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Conserved domains on  [gi|755551985|ref|XP_011244011|]
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protein lifeguard 1 isoform X1 [Mus musculus]

Protein Classification

Pro-rich and LFG_like domain-containing protein( domain architecture ID 12172238)

Pro-rich and LFG_like domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 128-341 7.07e-114

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


:

Pssm-ID: 198410  Cd Length: 217  Bit Score: 329.12  E-value: 7.07e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 128 DKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSI 207
Cdd:cd10428    4 DKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 208 LTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYA 287
Cdd:cd10428   84 FTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYA 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755551985 288 SLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10428  164 SLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 10-114 3.10e-09

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


:

Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 55.43  E-value: 3.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   10 SGDSYPPQNIVGPQAPMPPYVQAPyPGAPYPQAPFQPSPYGQPGYPHGP----SPYPQGGYPQGPYPQGGY-----PQGP 80
Cdd:pfam15240  41 QGGQGPQGPPPGGFPPQPPASDDP-PGPPPPGGPQQPPPQGGKQKPQGPppqgGPRPPPGKPQGPPPQGGNqqqgpPPPG 119

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755551985   81 YPQSPFPPNPYGQPP--PFQDPGSPQHGNYQeeGPP 114
Cdd:pfam15240 120 KPQGPPPQGGGPPPQggNQQGPPPPPPGNPQ--GPP 153
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 128-341 7.07e-114

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 329.12  E-value: 7.07e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 128 DKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSI 207
Cdd:cd10428    4 DKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 208 LTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYA 287
Cdd:cd10428   84 FTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYA 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755551985 288 SLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10428  164 SLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 133-340 1.21e-32

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 120.74  E-value: 1.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  133 QAFIRKVFLVLTLQLSVTlSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRK-HPWNLVALSILTVS 211
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  212 LSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGA 291
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755551985  292 LLFTCFLAVDTQLLLgNKQLSLSPEEYVFAALNLYTDIINIFLYILTII 340
Cdd:pfam01027 160 LLFSGFILYDTQRII-KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 132-342 2.58e-22

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 93.71  E-value: 2.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 132 RQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCcGDFRRKHPWNLVALSILT-- 209
Cdd:COG0670   19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTal 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 210 --VSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTScMGVLLVSVVVLFIFAILC-IFIRNRILEIVY 286
Cdd:COG0670   98 mgLTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSF-LGSFLFMGLIGLIIASLVnIFLQSPALSLAI 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755551985 287 ASLGALLFTCFLAVDTQLLlgnKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGR 342
Cdd:COG0670  177 SVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGG 229
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 10-114 3.10e-09

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 55.43  E-value: 3.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   10 SGDSYPPQNIVGPQAPMPPYVQAPyPGAPYPQAPFQPSPYGQPGYPHGP----SPYPQGGYPQGPYPQGGY-----PQGP 80
Cdd:pfam15240  41 QGGQGPQGPPPGGFPPQPPASDDP-PGPPPPGGPQQPPPQGGKQKPQGPppqgGPRPPPGKPQGPPPQGGNqqqgpPPPG 119

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755551985   81 YPQSPFPPNPYGQPP--PFQDPGSPQHGNYQeeGPP 114
Cdd:pfam15240 120 KPQGPPPQGGGPPPQggNQQGPPPPPPGNPQ--GPP 153
PHA03377 PHA03377
EBNA-3C; Provisional
 22-114 9.86e-08

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 53.90  E-value: 9.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   22 PQAPM-----PPYVQAPYPG---APYPQAPFQ----PSPYG-----QPGY--PHGPSP-YPQGGYPQGPYPQG---GYPQ 78
Cdd:PHA03377  744 HQAPYsgheePQAQQAPYPGywePRPPQAPYLgyqePQAQGvqvssYPGYagPWGLRAqHPRYRHSWAYWSQYpghGHPQ 823

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 755551985   79 GPY-PQSPFPPNpygqpppfQDPGSPQHGNYQ---------EEGPP 114
Cdd:PHA03377  824 GPWaPRPPHLPP--------QWDGSAGHGQDQvsqfphlqsETGPP 861
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
21-75 1.35e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 42.70  E-value: 1.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755551985  21 GPQAPMPPyvQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG 75
Cdd:COG3416   92 GGQRPPPA--PQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGGG 144
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 2-85 6.17e-04

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 40.80  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   2 SHEKSFLVSGDSYPPQnivgPQAPMPPYVQAPYPGAPYPQAPF-QPSPYGQ-PGYPHGPSPYPQGGYPQGPYPQGGYPQG 79
Cdd:cd21581  174 NLSKSGSWDFGSYYPQ----QHPSVVAFPDSRFGPLSGPQALTpDPQHYGYfQLFRHNAALFPDYAHSPGPGHLPLGQQP 249


                 ....*.
gi 755551985  80 PYPQSP 85
Cdd:cd21581  250 LLPDPP 255
 
Name Accession Description Interval E-value
LFG_like cd10428
Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; ...
 128-341 7.07e-114

Proteins similar to and including lifeguard (LFG), a putative regulator of apoptosis; Lifeguard (LFG) inhibits Fas-mediated apoptosis and interacts with the death receptor FasR/CD95/Apo1. LFG has been shown to interact with Bax and is supposed to be integral to cellular membranes such as the ER. A close homolog, PP1201 or RECS1, appears located in the Golgi compartment and also interacts with the Fas receptor CD95/Apo1. PP1201 is expressed in response to shear stress.


