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Conserved domains on  [gi|767947994|ref|XP_011514590|]
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zinc finger C3HC-type protein 1 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C3HC super family cl06834
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 71-134 1.12e-15

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


The actual alignment was detected with superfamily member pfam07967:

Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 1.12e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947994   71 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 134
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 super family cl07279
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 181-271 4.51e-10

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


The actual alignment was detected with superfamily member pfam08600:

Pssm-ID: 369989  Cd Length: 97  Bit Score: 56.33  E-value: 4.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994  181 ACILSVCGWacsSSLESMQLSLITCSQCMRKVGLWGFQQIEssmtDLDASFGLTSSPIPGL---EGRPERLPLVPESPRR 257
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKE----DGEASNKLVPAVVDRLdvlEEHREYCPWVNPKAQS 73

                          90
                  ....*....|....
gi 767947994  258 MMTRSQDATFSPGS 271
Cdd:pfam08600  74 GTGRSSDALDGLAS 87
Rsm1 super family cl07279
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 352-399 5.86e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


The actual alignment was detected with superfamily member pfam08600:

Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767947994  352 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 399
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
PHA03381 super family cl31824
tegument protein VP22; Provisional
 252-338 9.29e-03

tegument protein VP22; Provisional


The actual alignment was detected with superfamily member PHA03381:

Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 37.68  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994 252 PESPRRMMTRSQDATFSPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPT-TRTRPVTRSMGTGDTPGlevPSSPL 330
Cdd:PHA03381  85 ADPRPSRRPHAQPEASGPGPARGARGPAGSRGRGRRAESPSPRDPPNPKGASAPrGRKSACADSAALLDAPA---PAAPK 161


                 ....*...
gi 767947994 331 RKAKRARL 338
Cdd:PHA03381 162 RQKTPAGL 169
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 71-134 1.12e-15

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 1.12e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947994   71 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 134
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 181-271 4.51e-10

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 56.33  E-value: 4.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994  181 ACILSVCGWacsSSLESMQLSLITCSQCMRKVGLWGFQQIEssmtDLDASFGLTSSPIPGL---EGRPERLPLVPESPRR 257
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKE----DGEASNKLVPAVVDRLdvlEEHREYCPWVNPKAQS 73

                          90
                  ....*....|....
gi 767947994  258 MMTRSQDATFSPGS 271
Cdd:pfam08600  74 GTGRSSDALDGLAS 87
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 352-399 5.86e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767947994  352 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 399
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
PHA03381 PHA03381
tegument protein VP22; Provisional
 252-338 9.29e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 37.68  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994 252 PESPRRMMTRSQDATFSPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPT-TRTRPVTRSMGTGDTPGlevPSSPL 330
Cdd:PHA03381  85 ADPRPSRRPHAQPEASGPGPARGARGPAGSRGRGRRAESPSPRDPPNPKGASAPrGRKSACADSAALLDAPA---PAAPK 161


                 ....*...
gi 767947994 331 RKAKRARL 338
Cdd:PHA03381 162 RQKTPAGL 169
 
Name Accession Description Interval E-value
zf-C3HC pfam07967
C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic ...
 71-134 1.12e-15

C3HC zinc finger-like; This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain is involved in mRNA export from the nucleus.


Pssm-ID: 429759  Cd Length: 132  Bit Score: 73.18  E-value: 1.12e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 767947994   71 KQRCAELKKALCTAHEKFCFWPDSPSPDRFGMLPLDEPAILVSEFLDRFQSLCHLDLQLPSLRP 134
Cdd:pfam07967  69 NKLIEEYAKQLVTGHEENCPWRNNGCPESYERLPLAAPDTLLSDLKKRYDGLLQRFDQLPSLVN 132
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 181-271 4.51e-10

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 56.33  E-value: 4.51e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994  181 ACILSVCGWacsSSLESMQLSLITCSQCMRKVGLWGFQQIEssmtDLDASFGLTSSPIPGL---EGRPERLPLVPESPRR 257
Cdd:pfam08600   1 AFALALFGW---DSVPDGRLGLAGCGACFRRLGLWMFKPKE----DGEASNKLVPAVVDRLdvlEEHREYCPWVNPKAQS 73

                          90
                  ....*....|....
gi 767947994  258 MMTRSQDATFSPGS 271
Cdd:pfam08600  74 GTGRSSDALDGLAS 87
Rsm1 pfam08600
Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus
 352-399 5.86e-04

Rsm1-like; Rsm1 is a protein involved in mRNA export from the nucleus


Pssm-ID: 369989  Cd Length: 97  Bit Score: 39.00  E-value: 5.86e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 767947994  352 FDPTSQHRDWCPWVNitlgKESRENGGTEPDASAPAEPGWKAVLTILL 399
Cdd:pfam08600  54 LDVLEEHREYCPWVN----PKAQSGTGRSSDALDGLASGWELLAQALK 97
PHA03381 PHA03381
tegument protein VP22; Provisional
 252-338 9.29e-03

tegument protein VP22; Provisional


Pssm-ID: 177618 [Multi-domain]  Cd Length: 290  Bit Score: 37.68  E-value: 9.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767947994 252 PESPRRMMTRSQDATFSPGSEQAEKSPGPIVSRTRSWDSSSPVDRPEPEAASPT-TRTRPVTRSMGTGDTPGlevPSSPL 330
Cdd:PHA03381  85 ADPRPSRRPHAQPEASGPGPARGARGPAGSRGRGRRAESPSPRDPPNPKGASAPrGRKSACADSAALLDAPA---PAAPK 161


                 ....*...
gi 767947994 331 RKAKRARL 338
Cdd:PHA03381 162 RQKTPAGL 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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