|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
178-468 |
8.54e-54 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 189.39 E-value: 8.54e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 178 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 257
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 258 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 337
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 338 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 417
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 418 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 468
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
244-462 |
5.14e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 244 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 316
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 317 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 394
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755506076 395 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 462
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
302-394 |
3.13e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.72 E-value: 3.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 302 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 381
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 755506076 382 VLMENNADPNIQD 394
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1-325 |
6.49e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 78.53 E-value: 6.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNN-PEHAKLLIKHDSN 78
Cdd:PHA03095 30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGaDVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 79 IGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVVDVLTSyES 149
Cdd:PHA03095 110 VNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELLRLLID-AG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 150 CNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPSVKDDSD 227
Cdd:PHA03095 178 ADVYAVDDRFRSLLH--HHLQSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARN 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 228 LEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTpLFRACE 307
Cdd:PHA03095 255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT-LNTASV 328
|
330 340
....*....|....*....|....*.
gi 755506076 308 MGHRD--------VIQTLIKGGARVD 325
Cdd:PHA03095 329 AGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
57-156 |
2.17e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 57 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 136
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72
|
90 100
....*....|....*....|
gi 755506076 137 NLTVVDVLTSYEsCNITSYD 156
Cdd:pfam12796 73 HLEIVKLLLEKG-ADINVKD 91
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
521-794 |
4.60e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 67.12 E-value: 4.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 521 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 600
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 601 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 679
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 680 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 745
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 746 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 794
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
199-405 |
7.31e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 199 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 269
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 270 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 332
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 333 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 402
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 755506076 403 WSC 405
Cdd:cd22192 240 WTY 242
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
54-242 |
2.62e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.17 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 54 QTALHWSAYYNNPEHAKLLikhdsnigipdvegkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPL 129
Cdd:cd22192 52 ETALHVAALYDNLEAAVVL------------------------------------MEAAPE--LVNEpmtsDLYQGETAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 130 HFAVADGNLTVVDVLTSYESCNIT----------SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQ 196
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 197 GATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSDLE------GRTSFMWAAGKGN 242
Cdd:cd22192 169 GNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQPLDlvpnnqGLTPFKLAAKEGN 224
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
815-840 |
4.67e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.67e-05
10 20
....*....|....*....|....*.
gi 755506076 815 RKELFRRKNKAAAVIQRAWRSYQLRK 840
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
330-359 |
3.27e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.27e-04
10 20 30
....*....|....*....|....*....|
gi 755506076 330 DGHSLLHWAALGGNADVCQILIENKINPNV 359
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
461-487 |
5.89e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.89e-04
10 20
....*....|....*....|....*..
gi 755506076 461 AIQDIAAFKIQAVYKGYKVRKAFRDRK 487
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
132-385 |
6.09e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 132 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 210
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 211 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 289
Cdd:TIGR00870 95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 290 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 346
Cdd:TIGR00870 153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 755506076 347 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 385
Cdd:TIGR00870 230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
52-79 |
2.16e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.16e-03
10 20
....*....|....*....|....*...
gi 755506076 52 NKQTALHWSAYYNNPEHAKLLIKHDSNI 79
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
54-253 |
2.42e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 41.61 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 54 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAPTES----LLNWQD----Y 123
Cdd:TIGR00870 53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAFRKSgpleLANDQYtsefT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 124 EGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTfgrhAQIVHLLLErNKSGT 190
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS----PSIVALLSE-DPADI 201
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755506076 191 IPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGKGNDDVLRTMLSLK 253
Cdd:TIGR00870 202 LTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKEGRIVLFRLKLAIK 280
|
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
822-868 |
6.96e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.96e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 822 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 868
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
178-468 |
8.54e-54 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 189.39 E-value: 8.54e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 178 IVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLrtMLSLKSDID 257
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVA--LLLLAAGAD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 258 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHW 337
Cdd:COG0666 80 INAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 338 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 417
Cdd:COG0666 160 AAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLL 239
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 418 DFAAFPNqmENNEERYTPLDYALLGERHEVIQFMLEHGALSIAAIQDIAAF 468
Cdd:COG0666 240 EAGADLN--AKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTL 288
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
214-502 |
1.22e-50 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 180.54 E-value: 1.22e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 214 KVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDA 293
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 294 TDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAY 373
Cdd:COG0666 83 KDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 374 GGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMenNEERYTPLDYALLGERHEVIQFMLE 453
Cdd:COG0666 163 NGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAK--DNDGKTALDLAAENGNLEIVKLLLE 240
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 755506076 454 HGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAA 502
Cdd:COG0666 241 AGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
108-401 |
3.64e-46 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 167.44 E-value: 3.64e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 108 ILDAAPTESLLNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLFRTPLHWAALlgtfgRHAQIVHLLLERNK 187
Cdd:COG0666 3 LLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAAL-----AGDLLVALLLLAAG 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 188 SGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRtMLsLKSDIDINMSDKYGGT 267
Cdd:COG0666 78 ADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVK-LL-LEAGADVNAQDNDGNT 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 268 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVC 347
Cdd:COG0666 156 PLHLAAANGNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIV 235
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 755506076 348 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTAL 401
Cdd:COG0666 236 KLLLEAGADLNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
|
|
| ANKYR |
COG0666 |
Ankyrin repeat [Signal transduction mechanisms]; |
1-432 |
1.36e-34 |
|
Ankyrin repeat [Signal transduction mechanisms];
Pssm-ID: 440430 [Multi-domain] Cd Length: 289 Bit Score: 134.31 E-value: 1.36e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIG 80
Cdd:COG0666 2 LLLLLLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADIN 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 81 IPDVEGKIPLHWAANHKDpsavhtvrcildaaptesllnwqdyegrtplhfavadgnltvvdvltsyescnitsydnlfr 160
Cdd:COG0666 82 AKDDGGNTLLHAAARNGD-------------------------------------------------------------- 99
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 161 tplhwaallgtfgrhAQIVHLLLErnksgtipsdsQGAtplhyaaqsnfaetvkvflqhpsvkddsdlegrtsfmwaagk 240
Cdd:COG0666 100 ---------------LEIVKLLLE-----------AGA------------------------------------------ 111
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 241 gnddvlrtmlslksdiDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKG 320
Cdd:COG0666 112 ----------------DVNARDKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEA 175
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 321 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTA 400
Cdd:COG0666 176 GADVNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTA 255
|
410 420 430
....*....|....*....|....*....|..
gi 755506076 401 LHWSCNNGYLDAIKLLLDFAAFPNQMENNEER 432
Cdd:COG0666 256 LLLAAAAGAALIVKLLLLALLLLAAALLDLLT 287
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
244-462 |
5.14e-23 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 102.82 E-value: 5.14e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 244 DVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST-----VKLLLDNDAQVDATDVMKHTPLFRA--CEMGHRDVIQT 316
Cdd:PHA03100 49 DVVKILL--DNGADINSSTKNNSTPLHYLSNIKYNLTdvkeiVKLLLEYGANVNAPDNNGITPLLYAisKKSNSYSIVEY 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 317 LIKGGARVDLVDQDGHSLLHWAALGGNAD--VCQILIENKINPNVQDYagrtplqcaayggyINCmavLMENNADPNIQD 394
Cdd:PHA03100 127 LLDNGANVNIKNSDGENLLHLYLESNKIDlkILKLLIDKGVDINAKNR--------------VNY---LLSYGVPINIKD 189
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755506076 395 KEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEerYTPLDYALLGERHEVIQFMLEHGAlSIAAI 462
Cdd:PHA03100 190 VYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYG--DTPLHIAILNNNKEIFKLLLNNGP-SIKTI 254
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
302-394 |
3.13e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.72 E-value: 3.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 302 LFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIEnKINPNVQDYaGRTPLQCAAYGGYINCMA 381
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKDN-GRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 755506076 382 VLMENNADPNIQD 394
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
335-426 |
4.11e-22 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 91.33 E-value: 4.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 335 LHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMEnNADPNIQDkEGRTALHWSCNNGYLDAIK 414
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|..
gi 755506076 415 LLLDFAAFPNQM 426
Cdd:pfam12796 79 LLLEKGADINVK 90
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
269-361 |
3.17e-21 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 89.02 E-value: 3.17e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 269 LHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKgGARVDLVDqDGHSLLHWAALGGNADVCQ 348
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLE-HADVNLKD-NGRTALHYAARSGHLEIVK 78
|
90
....*....|...
