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Conserved domains on  [gi|755556625|ref|XP_011244743|]
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zinc finger protein 799 isoform X1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.12e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 75.20  E-value: 4.12e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755556625    3 SVTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNLSYIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-637 9.75e-10

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 250 KPYMCKQCGKTFARSSSLLTHERIHTGEKPYVC--KQCGKAFTDRSSLRFHEMMHSGEKPYKCTKCSKAFASSGAFRKHE 327
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 328 RTHTGEQlFVCLQCEKVFSCESAFRTHK----IIHSGECVCKQCGKAFTSHSSVKYHELMHSGEKPyvckqcGKTFRSPK 403
Cdd:COG5048  112 SSSSNSN-DNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 404 QVQIHKRTHTGEKPYVCKECGKAFTFLGSLQYHELIHTGEKPYLCKQCGKAFRSSRQVQIHERTHTGEKPYVCKQCGKAF 483
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 484 FSLYHLRRHEVIHSGS-------NPYVCKQCGKAFSWFSTFHSHKQT--HTGE--KPYLC--KQCGKAFCSRISWRRHEK 550
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 551 AHTTVKPYACV--QCGKAFRSPSYLKIHERIH-----TGEKPFIC--SQCGKPFRSFRYVKSHERSHTGEKP--FVCSEC 619
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410
                 ....*....|....*...
gi 755556625 620 GKAFSYYSSFHRHRRTHQ 637
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.12e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 75.20  E-value: 4.12e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755556625    3 SVTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNLSYIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 3.95e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.42  E-value: 3.95e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755556625   4 VTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 9.01e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.08  E-value: 9.01e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755556625     4 VTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-637 9.75e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 250 KPYMCKQCGKTFARSSSLLTHERIHTGEKPYVC--KQCGKAFTDRSSLRFHEMMHSGEKPYKCTKCSKAFASSGAFRKHE 327
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 328 RTHTGEQlFVCLQCEKVFSCESAFRTHK----IIHSGECVCKQCGKAFTSHSSVKYHELMHSGEKPyvckqcGKTFRSPK 403
Cdd:COG5048  112 SSSSNSN-DNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 404 QVQIHKRTHTGEKPYVCKECGKAFTFLGSLQYHELIHTGEKPYLCKQCGKAFRSSRQVQIHERTHTGEKPYVCKQCGKAF 483
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 484 FSLYHLRRHEVIHSGS-------NPYVCKQCGKAFSWFSTFHSHKQT--HTGE--KPYLC--KQCGKAFCSRISWRRHEK 550
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 551 AHTTVKPYACV--QCGKAFRSPSYLKIHERIH-----TGEKPFIC--SQCGKPFRSFRYVKSHERSHTGEKP--FVCSEC 619
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410
                 ....*....|....*...
gi 755556625 620 GKAFSYYSSFHRHRRTHQ 637
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-263 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556625  238 SLQIHERIHTGEKPYMCKQCGKTFAR 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 3-44 4.12e-17

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 75.20  E-value: 4.12e-17
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 755556625    3 SVTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNLSYIG 44
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-40 3.95e-14

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 66.42  E-value: 3.95e-14
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 755556625   4 VTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNL 40
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENL 37
KRAB smart00349
krueppel associated box;
4-40 9.01e-14

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 66.08  E-value: 9.01e-14
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 755556625     4 VTLEDVAVNFTLEEWTMLNASQKELYKDVMQDTLRNL 40
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNL 37
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
250-637 9.75e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 9.75e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 250 KPYMCKQCGKTFARSSSLLTHERIHTGEKPYVC--KQCGKAFTDRSSLRFHEMMHSGEKPYKCTKCSKAFASSGAFRKHE 327
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 328 RTHTGEQlFVCLQCEKVFSCESAFRTHK----IIHSGECVCKQCGKAFTSHSSVKYHELMHSGEKPyvckqcGKTFRSPK 403
Cdd:COG5048  112 SSSSNSN-DNNLLSSHSLPPSSRDPQLPdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSL------SKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 404 QVQIHKRTHTGEKPYVCKECGKAFTFLGSLQYHELIHTGEKPYLCKQCGKAFRSSRQVQIHERTHTGEKPYVCKQCGKAF 483
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 484 FSLYHLRRHEVIHSGS-------NPYVCKQCGKAFSWFSTFHSHKQT--HTGE--KPYLC--KQCGKAFCSRISWRRHEK 550
Cdd:COG5048  265 LPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHIL 344

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 551 AHTTVKPYACV--QCGKAFRSPSYLKIHERIH-----TGEKPFIC--SQCGKPFRSFRYVKSHERSHTGEKP--FVCSEC 619
Cdd:COG5048  345 LHTSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPC 424