Pssm-ID: 198410  Cd Length: 217  Bit Score: 329.12  E-value: 7.07e-114
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 128 DKNIRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSI 207
Cdd:cd10428    4 DKTIRRAFIRKVYSILTIQLLVTVAVIALFTFHDPVKKFVRKNPWLYYVSYIVFFITYIALACCEGLRRRFPWNLILLGI 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 208 LTVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYA 287
Cdd:cd10428   84 FTLAMSYMLGTIASFYDTKAVLIAVGITAVVCLGLTLFAFQTKYDFTSCGGVLFVLSIVLLIFGIVAIFFYVKWLHIVYA 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 755551985 288 SLGALLFTCFLAVDTQLLLGNKQLSLSPEEYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10428  164 SLGALLFSLYLAVDTQLLMGGRKYELSPEEYIFAALNIYVDIVNIFLYILQLIG 217
GAAP_like cd10429
Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a ...
 131-341 6.39e-54

Golgi antiapoptotic protein; GAAP (or transmembrane BAX inhibitor motif containing 4) is a regulator of apoptosis that is related to the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Human GAAP has been linked to the modulation of intracellular fluxes of Ca(2+), by suppressing influx from the extracellular medium and reducing release from intracellular stores. A viral homolog (vaccinia virus vGAAP) acts similar to its human counterpart in inhibiting apoptosis.


Pssm-ID: 198411  Cd Length: 233  Bit Score: 177.02  E-value: 6.39e-54
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 131 IRQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSyaiFFISLIVLSCCGDFRRKHPWNLVALSILTV 210
Cdd:cd10429   26 IRMAFLRKVYSILSVQLLATTAVSALFYLSPSIKTFVQSHPWLFLIS---LIGSLILLIALYWKRHSHPVNLILLSLFTL 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 211 SLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIF-IRNRILEIVYASL 289
Cdd:cd10429  103 CEAYTVGLVVSFYDGKIVLQALILTLGVFVGLTAYTFQTKRDFSSFGALLFILLWALILLALIFQFfPYSPTFELVYAGL 182

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|..
gi 755551985 290 GALLFTCFLAVDTQLLLGNkqlsLSPEEYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10429  183 GALLFSGYIVYDTQLIMKR----LSPDEYILAAISLYLDIINLFLSILRILA 230
BI-1-like cd06181
BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 ...
 131-341 2.64e-41

BAX inhibitor (BI)-1/YccA-like protein family; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. This superfamily also contains the lifeguard(LFG)-like proteins and other subfamilies which appear to be related by common descent and also function as inhibitors of apoptosis. In plants, BI-1 like proteins play a role in pathogen resistance. A prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198409  Cd Length: 202  Bit Score: 143.32  E-value: 2.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 131 IRQAFIRKVFLVLTLQLSVTLSTVAIFTFVgevkgfvreNVWTYYVSYAIFF-ISLIVLSC-CGDFRRKHPWNLVALSIL 208
Cdd:cd06181    1 STKDFLRKVYMILALQLLLTAATATAFTVC---------DPGWYWSPALMGLlTSMLALMAtAAMIRAKMPVNLILLFGF 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 209 TVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYAS 288
Cdd:cd06181   72 TGLMGYVVGPLLFFYGPTILLRALGGTALVFFGLTVYALQARKDFLFLGGPLMAGLGFLLLSFLLNTFFYSPWLHLVAAA 151

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755551985 289 LGALLFTCFLAVDTQLLLGNkqLSLSPEEYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd06181  152 VGLVLFCGFLLYDTQLIIHK--AEVGPEDYINACISLYLDIINIFIRLLTILA 202
Bax1-I pfam01027
Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family ...
 133-340 1.21e-32

Inhibitor of apoptosis-promoting Bax1; Programmed cell-death involves a set of Bcl-2 family proteins, some of which inhibit apoptosis (Bcl-2 and Bcl-XL) and some of which promote it (Bax and Bak). Human Bax inhibitor, BI-1, is an evolutionarily conserved integral membrane protein containing multiple membrane-spanning segments predominantly localized to intracellular membranes. It has 6-7 membrane-spanning domains. The C termini of the mammalian BI-1 proteins are comprised of basic amino acids resembling some nuclear targeting sequences, but otherwise the predicted proteins lack motifs that suggest a function. As plant BI-1 appears to localize predominantly to the ER, we hypothesized that plant BI-1 could also regulate cell death triggered by ER stress. BI-1 appears to exert its effect through an interaction with calmodulin. The budding yeast member of this family has been found unexpectedly to encode a BH3 domain-containing protein (Ybh3p) that regulates the mitochondrial pathway of apoptosis in a phylogenetically conserved manner. Examination of the crystal structure of a bacterial member of this family shows that these proteins mediate a calcium leak across the membrane that is pH-dependent. Calcium homoeostasis balances passive calcium leak with active calcium uptake. The structure exists in a pore-closed and pore-open conformation, at pHs of 8 and 6 respectively, and the pore can be opened by intracrystalline transition; together these findings suggest that pH controls the conformational transition.