gi 755506076 349 ILIENKINPNVQD 361
Cdd:pfam12796 79 LLLEKGADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
201-295 |
2.54e-20 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 86.32 E-value: 2.54e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 201 LHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLksdIDINMSDkYGGTALHAAALSGHVST 280
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH---ADVNLKD-NGRTALHYAARSGHLEI 76
|
90
....*....|....*
gi 755506076 281 VKLLLDNDAQVDATD 295
Cdd:pfam12796 77 VKLLLEKGADINVKD 91
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
118-456 |
4.47e-20 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 95.90 E-value: 4.47e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 118 LNWQDYEGRTPLHFAVADGNLTVVDVLTSYES-CNITSYDNLfrTPLHWA------------------------ALLGTF 172
Cdd:PHA02876 171 VNAKDIYCITPIHYAAERGNAKMVNLLLSYGAdVNIIALDDL--SVLECAvdsknidtikaiidnrsninkndlSLLKAI 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 173 GRHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQS-NFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGND-DVLRTML 250
Cdd:PHA02876 249 RNEDLETSLLLYDAGFSVNSIDDCKNTPLHHASQApSLSRLVPKLLERGADVNAKNIKGETPLYLMAKNGYDtENIRTLI 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 251 SLKSDIdiNMSDKYGGTALH-AAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 329
Cdd:PHA02876 329 MLGADV--NAADRLYITPLHqASTLDRNKDIVITLLELGANVNARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSQ 406
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 330 DGHSLLHWAALGGNAdvcqilienkinpnvqdyagrtplqcaayggYINcMAVLMENNADPNIQDKEGRTALHWSC-NNG 408
Cdd:PHA02876 407 KIGTALHFALCGTNP-------------------------------YMS-VKTLIDRGANVNSKNKDLSTPLHYACkKNC 454
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 755506076 409 YLDAIKLLLDFAAFPNQMeNNEERYtPLDYALlgERHEVIQFMLEHGA 456
Cdd:PHA02876 455 KLDVIEMLLDNGADVNAI-NIQNQY-PLLIAL--EYHGIVNILLHYGA 498
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
368-456 |
1.79e-19 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 84.01 E-value: 1.79e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 368 LQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFpnqmENNEERYTPLDYALLGERHEV 447
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADV----NLKDNGRTALHYAARSGHLEI 76
|
....*....
gi 755506076 448 IQFMLEHGA 456
Cdd:pfam12796 77 VKLLLEKGA 85
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
156-403 |
1.86e-18 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 89.70 E-value: 1.86e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 156 DNLFRTPLHwaALLGTF-GRHAQIVHLLLER----NKSgtipsDSQGATPLHYAAQsnFAETVkvflqhpsvkddsdleg 230
Cdd:PHA03095 44 GEYGKTPLH--LYLHYSsEKVKDIVRLLLEAgadvNAP-----ERCGFTPLHLYLY--NATTL----------------- 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 231 rtsfmwaagkgndDVLRTMLSLKSDIdiNMSDKYGGTALHAAaLSG---HVSTVKLLLDNDAQVDATDVMKHTPL----- 302
Cdd:PHA03095 98 -------------DVIKLLIKAGADV--NAKDKVGRTPLHVY-LSGfniNPKVIRLLLRKGADVNALDLYGMTPLavllk 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 303 FRACEMghrDVIQTLIKGGARVDLVDQDGHSLLHWAALG--GNADVCQILIENKINPNVQDYAGRTPLQCAAYGGyiNCM 380
Cdd:PHA03095 162 SRNANV---ELLRLLIDAGADVYAVDDRFRSLLHHHLQSfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGS--SCK 236
|
250 260
....*....|....*....|....*..
gi 755506076 381 AVLM----ENNADPNIQDKEGRTALHW 403
Cdd:PHA03095 237 RSLVlpllIAGISINARNRYGQTPLHY 263
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
115-329 |
1.89e-16 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 82.79 E-value: 1.89e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 115 ESLLNWQDYEGRTPLHFAVADGNLTVVDVLTsYESCNITSYDNLFRTPLHWAALLG-TFGRHAQIVHLLLERNKSGTIPs 193
Cdd:PHA03100 25 DDLNDYSYKKPVLPLYLAKEARNIDVVKILL-DNGADINSSTKNNSTPLHYLSNIKyNLTDVKEIVKLLLEYGANVNAP- 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 194 DSQGATPLHYAAQ--SNFAETVKVFLQHPSVKDDSDLEGRTSF-MWAAGKGND-DVLRTMLS--------------LKSD 255
Cdd:PHA03100 103 DNNGITPLLYAISkkSNSYSIVEYLLDNGANVNIKNSDGENLLhLYLESNKIDlKILKLLIDkgvdinaknrvnylLSYG 182
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755506076 256 IDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQ 329
Cdd:PHA03100 183 VPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTIIE 256
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
70-368 |
1.05e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 80.84 E-value: 1.05e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 70 KLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVHTVRCILDAApteSLLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYe 148
Cdd:PHA03095 31 RRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAG---ADVNAPERCGFTPLHLYLYNATtLDVIKLLIKA- 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 149 SCNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHyaaqsnfaetvkVFLQHPSVkddsdl 228
Cdd:PHA03095 107 GADVNAKDKVGRTPLH--VYLSGFNINPKVIRLLLRKGADVN-ALDLYGMTPLA------------VLLKSRNA------ 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 229 egrtsfmwaagkgNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVST--VKLLLDNDAQVDATDVMKHTPLFRAC 306
Cdd:PHA03095 166 -------------NVELLRLLI--DAGADVYAVDDRFRSLLHHHLQSFKPRAriVRELIRAGCDPAATDMLGNTPLHSMA 230
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755506076 307 EMG--HRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPL 368
Cdd:PHA03095 231 TGSscKRSLVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPL 294
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
252-456 |
3.26e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 79.30 E-value: 3.26e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 252 LKSDIDINMSDKYGGTALHAAALSGH---VSTVKLLLDNDAQVDATDVMKHTPLFraCEMGH---RDVIQTLIKGGARVD 325
Cdd:PHA03095 34 LAAGADVNFRGEYGKTPLHLYLHYSSekvKDIVRLLLEAGADVNAPERCGFTPLH--LYLYNattLDVIKLLIKAGADVN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 326 LVDQDGHSLLHwAALGG---NADVCQILIENKINPNVQDYAGRTPLqcAAYGGYINC----MAVLMENNADPNIQDKEGR 398
Cdd:PHA03095 112 AKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPL--AVLLKSRNAnvelLRLLIDAGADVYAVDDRFR 188
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 399 TALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGE--RHEVIQFMLEHGA 456
Cdd:PHA03095 189 SLLHHHLQSFKPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSscKRSLVLPLLIAGI 248
|
|
| PHA03095 |
PHA03095 |
ankyrin-like protein; Provisional |
1-325 |
6.49e-15 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222980 [Multi-domain] Cd Length: 471 Bit Score: 78.53 E-value: 6.49e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPG-EVDTQDKNKQTALHWSAYYNN-PEHAKLLIKHDSN 78
Cdd:PHA03095 30 VRRLLAAGADVNFRGEYGKTPLHLYLHYSSEKVKDIVRLLLEAGaDVNAPERCGFTPLHLYLYNATtLDVIKLLIKAGAD 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 79 IGIPDVEGKIPLHwaanhkdpsaVH-TVRCIlDAAPTESLL------NWQDYEGRTPLHFAV--ADGNLTVVDVLTSyES 149
Cdd:PHA03095 110 VNAKDKVGRTPLH----------VYlSGFNI-NPKVIRLLLrkgadvNALDLYGMTPLAVLLksRNANVELLRLLID-AG 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 150 CNITSYDNLFRTPLHwaALLGTFGRHAQIVHLLLERNKSGTiPSDSQGATPLHYAAQSNFAETVKV--FLQHPSVKDDSD 227
Cdd:PHA03095 178 ADVYAVDDRFRSLLH--HHLQSFKPRARIVRELIRAGCDPA-ATDMLGNTPLHSMATGSSCKRSLVlpLLIAGISINARN 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 228 LEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDkyGGTALHAAALSGHVSTVKLLLdndAQVDATDVMKHTpLFRACE 307
Cdd:PHA03095 255 RYGQTPLHYAAVFNNPRACRRLIALGADINAVSSD--GNTPLSLMVRNNNGRAVRAAL---AKNPSAETVAAT-LNTASV 328
|
330 340
....*....|....*....|....*.
gi 755506076 308 MGHRD--------VIQTLIKGGARVD 325
Cdd:PHA03095 329 AGGDIpsdatrlcVAKVVLRGAFSLL 354
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
242-440 |
1.35e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 77.31 E-value: 1.35e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 242 NDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGG 321
Cdd:PHA02874 103 EKDMIKTIL--DCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKG 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 322 ARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYggYINCMAVLMENNADPNIQDKEGRTAL 401
Cdd:PHA02874 181 AYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPLHNAII--HNRSAIELLINNASINDQDIDGSTPL 258
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 755506076 402 HWSCNNG-YLDAIKLLLDFAAFPNQMENNEEryTPLDYAL 440
Cdd:PHA02874 259 HHAINPPcDIDIIDILLYHKADISIKDNKGE--NPIDTAF 296
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
258-465 |
1.99e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 76.54 E-value: 1.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 258 INMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMG-----------------------HRDVI 314
Cdd:PHA02874 28 INISVDETTTPLIDAIRSGDAKIVELFIKHGADINHINTKIPHPLLTAIKIGahdiikllidngvdtsilpipciEKDMI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 315 QTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQD 394
Cdd:PHA02874 108 KTILDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANVKD 187
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755506076 395 KEGRTALHWSCNNGYLDAIKLLLDFAAfpNQMENNEERYTPLDYALLGERhEVIQFMLEHGALSiaaIQDI 465
Cdd:PHA02874 188 NNGESPLHNAAEYGDYACIKLLIDHGN--HIMNKCKNGFTPLHNAIIHNR-SAIELLINNASIN---DQDI 252
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
57-156 |
2.17e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.17e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 57 LHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTESllnwqDYEGRTPLHFAVADG 136
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGH---LEIVKLLLEHADVNL-----KDNGRTALHYAARSG 72
|
90 100
....*....|....*....|
gi 755506076 137 NLTVVDVLTSYEsCNITSYD 156
Cdd:pfam12796 73 HLEIVKLLLEKG-ADINVKD 91
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
129-227 |
2.64e-14 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 69.37 E-value: 2.64e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 129 LHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWAALLGtfgrHAQIVHLLLERNKSGtipSDSQGATPLHYAAQSN 208
Cdd:pfam12796 1 LHLAAKNGNLELVKLLLENG-ADANLQDKNGRTALHLAAKNG----HLEIVKLLLEHADVN---LKDNGRTALHYAARSG 72
|
90
....*....|....*....
