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Conserved domains on  [gi|755539945|ref|XP_011247603|]
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centrosomal protein of 112 kDa isoform X8 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Smc super family cl34174
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 150-491 9.26e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG1196:

Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 9.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 150 SELDKEKEDAQRKihkfeeaLKEKEEQLSRVTEVQRLQAQQadaaLEEFKRQVEVnsEKVYGEMKEQMEKVEADLT---- 225
Cdd:COG1196  168 SKYKERKEEAERK-------LEATEENLERLEDILGELERQ----LEPLERQAEK--AERYRELKEELKELEAELLllkl 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 226 RSKSLREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKTHL--LQQHSAEKDSLVRDHDREIENLEKQLRAANmEHENQ 303
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELeeLELELEEAQAEEYELLAELARLEQDIARLE-ERRRE 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 304 IQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAE 383
Cdd:COG1196  314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 384 TEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKAL 463
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                        330       340
                 ....*....|....*....|....*...
gi 755539945 464 QDELETRSHQVRSAEKKLHHKELEAQEQ 491
Cdd:COG1196  474 LLEAALAELLEELAEAAARLLLLLEAEA 501
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 150-491 9.26e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 9.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 150 SELDKEKEDAQRKihkfeeaLKEKEEQLSRVTEVQRLQAQQadaaLEEFKRQVEVnsEKVYGEMKEQMEKVEADLT---- 225
Cdd:COG1196  168 SKYKERKEEAERK-------LEATEENLERLEDILGELERQ----LEPLERQAEK--AERYRELKEELKELEAELLllkl 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 226 RSKSLREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKTHL--LQQHSAEKDSLVRDHDREIENLEKQLRAANmEHENQ 303
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELeeLELELEEAQAEEYELLAELARLEQDIARLE-ERRRE 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 304 IQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAE 383
Cdd:COG1196  314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 384 TEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKAL 463
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                        330       340
                 ....*....|....*....|....*...
gi 755539945 464 QDELETRSHQVRSAEKKLHHKELEAQEQ 491
Cdd:COG1196  474 LLEAALAELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 117-450 4.72e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 4.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   117 LQRKQQVKDQENKFHM--EKNHLKHTYEKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQRLQAQQADAA 194
Cdd:TIGR02168  673 LERRREIEELEEKIEEleEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   195 LEEFKRQVEVNSEkvygeMKEQMEKVEADLTRSKSLREKQSKEFLwQLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAE 274
Cdd:TIGR02168  753 SKELTELEAEIEE-----LEERLEEAEEELAEAEAEIEELEAQIE-QLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   275 KDSLVRDHD--REIENLEKQLRaanmehenQIQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLRE--EE 350
Cdd:TIGR02168  827 ESLERRIAAteRRLEDLEEQIE--------ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSelEE 898

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   351 KQRAAKDHETAVKKLKAEservkMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQ 430
Cdd:TIGR02168  899 LSEELRELESKRSELRRE-----LEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340
                   ....*....|....*....|....*..
gi 755539945   431 QLAAERRLQ-------DVIQKFEDEKQ 450
Cdd:TIGR02168  974 LKRLENKIKelgpvnlAAIEEYEELKE 1000
PRK12704 PRK12704
phosphodiesterase; Provisional
 109-263 1.35e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 109 KQQVQESELQRKQQVKDQENKFHMEKNHLKHTYEKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQRLQA 188
Cdd:PRK12704  30 EAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKRE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755539945 189 QQADAALEEFKRQvEVNSEKVYGEMKEQMEKVEADLTRSKSLREKQSKEFLwqLEDAKQRYEQQIVELKLEHEQE 263
Cdd:PRK12704 110 EELEKKEKELEQK-QQELEKKEEELEELIEEQLQELERISGLTAEEAKEIL--LEKVEEEARHEAAVLIKEIEEE 181
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
 82-281 2.80e-05

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 46.96  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   82 LLRQEHALstsktsgviEELEQNICQLKqqvqeseLQRKQQVKDqenkfhmeknhlkhtyekkVHELQSELDKEKEDAQR 161
Cdd:pfam10168 549 LKKHDLAR---------EEIQKRVKLLK-------LQKEQQLQE-------------------LQSLEEERKSLSERAEK 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  162 KIHKFEEALKEKEEQLSRVTEV-QRLQAQQADAALEEFKRQVEVNSekvygeMKEQMEKVEADLTRSKSLREKQSKeflw 240
Cdd:pfam10168 594 LAEKYEEIKDKQEKLMRRCKKVlQRLNSQLPVLSDAEREMKKELET------INEQLKHLANAIKQAKKKMNYQRY---- 663

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 755539945  241 QLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAEKDSLVRD 281
Cdd:pfam10168 664 QIAKSQSIRKKSSLSLSEKQRKTIKEILKQLGSEIDELIKQ 704
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 153-324 1.18e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.13  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  153 DKEKEDAQRKIHKfeealKEKEEQLSRVTEVQ-RLQA--QQA---------DAALEE-----------FKRQVEVNSEKV 209
Cdd:NF012221 1563 DKERAEADRQRLE-----QEKQQQLAAISGSQsQLEStdQNAletngqaqrDAILEEsravtkelttlAQGLDALDSQAT 1637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  210 Y-GEMKEQ---------MEKVEADLTRSKSLREKQskeflwqLEDAKQRYEQQIVELKLEHEQEKTHLLQ----QHSAEK 275
Cdd:NF012221 1638 YaGESGDQwrnpfagglLDRVQEQLDDAKKISGKQ-------LADAKQRHVDNQQKVKDAVAKSEAGVAQgeqnQANAEQ 1710

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755539945  276 DSLVRDHD---REIENLEKQLRAANMEHE-----NQIQESKKRDAQVIADMEAQVHK 324
Cdd:NF012221 1711 DIDDAKADaekRKDDALAKQNEAQQAESDanaaaNDAQSRGEQDASAAENKANQAQA 1767
 
