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Conserved domains on  [gi|767958149|ref|XP_011517262|]
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transducin-like enhancer protein 4 isoform X10 [Homo sapiens]

Protein Classification

WD40 domain-containing protein( domain architecture ID 10511324)

WD40 domain-containing protein similar to Drosophila melanogaster protein groucho and Homo sapiens transducin-like enhancer proteins; also contains a Groucho/TLE N-terminal Q-rich domain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-138 1.35e-92

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


:

Pssm-ID: 461094  Cd Length: 117  Bit Score: 285.86  E-value: 1.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149   24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767958149  104 QEHQQQVVQAVERAKQVTMAELNAIIG--QQLQAQHL 138
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
486-828 2.91e-44

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 2.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 486 LRAFPGNELEMELPRDTHRAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK- 564
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAd 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 565 GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISP 644
Cdd:COG2319  142 GTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSP 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 645 DSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSL 723
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSV 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 724 GYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKE-SSS 801
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 767958149 802 VLSCDISVDDKYIVTGSGDKKATVYEV 828
Cdd:COG2319  375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-138 1.35e-92

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 285.86  E-value: 1.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149   24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767958149  104 QEHQQQVVQAVERAKQVTMAELNAIIG--QQLQAQHL 138
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
486-828 2.91e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 2.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 486 LRAFPGNELEMELPRDTHRAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK- 564
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAd 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 565 GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISP 644
Cdd:COG2319  142 GTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSP 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 645 DSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSL 723
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSV 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 724 GYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKE-SSS 801
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 767958149 802 VLSCDISVDDKYIVTGSGDKKATVYEV 828
Cdd:COG2319  375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 543-827 1.85e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.87  E-value: 1.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 543 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCRLLPDGRTLIVGGEASTLSIWDLaa 621
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 622 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 701
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 702 SWDLREGR---QLQQHdfTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTG 777
Cdd:cd00200  161 LWDLRTGKcvaTLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGS 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767958149 778 KDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 827
Cdd:cd00200  239 EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 578-826 3.15e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 578 KSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPtprIKAELTSSAPACYALAISPDSKVCF------- 650
Cdd:PLN00181 471 KADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRSKLSGICWnsyiksq 547

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 651 --SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-C 726
Cdd:PLN00181 548 vaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpS 627

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 727 PTGEWLAVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSS 801
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHS 703

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767958149 802 VLS-------CDISVDDKYIVTGSGDKKATVY 826
Cdd:PLN00181 704 FMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 665-704 3.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767958149   665 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 704
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
667-704 4.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767958149  667 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 704
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
TLE_N pfam03920
Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor ...
 24-138 1.35e-92

Groucho/TLE N-terminal Q-rich domain; The N-terminal domain of the Grouch/TLE co-repressor proteins are involved in oligomerization.


Pssm-ID: 461094  Cd Length: 117  Bit Score: 285.86  E-value: 1.35e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149   24 FKFTISESCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFLS 103
Cdd:pfam03920   1 FKFTVPETCDRIKEEFQFLQAQYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNAICAQVIPFLS 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 767958149  104 QEHQQQVVQAVERAKQVTMAELNAIIG--QQLQAQHL 138
Cdd:pfam03920  81 QEHQQQVAQAVERAKQVTMAELNAIIGqqQQLQAQHL 117
WD40 COG2319
WD40 repeat [General function prediction only];
486-828 2.91e-44

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 165.08  E-value: 2.91e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 486 LRAFPGNELEMELPRDTHRAYSFHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGK- 564
Cdd:COG2319   62 LLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSAd 141

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 565 GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISP 644
Cdd:COG2319  142 GTVRLWDLA---TGKLLRTLT--GHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA--TGKLLRTLTGHTGAVRSVAFSP 214

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 645 DSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSL 723
Cdd:COG2319  215 DGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTlTGHSGGVNSV 294

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 724 GYCPTGEWLAVGMENSNVEVLHVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSKE-SSS 801
Cdd:COG2319  295 AFSPDGKLLASGSDDGTVRLWDLATGKLlRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGhTGA 374