gi 755506076 209 FAETVKVFLQHPSVKDDSD 227
Cdd:pfam12796 73 HLEIVKLLLEKGADINVKD 91
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
278-456 |
3.12e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 75.86 E-value: 3.12e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 278 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAA-----LGGNADVCQILIE 352
Cdd:PHA03100 15 VKNIKYIIMEDDLNDYSYKKPVLPLYLAKEARNIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLE 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 353 NKINPNVQDYAGRTPLQCAAYG--GYINCMAVLMENNADPNIQDKEGRTALHW--SCNNGYLDAIKLLLDFAAFPNQMEN 428
Cdd:PHA03100 95 YGANVNAPDNNGITPLLYAISKksNSYSIVEYLLDNGANVNIKNSDGENLLHLylESNKIDLKILKLLIDKGVDINAKNR 174
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 755506076 429 --------------NEERYTPLDYALLGERHEVIQFMLEHGA 456
Cdd:PHA03100 175 vnyllsygvpinikDVYGFTPLHYAVYNNNPEFVKYLLDLGA 216
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
269-437 |
3.58e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.80 E-value: 3.58e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 269 LHAAALSGHVSTVKLLLDNDAQVDatDVM---KHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNAD 345
Cdd:PHA02875 72 LHDAVEEGDVKAVEELLDLGKFAD--DVFykdGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIK 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 346 VCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGR-TALHWSCNNGYLDAIKLLLDFAAFPN 424
Cdd:PHA02875 150 GIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADCN 229
|
170
....*....|....
gi 755506076 425 QMENNE-ERYTPLD 437
Cdd:PHA02875 230 IMFMIEgEECTILD 243
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
119-359 |
5.73e-14 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 75.03 E-value: 5.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 119 NWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDNLfRTPLHWAALLGTfgrhAQIVHLLLERNKSGTIPSDSQGA 198
Cdd:PHA02875 29 NFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDI-ESELHDAVEEGD----VKAVEELLDLGKFADDVFYKDGM 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 199 TPLHYAAQSNfaetvkvflqhpsvkddsdlegrtsfmwaagkgNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHV 278
Cdd:PHA02875 104 TPLHLATILK---------------------------------KLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDI 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 279 STVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGH-SLLHWAALGGNADVCQILIENKINP 357
Cdd:PHA02875 149 KGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGANIDYFGKNGCvAALCYAIENNKIDIVRLFIKRGADC 228
|
..
gi 755506076 358 NV 359
Cdd:PHA02875 229 NI 230
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
1-83 |
2.48e-13 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 66.29 E-value: 2.48e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVDtqdkNKQTALHWSAYYNNPEHAKLLIKHDSNIG 80
Cdd:pfam12796 13 VKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKD----NGRTALHYAARSGHLEIVKLLLEKGADIN 88
|
...
gi 755506076 81 IPD 83
Cdd:pfam12796 89 VKD 91
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
132-406 |
3.16e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 72.72 E-value: 3.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 132 AVADGNLTVVD-VLTSYESCNITSYDNLfrTPLHWAALLgtfgRHAQIVHLLLernKSGTIPSDSQGA--TPLHYAAQSN 208
Cdd:PHA02875 9 AILFGELDIARrLLDIGINPNFEIYDGI--SPIKLAMKF----RDSEAIKLLM---KHGAIPDVKYPDieSELHDAVEEG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 209 FAETVKVFLQHPSVKDDSDL-EGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYggTALHAAALSGHVSTVKLLLDN 287
Cdd:PHA02875 80 DVKAVEELLDLGKFADDVFYkDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDH 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 288 DAQVDATDVMKHTPLFracemghrdviqtlikggarvdlvdqdghsllhWAALGGNADVCQILIENKINPNvqdYAGRTP 367
Cdd:PHA02875 158 KACLDIEDCCGCTPLI---------------------------------IAMAKGDIAICKMLLDSGANID---YFGKNG 201
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 755506076 368 ---LQCAAY-GGYINCMAVLMENNADPNIQ---DKEGRTALHWSCN 406
Cdd:PHA02875 202 cvaALCYAIeNNKIDIVRLFIKRGADCNIMfmiEGEECTILDMICN 247
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
45-319 |
3.99e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 72.69 E-value: 3.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 45 EVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHkdpSAVHTVRCILDAApteSLLNWQDYE 124
Cdd:PHA02874 116 DVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPIHIAIKH---NFFDIIKLLLEKG---AYANVKDNN 189
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 125 GRTPLHFAVADGNLTVVDVLTSYEScNITSYDNLFRTPLHWAALlgtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYA 204
Cdd:PHA02874 190 GESPLHNAAEYGDYACIKLLIDHGN-HIMNKCKNGFTPLHNAII------HNRSAIELLINNASIND-QDIDGSTPLHHA 261
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 205 aqsnfaetvkvfLQHPSVKddsdlegrtsfmwaagkgndDVLRTMLSLKSDIDINmsDKYGGTALHAA-ALSGHVSTVKL 283
Cdd:PHA02874 262 ------------INPPCDI--------------------DIIDILLYHKADISIK--DNKGENPIDTAfKYINKDPVIKD 307
|
250 260 270
....*....|....*....|....*....|....*.
gi 755506076 284 LLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 319
Cdd:PHA02874 308 IIANAVLIKEADKLKDSDFLEHIEIKDNKEFSDFIK 343
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
162-441 |
4.41e-13 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 72.61 E-value: 4.41e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 162 PLHWAALlgtfGRHAQIVHLLLERNKSGTIPsDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWaaGKG 241
Cdd:PHA02878 40 PLHQAVE----ARNLDVVKSLLTRGHNVNQP-DHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAF--NNR 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 242 NDDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVstVKLLLDNDAQVDATDVMK-HTPLFRACEMGHRDVIQTLIKG 320
Cdd:PHA02878 113 NVEIFKIILTNRYKNIQTIDLVYIDKKSKDDIIEAEI--TKLLLSYGADINMKDRHKgNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 321 GARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAygGY---INCMAVLMENNADPNIQDK-E 396
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYckdYDILKLLLEHGVDVNAKSYiL 268
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 755506076 397 GRTALHWSCNNGylDAIKLLLDFAAFPNQMenNEERYTPLDYALL 441
Cdd:PHA02878 269 GLTALHSSIKSE--RKLKLLLEYGADINSL--NSYKLTPLSSAVK 309
|
|
| PHA02874 |
PHA02874 |
ankyrin repeat protein; Provisional |
1-166 |
2.02e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165205 [Multi-domain] Cd Length: 434 Bit Score: 70.38 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMAPGEVdtQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIG 80
Cdd:PHA02874 140 IKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYANV--KDNNGESPLHNAAEYGDYACIKLLIDHGNHIM 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 81 IPDVEGKIPLHWAANHKdpsavhtvRCILDAAPTESLLNWQDYEGRTPLHFAVA-DGNLTVVDVLTsYESCNITSYDNLF 159
Cdd:PHA02874 218 NKCKNGFTPLHNAIIHN--------RSAIELLINNASINDQDIDGSTPLHHAINpPCDIDIIDILL-YHKADISIKDNKG 288
|
....*..