Pssm-ID: 460029  Cd Length: 207  Bit Score: 120.74  E-value: 1.21e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  133 QAFIRKVFLVLTLQLSVTlSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCCGDFRRK-HPWNLVALSILTVS 211
Cdd:pfam01027   1 RQFLRKVYGLLALGLLLT-AAVAYLVLSSPALLFPSLHPPLFWVLIIAPLGLLFGALLLARKRKYsSNVALLLLLAFTLL 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  212 LSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGA 291
Cdd:pfam01027  80 MGLTLGPLLLVYTGAIIATAFLGTAAIFGGLSLYALTTKRDLSFLGGFLFAGLIGLIVASLVNIFLPSSALSLAISYLGV 159

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*....
gi 755551985  292 LLFTCFLAVDTQLLLgNKQLSLSPEEYVFAALNLYTDIINIFLYILTII 340
Cdd:pfam01027 160 LLFSGFILYDTQRII-KRYGEYGDYDAILAALSLYLDFINLFLSLLRIL 207
YbhL COG0670
Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family ...
 132-342 2.58e-22

Integral membrane protein YbhL, putative Ca2+ regulator, Bax inhibitor (BI-1)/TMBIM family [Inorganic ion transport and metabolism];


Pssm-ID: 440434  Cd Length: 231  Bit Score: 93.71  E-value: 2.58e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 132 RQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVRENVWTYYVSYAIFFISLIVLSCcGDFRRKHPWNLVALSILT-- 209
Cdd:COG0670   19 LRKVLRNTYGLLALGLLLTALVAYLGMALPGLAALLFGSPGLFWVLLIAPLGLVFLLSK-LANRANSAAALALLFAYTal 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 210 --VSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTScMGVLLVSVVVLFIFAILC-IFIRNRILEIVY 286
Cdd:COG0670   98 mgLTLSPILLVYTGLSGPASIAQAFGGTAATFGGLSLYGYTTKRDLSF-LGSFLFMGLIGLIIASLVnIFLQSPALSLAI 176

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 755551985 287 ASLGALLFTCFLAVDTQLLlgnKQLSLSPEEYVFAALNLYTDIINIFLYILTIIGR 342
Cdd:COG0670  177 SVAGVLLFSGLTLYDTQRI---KHGYETNKQYIMAALSLYLDFINLFLSLLRLLGG 229
BI-1-like_bacterial cd10432
Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial ...
 132-341 3.79e-17

Bacterial BAX inhibitor (BI)-1/YccA-like proteins; This family is comprised of bacterial relatives of the mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, which have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. In plants, BI-1 like proteins play a role in pathogen resistance. A characterized prokaryotic member, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198414  Cd Length: 211  Bit Score: 78.76  E-value: 3.79e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 132 RQAFIRKVFLVLTLQLSVTLSTVAIFTFVGEVKGFVreNVWTYYVSYAIFFISLIVLSccgdFRRKHP---WNLVALSIL 208
Cdd:cd10432    2 LRSFMKKVYGLMAAGLLLTAVGAYVGASTPALLLIA--GSPLMWVLLIAELALVFGLS----FRINKMsvaTALPLFFAF 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 209 TVSLSYMVGMIASFYNTEAVIMAVGITTAVCFTVVIFSMQTRYDFTScMGVllvsvvvlFIFA---------ILCIFIRN 279
Cdd:cd10432   76 AALTGLTLSPILLVYTGASIAQAFFTTAATFGGLSLYGYTTKKDLSF-LGS--------FLFMgligliiasLVNIFLQS 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755551985 280 RILEIVYASLGALLFTCFLAVDTQLL--LGNKQLSLSPEE-YVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10432  147 SALQFAISAIGVLIFSGLIAYDTQRIkrMYEAGGGESGYKdAIMGALSLYLDFINLFLFLLRLFG 211
YccA_like cd10433
YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small ...
 147-341 1.21e-09

YccA-like proteins; A prokaryotic member of the BAX inhibitor (BI)-1 like family of small transmembrane proteins, Escherichia coli YccA, has been shown to interact with ATP-dependent protease FtsH, which degrades abnormal membrane proteins as part of a quality control mechanism to keep the integrity of biological membranes.