Name Accession Description Interval E-value
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 150-491 9.26e-11

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.57  E-value: 9.26e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 150 SELDKEKEDAQRKihkfeeaLKEKEEQLSRVTEVQRLQAQQadaaLEEFKRQVEVnsEKVYGEMKEQMEKVEADLT---- 225
Cdd:COG1196  168 SKYKERKEEAERK-------LEATEENLERLEDILGELERQ----LEPLERQAEK--AERYRELKEELKELEAELLllkl 234

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 226 RSKSLREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKTHL--LQQHSAEKDSLVRDHDREIENLEKQLRAANmEHENQ 303
Cdd:COG1196  235 RELEAELEELEAELEELEAELEELEAELAELEAELEELRLELeeLELELEEAQAEEYELLAELARLEQDIARLE-ERRRE 313

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 304 IQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAE 383
Cdd:COG1196  314 LEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALR 393

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 384 TEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKAL 463
Cdd:COG1196  394 AAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAA 473

                        330       340
                 ....*....|....*....|....*...
gi 755539945 464 QDELETRSHQVRSAEKKLHHKELEAQEQ 491
Cdd:COG1196  474 LLEAALAELLEELAEAAARLLLLLEAEA 501
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 97-470 1.25e-10

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 64.19  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  97 VIEELEQNICQLKQQVQESElqRKQQVKDQENKFHMEKNHLKHtyeKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQ 176
Cdd:COG1196  194 ILGELERQLEPLERQAEKAE--RYRELKEELKELEAELLLLKL---RELEAELEELEAELEELEAELEELEAELAELEAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 177 LsrvtEVQRLQAQQADAALEEFKRQVEvnsekvygEMKEQMEKVEADLTRSKSLREkqskeflwQLEDAKQRYEQQIVEL 256
Cdd:COG1196  269 L----EELRLELEELELELEEAQAEEY--------ELLAELARLEQDIARLEERRR--------ELEERLEELEEELAEL 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 257 KLEHEQEKTHLLQQHSAEKDSLVRDHDREIENLEKQLRAANMEHE-NQIQESKKRDAQVIADMEAQVHKLREELISVNSQ 335
Cdd:COG1196  329 EEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAElAEAEEELEELAEELLEALRAAAELAAQLEELEEA 408

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 336 RKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAE 415
Cdd:COG1196  409 EEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAE 488

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755539945 416 LQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETR 470
Cdd:COG1196  489 AAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAA 543
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 152-480 1.53e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 57.64  E-value: 1.53e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 152 LDKEKEDAQR-KIHKFEEALKEKEEQLSRVTEVQRlQAQQADAALEEFKRQVEvnsekvygEMKEQMEKVEADLTRSKSL 230
Cdd:COG1196  205 LERQAEKAERyRELKEELKELEAELLLLKLRELEA-ELEELEAELEELEAELE--------ELEAELAELEAELEELRLE 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 231 REKQSKEFlwqleDAKQRYEQQIVELKLEHEQEKTHLLQQHSAEKDSLVRDhDREIENLEKQLRAANmEHENQIQESKKR 310
Cdd:COG1196  276 LEELELEL-----EEAQAEEYELLAELARLEQDIARLEERRRELEERLEEL-EEELAELEEELEELE-EELEELEEELEE 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 311 DAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEK 390
Cdd:COG1196  349 AEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEE 428

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 391 ANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKfeDEKQQLIRDNDQAIKALQDELETR 470
Cdd:COG1196  429 ALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAEL--LEELAEAAARLLLLLEAEADYEGF 506

                        330
                 ....*....|
gi 755539945 471 SHQVRSAEKK 480
Cdd:COG1196  507 LEGVKAALLL 516
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 117-450 4.72e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.22  E-value: 4.72e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   117 LQRKQQVKDQENKFHM--EKNHLKHTYEKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQRLQAQQADAA 194
Cdd:TIGR02168  673 LERRREIEELEEKIEEleEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   195 LEEFKRQVEVNSEkvygeMKEQMEKVEADLTRSKSLREKQSKEFLwQLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAE 274
Cdd:TIGR02168  753 SKELTELEAEIEE-----LEERLEEAEEELAEAEAEIEELEAQIE-QLKEELKALREALDELRAELTLLNEEAANLRERL 826

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   275 KDSLVRDHD--REIENLEKQLRaanmehenQIQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLRE--EE 350
Cdd:TIGR02168  827 ESLERRIAAteRRLEDLEEQIE--------ELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSelEE 898

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   351 KQRAAKDHETAVKKLKAEservkMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQ 430
Cdd:TIGR02168  899 LSEELRELESKRSELRRE-----LEELREKLAQLELRLEGLEVRIDNLQERLSEEYSLTLEEAEALENKIEDDEEEARRR 973

                          330       340
                   ....*....|....*....|....*..
gi 755539945   431 QLAAERRLQ-------DVIQKFEDEKQ 450
Cdd:TIGR02168  974 LKRLENKIKelgpvnlAAIEEYEELKE 1000
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 2-547 1.97e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 54.17  E-value: 1.97e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   2 IKELEGRVQQLMGEAENSnLQRQKLTQEKLELERCYQItcNELQELKTRRNILHKEKEHLVNDYEQNVKLLKTKyDSDIN 81
Cdd:COG1196  195 LGELERQLEPLERQAEKA-ERYRELKEELKELEAELLL--LKLRELEAELEELEAELEELEAELEELEAELAEL-EAELE 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  82 LLRQEHALstsktsgviEELEQNICQLKQQVQESELQRKQQVKDQENKfhmEKNHLKHTYEKKVHELQSELDKEKEDAQR 161
Cdd:COG1196  271 ELRLELEE---------LELELEEAQAEEYELLAELARLEQDIARLEE---RRRELEERLEELEEELAELEEELEELEEE 338

