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Conserved domains on  [gi|767940075|ref|XP_011512928|]
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myoD family inhibitor isoform X4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MDFI super family cl21161
MyoD family inhibitor; Members of this family inhibits the transactivation activity of the ...
37-185 1.01e-35

MyoD family inhibitor; Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.


The actual alignment was detected with superfamily member pfam15316:

Pssm-ID: 464641  Cd Length: 168  Bit Score: 122.65  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940075   37 PLLPNDSGHPSELGGTRRAGNGALGGP---KAHRKLQTHPSLASQGSKKSKSSSKsttsQIPLQAQEDCCVHCILSCLFC 113
Cdd:pfam15316  25 PGLPNGSGVHNGVSEFSPADSPSLSTPvsqKMHRKSQSSLSSTSKSQKKSKGSAT----FSQRPAGDDCCVHCILACLFC 100
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767940075  114 EFLTLCNIVLDCATCGSCSSEDSCLCCCCCGsgecADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS 185
Cdd:pfam15316 101 EFLTLCNLVLLCATCGIECISCCCCCGDHMG----DDCNCPCDLDCGILEACCESSDCLEICMECCGICFPS 168
 
Name Accession Description Interval E-value
MDFI pfam15316
MyoD family inhibitor; Members of this family inhibits the transactivation activity of the ...
37-185 1.01e-35

MyoD family inhibitor; Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.


Pssm-ID: 464641  Cd Length: 168  Bit Score: 122.65  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940075   37 PLLPNDSGHPSELGGTRRAGNGALGGP---KAHRKLQTHPSLASQGSKKSKSSSKsttsQIPLQAQEDCCVHCILSCLFC 113
Cdd:pfam15316  25 PGLPNGSGVHNGVSEFSPADSPSLSTPvsqKMHRKSQSSLSSTSKSQKKSKGSAT----FSQRPAGDDCCVHCILACLFC 100
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767940075  114 EFLTLCNIVLDCATCGSCSSEDSCLCCCCCGsgecADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS 185
Cdd:pfam15316 101 EFLTLCNLVLLCATCGIECISCCCCCGDHMG----DDCNCPCDLDCGILEACCESSDCLEICMECCGICFPS 168
 
Name Accession Description Interval E-value
MDFI pfam15316
MyoD family inhibitor; Members of this family inhibits the transactivation activity of the ...
37-185 1.01e-35

MyoD family inhibitor; Members of this family inhibits the transactivation activity of the MyoD family of myogenic factors. They affect axin-mediated regulation of the Wnt and JNK signaling pathways, and regulate expression from viral promoters.


Pssm-ID: 464641  Cd Length: 168  Bit Score: 122.65  E-value: 1.01e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767940075   37 PLLPNDSGHPSELGGTRRAGNGALGGP---KAHRKLQTHPSLASQGSKKSKSSSKsttsQIPLQAQEDCCVHCILSCLFC 113
Cdd:pfam15316  25 PGLPNGSGVHNGVSEFSPADSPSLSTPvsqKMHRKSQSSLSSTSKSQKKSKGSAT----FSQRPAGDDCCVHCILACLFC 100
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767940075  114 EFLTLCNIVLDCATCGSCSSEDSCLCCCCCGsgecADCDLPCDLDCGILDACCESADCLEICMECCGLCFSS 185
Cdd:pfam15316 101 EFLTLCNLVLLCATCGIECISCCCCCGDHMG----DDCNCPCDLDCGILEACCESSDCLEICMECCGICFPS 168
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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