                        330       340
                 ....*....|....*....|....*..
gi 767958149 802 VLSCDISVDDKYIVTGSGDKKATVYEV 828
Cdd:COG2319  375 VTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
510-828 4.91e-41

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 155.84  E-value: 4.91e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 510 VSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVKVWDISHPGNKSPVSQLdclnR 589
Cdd:COG2319    2 LSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLG----H 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 590 DNYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLV 669
Cdd:COG2319   78 TAAVLSVAFSPDGRLLASASADGTVRLWDLA--TGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLL 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 670 RQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ---HdfTSQIFSLGYCPTGEWLAVGMENSNVEVLHV 746
Cdd:COG2319  156 RTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTltgH--TGAVRSVAFSPDGKLLASGSADGTVRLWDL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 747 -TKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI-FQSKESSSVLSCDISVDDKYIVTGSGDKKAT 824
Cdd:COG2319  234 aTGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLrTLTGHSGGVNSVAFSPDGKLLASGSDDGTVR 313


                 ....
gi 767958149 825 VYEV 828
Cdd:COG2319  314 LWDL 317
WD40 COG2319
WD40 repeat [General function prediction only];
536-788 4.10e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 153.14  E-value: 4.10e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 536 RQINTLN-HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEAST 613
Cdd:COG2319  153 KLLRTLTgHSGAVTSVAFSPDGKLLASGSDdGTVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKLLASGSADGT 227

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 614 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWT 693
Cdd:COG2319  228 VRLWDLA--TGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 694 GGLDNTVRSWDLREGRQLQQHD-FTSQIFSLGYCPTGEWLAVGMENSNVEVLHV-TKPDKYQLHLHESCVLSLKFAHCGK 771
Cdd:COG2319  306 GSDDGTVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLaTGELLRTLTGHTGAVTSVAFSPDGR 385

                        250
                 ....*....|....*..
gi 767958149 772 WFVSTGKDNLLNAWRTP 788
Cdd:COG2319  386 TLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 543-827 1.85e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.87  E-value: 1.85e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 543 HGEVVCAVTISNPTRHVYTGGK-GCVKVWDIShpgNKSPVSQLdCLNRDNyIRSCRLLPDGRTLIVGGEASTLSIWDLaa 621
Cdd:cd00200    8 HTGGVTCVAFSPDGKLLATGSGdGTIKVWDLE---TGELLRTL-KGHTGP-VRDVAASADGTYLASGSSDKTIRLWDL-- 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 622 PTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVR 701
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIK 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 702 SWDLREGR---QLQQHdfTSQIFSLGYCPTGEWLAVGMENSNVEVLHVTKPD-KYQLHLHESCVLSLKFAHCGKWFVSTG 777
Cdd:cd00200  161 LWDLRTGKcvaTLTGH--TGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKcLGTLRGHENGVNSVAFSPDGYLLASGS 238

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 767958149 778 KDNLLNAWRTPYGASIFQ-SKESSSVLSCDISVDDKYIVTGSGDKKATVYE 827
Cdd:cd00200  239 EDGTIRVWDLRTGECVQTlSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 591-828 6.09e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 6.09e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 591 NYIRSCRLLPDGRTLIVGGEASTLSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVR 670
Cdd:cd00200   10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLE--TGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVR 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 671 QFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREGRQLQQ-HDFTSQIFSLGYCPTGEWLAVGMENSNVEV--LHVT 747
Cdd:cd00200   88 TLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSPDGTFVASSSQDGTIKLwdLRTG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 748 KPdKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDKKATV 825
Cdd:cd00200  168 KC-VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLgtLRGHE-NGVNSVAFSPDGYLLASGSEDGTIRV 245


                 ...
gi 767958149 826 YEV 828
Cdd:cd00200  246 WDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 668-828 1.78e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.48  E-value: 1.78e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 668 LVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWDLREG---RQLQQHdfTSQIFSLGYCPTGEWLAVGMENSNVEVL 744
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGellRTLKGH--TGPVRDVAASADGTYLASGSSDKTIRLW 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 745 HVTKPDK-YQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASI--FQSKEsSSVLSCDISVDDKYIVTGSGDK 821
Cdd:cd00200   79 DLETGECvRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLttLRGHT-DWVNSVAFSPDGTFVASSSQDG 157