Pssm-ID: 198415  Cd Length: 205  Bit Score: 57.21  E-value: 1.21e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 147 LSVTLSTVAIFTFVGEVKGFVrenvwtyYVSYAIFFISLIVLSCCGDFRRKHPWNLVALSILT----VSLSYMVGMIASF 222
Cdd:cd10433   14 LSMTLAFSALGAGVSMAGGSP-------IMGLLLTLVGAYGLLFLIEKTRNSAWGIVLVFAFTgfmgYTLGPILNMYLAL 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 223 YNTEAVIM-AVGITTAVCFTVVIFSMQTRYDFTSCMGVLLVSVVVLFIFAILCIFIRNRILEIVYASLGALLFTCFLAVD 301
Cdd:cd10433   87 PNGGQIIMtALGGTAAIFFGLSAYALTTKKDFSFLGGFLFVGAIVLLLAAVANIFLQIPALSLAISAAFVLFSSGFILYD 166

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 755551985 302 TQLLLGNKQLSlspeeYVFAALNLYTDIINIFLYILTIIG 341
Cdd:cd10433  167 TSRIIHGGETN-----YIMATVSLYVSIYNLFVSLLNLLG 201
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 10-114 3.10e-09

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 55.43  E-value: 3.10e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   10 SGDSYPPQNIVGPQAPMPPYVQAPyPGAPYPQAPFQPSPYGQPGYPHGP----SPYPQGGYPQGPYPQGGY-----PQGP 80
Cdd:pfam15240  41 QGGQGPQGPPPGGFPPQPPASDDP-PGPPPPGGPQQPPPQGGKQKPQGPppqgGPRPPPGKPQGPPPQGGNqqqgpPPPG 119

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 755551985   81 YPQSPFPPNPYGQPP--PFQDPGSPQHGNYQeeGPP 114
Cdd:pfam15240 120 KPQGPPPQGGGPPPQggNQQGPPPPPPGNPQ--GPP 153
Pro-rich pfam15240
Proline-rich protein; This family includes several eukaryotic proline-rich proteins.
 4-123 8.66e-09

Proline-rich protein; This family includes several eukaryotic proline-rich proteins.


Pssm-ID: 464580 [Multi-domain]  Cd Length: 167  Bit Score: 54.27  E-value: 8.66e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985    4 EKSFLVSGDSYPPQNI-VGPQAPMPPYVQAPYPGAPYPQAPFQP-SPYGQPgyPHGPSPYPQGGYPQG-PYPQGGYPQGP 80
Cdd:pfam15240  27 DSPSLISEEEGQSQQGgQGPQGPPPGGFPPQPPASDDPPGPPPPgGPQQPP--PQGGKQKPQGPPPQGgPRPPPGKPQGP 104

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 755551985   81 YPQSPFPPNPYGQpppfqdPGSPQHGNYQEEGPPSYYDNQDFP 123
Cdd:pfam15240 105 PPQGGNQQQGPPP------PGKPQGPPPQGGGPPPQGGNQQGP 141
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 6-115 5.12e-08

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 54.77  E-value: 5.12e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985    6 SFLVSGDSYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYGQ-PGYPH----GPSPYPQGGYPQgPYP------QG 74
Cdd:pfam03154 229 TLIQQTPTLHPQRLPSPHPPLQPMTQPPPPSQVSPQPLPQPSLHGQmPPMPHslqtGPSHMQHPVPPQ-PFPltpqssQS 307

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 755551985   75 GYPQGPYPQSPFPPNPYGQPPPFQDPGSPQHGNYQEEGPPS 115
Cdd:pfam03154 308 QVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPA 348
PHA03377 PHA03377
EBNA-3C; Provisional
 22-114 9.86e-08

EBNA-3C; Provisional


Pssm-ID: 177614 [Multi-domain]  Cd Length: 1000  Bit Score: 53.90  E-value: 9.86e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   22 PQAPM-----PPYVQAPYPG---APYPQAPFQ----PSPYG-----QPGY--PHGPSP-YPQGGYPQGPYPQG---GYPQ 78
Cdd:PHA03377  744 HQAPYsgheePQAQQAPYPGywePRPPQAPYLgyqePQAQGvqvssYPGYagPWGLRAqHPRYRHSWAYWSQYpghGHPQ 823

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 755551985   79 GPY-PQSPFPPNpygqpppfQDPGSPQHGNYQ---------EEGPP 114
Cdd:PHA03377  824 GPWaPRPPHLPP--------QWDGSAGHGQDQvsqfphlqsETGPP 861
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 15-110 1.24e-06

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 50.47  E-value: 1.24e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   15 PPQNIVGPQAPMPPYVQAPYPGAPY-----PQAPFQPSP-YGQPGYPHGPSP-YPQGGYPQGPYPQGGYPQGPYPQSPfp 87
Cdd:PRK10263  751 PVQQPQQPVAPQQQYQQPQQPVAPQpqyqqPQQPVAPQPqYQQPQQPVAPQPqYQQPQQPVAPQPQYQQPQQPVAPQP-- 828

                          90       100
                  ....*....|....*....|...
gi 755551985   88 pnpygqppPFQDPGSPQHGNYQE 110
Cdd:PRK10263  829 --------QYQQPQQPVAPQPQD 843
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 27-85 2.15e-05

