505
PRK14951 PRK14951
DNA polymerase III subunits gamma and tau; Provisional
 377-527 2.56e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 237865 [Multi-domain]  Cd Length: 618  Bit Score: 42.01  E-value: 2.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  377 APEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADtssersiyklhQTASVWAPESPPVP 456
Cdd:PRK14951  363 AFKPAAAAEAAAPAEKKTPARPEAAAPAAAPVAQAAAAPAPAAAPAAAASAPAAP-----------PAAAPPAPVAAPAA 431

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767989822  457 QSPPGQArlearflENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAP 527
Cdd:PRK14951  432 AAPAAAP-------AAAPAAVALAPAPPAQAAPETVAIPVRVAPEPAVASAAPAPAAAPAAARLTPTEEGD 495
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
365-563 3.38e-03

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 41.40  E-value: 3.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  365 RRSLEGGGCparAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKLHQT 444
Cdd:PRK12323  364 RPGQSGGGA---GPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPARRSPAPEALAAARQAS 440

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  445 ASVWAPESPPVPQSPPgqarlearflenVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSP--ETAPAARTP 522
Cdd:PRK12323  441 ARGPGGAPAPAPAPAA------------APAAAARPAAAGPRPVAAAAAAAPARAAPAAAPAPADDDPPpwEELPPEFAS 508

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 767989822  523 QSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAP 563
Cdd:PRK12323  509 PAPAQPDAAPAGWVAESIPDPATADPDDAFETLAPAPAAAP 549
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 348-554 7.38e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 40.54  E-value: 7.38e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  348 GGRRERRKPSSEEGKRSRRSLEGGGC--PARAPEPGPTGPASPVGPTSSTGPAlLTGPASSPVGPPSGLQASVNLFPTIS 425
Cdd:PHA03307   81 ANESRSTPTWSLSTLAPASPAREGSPtpPGPSSPDPPPPTPPPASPPPSPAPD-LSEMLRPVGSPGPPPAASPPAAGASP 159

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767989822  426 VAPSADTSSERSIYKLHQ-----TASVWAPESPPVPQSPPGQARLEARFLENVAAAETEKQVALAQGRAETLAGAMPNEA 500
Cdd:PHA03307  160 AAVASDAASSRQAALPLSspeetARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDS 239

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 767989822  501 GGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPliPASPKAEP 554
Cdd:PHA03307  240 SSSESSGCGWGPENECPLPRPAPITLPTRIWEASGWNGPSSRPG--PASSSSSP 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH