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Conserved domains on  [gi|767918639|ref|XP_011509690|]
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protein phosphatase 1 regulatory subunit 7 isoform X1 [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1903219)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-286 7.21e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 135.68  E-value: 7.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  95 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 174
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 175 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 246
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767918639 247 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 286
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 15-130 1.85e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  15 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 85
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767918639  86 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 130
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-286 7.21e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 135.68  E-value: 7.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  95 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 174
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 175 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 246
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767918639 247 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 286
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-244 1.85e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  27 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 105
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 106 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 181
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918639 182 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 244
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 15-130 1.85e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  15 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 85
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767918639  86 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 130
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
55-176 1.46e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.23  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639   55 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 132
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767918639  133 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 176
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-268 7.06e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  34 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 107
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 108 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 159
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 160 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 226
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767918639 227 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 268
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 52-94 9.57e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 9.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767918639   52 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 94
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 268-286 3.74e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.74e-03
                           10
                   ....*....|....*....
gi 767918639   268 DPQYRRKVMLALPSVRQID 286
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
 
Name Accession Description Interval E-value
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 95-286 7.21e-39

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 135.68  E-value: 7.21e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  95 LTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRL 174
Cdd:cd21340    1 LKRITHLYLNDKNITKIDNLSLCKNLKVLYLYDNKITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 175 TKIEGLQNLVNLRELYLSHNGIEVIEGLENN--------NKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDL 246
Cdd:cd21340   81 SVVEGLENLTNLEELHIENQRLPPGEKLTFDprslaalsNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEEL 160

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 767918639 247 DE-LKGARSLETVYLERNPLQKDPQYRRKVMLALPSVRQID 286
Cdd:cd21340  161 LDlLSSWPSLRELDLTGNPVCKKPKYRDKIILASKSLEVLD 201
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
27-244 1.85e-26

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 107.33  E-value: 1.85e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  27 EVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNqikkiENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 105
Cdd:COG4886   71 LLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN-----EELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSN 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 106 NKISKI-ENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKLQN-LDALTNLTVLSMQSNRLTKI-EGLQ 181
Cdd:COG4886  146 NQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLPEpLGNLTNLEELDLSGNQLTDLpEPLA 225

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918639 182 NLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWS 244
Cdd:COG4886  226 NLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLK 288
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-263 6.58e-24

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 100.39  E-value: 6.58e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  37 LRQNLIKCIENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVNNKISKI-EN 113
Cdd:COG4886   98 LTELDLSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNLTNLKSLDLSNNQLTDLpEE 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 114 LSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDALTNLTVLSMQSNRLTKIEGLQNLVNLRELYL 191
Cdd:COG4886  178 LGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDL 257

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918639 192 SHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERN 263
Cdd:COG4886  258 SNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLL 329
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
4-269 1.03e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 85.37  E-value: 1.03e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639   4 INLDRDAEDVDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISF 83
Cdd:COG4886    1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  84 NLLRNIEGVDKLTRLKKLFLVNnkISKIENLSNLHQLQMLELGSNRIRAI-ENIDTLTNLESLFLGKNKITKL-QNLDAL 161
Cdd:COG4886   81 LLSLLLLGLTDLGDLTNLTELD--LSGNEELSNLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLpEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 162 TNLTVLSMQSNRLTKI-EGLQNLVNLRELYLSHNGIEVI-EGLENNNKLTMLDIASNRIKKI-ENISHLTELQEFWMNDN 238
Cdd:COG4886  159 TNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNN 238

                        250       260       270
                 ....*....|....*....|....*....|.
gi 767918639 239 LLeswSDLDELKGARSLETVYLERNPLQKDP 269
Cdd:COG4886  239 QL---TDLPELGNLTNLEELDLSNNQLTDLP 266
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
29-271 7.09e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 7.09e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  29 LKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLRNI-EGVDKLTRLKKLFLVN 105
Cdd:COG4886  158 LTNLKSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSN 237