gi 755506076 160 RTPLHWA 166
Cdd:PHA02874 289 ENPIDTA 295
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
128-401 |
2.96e-12 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 69.91 E-value: 2.96e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 128 PLHFAVADGNLTVVDVLTSyESCNITSYDNLFRTPLHWAA----LLGtfgrhaqIVHLLLERNKSGTIPSDSQGATPLHY 203
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLT-RGHNVNQPDHRDLTPLHIICkepnKLG-------MKEMIRSINKCSVFYTLVAIKDAFNN 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 204 aaqsNFAETVKVFL--QHPSVKDDSDLEGRTsfmwaagKGNDDVLRTM---LSLKSDIDINMSDKYGG-TALHAAALSGH 277
Cdd:PHA02878 112 ----RNVEIFKIILtnRYKNIQTIDLVYIDK-------KSKDDIIEAEitkLLLSYGADINMKDRHKGnTALHYATENKD 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 278 VSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWA-ALGGNADVCQILIENKIN 356
Cdd:PHA02878 181 QRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISvGYCKDYDILKLLLEHGVD 260
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 755506076 357 PNVQDYA-GRTPLQCAAYGGYIncMAVLMENNADPNIQDKEGRTAL 401
Cdd:PHA02878 261 VNAKSYIlGLTALHSSIKSERK--LKLLLEYGADINSLNSYKLTPL 304
|
|
| Ank_2 |
pfam12796 |
Ankyrin repeats (3 copies); |
90-186 |
2.97e-12 |
|
Ankyrin repeats (3 copies);
Pssm-ID: 463710 [Multi-domain] Cd Length: 91 Bit Score: 63.21 E-value: 2.97e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 90 LHWAANHKDPSAVHT-VRCILDAaptesllNWQDYEGRTPLHFAVADGNLTVVDVLTSYESCNITSYDnlfRTPLHWAAL 168
Cdd:pfam12796 1 LHLAAKNGNLELVKLlLENGADA-------NLQDKNGRTALHLAAKNGHLEIVKLLLEHADVNLKDNG---RTALHYAAR 70
|
90
....*....|....*...
gi 755506076 169 LGtfgrHAQIVHLLLERN 186
Cdd:pfam12796 71 SG----HLEIVKLLLEKG 84
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
521-794 |
4.60e-11 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 67.12 E-value: 4.60e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 521 LDTDPPRSHCSSSAPvlPCPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKPS 600
Cdd:PHA03307 176 LSSPEETARAPSSPP--AEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPEN 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 601 ETPIEHcrgPSACVHP-RSWEGGNSSKNQGTSSVEKRRGETNGKHRRCEegPSSARQPLCTGSGRPAEKGEDSSPAVASA 679
Cdd:PHA03307 254 ECPLPR---PAPITLPtRIWEASGWNGPSSRPGPASSSSSPRERSPSPS--PSSPGSGPAPSSPRASSSSSSSRESSSSS 328
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 680 SQQDHP--------------RKPNKRQDRAARPRGASQKRRTHQLRDRCSPAGSSRPGSAKGEVACADQSSLHRHTPRsk 745
Cdd:PHA03307 329 TSSSSEssrgaavspgpspsRSPSPSRPPPPADPSSPRKRPRPSRAPSSPAASAGRPTRRRARAAVAGRARRRDATGR-- 406
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 746 vtqdkLIGGVSSGLPLSTEASRSGCKQLYEDI--CASPETGVAhGPPPGQC 794
Cdd:PHA03307 407 -----FPAGRPRPSPLDAGAASGAFYARYPLLtpSGEPWPGSP-PPPPGRV 451
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
206-389 |
1.62e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 65.27 E-value: 1.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 206 QSNFAETVKVFLQH--------------PSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHA 271
Cdd:PLN03192 487 QEDNVVILKNFLQHhkelhdlnvgdllgDNGGEHDDPNMASNLLTVASTGNAALLEELLKAKLDPDI--GDSKGRTPLHI 564
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 272 AALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDlvDQDGHSLLHWAALGGNADVCQILI 351
Cdd:PLN03192 565 AASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILYHFASISD--PHAAGDLLCTAAKRNDLTAMKELL 642
|
170 180 190
....*....|....*....|....*....|....*...
gi 755506076 352 ENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNAD 389
Cdd:PLN03192 643 KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGAD 680
|
|
| PHA02798 |
PHA02798 |
ankyrin-like protein; Provisional |
278-437 |
1.69e-10 |
|
ankyrin-like protein; Provisional
Pssm-ID: 222931 [Multi-domain] Cd Length: 489 Bit Score: 64.47 E-value: 1.69e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 278 VSTVKLLLdndAQVDATDVMKHTPLFRacEMGHR-----DVIQTLIKGGARVDLVDQDGHS-----LLHWAALGGNADVC 347
Cdd:PHA02798 18 LSTVKLLI---KSCNPNEIVNEYSIFQ--KYLQRdspstDIVKLFINLGANVNGLDNEYSTplctiLSNIKDYKHMLDIV 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 348 QILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL---MENNADPNIQDKEGRTALH---WSCNNGYLDAIKLLLDFAA 421
Cdd:PHA02798 93 KILIENGADINKKNSDGETPLYCLLSNGYINNLEILlfmIENGADTTLLDKDGFTMLQvylQSNHHIDIEIIKLLLEKGV 172
|
170
....*....|....*.
gi 755506076 422 FPNQMeNNEERYTPLD 437
Cdd:PHA02798 173 DINTH-NNKEKYDTLH 187
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
331-383 |
2.75e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.51 E-value: 2.75e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 755506076 331 GHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVL 383
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
182-385 |
3.01e-10 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 64.12 E-value: 3.01e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 182 LLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSfMW------------------------- 236
Cdd:PLN03192 544 LLKAKLDPDI-GDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTA-LWnaisakhhkifrilyhfasisdpha 621
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 237 -------AAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDAT---DVMKHTPLFRAC 306
Cdd:PLN03192 622 agdllctAAKRNDLTAMKELL--KQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKAntdDDFSPTELRELL 699
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 307 ---EMGHRDVIqtlikggarVDLVDQDgHSLLHWAALGGNADVCQILIENKINPNVQDYAG----RTPLQCAAYGGYINC 379
Cdd:PLN03192 700 qkrELGHSITI---------VDSVPAD-EPDLGRDGGSRPGRLQGTSSDNQCRPRVSIYKGhpllRNERCCNEAGKLINL 769
|
....*.
gi 755506076 380 MAVLME 385
Cdd:PLN03192 770 PPSLEE 775
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
265-318 |
3.84e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 56.13 E-value: 3.84e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 755506076 265 GGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLI 318
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
230-285 |
5.41e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 55.74 E-value: 5.41e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 230 GRTSFMWAAGKGNDDVLRTMLSLKsdIDINMSDKYGGTALHAAALSGHVSTVKLLL 285
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKG--ADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
364-417 |
8.82e-10 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 54.97 E-value: 8.82e-10
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 755506076 364 GRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 417
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1-263 |
4.34e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 59.89 E-value: 4.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHrsPKCLAllLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHAKLLI--KHDSN 78
Cdd:PHA02878 53 VKSLLTRGHNVNQPDHRDLTPLHIICKE--PNKLG--MKEMIRSINKCSVFYTLVAIKDAFNNRNVEIFKIILtnRYKNI 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 79 IGIPDVEGKiplhwAANHKDPSAVHTVRCILDAAPTESLLNwqDYEGRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNL 158
Cdd:PHA02878 129 QTIDLVYID-----KKSKDDIIEAEITKLLLSYGADINMKD--RHKGNTALHYATENKDQRLTELLLSY-GANVNIPDKT 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 159 FRTPLHWAAllgtfgRHAQ--IVHLLLeRNKSGTIPSDSQGATPLHYAAQSNFA-ETVKVFLQH-PSVKDDSDLEGRTSF 234
Cdd:PHA02878 201 NNSPLHHAV------KHYNkpIVHILL-ENGASTDARDKCGNTPLHISVGYCKDyDILKLLLEHgVDVNAKSYILGLTAL 273
|
250 260
....*....|....*....|....*....
gi 755506076 235 MWAAgkGNDDVLRTMLSLKSDIDINMSDK 263
Cdd:PHA02878 274 HSSI--KSERKLKLLLEYGADINSLNSYK 300
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
243-466 |
4.67e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 60.46 E-value: 4.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 243 DDVLRTMLSLKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGA 322
Cdd:PHA02876 156 DELLIAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRS 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 323 RV---DL--------VDQDGHSLLHWAALGGNA-DVCQ------------------ILIENKINPNVQDYAGRTPLQCAA 372
Cdd:PHA02876 236 NInknDLsllkairnEDLETSLLLYDAGFSVNSiDDCKntplhhasqapslsrlvpKLLERGADVNAKNIKGETPLYLMA 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 373 YGGY-INCMAVLMENNADPNIQDKEGRTALHWSCN-NGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQF 450
Cdd:PHA02876 316 KNGYdTENIRTLIMLGADVNAADRLYITPLHQASTlDRNKDIVITLLELGANVNARDYCDK--TPIHYAAVRNNVVIINT 393
|
250
....*....|....*.
gi 755506076 451 MLEHGALSIAAIQDIA 466
Cdd:PHA02876 394 LLDYGADIEALSQKIG 409
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
334-417 |
5.52e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.91 E-value: 5.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 334 LLHWAAlGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAI 413
Cdd:PTZ00322 86 LCQLAA-SGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVV 164
|
....