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 46.61  E-value: 2.15e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755551985   27 PPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPspypqggYPQGPYPQGGYPQGPYPQSP 85
Cdd:PTZ00395  422 PGYNNAPNSNTPYNNPPNSNTPYSNPPNSNPP-------YSNLPYSNTPYSNAPLSNAP 473
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 15-85 2.92e-05

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 43.12  E-value: 2.92e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755551985   15 PPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSpYGQPGYPHGPSP----YPQGGYPQGPYPqgGYPQGPYPQSP 85
Cdd:pfam02389  12 PPQEPCVPTTKEPCHSKVPEPCNPKVPEPCCPK-VPEPCCPKVPEPccpkVPEPCCPKVPEP--CYPKVPEPCSP 83
BI-1 cd10430
BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small ...
 202-339 3.04e-05

BAX inhibitor (BI)-1; Mammalian members of the BAX inhibitor (BI)-1 like family of small transmembrane proteins have been shown to have an antiapoptotic effect either by stimulating the antiapoptotic function of Bcl-2, a well-characterized oncogene, or by inhibiting the proapoptotic effect of Bax, another member of the Bcl-2 family. Their broad tissue distribution and high degree of conservation suggests an important regulatory role. In plants, BI-1 like proteins play a role in pathogen resistance.


Pssm-ID: 198412  Cd Length: 213  Bit Score: 44.52  E-value: 3.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985 202 LVALSILT-VSLSYMVGMIASFyNTEAVIMAVGITTAV--CFTVVIFSMQTRYdFTSCMGVLLVSVVVLFIFAILCIFIR 278
Cdd:cd10430   71 LLGFAFLTgASLGPLLDLVIAI-NPSIIVTAFLGTAVIfaCFSLAALLAKRRE-YLYLGGLLSSALSILLLVSLANIFGG 148

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551985 279 NRILEIVYASLGALLFTCFLAVDTQLLLgnKQLSLSPEEYVFAALNLYTDIINIFLYILTI 339
Cdd:cd10430  149 SKFLFQAELYLGLLVFCGFVLFDTQMII--EKAENGDRDYIWHALDLFVDFVALFRRLLII 207
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-103 9.91e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.54  E-value: 9.91e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   15 PPQNIVG-PQAPMPPYV------QAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGgyPQGPYPQGGYPQGPYPQSPFP 87
Cdd:PHA03247 2867 PSRSPAAkPAAPARPPVrrlarpAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQP--PPPPQPQPPPPPPPRPQPPLA 2944

                          90
                  ....*....|....*.
gi 755551985   88 PNPYGQPPPFQDPGSP 103
Cdd:PHA03247 2945 PTTDPAGAGEPSGAVP 2960
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 13-115 1.13e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.99  E-value: 1.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   13 SYPPQNIVGPQAPM----------PPYVQAPYP---GAPYPQAPFQPSPygQPgyphGPSPYPQGGYPQGPYP-QGGYPQ 78
Cdd:pfam03154 215 SQPPNQTQSTAAPHtliqqtptlhPQRLPSPHPplqPMTQPPPPSQVSP--QP----LPQPSLHGQMPPMPHSlQTGPSH 288

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 755551985   79 GPYPQSPFPPNPYGQPPPFQDPGSPQ-----HGNYQEEGPPS 115
Cdd:pfam03154 289 MQHPVPPQPFPLTPQSSQSQVPPGPSpaapgQSQQRIHTPPS 330
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
21-75 1.35e-04

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 42.70  E-value: 1.35e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 755551985  21 GPQAPMPPyvQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG 75
Cdd:COG3416   92 GGQRPPPA--PQPSQPGPQQQPAPPSGPWGQAAPQQPGYGQPQYGQPAAGPSGGG 144
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 11-69 1.37e-04

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 41.65  E-value: 1.37e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 755551985   11 GDSYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYgQPGYPHGPSpYPQGGYPQG 69
Cdd:pfam12868  87 GSTPQPPVDPQPNAPPPPYNPADYPPPPGAAPPPQPYQY-PPPPGPDPY-APRPRRADE 143
PHA03247 PHA03247
large tegument protein UL36; Provisional
 13-85 1.49e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 43.77  E-value: 1.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   13 SYPPQNIVGPQAPM----PPYVQAPYPGAP-------YPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPY 81
Cdd:PHA03247 2849 SLPLGGSVAPGGDVrrrpPSRSPAAKPAAParppvrrLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQ 2928


                  ....
gi 755551985   82 PQSP 85
Cdd:PHA03247 2929 PQPP 2932
Cornifin pfam02389
Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small ...
 22-85 2.16e-04

Cornifin (SPRR) family; SPRR genes (formerly SPR) encode a novel class of polypeptides (small proline rich proteins) that are strongly induced during differentiation of human epidermal keratinocytes in vitro and in vivo. The most characteriztic feature of the SPRR gene family resides in the structure of the central segments of the encoded polypeptides that are built up from tandemly repeated units of either eight (SPRR1 and SPRR3) or nine (SPRR2) amino acids with the general consensus XKXPEPXX where X is any amino acid. In order to avoid bacterial contamination due to the high polar-nature of the HMM the threshold has been set very high.