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 106 NKISKIENLSNLHQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKIEGLQNLVN 185
Cdd:COG4886  238 NQLTDLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILL 317

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 186 LRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSDLDELKGARSLETVYLERNPL 265
Cdd:COG4886  318 LLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTT 397


                 ....*.
gi 767918639 266 QKDPQY 271
Cdd:COG4886  398 AGVLLL 403
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 19-177 8.71e-14

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 69.04  E-value: 8.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  19 RIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLYDNQIKKIENLEALTELEILDISFNLLRNIEGVDKLTRL 98
Cdd:cd21340   35 KITKIENLEFLTNLTHLYLQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHIENQRLPPGEKLTFDPRS 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  99 kklflvnnkiskIENLSNlhQLQMLELGSNRIRAIENIDTLTNLESLFLGKNKITKLQNLD----ALTNLTVLSMQSNRL 174
Cdd:cd21340  115 ------------LAALSN--SLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEELLdllsSWPSLRELDLTGNPV 180


                 ...
gi 767918639 175 TKI 177
Cdd:cd21340  181 CKK 183
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
11-258 4.09e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.81  E-value: 4.09e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  11 EDVDLNHYRIGKI-EGFEVLKKVKTLCLRQNLIKCI-ENLEELQSLRELDLYDNQIKKI-ENLEALTELEILDISFNLLR 87
Cdd:COG4886  162 KSLDLSNNQLTDLpEELGNLTNLKELDLSNNQITDLpEPLGNLTNLEELDLSGNQLTDLpEPLANLTNLETLDLSNNQLT 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  88 NIEGVDKLTRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIR--AIENIDTLTNLESLFLGKNKITKLQNLDALTNLT 165
Cdd:COG4886  242 DLPELGNLTNLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTdlKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 166 VLSMQSNRLTKIEGLQNLVNLRELYLSHNGIEVIEGLENNNKLTMLDIASNRIKKIENISHLTELQEFWMNDNLLESWSD 245
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|...
gi 767918639 246 LDELKGARSLETV 258
Cdd:COG4886  402 LLTLALLDAVNTE 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 15-130 1.85e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 65.19  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  15 LNHYRIGKIEGFEVLKKVKTLCLRQNLIKCIENLEELQSLRELDLyDNQ--------IKKIENLEALTE-LEILDISFNL 85
Cdd:cd21340   53 LQNNQIEKIENLENLVNLKKLYLGGNRISVVEGLENLTNLEELHI-ENQrlppgeklTFDPRSLAALSNsLRVLNISGNN 131

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 767918639  86 LRNIEGVDKLTRLKKLFLVNNKISKIEN----LSNLHQLQMLELGSNRI 130
Cdd:cd21340  132 IDSLEPLAPLRNLEQLDASNNQISDLEElldlLSSWPSLRELDLTGNPV 180
LRR_9 pfam14580
Leucine-rich repeat;
55-176 1.46e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 53.23  E-value: 1.46e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639   55 RELDLYDNQIKKIENLEA-LTELEILDISFNLLRNIEGVDKLTRLKKLFLVNNKISKI-ENLSnlhqlqmlelgsnrira 132
Cdd:pfam14580  22 RELDLRGYKIPIIENLGAtLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLG----------------- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 767918639  133 ieniDTLTNLESLFLGKNKITKLQNLDALT---NLTVLSMQSNRLTK 176
Cdd:pfam14580  85 ----EALPNLTELILTNNNLQELGDLDPLAslkKLTFLSLLRNPVTN 127
LRR_9 pfam14580
Leucine-rich repeat;
123-286 2.51e-08

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 52.46  E-value: 2.51e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  123 LELGSNRIRAIENID-TLTNLESLFLGKNKITKLQNLDALTNLTVLSMQSNRLTKI-EGL-QNLVNLRELYLSHNgievi 199
Cdd:pfam14580  24 LDLRGYKIPIIENLGaTLDQFDTIDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLgEALPNLTELILTNN----- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  200 eglennnkltmldiasnrikkienisHLTELqefwmndnlleswSDLDELKGARSLETVYLERNPLQKDPQYRRKVMLAL 279
Cdd:pfam14580  99 --------------------------NLQEL-------------GDLDPLASLKKLTFLSLLRNPVTNKPHYRLYVIYKV 139