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 162 KIHKFEEALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVEVNSEKVygEMKEQMEKVEADLTRSKSLREKQSkeflwQ 241
Cdd:COG1196  339 LEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAE--ELLEALRAAAELAAQLEELEEAEE-----A 411

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 242 LEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAEKDSLvrdhdREIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQ 321
Cdd:COG1196  412 LLERLERLEEELEELEEALAELEEEEEEEEEALEEAA-----EEEAELEEEEEALLELLAELLEEAALLEAALAELLEEL 486

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 322 VHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKE 401
Cdd:COG1196  487 AEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYL 566

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 402 YTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSHQVRSAEKKL 481
Cdd:COG1196  567 KAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRL 646

                        490       500       510       520       530       540
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539945 482 HHKELEAQEQIMYIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTTYQSRR 547
Cdd:COG1196  647 REVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEA 712
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 207-515 7.96e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.90  E-value: 7.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   207 EKVYGEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDAKQRYEQQivelkleheQEKTHLLQQHSAEKDSLVRDHDREI 286
Cdd:TIGR02168  192 EDILNELERQLKSLERQAEKAERYKELKAELRELELALLVLRLEEL---------REELEELQEELKEAEEELEELTAEL 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   287 ENLEKQLRAANMEHE------NQIQESKKRDAQVIADMEAQVHKLREELISVNSQRKQqlIELGLLREEEKQRAAKDHET 360
Cdd:TIGR02168  263 QELEEKLEELRLEVSeleeeiEELQKELYALANEISRLEQQKQILRERLANLERQLEE--LEAQLEELESKLDELAEELA 340

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   361 AVKKlKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQI---IAELQTTISSLKEESSRQQLAAERR 437
Cdd:TIGR02168  341 ELEE-KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLelqIASLNNEIERLEARLERLEDRRERL 419

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 755539945   438 LQDViqkfEDEKQQLIRDNDQAIKALQDELETRSHQVRSAEKKLHHKELEAQEQIMYIRQEYETKFKGLMPASLRQEL 515
Cdd:TIGR02168  420 QQEI----EELLKKLEEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDS 493
PRK12704 PRK12704
phosphodiesterase; Provisional
 109-263 1.35e-05

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 47.85  E-value: 1.35e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 109 KQQVQESELQRKQQVKDQENKFHMEKNHLKHTYEKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQRLQA 188
Cdd:PRK12704  30 EAKIKEAEEEAKRILEEAKKEAEAIKKEALLEAKEEIHKLRNEFEKELRERRNELQKLEKRLLQKEENLDRKLELLEKRE 109

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755539945 189 QQADAALEEFKRQvEVNSEKVYGEMKEQMEKVEADLTRSKSLREKQSKEFLwqLEDAKQRYEQQIVELKLEHEQE 263
Cdd:PRK12704 110 EELEKKEKELEQK-QQELEKKEEELEELIEEQLQELERISGLTAEEAKEIL--LEKVEEEARHEAAVLIKEIEEE 181
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 171-391 1.80e-05

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 47.51  E-value: 1.80e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 171 KEKEEQLSRVTEVQRLQAQQADAALEEFKRQVevnsEKVYGEMKEQMEKVEAdltrskslREKQSKeflwqlEDAKQRYE 250
Cdd:PRK00409 515 KEKLNELIASLEELERELEQKAEEAEALLKEA----EKLKEELEEKKEKLQE--------EEDKLL------EEAEKEAQ 576

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 251 QQIVELKLEHEQEKTHLLQQHSAEKDSLVRdhdREIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLRE--E 328
Cdd:PRK00409 577 QAIKEAKKEADEIIKELRQLQKGGYASVKA---HELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLSLGQkgE 653

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755539945 329 LISVNSQRKQQL--------IELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEKA 391
Cdd:PRK00409 654 VLSIPDDKEAIVqagimkmkVPLSDLEKIQKPKKKKKKKPKTVKPKPRTVSLELDLRGMRYEEALERLDKY 724
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 217-529 2.21e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 47.36  E-value: 2.21e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   217 MEKVEADLTRSKSLREKQSKEfLWQLEDAKQRYEQQIVELKLEHEQekthLLQQHSAEKDSLVRdHDREIENLEKQLRAA 296
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKA-LAELRKELEELEEELEQLRKELEE----LSRQISALRKDLAR-LEAEVEQLEERIAQL 752

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   297 NMEHENQIQESKKRDAQvIADMEAQVHKLREELISVNSQRKQQLIELGLLREE--EKQRAAKDHETAVKKLKaesERVKM 374
Cdd:TIGR02168  753 SKELTELEAEIEELEER-LEEAEEELAEAEAEIEELEAQIEQLKEELKALREAldELRAELTLLNEEAANLR---ERLES 828

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   375 ELKKTHAAETEMT-LEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKfeDEKQQLI 453
Cdd:TIGR02168  829 LERRIAATERRLEdLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEEL--SEELREL 906

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   454 RDNDQAIKALQDELETRSHQVRSAEKKLhhkELEAQEQIMYIRQEYETKFKGLMP-----ASLRQELEDTISSLKSQVNF 528
Cdd:TIGR02168  907 ESKRSELRRELEELREKLAQLELRLEGL---EVRIDNLQERLSEEYSLTLEEAEAlenkiEDDEEEARRRLKRLENKIKE 983


                   .
gi 755539945   529 L 529
Cdd:TIGR02168  984 L 984
Nup88 pfam10168
Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal ...
 82-281 2.80e-05

Nuclear pore component; Nup88 can be divided into two structural domains; the N-terminal two-thirds of the protein has no obvious structural motifs but is the region for binding to Nup98, one of the components of the nuclear pore. the C-terminal end is a predicted coiled-coil domain. Nup88 is overexpressed in tumour cells.


Pssm-ID: 462975 [Multi-domain]  Cd Length: 713  Bit Score: 46.96  E-value: 2.80e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   82 LLRQEHALstsktsgviEELEQNICQLKqqvqeseLQRKQQVKDqenkfhmeknhlkhtyekkVHELQSELDKEKEDAQR 161
Cdd:pfam10168 549 LKKHDLAR---------EEIQKRVKLLK-------LQKEQQLQE-------------------LQSLEEERKSLSERAEK 593

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  162 KIHKFEEALKEKEEQLSRVTEV-QRLQAQQADAALEEFKRQVEVNSekvygeMKEQMEKVEADLTRSKSLREKQSKeflw 240
Cdd:pfam10168 594 LAEKYEEIKDKQEKLMRRCKKVlQRLNSQLPVLSDAEREMKKELET------INEQLKHLANAIKQAKKKMNYQRY---- 663

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 755539945  241 QLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSAEKDSLVRD 281
Cdd:pfam10168 664 QIAKSQSIRKKSSLSLSEKQRKTIKEILKQLGSEIDELIKQ 704
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
189-426 3.15e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.83  E-value: 3.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  189 QQADAALEEFKRqvevnsekvYGEMKEQMEKVEADLTRSKSLREKQSKefLWQLEDAKQRYEQQIVELKLEHEQEKTHLL 268
Cdd:COG4913   225 EAADALVEHFDD---------LERAHEALEDAREQIELLEPIRELAER--YAAARERLAELEYLRAALRLWFAQRRLELL 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  269 QQHSAEKDSLVRDHDREIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELISVNSQRKQ---QLIELGL 345
Cdd:COG4913   294 EAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGGDRLEQLEREIERLERELEERERRRARleaLLAALGL 373

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  346 ---LREEEKQRAAKDHETAVKKLKAESERVkmelkKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISS 422
Cdd:COG4913   374 plpASAEEFAALRAEAAALLEALEEELEAL-----EEALAEAEAALRDLRRELRELEAEIASLERRKSNIPARLLALRDA 448


                  ....
gi 755539945  423 LKEE 426
Cdd:COG4913   449 LAEA 452
46 PHA02562
endonuclease subunit; Provisional
 277-483 3.85e-05

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 46.55  E-value: 3.85e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 277 SLVRDHDREIENLEKQLRAANME---HENQIQESKKRDAQVIADMEAQVHKLREE---LISVNSQRKQQLIELglLREEE 350
Cdd:PHA02562 174 DKIRELNQQIQTLDMKIDHIQQQiktYNKNIEEQRKKNGENIARKQNKYDELVEEaktIKAEIEELTDELLNL--VMDIE 251

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 351 KQRAA-KDHETAVKKLKAESERVKMELK-----------KTHAAETEMTLEKANSRLKQIEKEYTQ---KLAKSSQIIAE 415
Cdd:PHA02562 252 DPSAAlNKLNTAAAKIKSKIEQFQKVIKmyekggvcptcTQQISEGPDRITKIKDKLKELQHSLEKldtAIDELEEIMDE 331

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755539945 416 LQTTISSLKE-----ESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSHQVRSAEKKLHH 483
Cdd:PHA02562 332 FNEQSKKLLElknkiSTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDELDKIVKTKSELVKEKYH 404
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1-468 6.93e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 45.70  E-value: 6.93e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   1 MIKELEGRVQQLMGEAENSNLQRQKLTQEKLELERCYQITCNELQELKTRRNILHKEKEHLVNDYEQNVKLLKTKYDSDI 80
Cdd:COG1196  310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELL 389

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  81 NLLRQEHALSTSKTS--GVIEELEQNICQLKQQVQESELQRKQQVKDQEnkfhmeknhlkhtyEKKVHELQSELDKEKED 158
Cdd:COG1196  390 EALRAAAELAAQLEEleEAEEALLERLERLEEELEELEEALAELEEEEE--------------EEEEALEEAAEEEAELE 455

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 159 AQRKIHKFEEALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVEVNSE-KVYGEMKEQMEKVEADLTRSKSLREKQSKE 237
Cdd:COG1196  456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEgFLEGVKAALLLAGLRGLAGAVAVLIGVEAA 535

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 238 FLWQLEDAKQRYEQQIVELKLEHEQEKTHLLQQHSA--------EKDSLVRDHDREIENLEKQLRAANMEHENQIQESKK 309
Cdd:COG1196  536 YEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAgratflplDKIRARAALAAALARGAIGAAVDLVASDLREADARY 615

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 310 RDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKThAAETEMTLE 389
Cdd:COG1196  616 YVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELA-ERLAEEELE 694

                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755539945 390 KANSRLKQIEKEYTQKLAKSSQIIAELQttiSSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELE 468
Cdd:COG1196  695 LEEALLAEEEEERELAEAEEERLEEELE---EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770
PTZ00121 PTZ00121
MAEBL; Provisional
 124-502 7.20e-05

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 45.90  E-value: 7.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  124 KDQENKFHMEKNHLKHTYEKKVHELQSELDKEKEDAQRKIHKfEEALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVE 203
Cdd:PTZ00121 1310 KAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAE-AEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAE 1388

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  204 VNSEKVYGEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDAKQRYEQQivelKLEHEQEKTHLLQQHSAEKdslvrdhd 283
Cdd:PTZ00121 1389 EKKKADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAK----KKAEEAKKADEAKKKAEEA-------- 1456

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  284 REIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELISVNSQRKQQlielGLLREEEKQRAAKDHETAVK 363
Cdd:PTZ00121 1457 KKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA----DEAKKAEEAKKADEAKKAEE 1532

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  364 KLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQ 443
Cdd:PTZ00121 1533 AKKADEAKKAEEKKKADELKKAEELKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKMKAEEA 1612

