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Conserved domains on  [gi|755553177|ref|XP_011244130|]
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guanine nucleotide-binding protein subunit beta-like protein 1 isoform X2 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-396 3.14e-26

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 330
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755553177 331 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-396 3.14e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 330
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755553177 331 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-396 1.37e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 248 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 327
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 328 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 247-396 1.50e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 247 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 325
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755553177 326 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 396
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-395 5.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755553177   357 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 395
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
358-395 2.45e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755553177  358 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 395
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
253-396 3.14e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.14e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 330
Cdd:COG2319  134 TLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 208

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755553177 331 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  209 SVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDL 275
WD40 COG2319
WD40 repeat [General function prediction only];
253-396 3.67e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.85  E-value: 3.67e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHeltNPGIA 330
Cdd:COG2319  260 LLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFspDGKLL--ASGSDDGTVRLWDLATGKLLRTLTGH---TGAVR 334

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755553177 331 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  335 SVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGrTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
253-396 1.85e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 106.53  E-value: 1.85e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDF--DSQKAkgISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIA 330
Cdd:COG2319  176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLL--ASGSADGTVRLWDLATGKLLRTLTGHS---GSVR 250

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755553177 331 EVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  251 SVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGkLLASGSDDGTVRLWDL 317
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-396 1.37e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.94  E-value: 1.37e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 248 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 327
Cdd:cd00200   18 SPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHT---S 94

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 328 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:cd00200   95 YVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGtFVASSSQDGTIKLWDL 164
WD40 COG2319
WD40 repeat [General function prediction only];
248-396 4.04e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 94.21  E-value: 4.04e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 248 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnP 327
Cdd:COG2319   45 SPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHT---G 121

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 328 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319  122 AVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGkLLASGSDDGTVRLWDL 191
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 253-395 6.03e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 92.01  E-value: 6.03e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEV 332
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHE---NGVNSV 225

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755553177 333 TIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 395
Cdd:cd00200  226 AFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGkRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 248-396 1.81e-18

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 84.69  E-value: 1.81e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 248 SSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnp 327
Cdd:cd00200  102 SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTG--- 178

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 328 GIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:cd00200  179 EVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGyLLASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 276-396 5.35e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 80.46  E-value: 5.35e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 276 QITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHELtnpGIAEVTIRPDHKILATAGWDHRIRVFHW 355
Cdd:cd00200    4 TLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTG---PVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|..
gi 755553177 356 RTMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWSL 396
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDV 122
WD40 COG2319
WD40 repeat [General function prediction only];
253-357 4.99e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.94  E-value: 4.99e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 253 LLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGISGSAGKVLAVWSLDDQQSLQVKKTHEltnPGIAEV 332
Cdd:COG2319  302 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHT---GAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 755553177 333 TIRPDHKILATAGWDHRIRVFHWRT 357
Cdd:COG2319  379 AFSPDGRTLASGSADGTVRLWDLAT 403
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 247-396 1.50e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 53.55  E-value: 1.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 247 NSSLRPLLLAGYEDGSVTLWDISERKVCSQITCHEEPVMGLDFDSQKAKGI-SGSAGKVLAVWSLDDQQSLQVKKthelT 325
Cdd:PLN00181 541 NSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLaSGSDDGSVKLWSINQGVSIGTIK----T 616

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755553177 326 NPGIAEVTIRPDH-KILATAGWDHRIRVFHWRTMK-PLAVLAFHSAPVYCVAFAADGLLAAGSKDQRISIWSL 396
Cdd:PLN00181 617 KANICCVQFPSESgRSLAFGSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDL 689
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 357-395 5.32e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 5.32e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755553177   357 TMKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 395
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
358-395 2.45e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.18  E-value: 2.45e-05
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 755553177  358 MKPLAVLAFHSAPVYCVAFAADG-LLAAGSKDQRISIWS 395
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGkLLASGSDDGTVKVWD 39
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 367-399 1.96e-03

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 39.63  E-value: 1.96e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755553177 367 HSAPVYCVAFAADG-LLAAGSKDQRISIWSLYPC 399
Cdd:cd00200    8 HTGGVTCVAFSPDGkLLATGSGDGTIKVWDLETG 41
WD40 COG2319
WD40 repeat [General function prediction only];
294-396 7.16e-03

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 38.35  E-value: 7.16e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755553177 294 AKGISGSAGKVLAVWSLDDQQSLQVKKTHELTNPGIAEVTIRPDHKILATAGWDHRIRVFHWRTMKPLAVLAFHSAPVYC 373
Cdd:COG2319    4 ADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLS 83

                         90       100
                 ....*....|....*....|....
gi 755553177 374 VAFAADG-LLAAGSKDQRISIWSL 396
Cdd:COG2319   84 VAFSPDGrLLASASADGTVRLWDL 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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