                  ....*..
gi 767918639  280 PSVRQID 286
Cdd:pfam14580 140 PQLRLLD 146
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 1-272 3.08e-08

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 54.41  E-value: 3.08e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639   1 METINLDRDAEDVDLNHYRIGKiEGFEVLKKVktlcLRQNlikcienleelQSLRELDLYDNQIKKiENLEALteleild 80
Cdd:COG5238  173 MAKALQNNSVETVYLGCNQIGD-EGIEELAEA----LTQN-----------TTVTTLWLKRNPIGD-EGAEIL------- 228

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  81 isfnllrnIEGVDKLTRLKKLFLVNNKISK------IENLSNLHQLQMLELGSNRIRA------IENIDTLTNLESLFLG 148
Cdd:COG5238  229 --------AEALKGNKSLTTLDLSNNQIGDegvialAEALKNNTTVETLYLSGNQIGAegaialAKALQGNTTLTSLDLS 300

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 149 KNKITKlQNLDALtnltvlsmqsnrltkIEGLQNLVNLRELYLSHNGIEV------IEGLENNNKLTMLDIASNRI---- 218
Cdd:COG5238  301 VNRIGD-EGAIAL---------------AEGLQGNKTLHTLNLAYNGIGAqgaialAKALQENTTLHSLDLSDNQIgdeg 364

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 767918639 219 -----KKIENISHLTELQEFWMNDNLLESWSDLDELKGARsLETVYLERNPLQKDPQYR 272
Cdd:COG5238  365 aialaKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNLIGAEAQQR 422
LRR_8 pfam13855
Leucine rich repeat;
162-218 4.44e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.59  E-value: 4.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918639  162 TNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRI 218
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 34-268 7.06e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.07  E-value: 7.06e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  34 TLCLRQNLI--KCIENLEELQSLRELDLYDNQIK-KIEN-LEALTELEILDISFNLLRNIEGVD--KLTRLKKLFLVNNK 107
Cdd:PLN00113 144 TLDLSNNMLsgEIPNDIGSFSSLKVLDLGGNVLVgKIPNsLTNLTSLEFLTLASNQLVGQIPRElgQMKSLKWIYLGYNN 223

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 108 IS-----KIENLSNLHQLQMLElgSNRIRAI-ENIDTLTNLESLFLGKNKIT-----------KLQNLD----------- 159
Cdd:PLN00113 224 LSgeipyEIGGLTSLNHLDLVY--NNLTGPIpSSLGNLKNLQYLFLYQNKLSgpippsifslqKLISLDlsdnslsgeip 301

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639 160 ----ALTNLTVLSMQSNRLT-KI-EGLQNLVNLRELYLSHNGI--EVIEGLENNNKLTMLDIASNRI-----KKIENISH 226
Cdd:PLN00113 302 elviQLQNLEILHLFSNNFTgKIpVALTSLPRLQVLQLWSNKFsgEIPKNLGKHNNLTVLDLSTNNLtgeipEGLCSSGN 381

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 767918639 227 LTELQEFwmnDNLLESWSDLDeLKGARSLETVYLERNPLQKD 268
Cdd:PLN00113 382 LFKLILF---SNSLEGEIPKS-LGACRSLRRVRLQDNSFSGE 419
LRR_8 pfam13855
Leucine rich repeat;
140-196 1.03e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.43  E-value: 1.03e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918639  140 TNLESLFLGKNKITKL--QNLDALTNLTVLSMQSNRLTKIEG--LQNLVNLRELYLSHNGI 196
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 162-194 5.41e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.84  E-value: 5.41e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 767918639  162 TNLTVLSMQSNRLTKIEGLQNLVNLRELYLSHN 194
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGN 33
LRR_8 pfam13855
Leucine rich repeat;
74-130 5.51e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 5.51e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918639   74 TELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKISKIEN--LSNLHQLQMLELGSNRI 130
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGafKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 52-94 9.57e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.45  E-value: 9.57e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767918639   52 QSLRELDLYDNQIKKIENLEALTELEILDISFN-LLRNIEGVDK 94
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 140-182 9.96e-04