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755539945  444 KFEDEKQQlirDNDQAIKALQDELETRSHQVRSAEKKLHHKELEAQEQIMYIRQEYETK 502
Cdd:PTZ00121 1613 KKAEEAKI---KAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEAK 1668
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 149-464 7.82e-05

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.83  E-value: 7.82e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   149 QSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEV---QRLQAQQADAALEEFKRQVEVNSEKVYGEMKEQMEKVEADLT 225
Cdd:TIGR02169  225 GYELLKEKEALERQKEAIERQLASLEEELEKLTEEiseLEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIA 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   226 RSKSlREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKTHlLQQHSAEKDSLVrdhdREIENLEKQLRAANMEHEnQIQ 305
Cdd:TIGR02169  305 SLER-SIAEKERELEDAEERLAKLEAEIDKLLAEIEELERE-IEEERKRRDKLT----EEYAELKEELEDLRAELE-EVD 377

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   306 ESKKRDAQVIADMEAQVHKLREELISVNSQRKQQLIELGLLREE--EKQRAAKDHETAVKKLKAESERVKMELKK--THA 381
Cdd:TIGR02169  378 KEFAETRDELKDYREKLEKLKREINELKRELDRLQEELQRLSEElaDLNAAIAGIEAKINELEEEKEDKALEIKKqeWKL 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   382 AETEMTLEKANSRLKQIEKEYTQ---KLAKSSQIIAELQTTISSLkEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQ 458
Cdd:TIGR02169  458 EQLAADLSKYEQELYDLKEEYDRvekELSKLQRELAEAEAQARAS-EERVRGGRAVEEVLKASIQGVHGTVAQLGSVGER 536


                   ....*.
gi 755539945   459 AIKALQ 464
Cdd:TIGR02169  537 YATAIE 542
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 14-329 7.90e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.82  E-value: 7.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945    14 GEAENSNLQRQKLTQEKLELERCYQITCNELQELKTRRNilhkEKEHLVNDYEQNVKLLKTKydsdinLLRQEHALSTSK 93
Cdd:TIGR02168  663 GGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALA----ELRKELEELEEELEQLRKE------LEELSRQISALR 732

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945    94 TSGVIEELEQNICQLKQQVQESELQRKQQVKDQENKFHMEKNHLKHTYEKKVHELQSELDKEKEDAQrkihKFEEALKEK 173
Cdd:TIGR02168  733 KDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELK----ALREALDEL 808

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   174 EEQLSRVTE---VQRLQAQQADAALEEFKRQVEVNSEKVyGEMKEQMEKVEADLTRSKSLREKQSKEfLWQLEDAKQRYE 250
Cdd:TIGR02168  809 RAELTLLNEeaaNLRERLESLERRIAATERRLEDLEEQI-EELSEDIESLAAEIEELEELIEELESE-LEALLNERASLE 886

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   251 QQIVELKL----------EHEQEKTHLLQQHSAEKDSLVRDHDR------EIENLEKQLRA-ANMEHENQIQESKKRDAQ 313
Cdd:TIGR02168  887 EALALLRSeleelseelrELESKRSELRRELEELREKLAQLELRleglevRIDNLQERLSEeYSLTLEEAEALENKIEDD 966

                          330
                   ....*....|....*.
gi 755539945   314 vIADMEAQVHKLREEL 329
Cdd:TIGR02168  967 -EEEARRRLKRLENKI 981
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 150-479 1.49e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 44.67  E-value: 1.49e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   150 SELDKEKEDAQRKIHKFEEALKEKEEQLSRV-TEVQRLQAQQADA----ALEEFKRQVEVNSE-KVYGEMKEQMEKVEAD 223
Cdd:TIGR02169  166 AEFDRKKEKALEELEEVEENIERLDLIIDEKrQQLERLRREREKAeryqALLKEKREYEGYELlKEKEALERQKEAIERQ 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   224 LTRskslREKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEKThLLQQHSAEKDSLVRDHDREIENLEKQLRAANMEHENQ 303
Cdd:TIGR02169  246 LAS----LEEELEKLTEEISELEKRLEEIEQLLEELNKKIKD-LGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDA 320

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   304 IQESKKRDAQvIADMEAQVHKLREELISVNSQRKQQLIELGLLREE--EKQRAAKDHETAVKKLKAESERVKMELKKTHA 381
Cdd:TIGR02169  321 EERLAKLEAE-IDKLLAEIEELEREIEEERKRRDKLTEEYAELKEEleDLRAELEEVDKEFAETRDELKDYREKLEKLKR 399

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   382 AETEmtLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQL---AAERRLQDVIQKFEDEKQQlIRDNDQ 458
Cdd:TIGR02169  400 EINE--LKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALeikKQEWKLEQLAADLSKYEQE-LYDLKE 476

                          330       340
                   ....*....|....*....|.
gi 755539945   459 AIKALQDELETRSHQVRSAEK 479
Cdd:TIGR02169  477 EYDRVEKELSKLQRELAEAEA 497
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 145-508 1.55e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 44.73  E-value: 1.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  145 VHELQSELDKEKEDAQRKIHKFE-EALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVevnseKVYGEMKEQMEKVEAD 223
Cdd:pfam17380 275 LHIVQHQKAVSERQQQEKFEKMEqERLRQEKEEKAREVERRRKLEEAEKARQAEMDRQA-----AIYAEQERMAMERERE 349

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  224 LTRSKSLREKQSKEFLWQLEDAKQRYEQQIVE-LKLEHEQEKTHLLQQHSAEKDSLVRDHDREIENLEKQLRAANMEHEN 302
Cdd:pfam17380 350 LERIRQEERKRELERIRQEEIAMEISRMRELErLQMERQQKNERVRQELEAARKVKILEEERQRKIQQQKVEMEQIRAEQ 429