Pssm-ID: 280537 [Multi-domain]  Cd Length: 135  Bit Score: 40.81  E-value: 2.16e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551985   22 PQAPMPPYVQAPYPGAPYPQAPFQPSpYGQPGYPHGPSP----YPQGGYPQGP------YPQGGYPQGPYPQSP 85
Cdd:pfam02389  43 PKVPEPCCPKVPEPCCPKVPEPCCPK-VPEPCYPKVPEPcspkVPEPCHPKAPepchpkVPEPCYPKAPEPCQP 115
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 10-84 2.17e-04

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 40.88  E-value: 2.17e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   10 SGDSYPPQnivgPQAPMPPYVQAP----YPG--------APYPQAPFQPSPYGQPGyPHGPSPYPQGGYPQGPYPQGGYP 77
Cdd:pfam12868  52 YEDPYSPS----PYPPSPAGPYASqgqyYPEtnyfppppGSTPQPPVDPQPNAPPP-PYNPADYPPPPGAAPPPQPYQYP 126


                  ....*..
gi 755551985   78 QGPYPQS 84
Cdd:pfam12868 127 PPPGPDP 133
DUF3824 pfam12868
Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It ...
 27-118 3.07e-04

Domain of unknwon function (DUF3824); This is a repeating domain found in fungal proteins. It is proline-rich, and the function is not known.


Pssm-ID: 372351 [Multi-domain]  Cd Length: 145  Bit Score: 40.49  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   27 PPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPS-PYPQGGYPQGPY-PQGGYPQGPYPQSPFPPNPYGQPPPFQDPGSPQ 104
Cdd:pfam12868  49 RDYYEDPYSPSPYPPSPAGPYASQGQYYPETNYfPPPPGSTPQPPVdPQPNAPPPPYNPADYPPPPGAAPPPQPYQYPPP 128

                          90
                  ....*....|....
gi 755551985  105 HGNYQEEGPPSYYD 118
Cdd:pfam12868 129 PGPDPYAPRPRRAD 142
PHA03247 PHA03247
large tegument protein UL36; Provisional
 3-72 3.38e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 42.62  E-value: 3.38e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 755551985    3 HEKSFLVSGDSYPPQNIVGPQAPMPPYVQAPYPG-APYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYP 72
Cdd:PHA03247  390 HAATPFARGPGGDDQTRPAAPVPASVPTPAPTPVpASAPPPPATPLPSAEPGSDDGPAPPPERQPPAPATE 460
PHA03378 PHA03378
EBNA-3B; Provisional
 11-85 3.82e-04

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 42.36  E-value: 3.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  11 GDSYPPQNIVGPQAP-------MPPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGG-------Y 76
Cdd:PHA03378 732 GRARPPAAAPGRARPpaaapgrARPPAAAPGRARPPAAAPGAPTPQPPPQAPPAPQQRPRGAPTPQPPPQAGptsmqlmP 811


                 ....*....
gi 755551985  77 PQGPYPQSP 85
Cdd:PHA03378 812 RAAPGQQGP 820
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 12-115 5.49e-04

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 41.99  E-value: 5.49e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   12 DSYPPQ-NIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGY--PQGPYPQGGYPQGPYPQSPfPP 88
Cdd:PRK10263  378 EGYPQQsQYAQPAVQYNEPLQQPVQPQQPYYAPAAEQPAQQPYYAPAPEQPAQQPYyaPAPEQPVAGNAWQAEEQQS-TF 456

                          90       100
                  ....*....|....*....|....*..
gi 755551985   89 NPYGQPPPFQDPGSPQHGNYQEEGPPS 115
Cdd:PRK10263  457 APQSTYQTEQTYQQPAAQEPLYQQPQP 483
PHA03247 PHA03247
large tegument protein UL36; Provisional
 21-85 5.69e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.85  E-value: 5.69e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551985   21 GPQAPMPPYVQAPYPGA-PYPQAPfqPSPYGQPGYPHGPSPYPQGGYPQGPYPqggyPQGPYPQSP 85
Cdd:PHA03247  398 GPGGDDQTRPAAPVPASvPTPAPT--PVPASAPPPPATPLPSAEPGSDDGPAP----PPERQPPAP 457
PAT1 pfam09770
Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate ...
 11-85 5.69e-04

Topoisomerase II-associated protein PAT1; Members of this family are necessary for accurate chromosome transmission during cell division.