gi 755506076 414 KLLL 417
Cdd:PTZ00322 165 QLLS 168
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
268-456 |
6.35e-09 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 59.23 E-value: 6.35e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 268 ALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNA-DV 346
Cdd:PHA02875 5 ALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVkAV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 347 CQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqM 426
Cdd:PHA02875 85 EELLDLGKFADDVFYKDGMTPLHLATILKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDHKACLD-I 163
|
170 180 190
....*....|....*....|....*....|
gi 755506076 427 ENNEErYTPLDYALLGERHEVIQFMLEHGA 456
Cdd:PHA02875 164 EDCCG-CTPLIIAMAKGDIAICKMLLDSGA 192
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
382-454 |
6.90e-09 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 59.53 E-value: 6.90e-09
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755506076 382 VLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGERHEVIQFMLEH 454
Cdd:PTZ00322 100 ILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGK--TPLELAEENGFREVVQLLSRH 170
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
199-405 |
7.31e-09 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 59.64 E-value: 7.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 199 TPLHYAAQSNFAETVKVFLQHPSVkddsDLE-----GRTSFMWAAGKGNDDVLRTMLSLKSDIdINM---SDKYGG-TAL 269
Cdd:cd22192 19 SPLLLAAKENDVQAIKKLLKCPSC----DLFqrgalGETALHVAALYDNLEAAVVLMEAAPEL-VNEpmtSDLYQGeTAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 270 HAAALSGHVSTVKLLLDNDAQV---DATDVM------------KHTPLFRACeMGHRDVIQTLIKGGArvDLVDQD--GH 332
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVvspRATGTFfrpgpknliyygEHPLSFAAC-VGNEEIVRLLIEHGA--DIRAQDslGN 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 333 SLLHWAALGGNAD-VCQI--LI---ENKINP----NVQDYAGRTPLQCAAYGGYINCMAVLMENnadpniqdkegRTALH 402
Cdd:cd22192 171 TVLHILVLQPNKTfACQMydLIlsyDKEDDLqpldLVPNNQGLTPFKLAAKEGNIVMFQHLVQK-----------RRHIQ 239
|
...
gi 755506076 403 WSC 405
Cdd:cd22192 240 WTY 242
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
126-308 |
2.83e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 57.31 E-value: 2.83e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 126 RTPLHFAVADGNLTVVDVLTSYEscniTSYDNLF----RTPLHwaalLGTFGRHAQIVHLLLERNKSGTIPSDSQgATPL 201
Cdd:PHA02875 69 ESELHDAVEEGDVKAVEELLDLG----KFADDVFykdgMTPLH----LATILKKLDIMKLLIARGADPDIPNTDK-FSPL 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 202 HYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSlkSDIDINMSDKYGGTALHAAALSGH-VST 280
Cdd:PHA02875 140 HLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGDIAICKMLLD--SGANIDYFGKNGCVAALCYAIENNkIDI 217
|
170 180 190
....*....|....*....|....*....|.
gi 755506076 281 VKLLLDNDAQVD-ATDVM--KHTPLFRACEM 308
Cdd:PHA02875 218 VRLFIKRGADCNiMFMIEgeECTILDMICNM 248
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
88-364 |
5.07e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.43 E-value: 5.07e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 88 IPLHWAANHKDpsaVHTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGN-LTVVDVLTSYESCNITSYDNLFRTPLHW- 165
Cdd:PHA02878 39 IPLHQAVEARN---LDVVKSLLTRGHN---VNQPDHRDLTPLHIICKEPNkLGMKEMIRSINKCSVFYTLVAIKDAFNNr 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 166 ------AALLGTFGR------------------HAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQHPS 221
Cdd:PHA02878 113 nveifkIILTNRYKNiqtidlvyidkkskddiiEAEITKLLLSYGADINMKDRHKGNTALHYATENKDQRLTELLLSYGA 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 222 VKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDInmSDKYGGTALHAAalSGHV---STVKLLLDNDAQVDA-TDVM 297
Cdd:PHA02878 193 NVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDA--RDKCGNTPLHIS--VGYCkdyDILKLLLEHGVDVNAkSYIL 268
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755506076 298 KHTPLFRAceMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALG-GNADVCQILIEN-----KINPNVQDYAG 364
Cdd:PHA02878 269 GLTALHSS--IKSERKLKLLLEYGADINSLNSYKLTPLSSAVKQyLCINIGRILISNicllkRIKPDIKNSEG 339
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
200-456 |
6.75e-08 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 56.04 E-value: 6.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 200 PLHYAAQSNFAETVKVFLQHPSVKDDSDLEGRTSFMWAAGKGNDDVLRTMLSLKSDIDINMSDKYGGTALHaaalSGHVS 279
Cdd:PHA02878 40 PLHQAVEARNLDVVKSLLTRGHNVNQPDHRDLTPLHIICKEPNKLGMKEMIRSINKCSVFYTLVAIKDAFN----NRNVE 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 280 TVKLLLDNDAQVDATDVMKHTplfraCEMGHRDVIQT-----LIKGGARVDLVDQD-GHSLLHWAALGGNADVCQILIEN 353
Cdd:PHA02878 116 IFKIILTNRYKNIQTIDLVYI-----DKKSKDDIIEAeitklLLSYGADINMKDRHkGNTALHYATENKDQRLTELLLSY 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 354 KINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCnnGYLdaikllldfaafpnqmenneery 433
Cdd:PHA02878 191 GANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGASTDARDKCGNTPLHISV--GYC----------------------- 245
|
250 260
....*....|....*....|...
gi 755506076 434 tpLDYallgerhEVIQFMLEHGA 456
Cdd:PHA02878 246 --KDY-------DILKLLLEHGV 259
|
|
| PLN03192 |
PLN03192 |
Voltage-dependent potassium channel; Provisional |
338-424 |
7.81e-08 |
|
Voltage-dependent potassium channel; Provisional
Pssm-ID: 215625 [Multi-domain] Cd Length: 823 Bit Score: 56.41 E-value: 7.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 338 AALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLL 417
Cdd:PLN03192 532 VASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHACNVHIRDANGNTALWNAISAKHHKIFRILY 611
|
....*..
gi 755506076 418 DFAAFPN 424
Cdd:PLN03192 612 HFASISD 618
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
300-351 |
8.63e-08 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 49.58 E-value: 8.63e-08
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 755506076 300 TPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILI 351
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
63-258 |
1.25e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 55.00 E-value: 1.25e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 63 YNNPEHAKLLIKHDS--NIGIPDVEGkiPLHWAANHKDpsaVHTVRCILDAAPTESLLNWQDyeGRTPLHFAVADGNLTV 140
Cdd:PHA02875 45 FRDSEAIKLLMKHGAipDVKYPDIES--ELHDAVEEGD---VKAVEELLDLGKFADDVFYKD--GMTPLHLATILKKLDI 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 141 VDVLTSYES-CNITSYDNLfrTPLHWAALLGTFgrhaQIVHLLLErNKSGTIPSDSQGATPLHYAAQSNFAETVKVFLQH 219
Cdd:PHA02875 118 MKLLIARGAdPDIPNTDKF--SPLHLAVMMGDI----KGIELLID-HKACLDIEDCCGCTPLIIAMAKGDIAICKMLLDS 190
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 755506076 220 PSVKDDSDLEGRTSFMWAAGKGND-DVLRTMLSLKSDIDI 258
Cdd:PHA02875 191 GANIDYFGKNGCVAALCYAIENNKiDIVRLFIKRGADCNI 230
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
350-402 |
4.40e-07 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 47.73 E-value: 4.40e-07
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 755506076 350 LIENK-INPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEGRTALH 402
Cdd:pfam13857 1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALD 54
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
19-152 |
5.92e-07 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 53.07 E-value: 5.92e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 19 MTPLHLSTRHRSPKCLALLLKFMAPGEVDTQDKNkqTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKD 98
Cdd:PHA02875 103 MTPLHLATILKKLDIMKLLIARGADPDIPNTDKF--SPLHLAVMMGDIKGIELLIDHKACLDIEDCCGCTPLIIAMAKGD 180
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 755506076 99 psaVHTVRCILDAAPTesllnwQDYEGRTP----LHFAVADGNLTVVDVLTSYES-CNI 152
Cdd:PHA02875 181 ---IAICKMLLDSGAN------IDYFGKNGcvaaLCYAIENNKIDIVRLFIKRGAdCNI 230
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
387-439 |
1.65e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.80 E-value: 1.65e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|...
gi 755506076 387 NADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYA 439
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLN--LKDEEGLTALDLA 56
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
273-350 |
2.04e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.82 E-value: 2.04e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755506076 273 ALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQIL 350
Cdd:PTZ00322 90 AASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
320-371 |
2.22e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 45.42 E-value: 2.22e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|..
gi 755506076 320 GGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCA 371
Cdd:pfam13857 5 GPIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| TRPV5-6 |
cd22192 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ... |
54-242 |
2.62e-06 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.