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 36.07  E-value: 9.96e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767918639  140 TNLESLFLGKNKITKLQNLDALTNLTVLSMQSN-RLTKIEGLQN 182
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_9 pfam14580
Leucine-rich repeat;
13-88 1.57e-03

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 38.59  E-value: 1.57e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 767918639   13 VDLNHYRIGKIEGFEVLKKVKTLCLRQNLIKCI-ENLEE-LQSLRELDLYDNQIKKIENLEALTELEILDiSFNLLRN 88
Cdd:pfam14580  47 IDFSDNEIRKLDGFPLLRRLKTLLLNNNRICRIgEGLGEaLPNLTELILTNNNLQELGDLDPLASLKKLT-FLSLLRN 123
LRR_8 pfam13855
Leucine rich repeat;
96-152 1.61e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.96  E-value: 1.61e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 767918639   96 TRLKKLFLVNNKISKI--ENLSNLHQLQMLELGSNRIRAIEN--IDTLTNLESLFLGKNKI 152
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
185-240 2.91e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 35.58  E-value: 2.91e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639  185 NLRELYLSHNGIEVIEG--LENNNKLTMLDIASNRIKKIEN--ISHLTELQEFWMNDNLL 240
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDgaFKGLSNLKVLDLSNNLLTTLSPgaFSGLPSLRYLDLSGNRL 61
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 96-141 3.03e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.91  E-value: 3.03e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 767918639   96 TRLKKLFLVNNKISKIENLSNLHQLQMLELGSNRIraIENIDTLTN 141
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSGNNK--ITDLSDLAN 44
LRRcap smart00446
occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich ...
 268-286 3.74e-03

occurring C-terminal to leucine-rich repeats; A motif occurring C-terminal to leucine-rich repeats in "sds22-like" and "typical" LRR-containing proteins.


Pssm-ID: 197729  Cd Length: 19  Bit Score: 34.20  E-value: 3.74e-03
                           10
                   ....*....|....*....
gi 767918639   268 DPQYRRKVMLALPSVRQID 286
Cdd:smart00446   1 LAHYREKVIELLPQLRKLD 19
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 185-226 4.20e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.53  E-value: 4.20e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 767918639  185 NLRELYLSHNGIEVIEGLENNNKLTMLDIASN-RIKKIENISH 226
Cdd:pfam12799   2 NLEVLDLSNNQITDIPPLAKLPNLETLDLSGNnKITDLSDLAN 44
LRR_4 pfam12799
Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a ...
 74-116 5.64e-03

Leucine Rich repeats (2 copies); Leucine rich repeats are short sequence motifs present in a number of proteins with diverse functions and cellular locations. These repeats are usually involved in protein-protein interactions. Each Leucine Rich Repeat is composed of a beta-alpha unit. These units form elongated non-globular structures. Leucine Rich Repeats are often flanked by cysteine rich domains.


Pssm-ID: 463713 [Multi-domain]  Cd Length: 44  Bit Score: 34.14  E-value: 5.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 767918639   74 TELEILDISFNLLRNIEGVDKLTRLKKLFLV-NNKISKIENLSN 116
Cdd:pfam12799   1 PNLEVLDLSNNQITDIPPLAKLPNLETLDLSgNNKITDLSDLAN 44
LRR_8 pfam13855
Leucine rich repeat;
53-108 9.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 34.04  E-value: 9.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918639   53 SLRELDLYDNQIKKI--ENLEALTELEILDISFNLLRNIEGV--DKLTRLKKLFLVNNKI 108
Cdd:pfam13855   2 NLRSLDLSNNRLTSLddGAFKGLSNLKVLDLSNNLLTTLSPGafSGLPSLRYLDLSGNRL 61
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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