Pssm-ID: 401645 [Multi-domain]  Cd Length: 846  Bit Score: 41.95  E-value: 5.69e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 755551985   11 GDSYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYGQPGY----PHGPSPYPQGGYPQGPYPQGGYPQGPYPQSP 85
Cdd:pfam09770 258 GQGHPVTILQRPQSPQPDPAQPSIQPQAQQFHQQPPPVPVQPTQilqnPNRLSAARVGYPQNPQPGVQPAPAHQAHRQQ 336
KLF1_N cd21581
N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as ...
 2-85 6.17e-04

N-terminal domain of Kruppel-like Factor 1; Kruppel-like Factor 1 (KLF1, also known as Krueppel-like factor 1 or Erythroid Kruppel-like Factor/EKLF) was the first Kruppel-like factor discovered. It was found to be vitally important for embryonic erythropoiesis in promoting the switch from fetal hemoglobin (Hemoglobin F) to adult hemoglobin (Hemoglobin A) gene expression by binding to highly conserved CACCC domains. EKLF ablation in mouse embryos produces a lethal anemic phenotype, causing death by embryonic day 14, and natural mutations lead to beta+ thalassemia in humans. However, expression of embryonic hemoglobin and fetal hemoglobin genes is normal in EKLF-deficient mice, suggesting other factors may be involved. KLF1 functions as a transcriptional activator. It belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specifity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF1, which is related to the N-terminal domains of KLF2 and KLF4.


Pssm-ID: 409227 [Multi-domain]  Cd Length: 278  Bit Score: 40.80  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   2 SHEKSFLVSGDSYPPQnivgPQAPMPPYVQAPYPGAPYPQAPF-QPSPYGQ-PGYPHGPSPYPQGGYPQGPYPQGGYPQG 79
Cdd:cd21581  174 NLSKSGSWDFGSYYPQ----QHPSVVAFPDSRFGPLSGPQALTpDPQHYGYfQLFRHNAALFPDYAHSPGPGHLPLGQQP 249


                 ....*.
gi 755551985  80 PYPQSP 85
Cdd:cd21581  250 LLPDPP 255
PHA03247 PHA03247
large tegument protein UL36; Provisional
 13-85 8.33e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.46  E-value: 8.33e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755551985   13 SYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPqggyPQGPYPQGGYPQGPYPQSP 85
Cdd:PHA03247 2892 SRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQPPPPPPPRPQP----PLAPTTDPAGAGEPSGAVP 2960
PBP1 COG5180
PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification]; ...
 14-85 1.35e-03

PAB1-binding protein, interacts with poly(A)-binding protein [RNA processing and modification];


Pssm-ID: 444064 [Multi-domain]  Cd Length: 548  Bit Score: 40.43  E-value: 1.35e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 755551985  14 YPPQNIVGPQApMPPyVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPyPQGGYPQGPY-PQGGYPQ--GPYPQSP 85
Cdd:COG5180  330 RPGQPTERPAG-VPE-AASDAGQPPSAYPPAEEAVPGKPLEQGAPRP-GSSGGDGAPFqPPNGAPQpgLGRRGAP 401
PHA03247 PHA03247
large tegument protein UL36; Provisional
 12-82 1.67e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 1.67e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 755551985   12 DSYPPQNIVGPQAPMPPYVQAPYPGAPYPQAPFQPSPYGQPGYPhgPSPYPQGGY--PQGPYPQGGYPQGPYP 82
Cdd:PHA03247 2803 DPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPGPP--PPSLPLGGSvaPGGDVRRRPPSRSPAA 2873
DUF1373 pfam07117
Protein of unknown function (DUF1373); This family consists of several hypothetical proteins ...
 33-116 1.97e-03

Protein of unknown function (DUF1373); This family consists of several hypothetical proteins which seem to be specific to Oryzias latipes (Japanese ricefish). Members of this family are typically around 200 residues in length. The function of this family is unknown.


Pssm-ID: 462093 [Multi-domain]  Cd Length: 212  Bit Score: 39.01  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   33 PYPGAPYPQAPFQPSPYGQPGYphGPSPyPQGGYPQGPYPQGGYPQGPYPQSPFPpnpygqpppfQDPGSPQ-----HGN 107
Cdd:pfam07117  17 CLGGGGNMAMARPMSLPLPPGQ--EPEP-PRPEEEEGQGGGGGTFPFPGSPEPEP----------GGGGSGPmpmsaSAP 83


                  ....*....
gi 755551985  108 YQEEGPPSY 116
Cdd:pfam07117  84 EPEPAKAKP 92
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 16-127 2.91e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 39.68  E-value: 2.91e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   16 PQNIVGPQAPMPpyvqAPYPGAPYPQAPFQPSPYGQPGYPhGPSPYPQGGYPQGPYPQGGYP-----QGPYPQSPFPPNP 90
Cdd:PRK10263  336 PVEPVTQTPPVA----SVDVPPAQPTVAWQPVPGPQTGEP-VIAPAPEGYPQQSQYAQPAVQyneplQQPVQPQQPYYAP 410

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755551985   91 YGQPPPFQDPGSPQHGNYQEEGPPSYYDNQDFPAVNW 127
Cdd:PRK10263  411 AAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAW 447
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 22-85 3.15e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 3.15e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 755551985  22 PQAPMPPYVQAPYPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQGGYPQGPYPQSP 85
Cdd:PRK07764 424 APAAAPQPAPAPAPAPAPPSPAGNAPAGGAPSPPPAAAPSAQPAPAPAAAPEPTAAPAPAPPAA 487
PHA03247 PHA03247
large tegument protein UL36; Provisional
 15-75 3.64e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 39.54  E-value: 3.64e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 755551985   15 PPQNIVGPQAPMPPYVQAPYPGAPYPQAP--FQPSPygQPgyPHGPSPYPQG-GYPQG--PYPQGG 75
Cdd:PHA03247 2904 QPERPPQPQAPPPPQPQPQPPPPPQPQPPppPPPRP--QP--PLAPTTDPAGaGEPSGavPQPWLG 2965
PTZ00395 PTZ00395
Sec24-related protein; Provisional
 29-86 3.86e-03