Pssm-ID: 411976 [Multi-domain] Cd Length: 609 Bit Score: 51.17 E-value: 2.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 54 QTALHWSAYYNNPEHAKLLikhdsnigipdvegkiplhwaanhkdpsavhtvrciLDAAPTesLLNW----QDYEGRTPL 129
Cdd:cd22192 52 ETALHVAALYDNLEAAVVL------------------------------------MEAAPE--LVNEpmtsDLYQGETAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 130 HFAVADGNLTVVDVLTSYESCNIT----------SYDNLF---RTPLHWAALLGtfgrHAQIVHLLLERNKSgTIPSDSQ 196
Cdd:cd22192 94 HIAVVNQNLNLVRELIARGADVVSpratgtffrpGPKNLIyygEHPLSFAACVG----NEEIVRLLIEHGAD-IRAQDSL 168
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 197 GATPLHY---AAQSNFA-ETVKVFLQHPSVKDDSDLE------GRTSFMWAAGKGN 242
Cdd:cd22192 169 GNTVLHIlvlQPNKTFAcQMYDLILSYDKEDDLQPLDlvpnnqGLTPFKLAAKEGN 224
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
252-319 |
2.97e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 51.05 E-value: 2.97e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755506076 252 LKSDIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPLFRACEMGHRDVIQTLIK 319
Cdd:PTZ00322 102 LTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSR 169
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
397-452 |
3.00e-06 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 44.96 E-value: 3.00e-06
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 397 GRTALHWSCNNGYLDAIKLLLDFAAFPNqmENNEERYTPLDYALLGERHEVIQFML 452
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGADIN--AVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
143-231 |
6.80e-06 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 49.90 E-value: 6.80e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 143 VLTSYESCNITSYDNlfRTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFLQHPsv 222
Cdd:PTZ00322 101 LLTGGADPNCRDYDG--RTPLHIACANG----HVQVVRVLLEFGADPTL-LDKDGKTPLELAEENGFREVVQLLSRHS-- 171
|
....*....
gi 755506076 223 KDDSDLEGR 231
Cdd:PTZ00322 172 QCHFELGAN 180
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
43-93 |
1.46e-05 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 43.10 E-value: 1.46e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 43 PGEVDTQDKNKQTALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWA 93
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTALDLA 56
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
815-840 |
4.67e-05 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 41.37 E-value: 4.67e-05
10 20
....*....|....*....|....*.
gi 755506076 815 RKELFRRKNKAAAVIQRAWRSYQLRK 840
Cdd:cd23767 1 EEEELQRMNRAATLIQALWRGYKVRK 26
|
|
| PTZ00322 |
PTZ00322 |
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional |
314-384 |
4.85e-05 |
|
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
Pssm-ID: 140343 [Multi-domain] Cd Length: 664 Bit Score: 47.20 E-value: 4.85e-05
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755506076 314 IQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLM 384
Cdd:PTZ00322 98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLS 168
|
|
| PHA03378 |
PHA03378 |
EBNA-3B; Provisional |
520-784 |
5.32e-05 |
|
EBNA-3B; Provisional
Pssm-ID: 223065 [Multi-domain] Cd Length: 991 Bit Score: 47.37 E-value: 5.32e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 520 QLDTDPPRSHCSSSAPVLPCPPSPQNEASKQDATPSKQppaSHTVQSPDPEHSRPPGRCPGRASQGDSSIDLQGTASRKP 599
Cdd:PHA03378 575 QPLTSPTTSQLASSAPSYAQTPWPVPHPSQTPEPPTTQ---SHIPETSAPRQWPMPLRPIPMRPLRMQPITFNVLVFPTP 651
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 600 SETP-IEHCRGPSACVHPRSWEGGNSSKNQGTSsveKRRGETNGKHRRCEEGPSSARQPLC--TGSGRPAEKGEDSSPAV 676
Cdd:PHA03378 652 HQPPqVEITPYKPTWTQIGHIPYQPSPTGANTM---LPIQWAPGTMQPPPRAPTPMRPPAAppGRAQRPAAATGRARPPA 728
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 677 ASASQQDHP-------RKPNKRQDRAARPRGASQKRR-------------------THQLRDRCSPAGSSRPGSAKGEVA 730
Cdd:PHA03378 729 AAPGRARPPaaapgraRPPAAAPGRARPPAAAPGRARppaaapgaptpqpppqappAPQQRPRGAPTPQPPPQAGPTSMQ 808
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 755506076 731 CADQSSLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRsGCKQLYEDICASPETG 784
Cdd:PHA03378 809 LMPRAAPGQQGPTKQILRQLLTGGVKRGRPSLKKPAA-LERQAAAGPTPSPGSG 861
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
297-456 |
7.20e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 46.52 E-value: 7.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 297 MKHTPLFRACEMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGY 376
Cdd:PHA02875 1 MDQVALCDAILFGELDIARRLLDIGINPNFEIYDGISPIKLAMKFRDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 377 INCMAVLMENNADPN-IQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQmeNNEERYTPLDYALLGERHEVIQFMLEHG 455
Cdd:PHA02875 81 VKAVEELLDLGKFADdVFYKDGMTPLHLATILKKLDIMKLLIARGADPDI--PNTDKFSPLHLAVMMGDIKGIELLIDHK 158
|
.
gi 755506076 456 A 456
Cdd:PHA02875 159 A 159
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
264-295 |
9.51e-05 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 40.35 E-value: 9.51e-05
10 20 30
....*....|....*....|....*....|...
gi 755506076 264 YGGTALHAAALS-GHVSTVKLLLDNDAQVDATD 295
Cdd:pfam00023 1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
|
|
| PHA02875 |
PHA02875 |
ankyrin repeat protein; Provisional |
1-144 |
9.74e-05 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165206 [Multi-domain] Cd Length: 413 Bit Score: 45.75 E-value: 9.74e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRA--NWMQKDLEemTPLHLSTRHRSPKCLALLL---KFMApgevDTQDKNKQTALHWSAYYNNPEHAKLLIKH 75
Cdd:PHA02875 51 IKLLMKHGAipDVKYPDIE--SELHDAVEEGDVKAVEELLdlgKFAD----DVFYKDGMTPLHLATILKKLDIMKLLIAR 124
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755506076 76 DSNIGIPDVEGKIPLHWAANHKDpsaVHTVRCILDAAPTeslLNWQDYEGRTPLHFAVADGNLTVVDVL 144
Cdd:PHA02875 125 GADPDIPNTDKFSPLHLAVMMGD---IKGIELLIDHKAC---LDIEDCCGCTPLIIAMAKGDIAICKML 187
|
|
| PHA03100 |
PHA03100 |
ankyrin repeat protein; Provisional |
2-109 |
1.41e-04 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222984 [Multi-domain] Cd Length: 422 Bit Score: 45.43 E-value: 1.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 2 KLLLTRRANWMQKDLEEMTPLHLSTRHRSPKC------------------LALLLKFMAPgeVDTQDKNKQTALHWSAYY 63
Cdd:PHA03100 125 EYLLDNGANVNIKNSDGENLLHLYLESNKIDLkilkllidkgvdinaknrVNYLLSYGVP--INIKDVYGFTPLHYAVYN 202
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 755506076 64 NNPEHAKLLIKHDSNIGIPDVEGKIPLHWAA--NHKD---------PSAVHTVRCIL 109
Cdd:PHA03100 203 NNPEFVKYLLDLGANPNLVNKYGDTPLHIAIlnNNKEifklllnngPSIKTIIETLL 259
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
255-302 |
1.94e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 40.02 E-value: 1.94e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 755506076 255 DIDINMSDKYGGTALHAAALSGHVSTVKLLLDNDAQVDATDVMKHTPL 302
Cdd:pfam13857 6 PIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
160-217 |
2.50e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.57 E-value: 2.50e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 755506076 160 RTPLHWAALLGtfgrHAQIVHLLLERNKSGTIpSDSQGATPLHYAAQSNFAETVKVFL 217
Cdd:pfam13637 2 LTALHAAAASG----HLELLRLLLEKGADINA-VDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
125-183 |
3.13e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 39.57 E-value: 3.13e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 755506076 125 GRTPLHFAVADGNLTVVDVLTSYeSCNITSYDNLFRTPLHWAAllgtFGRHAQIVHLLL 183
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEK-GADINAVDGNGETALHFAA----SNGNVEVLKLLL 54
|
|
| PHA02791 |
PHA02791 |
ankyrin-like protein; Provisional |
122-319 |
3.22e-04 |
|
ankyrin-like protein; Provisional
Pssm-ID: 165154 [Multi-domain] Cd Length: 284 Bit Score: 43.88 E-value: 3.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 122 DYEGRTPLHFAVADGNLTVVDVLTsyescNITSYDNLFRT--PLHWAALLgtfgRHAQIVHLLLernKSGTIPS--DSQG 197
Cdd:PHA02791 27 DVHGHSALYYAIADNNVRLVCTLL-----NAGALKNLLENefPLHQAATL----EDTKIVKILL---FSGMDDSqfDDKG 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 198 ATPLHYAAQSNFAETVKVFLQHP-SVKDDSDLEGRTSFMWAAGKGNDDVLRTMLS-LKSDIDINMSDkyggTALHAAALS 275
Cdd:PHA02791 95 NTALYYAVDSGNMQTVKLFVKKNwRLMFYGKTGWKTSFYHAVMLNDVSIVSYFLSeIPSTFDLAILL----SCIHITIKN 170
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 755506076 276 GHVSTVKLLLDNDAQVDATDVMKHTPLFR-ACEMGHRDVIQTLIK 319
Cdd:PHA02791 171 GHVDMMILLLDYMTSTNTNNSLLFIPDIKlAIDNKDLEMLQALFK 215
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
330-359 |
3.27e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 38.72 E-value: 3.27e-04
10 20 30
....*....|....*....|....*....|
gi 755506076 330 DGHSLLHWAALGGNADVCQILIENKINPNV 359
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
224-272 |
5.18e-04 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 38.87 E-value: 5.18e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 755506076 224 DDSDLEGRTSFMWAAGKGNDDVLRTMLslKSDIDINMSDKYGGTALHAA 272
Cdd:pfam13857 10 NRLDGEGYTPLHVAAKYGALEIVRVLL--AYGVDLNLKDEEGLTALDLA 56
|
|
| IQCD |
cd23767 |
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory ... |
461-487 |
5.89e-04 |
|
IQ (isoleucine-glutamine) motif containing D (IQCD); IQCD, also called dynein regulatory complex protein 10 (DRC10), belongs to the IQ motif-containing protein family which contains a C-terminal conserved IQ motif domain and two coiled-coil domains. The IQ motif ([ILV]QxxxRxxxx[RK]), where x stands for any amino-acid residue, interacts with calmodulin (CaM) in a calcium-independent manner and is present in proteins with a wide diversity of biological functions. The IQCD protein was found to primarily accumulate in the acrosome area of round and elongating spermatids of the testis during late stage of spermiogenesis and was then localized to the acrosome and tail regions of mature spermatozoa. The expression of IQCD follows the trajectory of acrosome development during spermatogenesis. IQCD is associated with neuroblastoma and neurodegenerative diseases, and is reported to interact with the nuclear retinoid X receptor in the presence of 9-cis-retinoic acid, thereby activating the transcriptional activity of the receptor.