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  303 QiqESKKRDAQVIADMEA-QVHKLREElisvnSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHA 381
Cdd:pfam17380 430 E--EARQREVRRLEEERArEMERVRLE-----EQERQQQVERLRQQEEERKRKKLELEKEKRDRKRAEEQRRKILEKELE 502

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  382 AETEMTLEKANSRlKQIEKEYTQKlaksSQIIAELQTTISSLKEESSRQQLAAERRLQDVIQKFEDEKQQLirdndqaiK 461
Cdd:pfam17380 503 ERKQAMIEEERKR-KLLEKEMEER----QKAIYEEERRREAEEERRKQQEMEERRRIQEQMRKATEERSRL--------E 569

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 755539945  462 ALQDELETRSHQVRSAEKKlhhKELEAQEQIMYIRQEYETKFKGLMP 508
Cdd:pfam17380 570 AMEREREMMRQIVESEKAR---AEYEATTPITTIKPIYRPRISEYQP 613
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 314-547 1.65e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.54  E-value: 1.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 314 VIADMEAQVHKLREE------LISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELkkthaAETEMT 387
Cdd:COG1196  194 ILGELERQLEPLERQaekaerYRELKEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAEL-----AELEAE 268

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 388 LEKANSRLKQIEKEYTQKLAKSSQIIAELQTTISSLKEESSRQQLAAERRLQ-----DVIQKFEDEKQQLIRDNDQAIKA 462
Cdd:COG1196  269 LEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEEleeelAELEEELEELEEELEELEEELEE 348

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 463 LQDELETRSHQVRSAEKKLHHKELEAQEQimyIRQEYETKFKGLMPASLRQELEDTISSLKSQVNFLQKRASILQEELTT 542
Cdd:COG1196  349 AEEELEEAEAELAEAEEALLEAEAELAEA---EEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEE 425


                 ....*
gi 755539945 543 YQSRR 547
Cdd:COG1196  426 LEEAL 430
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 2-310 1.96e-04

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 44.28  E-value: 1.96e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945     2 IKELEGRVQQLMGEAENSNLQRQKLTQEKLELERCYQITCNELQELKTRRNILHKEKEHLVNDYEQNVKLLKTKYDSDIN 81
Cdd:TIGR02168  679 IEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTE 758

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945    82 LLRQEHALST--SKTSGVIEELEQNICQLKQQVQESELQRKQQvKDQENKFHMEKNHLKHTYEKKVHELQSeLDKEKEDA 159
Cdd:TIGR02168  759 LEAEIEELEErlEEAEEELAEAEAEIEELEAQIEQLKEELKAL-REALDELRAELTLLNEEAANLRERLES-LERRIAAT 836

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   160 QRKIHKFEEALKEKEEQLSRVT------EVQRLQAQQADAALEEFKRQVEVNSEKVYGEMKEQMEKVEADLTRSKSLREK 233
Cdd:TIGR02168  837 ERRLEDLEEQIEELSEDIESLAaeieelEELIEELESELEALLNERASLEEALALLRSELEELSEELRELESKRSELRRE 916

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   234 --QSKEFLWQLEDAKQRYEQQIVELK---LEHEQEKTHLLQQHSAEKDSLVRDHDREIENLEKQLRA---ANMEHENQIQ 305
Cdd:TIGR02168  917 leELREKLAQLELRLEGLEVRIDNLQerlSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKElgpVNLAAIEEYE 996


                   ....*
gi 755539945   306 ESKKR 310
Cdd:TIGR02168  997 ELKER 1001
PTZ00121 PTZ00121
MAEBL; Provisional
 99-466 2.75e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.98  E-value: 2.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   99 EELEQNICQLKQQVQESELQRKQQVKDQENKFHMEKNhlKHTYEKKVHELQSELDKEKEDAQRKIHKFEEalKEKEEQLS 178
Cdd:PTZ00121 1414 AAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAK--KKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAK 1489

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  179 RVTEVQRLQAQQADAALEEFKRQVEV---NSEKVYGEMKEQMEKVEADltRSKSLREKQSKEFLWQLEDAKQRYEQQIVE 255
Cdd:PTZ00121 1490 KKAEEAKKKADEAKKAAEAKKKADEAkkaEEAKKADEAKKAEEAKKAD--EAKKAEEKKKADELKKAEELKKAEEKKKAE 1567

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  256 LKLEHEQEKTHLL-------QQHSAEKDSLVRDHDREIENLEKQLRAANME----HENQIQESKKRDAQVIADMEAQVHK 324
Cdd:PTZ00121 1568 EAKKAEEDKNMALrkaeeakKAEEARIEEVMKLYEEEKKMKAEEAKKAEEAkikaEELKKAEEEKKKVEQLKKKEAEEKK 1647

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  325 LREELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQ 404
Cdd:PTZ00121 1648 KAEELKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEE 1727

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755539945  405 KLAKSSQIIAELQTtiSSLKEESSRQQLAAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDE 466
Cdd:PTZ00121 1728 NKIKAEEAKKEAEE--DKKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDE 1787
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
148-366 3.57e-04

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 43.47  E-value: 3.57e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 148 LQSELDKEKEDAQRKIHKFEEALKEKEEQLsrvtevqrlqaQQADAALEEFKRQ---VEVNSE-----KVYGEMKEQMEK 219
Cdd:COG3206  162 LEQNLELRREEARKALEFLEEQLPELRKEL-----------EEAEAALEEFRQKnglVDLSEEaklllQQLSELESQLAE 230

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 220 VEADLTRSKSLR---EKQSKEFLWQLEDAK-----QRYEQQIVELKLEHEQEKTHLLQQHSAekdslVRDHDREIENLEK 291
Cdd:COG3206  231 ARAELAEAEARLaalRAQLGSGPDALPELLqspviQQLRAQLAELEAELAELSARYTPNHPD-----VIALRAQIAALRA 305

