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Conserved domains on  [gi|755542173|ref|XP_011242294|]
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protein delta homolog 1 isoform X1 [Mus musculus]

Protein Classification

calcium-binding EGF-like domain-containing protein( domain architecture ID 10041892)

calcium-binding epidermal growth factor (EGF)-like domain-containing protein may play a crucial role in numerous protein-protein interactions; similar to Homo sapiens Notch homolog 2 N-terminal-like proteins and protein delta homologs

CATH:  2.10.25.10
Gene Ontology:  GO:0005515|GO:0005509
PubMed:  3282918|2288911|7606779
SCOP:  4003198

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 88-125 4.81e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.81e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755542173  88 DVRACTST-PCANNGTCVDLEkGQYECSCTPGFSGKDCQ 125
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 177-207 6.78e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.78e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755542173 177 TPNPCENDGVCTDIGGDFRCRCPAGFVDKTC 207
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 135-168 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755542173 135 GSPCQHGGACVDDEGqasHASCLCPPGFSGNFCE 168
Cdd:cd00054    8 GNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 88-125 4.81e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.81e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755542173  88 DVRACTST-PCANNGTCVDLEkGQYECSCTPGFSGKDCQ 125
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 177-207 6.78e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.78e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755542173 177 TPNPCENDGVCTDIGGDFRCRCPAGFVDKTC 207
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 176-206 1.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755542173  176 CTPNPCENDGVCTDIGGDFRCRCPAGFVDKT 206
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
174-206 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 755542173   174 NSC-TPNPCENDGVCTDIGGDFRCRCPAGFVDKT 206
Cdd:smart00179   3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTDGR 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 92-123 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 1.63e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 755542173   92 CTSTPCANNGTCVDLEkGQYECSCTPGFSGKD 123
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 135-168 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755542173 135 GSPCQHGGACVDDEGqasHASCLCPPGFSGNFCE 168
Cdd:cd00054    8 GNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
88-125 2.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 2.24e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755542173    88 DVRACTST-PCANNGTCVDLEkGQYECSCTPGFS-GKDCQ 125
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
 
Name Accession Description Interval E-value
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 88-125 4.81e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.93  E-value: 4.81e-05
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 755542173  88 DVRACTST-PCANNGTCVDLEkGQYECSCTPGFSGKDCQ 125
Cdd:cd00054    1 DIDECASGnPCQNGGTCVNTV-GSYRCSCPPGYTGRNCE 38
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 177-207 6.78e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 39.54  E-value: 6.78e-05
                         10        20        30
                 ....*....|....*....|....*....|.
gi 755542173 177 TPNPCENDGVCTDIGGDFRCRCPAGFVDKTC 207
Cdd:cd00054    7 SGNPCQNGGTCVNTVGSYRCSCPPGYTGRNC 37
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 176-206 1.99e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 38.13  E-value: 1.99e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 755542173  176 CTPNPCENDGVCTDIGGDFRCRCPAGFVDKT 206
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICPEGYTGKR 31
EGF_CA smart00179
Calcium-binding EGF-like domain;
174-206 1.03e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 36.46  E-value: 1.03e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 755542173   174 NSC-TPNPCENDGVCTDIGGDFRCRCPAGFVDKT 206
Cdd:smart00179   3 DECaSGNPCQNGGTCVNTVGSYRCECPPGYTDGR 36
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 92-123 1.63e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 35.44  E-value: 1.63e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 755542173   92 CTSTPCANNGTCVDLEkGQYECSCTPGFSGKD 123
Cdd:pfam00008   1 CAPNPCSNGGTCVDTP-GGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 135-168 2.14e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.31  E-value: 2.14e-03
                         10        20        30
                 ....*....|....*....|....*....|....
gi 755542173 135 GSPCQHGGACVDDEGqasHASCLCPPGFSGNFCE 168
Cdd:cd00054    8 GNPCQNGGTCVNTVG---SYRCSCPPGYTGRNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
88-125 2.24e-03

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 35.30  E-value: 2.24e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 755542173    88 DVRACTST-PCANNGTCVDLEkGQYECSCTPGFS-GKDCQ 125
Cdd:smart00179   1 DIDECASGnPCQNGGTCVNTV-GSYRCECPPGYTdGRNCE 39
EGF cd00053
Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large ...
 177-207 4.18e-03

Epidermal growth factor domain, found in epidermal growth factor (EGF) presents in a large number of proteins, mostly animal; the list of proteins currently known to contain one or more copies of an EGF-like pattern is large and varied; the functional significance of EGF-like domains in what appear to be unrelated proteins is not yet clear; a common feature is that these repeats are found in the extracellular domain of membrane-bound proteins or in proteins known to be secreted (exception: prostaglandin G/H synthase); the domain includes six cysteine residues which have been shown to be involved in disulfide bonds; the main structure is a two-stranded beta-sheet followed by a loop to a C-terminal short two-stranded sheet; Subdomains between the conserved cysteines vary in length; the region between the 5th and 6th cysteine contains two conserved glycines of which at least one is present in most EGF-like domains; a subset of these bind calcium.


Pssm-ID: 238010  Cd Length: 36  Bit Score: 34.76  E-value: 4.18e-03
                         10        20        30
                 ....*....|....*....|....*....|..
gi 755542173 177 TPNPCENDGVCTDIGGDFRCRCPAGFV-DKTC 207
Cdd:cd00053    4 ASNPCSNGGTCVNTPGSYRCVCPPGYTgDRSC 35
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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