                 ....*..
gi 767958149 822 KATVYEV 828
Cdd:cd00200  158 TIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
536-665 1.41e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 73.41  E-value: 1.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 536 RQINTLN-HGEVVCAVTISNPTRHVYTGGKGC-VKVWDIShpgNKSPVSQLDclNRDNYIRSCRLLPDGRTLIVGGEAST 613
Cdd:COG2319  279 ELLRTLTgHSGGVNSVAFSPDGKLLASGSDDGtVRLWDLA---TGKLLRTLT--GHTGAVRSVAFSPDGKTLASGSDDGT 353

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 767958149 614 LSIWDLAapTPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHN 665
Cdd:COG2319  354 VRLWDLA--TGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 578-826 3.15e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 54.32  E-value: 3.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 578 KSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPtprIKAELTSSAPACYALAISPDSKVCF------- 650
Cdd:PLN00181 471 KADLKQGDLLNSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESI---IKDGRDIHYPVVELASRSKLSGICWnsyiksq 547

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 651 --SCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISN-DGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGY-C 726
Cdd:PLN00181 548 vaSSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFpS 627

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 727 PTGEWLAVGMENSNVEVLHVTKPdkyQLHL-----HESCVLSLKFAHCGKwFVSTGKDNLLNAWRTPYGASIFQSKESSS 801
Cdd:PLN00181 628 ESGRSLAFGSADHKVYYYDLRNP---KLPLctmigHSKTVSYVRFVDSST-LVSSSTDNTLKLWDLSMSISGINETPLHS 703

                        250       260       270
                 ....*....|....*....|....*....|..
gi 767958149 802 VLS-------CDISVDDKYIVTGSGDKKATVY 826
Cdd:PLN00181 704 FMGhtnvknfVGLSVSDGYIATGSETNEVFVY 735
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 665-704 3.41e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 3.41e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767958149   665 NQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 704
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
667-704 4.22e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 4.22e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 767958149  667 TLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTVRSWD 704
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 623-662 8.48e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 8.48e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 767958149   623 TPRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWD 662
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 628-709 1.04e-03

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.37  E-value: 1.04e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149  628 AELTSSAPACYALAISPDSKVCFSCcsdGNiavWD-------LHNQTLVRQFQGHTDGASCIDISNDGTKLWTGGLDNTV 700
Cdd:pfam20426  75 AENVELGAQCFATLQTPSENFLISC---GN---WEnsfqvisLNDGRMVQSIRQHKDVVSCVAVTSDGSILATGSYDTTV 148


                  ....*....
gi 767958149  701 RSWDLREGR 709
Cdd:pfam20426 149 MVWEVLRGR 157
COG5276 COG5276
Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function ...
 558-704 6.49e-03

Uncharacterized secreted protein, contains LVIVD repeats, choice-of-anchor domain [Function unknown];


Pssm-ID: 444087 [Multi-domain]  Cd Length: 320  Bit Score: 39.54  E-value: 6.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767958149 558 HVYTG-GKGCVKVWDISHPGNKSPVSQLDCLNRDNYirscRLLPDGRTLIVGGEAST-LSIWDLAAPT-PRIKAELTSSA 634
Cdd:COG5276   31 YAYVAgGSNGLAIVDVSDPANPVLVGSLPTPGGTWR----DVKVSGDYLYVASEGSEgLQIFDISDPAnPKLVGRYDTGG 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767958149 635 PACYALAISpDSKVCFSCCSDGNIAVWDLHNQT---LVRQFQgHTDGASCIDISNDGTKLWTGGLDNTVRSWD 704
Cdd:COG5276  107 SGAHNIAVD-GNYAYVAGGSDNGLVIVDISDPTnpvLVGRYS-LPGQAYLHDVQVVGDYAYVADWEDGLVIVD 177
WD40 pfam00400
WD domain, G-beta repeat;
638-662 9.15e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 9.15e-03
                          10        20
                  ....*....|....*....|....*
gi 767958149  638 YALAISPDSKVCFSCCSDGNIAVWD 662
Cdd:pfam00400  15 TSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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