NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|767925825|ref|XP_011510762|]
View 

coiled-coil domain-containing protein 50 isoform X1 [Homo sapiens]

Protein Classification

CCDC50_N domain-containing protein( domain architecture ID 10633834)

CCDC50_N domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
CCDC50_N pfam15295
Coiled-coil domain-containing protein 50 N-terminus;
4-128 9.62e-47

Coiled-coil domain-containing protein 50 N-terminus;


:

Pssm-ID: 464621 [Multi-domain]  Cd Length: 126  Bit Score: 154.11  E-value: 9.62e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825    4 VSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAKQLQ-EEDLKAQAQLQKRYKDLEQ 82
Cdd:pfam15295   1 LSIDQSNLPRVTEVCQEFAVLEDGALAHNLQEQEIEHHYATNIQRNQLVQNDIRVAKQLQeEEELQAQTLFQRRLAQLEE 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767925825   83 QDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRK 128
Cdd:pfam15295  81 QDEEIAKEIQEELQREAEERRRREEEDEEIARQLQERERERERRRK 126
 
Name Accession Description Interval E-value
CCDC50_N pfam15295
Coiled-coil domain-containing protein 50 N-terminus;
4-128 9.62e-47

Coiled-coil domain-containing protein 50 N-terminus;


Pssm-ID: 464621 [Multi-domain]  Cd Length: 126  Bit Score: 154.11  E-value: 9.62e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825    4 VSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAKQLQ-EEDLKAQAQLQKRYKDLEQ 82
Cdd:pfam15295   1 LSIDQSNLPRVTEVCQEFAVLEDGALAHNLQEQEIEHHYATNIQRNQLVQNDIRVAKQLQeEEELQAQTLFQRRLAQLEE 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767925825   83 QDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRK 128
Cdd:pfam15295  81 QDEEIAKEIQEELQREAEERRRREEEDEEIARQLQERERERERRRK 126
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
47-127 1.99e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 38.23  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825  47 QRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYKDLEQQdceiAQEIQE--KLAIEAERRRIQEKKDEDIARLLQ--EKELQ 122
Cdd:COG0711   31 ERQEKIADGLAEAERAKEEAEAALAEYEEKLAEARAE----AAEIIAeaRKEAEAIAEEAKAEAEAEAERIIAqaEAEIE 106

                 ....*
gi 767925825 123 EEKKR 127
Cdd:COG0711  107 QERAK 111
 
Name Accession Description Interval E-value
CCDC50_N pfam15295
Coiled-coil domain-containing protein 50 N-terminus;
4-128 9.62e-47

Coiled-coil domain-containing protein 50 N-terminus;


Pssm-ID: 464621 [Multi-domain]  Cd Length: 126  Bit Score: 154.11  E-value: 9.62e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825    4 VSIDQSKLPGVKEVCRDFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQVAKQLQ-EEDLKAQAQLQKRYKDLEQ 82
Cdd:pfam15295   1 LSIDQSNLPRVTEVCQEFAVLEDGALAHNLQEQEIEHHYATNIQRNQLVQNDIRVAKQLQeEEELQAQTLFQRRLAQLEE 80
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 767925825   83 QDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQEKELQEEKKRK 128
Cdd:pfam15295  81 QDEEIAKEIQEELQREAEERRRREEEDEEIARQLQERERERERRRK 126
Macoilin pfam09726
Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 ...
2-141 1.68e-04

Macoilin family; The Macoilin proteins has an N-terminal portion that is composed of 5 trasnmembrane helices, followed by a C-terminal coiled-coil region. Macoilin is a highly conserved protein present in eukaryotes. Macoilin appears to be found in the ER and be involved in the function of neurons.


Pssm-ID: 462859 [Multi-domain]  Cd Length: 670  Bit Score: 43.30  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825    2 AEVSIDQSKLPGVKEVCR---DFAVLEDHTLAHSLQEQEIEHHLASNVQRNRLVQHDLQvakQLQEEDlkaqAQLQKRYK 78
Cdd:pfam09726 382 AENCIPNNQLSKPDALVRleqDIKKLKAELQASRQTEQELRSQISSLTSLERSLKSELG---QLRQEN----DLLQTKLH 454
                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767925825   79 DLEQQdceiaqEIQEKLAIEAERRRIQEKKDediARLLQEKELQEEKKRKKHfPEFPATRAYA 141
Cdd:pfam09726 455 NAVSA------KQKDKQTVQQLEKRLKAEQE---ARASAEKQLAEEKKRKKE-EEATAARAVA 507
AtpF COG0711
FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ...
47-127 1.99e-03

FoF1-type ATP synthase, membrane subunit b or b' [Energy production and conversion]; FoF1-type ATP synthase, membrane subunit b or b' is part of the Pathway/BioSystem: FoF1-type ATP synthase


Pssm-ID: 440475 [Multi-domain]  Cd Length: 152  Bit Score: 38.23  E-value: 1.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825  47 QRNRLVQHDLQVAKQLQEEDLKAQAQLQKRYKDLEQQdceiAQEIQE--KLAIEAERRRIQEKKDEDIARLLQ--EKELQ 122
Cdd:COG0711   31 ERQEKIADGLAEAERAKEEAEAALAEYEEKLAEARAE----AAEIIAeaRKEAEAIAEEAKAEAEAEAERIIAqaEAEIE 106

                 ....*
gi 767925825 123 EEKKR 127
Cdd:COG0711  107 QERAK 111
Selenoprotein_S pfam06936
Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) ...
72-129 4.14e-03

Selenoprotein S (SelS); This family consists of several mammalian selenoprotein S (SelS) sequences. SelS is a plasma membrane protein and is present in a variety of tissues and cell types. Selenoprotein S (SelS) is an intrinsically disordered protein. It formsa selenosulfide bond between cys 174 and Sec 188, that has a redox potential -234 mV. In vitro, SelS is an efficient reductase that depends on the presence of selenocysteine. Due to the high reactivity, SelS also has peroxidase activity that can catalyze the reduction of hydrogen peroxide. It is also resistant to inactivation by hydrogen peroxide which might provide evolutionary advantage compared to cysteine containing peroxidases.


Pssm-ID: 462043 [Multi-domain]  Cd Length: 192  Bit Score: 37.89  E-value: 4.14e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 767925825   72 QLQKRYKDLEQQDCEIAQEIQEKLAIEAERRRIQEKKDEDIARLLQE-KELQEEKKRKK 129
Cdd:pfam06936  60 ALRQRSSDHSAATVDPDLVVKRQEALEASRLRMQEELDAQAEKFKEKqKQLEEEKRRQK 118
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
22-130 9.21e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 37.99  E-value: 9.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767925825  22 AVLEDHTLAHSLQEQEIEHHLASNVQRNRLV---QHDLQVAKQLQEEDLKAQAQLQKRYKDLEQQdceIAQEIQEKLAIE 98
Cdd:COG1196  267 AELEELRLELEELELELEEAQAEEYELLAELarlEQDIARLEERRRELEERLEELEEELAELEEE---LEELEEELEELE 343
                         90       100       110
                 ....*....|....*....|....*....|..
gi 767925825  99 AERRRIQEKKDEDIARLLQEKELQEEKKRKKH 130
Cdd:COG1196  344 EELEEAEEELEEAEAELAEAEEALLEAEAELA 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH