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Conserved domains on  [gi|767918545|ref|XP_011509650|]
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peptidyl-prolyl cis-trans isomerase FKBP7 isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
EFh_CREC super family cl25354
EF-hand, calcium binding motif, found in CREC-EF hand family; The CREC (Cab45/reticulocalbin ...
42-113 6.45e-06

EF-hand, calcium binding motif, found in CREC-EF hand family; The CREC (Cab45/reticulocalbin/ERC45/calumenin)-EF hand family contains a group of six EF-hand, low-affinity Ca2+-binding proteins, including reticulocalbin (RCN-1), ER Ca2+-binding protein of 55 kDa (ERC-55, also known as TCBP-49 or E6BP), reticulocalbin-3 (RCN-3), Ca2+-binding protein of 45 kDa (Cab45 and its splice variant Cab45b), and calumenin ( also known as crocalbin or CBP-50). The proteins are not only localized in various parts of the secretory pathway, but also found in the cytosolic compartment and at the cell surface. They interact with different ligands or proteins and have been implicated in the secretory process, chaperone activity, signal transduction as well as in a large variety of disease processes.


The actual alignment was detected with superfamily member cd16224:

Pssm-ID: 330175 [Multi-domain]  Cd Length: 268  Bit Score: 43.19  E-value: 6.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918545  42 RSIETFKQIDMDNDRQLSKAEINLYLQREFekdekpRDKSYQDAvlEDIFKKNDHDGDGFISPKEYNVYQHD 113
Cdd:cd16224   37 RLKSIIKKIDTDSDGFLTEEELSSWIQQSF------RHYALEDA--KQQFPEYDKDGDGAVTWDEYNMQMYD 100
FkpA super family cl29492
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
15-37 2.91e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


The actual alignment was detected with superfamily member COG0545:

Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 37.08  E-value: 2.91e-04
                         10        20
                 ....*....|....*....|...
gi 767918545  15 STAAEGKIPPDATLIFEIELYAV 37
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVELLDV 104
 
Name Accession Description Interval E-value
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
42-113 6.45e-06

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 43.19  E-value: 6.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918545  42 RSIETFKQIDMDNDRQLSKAEINLYLQREFekdekpRDKSYQDAvlEDIFKKNDHDGDGFISPKEYNVYQHD 113
Cdd:cd16224   37 RLKSIIKKIDTDSDGFLTEEELSSWIQQSF------RHYALEDA--KQQFPEYDKDGDGAVTWDEYNMQMYD 100
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
20-106 9.39e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.70  E-value: 9.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918545  20 GKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLqrefekdekpRDKSYQDAVLEDIFKKNDHDGD 99
Cdd:COG5126   48 GRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----------TALGVSEEEADELFARLDTDGD 117

                 ....*..
gi 767918545 100 GFISPKE 106
Cdd:COG5126  118 GKISFEE 124
EF-hand_7 pfam13499
EF-hand domain pair;
45-107 1.79e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.85  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918545   45 ETFKQIDMDNDRQLSKAEINLYLQReFEKDEKPRDKSyqdavLEDIFKKNDHDGDGFISPKEY 107
Cdd:pfam13499   6 EAFKLLDSDGDGYLDVEELKKLLRK-LEEGEPLSDEE-----VEELFKEFDLDKDGRISFEEF 62
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
15-37 2.91e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 37.08  E-value: 2.91e-04
                         10        20
                 ....*....|....*....|...
gi 767918545  15 STAAEGKIPPDATLIFEIELYAV 37
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
17-34 5.49e-04

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 36.41  E-value: 5.49e-04
                          10
                  ....*....|....*...
gi 767918545   17 AAEGKIPPDATLIFEIEL 34
Cdd:pfam00254  76 LAGPVIPPNATLVFEVEL 93
 
Name Accession Description Interval E-value
EFh_CREC_RCN2 cd16224
EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed ...
42-113 6.45e-06

EF-hand, calcium binding motif, found in reticulocalbin-2 (RCN2); RCN2, also termed calcium-binding protein ERC-55, or E6-binding protein (E6BP), or TCBP-49, is an endoplasmic reticulum resident low-affinity Ca2+-binding protein that has been implicated in immunity, redox homeostasis, cell cycle regulation and coagulation. It is associated with tumorigenesis, in particular with transformation of cells of the cervix induced by human papillomavirus (HPV), through binding to human papillomavirus (HPV) E6 oncogenic protein. It specifically interacts with vitamin D receptor among nuclear receptors. RCN2 contains an N-terminal signal sequence followed by six copies of the EF-hand Ca2+-binding motif, and a C-terminal His-Asp-Glu-Leu (HDEL) tetrapeptide that is required for retention of RCN2 in the endoplasmic reticulum (ER).


Pssm-ID: 320022 [Multi-domain]  Cd Length: 268  Bit Score: 43.19  E-value: 6.45e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918545  42 RSIETFKQIDMDNDRQLSKAEINLYLQREFekdekpRDKSYQDAvlEDIFKKNDHDGDGFISPKEYNVYQHD 113
Cdd:cd16224   37 RLKSIIKKIDTDSDGFLTEEELSSWIQQSF------RHYALEDA--KQQFPEYDKDGDGAVTWDEYNMQMYD 100
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
20-106 9.39e-06

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.70  E-value: 9.39e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918545  20 GKIPPDATLIFEIELYAVTKGPRSIETFKQIDMDNDRQLSKAEINLYLqrefekdekpRDKSYQDAVLEDIFKKNDHDGD 99
Cdd:COG5126   48 GRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----------TALGVSEEEADELFARLDTDGD 117

                 ....*..
gi 767918545 100 GFISPKE 106
Cdd:COG5126  118 GKISFEE 124
EFh_CREC_cab45 cd16225
EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also ...
44-110 2.35e-05

EF-hand, calcium binding motif, found in 45 kDa calcium-binding protein (Cab45); Cab45, also termed stromal cell-derived factor 4 (SDF-4), is a soluble, lumenal Golgi resident low-affinity Ca2+-binding protein that contains six copies of the EF-hand Ca2+-binding motif. It is required for secretory pathway calcium ATPase1 (SPCA1)-dependent Ca2+ import into the trans-Golgi network (TGN) and plays an essential role in Ca2+-dependent secretory cargo sorting at the TGN.


Pssm-ID: 320023 [Multi-domain]  Cd Length: 278  Bit Score: 41.52  E-value: 2.35e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 767918545  44 IETFKQIDMDNDRQLSKAEINLYLQREFEkdekprdKSYQDAVLED--IFKKNDHDGDGFISPKEYNVY 110
Cdd:cd16225   37 KEIFKKVDVNTDGFLSAEELEDWIMEKTQ-------EHFQEAVEENeqIFKAVDTDKDGNVSWEEYRVH 98
EF-hand_7 pfam13499
EF-hand domain pair;
45-107 1.79e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 36.85  E-value: 1.79e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 767918545   45 ETFKQIDMDNDRQLSKAEINLYLQReFEKDEKPRDKSyqdavLEDIFKKNDHDGDGFISPKEY 107
Cdd:pfam13499   6 EAFKLLDSDGDGYLDVEELKKLLRK-LEEGEPLSDEE-----VEELFKEFDLDKDGRISFEEF 62
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
15-37 2.91e-04

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 37.08  E-value: 2.91e-04
                         10        20
                 ....*....|....*....|...
gi 767918545  15 STAAEGKIPPDATLIFEIELYAV 37
Cdd:COG0545   82 ERGAGGVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
17-34 5.49e-04

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 36.41  E-value: 5.49e-04
                          10
                  ....*....|....*...
gi 767918545   17 AAEGKIPPDATLIFEIEL 34
Cdd:pfam00254  76 LAGPVIPPNATLVFEVEL 93
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
45-106 8.25e-04

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 35.22  E-value: 8.25e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 767918545  45 ETFKQIDMDNDRQLSKAEINLYLQREFEKDEKPRdksyqdavLEDIFKKNDHDGDGFISPKE 106
Cdd:cd00051    4 EAFRLFDKDGDGTISADELKAALKSLGEGLSEEE--------IDEMIREVDKDGDGKIDFEE 57
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
38-107 1.17e-03

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 36.31  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 767918545  38 TKGPRSIETFKQIDMDNDRQLSKAEINLYLQR--------------------EFEKDEKPRDKSYQDAVLEDIFKKNDHD 97
Cdd:COG5126    2 LQRRKLDRRFDLLDADGDGVLERDDFEALFRRlwatlfseadtdgdgrisreEFVAGMESLFEATVEPFARAAFDLLDTD 81
                         90
                 ....*....|
gi 767918545  98 GDGFISPKEY 107
Cdd:COG5126   82 GDGKISADEF 91
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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