Pssm-ID: 467745 [Multi-domain] Cd Length: 37 Bit Score: 38.29 E-value: 5.89e-04
10 20
....*....|....*....|....*..
gi 755506076 461 AIQDIAAFKIQAVYKGYKVRKAFRDRK 487
Cdd:cd23767 6 QRMNRAATLIQALWRGYKVRKELKKKK 32
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
132-385 |
6.09e-04 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 43.53 E-value: 6.09e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 132 AVADGNLTVV-DVLTSYESCNITSYDNLFRTPLHWAALLGtfgRHAQIVHLLLERNKSGTIpsdsqGATPLHyAAQSNFA 210
Cdd:TIGR00870 24 AAERGDLASVyRDLEEPKKLNINCPDRLGRSALFVAAIEN---ENLELTELLLNLSCRGAV-----GDTLLH-AISLEYV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 211 ETVKVFLQHPsvkDDSDLEGRTSFMwaagkgnddvlrtmlslksDIDINMSDKYGG-TALHAAALSGHVSTVKLLLDNDA 289
Cdd:TIGR00870 95 DAVEAILLHL---LAAFRKSGPLEL-------------------ANDQYTSEFTPGiTALHLAAHRQNYEIVKLLLERGA 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 290 QVDA------------TDVMKHT--PL-FRACeMGHRDVIQTLIKGGARVDLVDQDGHSLLHWAALggNAD--------V 346
Cdd:TIGR00870 153 SVPAracgdffvksqgVDSFYHGesPLnAAAC-LGSPSIVALLSEDPADILTADSLGNTLLHLLVM--ENEfkaeyeelS 229
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 755506076 347 CQI-------------LIENKINPNvqdYAGRTPLQCAAYGGYINCMAVLME 385
Cdd:TIGR00870 230 CQMynfalslldklrdSKELEVILN---HQGLTPLKLAAKEGRIVLFRLKLA 278
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
396-424 |
6.13e-04 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.95 E-value: 6.13e-04
10 20
....*....|....*....|....*....
gi 755506076 396 EGRTALHWSCNNGYLDAIKLLLDFAAFPN 424
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADIN 29
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
330-361 |
7.35e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 7.35e-04
10 20 30
....*....|....*....|....*....|...
gi 755506076 330 DGHSLLHWAAL-GGNADVCQILIENKINPNVQD 361
Cdd:pfam00023 1 DGNTPLHLAAGrRGNLEIVKLLLSKGADVNARD 33
|
|
| Ank |
pfam00023 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
364-395 |
8.94e-04 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.
Pssm-ID: 459634 [Multi-domain] Cd Length: 34 Bit Score: 37.65 E-value: 8.94e-04
10 20 30
....*....|....*....|....*....|...
gi 755506076 364 GRTPLQCAAY-GGYINCMAVLMENNADPNIQDK 395
Cdd:pfam00023 2 GNTPLHLAAGrRGNLEIVKLLLSKGADVNARDK 34
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
330-359 |
1.04e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 37.24 E-value: 1.04e-03
10 20 30
....*....|....*....|....*....|
gi 755506076 330 DGHSLLHWAALGGNADVCQILIENKINPNV 359
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
364-392 |
1.16e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 37.18 E-value: 1.16e-03
10 20
....*....|....*....|....*....
gi 755506076 364 GRTPLQCAAYGGYINCMAVLMENNADPNI 392
Cdd:smart00248 2 GRTPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| PRK12678 |
PRK12678 |
transcription termination factor Rho; Provisional |
463-713 |
1.78e-03 |
|
transcription termination factor Rho; Provisional
Pssm-ID: 237171 [Multi-domain] Cd Length: 672 Bit Score: 42.20 E-value: 1.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 463 QDIAAFKI---QAVYKGYKVRKAFRDRKNLLMKH-EQLRKDAAAKKREEENKRKEAEQQKGQLDTDPPRSHCSSSAPVLP 538
Cdd:PRK12678 21 GGLAGMKLpelRALAKQLGIKGTSGMRKGELIAAiKEARGGGAAAAAATPAAPAAAARRAARAAAAARQAEQPAAEAAAA 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 539 CPPSPQNEASKQDATPSKQPPASHTVQSPDPEHSRPPGRCP----GRASQGDSSIDLQGTASRKPSETPIEHCRGPSACV 614
Cdd:PRK12678 101 KAEAAPAARAAAAAAAEAASAPEAAQARERRERGEAARRGAarkaGEGGEQPATEARADAAERTEEEERDERRRRGDRED 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 615 HPRSWEGGNSSKNQGTSSvEKRRGETNGKHRRCEEGPSSARQplctGSGRPAEKGEDSSPAVASASQQDHPRKPNKRQDR 694
Cdd:PRK12678 181 RQAEAERGERGRREERGR-DGDDRDRRDRREQGDRREERGRR----DGGDRRGRRRRRDRRDARGDDNREDRGDRDGDDG 255
|
250
....*....|....*....
gi 755506076 695 AARPRGASQKRRThqlRDR 713
Cdd:PRK12678 256 EGRGGRRGRRFRD---RDR 271
|
|
| PHA03307 |
PHA03307 |
transcriptional regulator ICP4; Provisional |
546-789 |
1.80e-03 |
|
transcriptional regulator ICP4; Provisional
Pssm-ID: 223039 [Multi-domain] Cd Length: 1352 Bit Score: 42.47 E-value: 1.80e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 546 EASKQDATPSKQPPASHTVQSPDPeHSRPPGRCPGRASQGDSSIDLQGTASRKPSETPIEHCRGPSACVHPRsweggNSS 625
Cdd:PHA03307 12 EAAAEGGEFFPRPPATPGDAADDL-LSGSQGQLVSDSAELAAVTVVAGAAACDRFEPPTGPPPGPGTEAPAN-----ESR 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 626 KNQGTSSVEKRRGETNGKHRRCEEGPSSARQPLCTGSgrPAEKGEDSSPAVASASQQDHPRKPNKRQDRAARPRGASQKR 705
Cdd:PHA03307 86 STPTWSLSTLAPASPAREGSPTPPGPSSPDPPPPTPP--PASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 706 RTHQlrdrcSPAGSSRPGSAKGEVACADQS---------SLHRHTPRSKVTQDKLIGGVSSGLPLSTEASRSGCKQLYED 776
Cdd:PHA03307 164 SDAA-----SSRQAALPLSSPEETARAPSSppaepppstPPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSD 238
|
250
....*....|...
gi 755506076 777 ICASPETGVAHGP 789
Cdd:PHA03307 239 SSSSESSGCGWGP 251
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
55-103 |
1.81e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 37.25 E-value: 1.81e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 755506076 55 TALHWSAYYNNPEHAKLLIKHDSNIGIPDVEGKIPLHWAANHKDPSAVH 103
Cdd:pfam13637 3 TALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLK 51
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
267-293 |
2.03e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.03e-03
10 20
....*....|....*....|....*..
gi 755506076 267 TALHAAALSGHVSTVKLLLDNDAQVDA 293
Cdd:smart00248 4 TPLHLAAENGNLEVVKLLLDKGADINA 30
|
|
| TRPV |
cd21882 |
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ... |
230-405 |
2.05e-03 |
|
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).