Sec24-related protein; Provisional


Pssm-ID: 185594 [Multi-domain]  Cd Length: 1560  Bit Score: 39.29  E-value: 3.86e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 755551985   29 YVQAPYPGAPYPQAPFQPSPYGQPGYPHgpSPYPQGGYPQGPYPQGGYPQGPYPQSPF 86
Cdd:PTZ00395  399 QSNAAQSNAGFSNAGYSNPGNSNPGYNN--APNSNTPYNNPPNSNTPYSNPPNSNPPY 454
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 9-116 4.82e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.98  E-value: 4.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985    9 VSGDSYPPQNIVGPQAPMPPYVQA-----PYPGAPYPQAPFQPSPYGQ-PGYPHGPSPYPQGGYPQGPYPQGGYPQGPYP 82
Cdd:pfam03154 261 VSPQPLPQPSLHGQMPPMPHSLQTgpshmQHPVPPQPFPLTPQSSQSQvPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPP 340

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 755551985   83 -QSPFPPNPYGQPPPFQDPGSP--QHGNYQEEGPPSY 116
Cdd:pfam03154 341 rEQPLPPAPLSMPHIKPPPTTPipQLPNPQSHKHPPH 377
dnaA PRK14086
chromosomal replication initiator protein DnaA;
12-120 5.04e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 38.65  E-value: 5.04e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985  12 DSYPPQNIVGPQAPMPPYVQAP--YPGAPYPQAPFQPSPYGQPGYPHGPSPYPQGGYPQGPYPQggyPQGPYP-QSPFPP 88
Cdd:PRK14086 119 EGYGGPRADDRPPGLPRQDQLPtaRPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYAS---PASYAPeQERDRE 195

                         90       100       110
                 ....*....|....*....|....*....|..
gi 755551985  89 NPYGQPPPFQDPGSPQHGNYQEEGPPSYYDNQ 120
Cdd:PRK14086 196 PYDAGRPEYDQRRRDYDHPRPDWDRPRRDRTD 227
PHA03247 PHA03247
large tegument protein UL36; Provisional
 8-85 6.11e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 38.77  E-value: 6.11e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985    8 LVSGDSYPPQNIVGPQAP-------MPPYVQAPYPGAP-------YPQAPFQPSPYGQPGYPHGPSPYPQggyPQGPYPQ 73
Cdd:PHA03247 2543 LASDDAGDPPPPLPPAAPpaapdrsVPPPRPAPRPSEPavtsrarRPDAPPQSARPRAPVDDRGDPRGPA---PPSPLPP 2619

                          90
                  ....*....|..
gi 755551985   74 GGYPQGPYPQSP 85
Cdd:PHA03247 2620 DTHAPDPPPPSP 2631
COG3416 COG3416
Uncharacterized conserved protein, DUF2076 domain [Function unknown];
31-83 7.27e-03

Uncharacterized conserved protein, DUF2076 domain [Function unknown];


Pssm-ID: 442642 [Multi-domain]  Cd Length: 237  Bit Score: 37.31  E-value: 7.27e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 755551985  31 QAPYPGAPYPQAPFQPSPyGQPGYphGPSPYPQGGYPQgpyPQGGYPQGPYPQ 83
Cdd:COG3416   96 PPPAPQPSQPGPQQQPAP-PSGPW--GQAAPQQPGYGQ---PQYGQPAAGPSG 142
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 15-86 7.58e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 38.21  E-value: 7.58e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 755551985   15 PPQNIVGPQAPMP---PYVQAPYPGAPYPQA-PFQPSPYGQPGYPHGPS-PYPQGGYPQGPYPQGGYPQGPYPQSPF 86
Cdd:pfam03154 391 PPPPALKPLSSLSthhPPSAHPPPLQLMPQSqQLPPPPAQPPVLTQSQSlPPPAASHPPTSGLHQVPSQSPFPQHPF 467
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 15-100 9.25e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 37.82  E-value: 9.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755551985   15 PPQNIVGP------QAPMPPYVQAPYPGAPYPQAPfQPSPYGQPGYPHGPSPYPQGGYPQ---GPYPQGGYPQGPYPQSP 85
Cdd:pfam03154 294 PPQPFPLTpqssqsQVPPGPSPAAPGQSQQRIHTP-PSQSQLQSQQPPREQPLPPAPLSMphiKPPPTTPIPQLPNPQSH 372

                          90
                  ....*....|....*
gi 755551985   86 FPPNPYGQPPPFQDP 100
Cdd:pfam03154 373 KHPPHLSGPSPFQMN 387
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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