                        410
                 ....*....|....*...
gi 755556625 620 GKAFSYYSSFHRHRRTHQ 637
Cdd:COG5048  425 SKSFNRHYNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
222-633 6.74e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 6.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 222 KSYVCKQCGKAFPFPSSLQIHERIHTGEKPYMC--KQCGKTFARSSSLLTHERIHTGEKPYVCKQCGK--AFTDRSSLRF 297
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPlsNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 298 HEMMHSgEKPYKCTKCSKAFASSGAFRKHERTHTGEQLFVCLQC-EKVFSCESAFRTHkIIHSGECVCKQCGKAFTSHSS 376
Cdd:COG5048  112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLLIS 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 377 vkyHELMHSGEKPYVCKQCGKTFRSPKQVQIHKRTH-TGEKPYVCKECGKAFTFLGSLQYHE----LIHTGEKPYLCKQC 451
Cdd:COG5048  190 ---SNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENsSSSLPLTTNSQLSPKSLLSQSPSSLsssdSSSSASESPRSSLP 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 452 GKAFRSSRQVQIHERTHTG-EKPYVCKQCGKAFFSLYHLRRH--EVIHSGSN--PYVC--KQCGKAFSWFSTFHSHKQTH 524
Cdd:COG5048  267 TASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHlrSVNHSGESlkPFSCpySLCGKLFSRNDALKRHILLH 346

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 525 TGEKPYLCK--QCGKAFCSRISWRRHEKAH-----TTVKPYACV--QCGKAFRSPSYLKIHERIHTGEKP--FICSQCGK 593
Cdd:COG5048  347 TSISPAKEKllNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|
gi 755556625 594 PFRSFRYVKSHERSHTGEKPFVCSECGKAFSYYSSFHRHR 633
Cdd:COG5048  427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
146-522 2.69e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 146 SGNTSISSTPFQKQktirTEEKPETSHC--KEDSRCLPSSQNDGKSS-SGEPHYEC--KQCGKAFTSSSSFRRHEEYHSR 220
Cdd:COG5048   13 NSVLSSTPKSTLKS----LSNAPRPDSCpnCTDSFSRLEHLTRHIRShTGEKPSQCsySGCDKSFSRPLELSRHLRTHHN 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 221 EKSYVC-KQCGKAFPFPSSLQIHERIHTGEKPYMCKQCGKTFARSSSLLTHERIHTGEKPYVCKQCGKAFTDR-----SS 294
Cdd:COG5048   89 NPSDLNsKSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTpqsnsLH 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 295 LRFHEMMHSGEKPYKCTKCSKAFASSGAFRKHERTHT------------------------GEQLFVC----LQCEKVFS 346
Cdd:COG5048  169 PPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLsssysipssssdqnlensssslplTTNSQLSpkslLSQSPSSL 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 347 CESAFRTHKIIHSGECVCKqcgKAFTSHSSVKYHELMHSG-EKPYVCKQCGKTFRSPKQVQIHKRT--HTGE--KPYVCK 421
Cdd:COG5048  249 SSSDSSSSASESPRSSLPT---ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCP 325

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755556625 422 E--CGKAFTFLGSLQYHELIHTGEKPYLCK-------------------------------------QCGKAFRSSRQVQ 462
Cdd:COG5048  326 YslCGKLFSRNDALKRHILLHTSISPAKEKllnssskfspllnneppqslqqykdlkndkksetlsnSCIRNFKRDSNLS 405

                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 755556625 463 IHERTHTGEKPYVCK--QCGKAFFSLYHLRRHEVIHSGSNPYVCKQCGKAFSWFSTFHSHKQ 522
Cdd:COG5048  406 LHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGKD 467
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 362-436 9.11e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.01  E-value: 9.11e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755556625 362 CVCKQCGKAFTSHSSVKYHELM-HsgekpyvCKQCGKTFRSPKQVQIHKrthTGEKPYVCKECGKAFTFLGSLQYH 436
Cdd:COG5189  352 CPVEGCNKKYKNQNGLKYHMLHgH-------QNQKLHENPSPEKMNIFS---AKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
238-263 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556625  238 SLQIHERIHTGEKPYMCKQCGKTFAR 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
600-625 1.55e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.55e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556625  600 YVKSHERSHTGEKPFVCSECGKAFSY 625
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
266-290 2.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.10e-03
                          10        20
                  ....*....|....*....|....*
gi 755556625  266 SLLTHERIHTGEKPYVCKQCGKAFT 290
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
408-428 3.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.37e-03
                          10        20
                  ....*....|....*....|.
gi 755556625  408 HKRTHTGEKPYVCKECGKAFT 428
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
432-457 3.64e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.64e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556625  432 SLQYHELIHTGEKPYLCKQCGKAFRS 457
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
294-319 5.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 5.04e-03
                          10        20
                  ....*....|....*....|....*.
gi 755556625  294 SLRFHEMMHSGEKPYKCTKCSKAFAS 319
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-483 6.84e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.84e-03
                          10        20
                  ....*....|....*....|
gi 755556625  464 HERTHTGEKPYVCKQCGKAF 483
Cdd:pfam13465   5 HMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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