Pssm-ID: 411975 [Multi-domain] Cd Length: 600 Bit Score: 41.79 E-value: 2.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 230 GRTSFMWAAGKGNDDVLRTML----------SLKSDIDINMSDKY--GGTALHAAALSGHVSTVKLLLDNDAQVDAT--- 294
Cdd:cd21882 26 GKTCLHKAALNLNDGVNEAIMllleaapdsgNPKELVNAPCTDEFyqGQTALHIAIENRNLNLVRLLVENGADVSARatg 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 295 DVMKHTPL-----------FRACeMGHRDVIQTLIKGGARV-DLVDQD--GHSLLHWAALGGN------ADVCQ-----I 349
Cdd:cd21882 106 RFFRKSPGnlfyfgelplsLAAC-TNQEEIVRLLLENGAQPaALEAQDslGNTVLHALVLQADntpensAFVCQmynllL 184
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755506076 350 LIENKINPNVQ-----DYAGRTPLQCAAYGGYINCMAVLMENNADPNIQDKEgRTALHWSC 405
Cdd:cd21882 185 SYGAHLDPTQQleeipNHQGLTPLKLAAVEGKIVMFQHILQREFSGPYQPLS-RKFTEWTY 244
|
|
| ANK |
smart00248 |
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ... |
52-79 |
2.16e-03 |
|
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.
Pssm-ID: 197603 [Multi-domain] Cd Length: 30 Bit Score: 36.41 E-value: 2.16e-03
10 20
....*....|....*....|....*...
gi 755506076 52 NKQTALHWSAYYNNPEHAKLLIKHDSNI 79
Cdd:smart00248 1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
89-144 |
2.34e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 2.34e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 89 PLHWAANHKDPSAVHtvRCILDAAPteslLNWQDYEGRTPLHFAVADGNLTVVDVL 144
Cdd:pfam13637 4 ALHAAAASGHLELLR--LLLEKGAD----INAVDGNGETALHFAASNGNVEVLKLL 53
|
|
| trp |
TIGR00870 |
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ... |
54-253 |
2.42e-03 |
|
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273311 [Multi-domain] Cd Length: 743 Bit Score: 41.61 E-value: 2.42e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 54 QTALHWSAYYNNP-EHAKLLIKHDSNIgipdVEGKIPLHWAA-NHKDpsAVHTVRCILDAAPTES----LLNWQD----Y 123
Cdd:TIGR00870 53 RSALFVAAIENENlELTELLLNLSCRG----AVGDTLLHAISlEYVD--AVEAILLHLLAAFRKSgpleLANDQYtsefT 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 124 EGRTPLHFAVADGNLTVVDVL------TSYES----CNITSYDNLF---RTPLHWAALLGTfgrhAQIVHLLLErNKSGT 190
Cdd:TIGR00870 127 PGITALHLAAHRQNYEIVKLLlergasVPARAcgdfFVKSQGVDSFyhgESPLNAAACLGS----PSIVALLSE-DPADI 201
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755506076 191 IPSDSQGATPLHYAAQSN--------FAETVKVF-LQHPSVKDDS-DLE------GRTSFMWAAGKGNDDVLRTMLSLK 253
Cdd:TIGR00870 202 LTADSLGNTLLHLLVMENefkaeyeeLSCQMYNFaLSLLDKLRDSkELEvilnhqGLTPLKLAAKEGRIVLFRLKLAIK 280
|
|
| Ank_4 |
pfam13637 |
Ankyrin repeats (many copies); |
18-73 |
2.74e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 372654 [Multi-domain] Cd Length: 54 Bit Score: 36.87 E-value: 2.74e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 755506076 18 EMTPLHLSTRHRSPKCLALLLKFMAPgeVDTQDKNKQTALHWSAYYNNPEHAKLLI 73
Cdd:pfam13637 1 ELTALHAAAASGHLELLRLLLEKGAD--INAVDGNGETALHFAASNGNVEVLKLLL 54
|
|
| Ank_5 |
pfam13857 |
Ankyrin repeats (many copies); |
117-166 |
2.74e-03 |
|
Ankyrin repeats (many copies);
Pssm-ID: 433530 [Multi-domain] Cd Length: 56 Bit Score: 36.94 E-value: 2.74e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|
gi 755506076 117 LLNWQDYEGRTPLHFAVADGNLTVVDVLTSYEsCNITSYDNLFRTPLHWA 166
Cdd:pfam13857 8 DLNRLDGEGYTPLHVAAKYGALEIVRVLLAYG-VDLNLKDEEGLTALDLA 56
|
|
| Ank_3 |
pfam13606 |
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ... |
264-293 |
2.96e-03 |
|
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.
Pssm-ID: 463933 [Multi-domain] Cd Length: 30 Bit Score: 36.08 E-value: 2.96e-03
10 20 30
....*....|....*....|....*....|
gi 755506076 264 YGGTALHAAALSGHVSTVKLLLDNDAQVDA 293
Cdd:pfam13606 1 DGNTPLHLAARNGRLEIVKLLLENGADINA 30
|
|
| PHA02876 |
PHA02876 |
ankyrin repeat protein; Provisional |
313-489 |
3.00e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 165207 [Multi-domain] Cd Length: 682 Bit Score: 41.59 E-value: 3.00e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 313 VIQTLIKGGARVDLVDQDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNADPNI 392
Cdd:PHA02876 160 IAEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDNRSNINK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 393 QDkegrTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEEryTPLDYALLGER-HEVIQFMLEHGAlsiaaiqDIAAFKIQ 471
Cdd:PHA02876 240 ND----LSLLKAIRNEDLETSLLLYDAGFSVNSIDDCKN--TPLHHASQAPSlSRLVPKLLERGA-------DVNAKNIK 306
|
170
....*....|....*...
gi 755506076 472 AVYKGYKVRKAFRDRKNL 489
Cdd:PHA02876 307 GETPLYLMAKNGYDTENI 324
|
|
| PRK14954 |
PRK14954 |
DNA polymerase III subunits gamma and tau; Provisional |
441-642 |
4.06e-03 |
|
DNA polymerase III subunits gamma and tau; Provisional
Pssm-ID: 184918 [Multi-domain] Cd Length: 620 Bit Score: 41.08 E-value: 4.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 441 LGERHEVIQ--FMLEHGALSIAAIQDIAAF--------KIQAVYKgykvrkaFRDRKNLLMKHEQLRKD---AAAKKREE 507
Cdd:PRK14954 316 LIERPESVKerYQQSAGGLTPAAVMQMTDFlmktqgelKFQFEYQ-------FRFELALLRLIELVRNDggvAPSPAGSP 388
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 508 ENKRKEAEQQKGQLDTDPPRSHCSSSA--PVLPCPPSpqneaskQDATPSKQPPashtVQSPDPEHSRPPGRCPGRASQG 585
Cdd:PRK14954 389 DVKKKAPEPDLPQPDRHPGPAKPEAPGarPAELPSPA-------SAPTPEQQPP----VARSAPLPPSPQASAPRNVASG 457
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 755506076 586 DSSIDLqGTASRKPSETPIEHCRGpsACVHPRSWEGGNSSKNQGTSSVEKRRGETNG 642
Cdd:PRK14954 458 KPGVDL-GSWQGKFMNFTRNGSRK--QPVQASSSDAAQTGVFEGVAELEKLRMEWNQ 511
|
|
| PHA02878 |
PHA02878 |
ankyrin repeat protein; Provisional |
1-133 |
5.44e-03 |
|
ankyrin repeat protein; Provisional
Pssm-ID: 222939 [Multi-domain] Cd Length: 477 Bit Score: 40.25 E-value: 5.44e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755506076 1 MKLLLTRRANWMQKDLEEMTPLHLSTRHRSPKCLALLLKFMApgEVDTQDKNKQTALHWS-AYYNNPEHAKLLIKHDSNI 79
Cdd:PHA02878 184 TELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA--STDARDKCGNTPLHISvGYCKDYDILKLLLEHGVDV 261
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 755506076 80 GIPD-VEGKIPLHWAANHKDpsavhTVRCILDAAPTESLLNWqdyEGRTPLHFAV 133
Cdd:PHA02878 262 NAKSyILGLTALHSSIKSER-----KLKLLLEYGADINSLNS---YKLTPLSSAV 308
|
|
| C11orf65 |
cd21090 |
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 ... |
822-868 |
6.96e-03 |
|
chromosome 11 open reading frame 65 and homologs; Chromosome 11 open reading frame 65 (C11orf65) is an uncharacterized protein that may be associated with potential sensitivity to metformin in type 2 diabetes (diabetes mellitus) patients without cancer.
Pssm-ID: 411042 Cd Length: 260 Bit Score: 39.61 E-value: 6.96e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 755506076 822 KNKAAAVIQRAWRSY---QLRKHLSRLLHLKQLG-AREVLRCTQVCTALLL 868
Cdd:cd21090 4 REEAARIIQRAWRRHidvQVFRYYKDLINFRGQGdPRLMLKCINPKEAELL 54
|
|
| |