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755539945 292 QLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREELISVNSQRkQQLIELgllrEEEKQRAAKDHETAVKKLK 366
Cdd:COG3206  306 QLQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELE-AELRRL----EREVEVARELYESLLQRLE 375
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 268-543 5.60e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 42.75  E-value: 5.60e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   268 LQQHSAEKDSLVRDHD------REIENLEKQLRAANMEHENQIQESKKRDAQVIADMEAQVHKLREelisvnSQRKQQLI 341
Cdd:TIGR02169  676 LQRLRERLEGLKRELSslqselRRIENRLDELSQELSDASRKIGEIEKEIEQLEQEEEKLKERLEE------LEEDLSSL 749

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   342 ELGLLREEEKQraakdhetavKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEKEYTQKLAKSSQIIAELQTTIS 421
Cdd:TIGR02169  750 EQEIENVKSEL----------KELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQ 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   422 SLKEESSRQQLAAERRlqdviqKFEDEKQQLIRDNDQAIKALQDELETRSHQVRSAEKKLHHKELEAQEQIMYIRQEYET 501
Cdd:TIGR02169  820 KLNRLTLEKEYLEKEI------QELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDE 893

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|...
gi 755539945   502 KFKGLMPASLR-QELEDTISSLKSQVNFLQKRASILQEELTTY 543
Cdd:TIGR02169  894 LEAQLRELERKiEELEAQIEKKRKRLSELKAKLEALEEELSEI 936
PRK00409 PRK00409
recombination and DNA strand exchange inhibitor protein; Reviewed
 97-233 1.13e-03

recombination and DNA strand exchange inhibitor protein; Reviewed


Pssm-ID: 234750 [Multi-domain]  Cd Length: 782  Bit Score: 41.74  E-value: 1.13e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  97 VIEELEQNICQLKQQVQESELQRKQQvkdqeNKFHMEknhlkhtYEKKVHELQSELDKEKEDAQRKIHK-FEEALKEKEE 175
Cdd:PRK00409 521 LIASLEELERELEQKAEEAEALLKEA-----EKLKEE-------LEEKKEKLQEEEDKLLEEAEKEAQQaIKEAKKEADE 588

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755539945 176 QLSRVTEVQRLQ-----AQQADAALEEFKRQVEVNSEKVYGEMKEQMEKVEADLTRSKSLREK 233
Cdd:PRK00409 589 IIKELRQLQKGGyasvkAHELIEARKRLNKANEKKEKKKKKQKEKQEELKVGDEVKYLSLGQK 651
MARTX_Nterm NF012221
MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model ...
 153-324 1.18e-03

MARTX multifunctional-autoprocessing repeats-in-toxin holotoxin N-terminal region; This model describes the N-terminal 1900 amino acids of MARTX family multifunctional-autoprocessing repeats-in-toxin holotoxins, which contain both repeat regions that facilitate their entry into eukaryotic target cells, and multiple effector domains.


Pssm-ID: 467957 [Multi-domain]  Cd Length: 1848  Bit Score: 42.13  E-value: 1.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  153 DKEKEDAQRKIHKfeealKEKEEQLSRVTEVQ-RLQA--QQA---------DAALEE-----------FKRQVEVNSEKV 209
Cdd:NF012221 1563 DKERAEADRQRLE-----QEKQQQLAAISGSQsQLEStdQNAletngqaqrDAILEEsravtkelttlAQGLDALDSQAT 1637

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  210 Y-GEMKEQ---------MEKVEADLTRSKSLREKQskeflwqLEDAKQRYEQQIVELKLEHEQEKTHLLQ----QHSAEK 275
Cdd:NF012221 1638 YaGESGDQwrnpfagglLDRVQEQLDDAKKISGKQ-------LADAKQRHVDNQQKVKDAVAKSEAGVAQgeqnQANAEQ 1710

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 755539945  276 DSLVRDHD---REIENLEKQLRAANMEHE-----NQIQESKKRDAQVIADMEAQVHK 324
Cdd:NF012221 1711 DIDDAKADaekRKDDALAKQNEAQQAESDanaaaNDAQSRGEQDASAAENKANQAQA 1767
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
151-526 1.28e-03

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 41.59  E-value: 1.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 151 ELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQRLQAQQADAALEEFKRQVEvNSEKVYGEMKEQMEKVEADLTRSKSl 230
Cdd:PRK03918 342 ELKKKLKELEKRLEELEERHELYEEAKAKKEELERLKKRLTGLTPEKLEKELE-ELEKAKEEIEEEISKITARIGELKK- 419

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 231 REKQSKEFLWQLEDAKQRYEQQIVELKLEHEQEkthLLQQHSAEKDSlVRDHDREIENLEKQLRAANMEHENQIQESKKR 310
Cdd:PRK03918 420 EIKELKKAIEELKKAKGKCPVCGRELTEEHRKE---LLEEYTAELKR-IEKELKEIEEKERKLRKELRELEKVLKKESEL 495

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 311 DAQviadmeaqvHKLREELISVnsqrKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVKMELKKTHA-----AETE 385
Cdd:PRK03918 496 IKL---------KELAEQLKEL----EEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEElkkklAELE 562

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 386 MTLEKANSRLKQIEKEYTQKLAKSsqiIAELQTTISSLKEESSR--QQLAAERRLQDVIQKFEDEKQQL--IRDNDQAIK 461
Cdd:PRK03918 563 KKLDELEEELAELLKELEELGFES---VEELEERLKELEPFYNEylELKDAEKELEREEKELKKLEEELdkAFEELAETE 639

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755539945 462 ALQDELETRSHQVRSAEKKLHHKELEaqEQIMYIRQEYETKFKGLMPA-SLRQELEDTISSLKSQV 526
Cdd:PRK03918 640 KRLEELRKELEELEKKYSEEEYEELR--EEYLELSRELAGLRAELEELeKRREEIKKTLEKLKEEL 703
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 142-403 1.91e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 41.07  E-value: 1.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 142 EKKVHELQSELDKEKEDAQRKIHKFEEALKEKEEQLSRVTEVQrlqaqqaDAALEEFKRQVEVNSEKVYGEMKEQMEKVE 221
Cdd:PRK05771  38 EELSNERLRKLRSLLTKLSEALDKLRSYLPKLNPLREEKKKVS-------VKSLEELIKDVEEELEKIEKEIKELEEEIS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 222 adltrskslrekqskeflwQLEDAKQRYEQQIVELK--------LEHEQEKTHLlqqhsaekdsLVRDHDREIENLEKQL 293
Cdd:PRK05771 111 -------------------ELENEIKELEQEIERLEpwgnfdldLSLLLGFKYV----------SVFVGTVPEDKLEELK 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945 294 RAANMEHENQIQESKKRDAQVIADMEAQVHKLREELisvnsqRKQQLIELGLLREEEKQRAAKDHETAVKKLKAESERVK 373
Cdd:PRK05771 162 LESDVENVEYISTDKGYVYVVVVVLKELSDEVEEEL------KKLGFERLELEEEGTPSELIREIKEELEEIEKERESLL 235

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 755539945 374 MELKKTHAAET----------EMTLEKANSRLKQIEKEYT 403
Cdd:PRK05771 236 EELKELAKKYLeellalyeylEIELERAEALSKFLKTDKT 275
PTZ00121 PTZ00121
MAEBL; Provisional
 99-415 2.36e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 2.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   99 EELEQNICQLKQQVQESELQRKQQVKDQENKFHMEKNHL----KHTYEKKVHELQSELDKEKEDAQRKIHKFEEALKEKE 174
Cdd:PTZ00121 1486 DEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKAdeakKAEEAKKADEAKKAEEKKKADELKKAEELKKAEEKKK 1565

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  175 EQLSRVTEVQRL-------QAQQADAALEEFKRQVEVNSEKVYGEM--KEQMEKVEADLTRSKSLREKQSKEFLWQLEDA 245
Cdd:PTZ00121 1566 AEEAKKAEEDKNmalrkaeEAKKAEEARIEEVMKLYEEEKKMKAEEakKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEE 1645

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  246 KQRYEQqivelkLEHEQEKTHLLQQHSAEKDSLVRDHDREIENLEKQLRAAnmEHENQIQESKKRDAQVIADMEAQVHKL 325
Cdd:PTZ00121 1646 KKKAEE------LKKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKA--AEALKKEAEEAKKAEELKKKEAEEKKK 1717

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945  326 REELISVNSQRKQQLIELGLLREEEKQRAA-----KDHETAVKKLKAESERVKMELKKTHAAETEMTLEKANSRLKQIEK 400
Cdd:PTZ00121 1718 AEELKKAEEENKIKAEEAKKEAEEDKKKAEeakkdEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVD 1797

                         330
                  ....*....|....*
gi 755539945  401 EYTQKLAKSSQIIAE 415
Cdd:PTZ00121 1798 KKIKDIFDNFANIIE 1812
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-542 6.58e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 39.27  E-value: 6.58e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945     7 GRVQQLMGEAENSNLQRQKLTQEKLELERCYQITCNELQELKTRRNILHKEKEHLVNDYeQNVKLLKTKYDSDINLLRQE 86
Cdd:TIGR02168  232 LRLEELREELEELQEELKEAEEELEELTAELQELEEKLEELRLEVSELEEEIEELQKEL-YALANEISRLEQQKQILRER 310

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945    87 HALSTSKTSGVIEELEQNIcQLKQQVQESELQRKQQVKDQENKFHMEKNHLKhtyekKVHELQSELDKEKEDAQRKIHKF 166
Cdd:TIGR02168  311 LANLERQLEELEAQLEELE-SKLDELAEELAELEEKLEELKEELESLEAELE-----ELEAELEELESRLEELEEQLETL 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   167 EEALKEKEEQLsrvtEVQRLQAQQADAALEEFKRQVEVNSEKVYGEMKEQMEKVEADLTRSKSLREKQSKEFLWQLEDAK 246
Cdd:TIGR02168  385 RSKVAQLELQI----ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEELERLE 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   247 QRYE--QQIVELKLEHEQEKTHLLQQHSAEKDSLVRDHDREI------------------------------ENLEKQLR 294
Cdd:TIGR02168  461 EALEelREELEEAEQALDAAERELAQLQARLDSLERLQENLEgfsegvkallknqsglsgilgvlselisvdEGYEAAIE 540

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   295 AANMEHENQIQESKKRDAQVIADMEAQVHKLRE---ELISVNSQRKQQLIELGLLREEEKQRAAKDHETAVKKLK----- 366
Cdd:TIGR02168  541 AALGGRLQAVVVENLNAAKKAIAFLKQNELGRVtflPLDSIKGTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRkalsy 620

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   367 -------AESERVKMEL-KKTHAAETEMTLE-----KANSRLKQIEKEYTQKLAKSSQI-IAELQTTISSLKEESSRQQL 432
Cdd:TIGR02168  621 llggvlvVDDLDNALELaKKLRPGYRIVTLDgdlvrPGGVITGGSAKTNSSILERRREIeELEEKIEELEEKIAELEKAL 700

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755539945   433 AAERRLQDVIQKFEDEKQQLIRDNDQAIKALQDELETRSHQVRSAEKK---LHHKELEAQEQIMYIRQEYETKFKGLMPA 509
Cdd:TIGR02168  701 AELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERiaqLSKELTELEAEIEELEERLEEAEEELAEA 780

                          570       580       590
                   ....*....|....*....|....*....|....
gi 755539945   510 -SLRQELEDTISSLKSQVNFLQKRASILQEELTT 542
Cdd:TIGR02168  781 eAEIEELEAQIEQLKEELKALREALDELRAELTL 814
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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