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Conserved domains on  [gi|755533149|ref|XP_011241494|]
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protein broad-minded isoform X2 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RabGAP-TBC super family cl46302
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
12-857 0e+00

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


The actual alignment was detected with superfamily member pfam14961:

Pssm-ID: 480642  Cd Length: 1292  Bit Score: 1473.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    12 LQAMLRQLFQSVKEKITGAPSLECAEEILLRLEETDENFHNYEFVKYLRQHICNMLGSMIEEEMEKCTSDQNQGEDSGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    92 TVVQHVTKRTQESKEYKEMMHSLKNIMMVVVEAMINKFEEDETRSEDRQRKM---QSGSCCTDNCSDSDSSFNQSYKF-C 167
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSqheQLSSHYTDNCSDSDSSFNQSYTFmS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   168 QGKLRLILDQLDPGQPKEVRYEALQTLCSAPPSDVLSCENWTTLCEKLTTSLSDPDPMFTDRILKFYAQTFTLSPLHMTK 247
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   248 EIYTSLAKYLEVYFLSRENHLPTLSTGVDITSPNVTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLSVKHE 327
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   328 QS--HLVPQKILDPIYFFALVDTKAVWFKKWMHAYYSRTAVLRLLEKKYKCLITTAVQQCVQYLELCEAMKADEI----L 401
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKTTeishS 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   402 RHPKHCGTKQKSFYySGQELQYIYFIHSLCLLGRLLIYTQGRKLFPIKLKNRKDSVSLTNLLVLFTQLIYYSPSCPKMTS 481
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   482 IMCSENYSPASMVTDVLRMLCDQKECAVECLYNSTVTEALLLPIHNLTKGTAAAPDCSETALIHIADILARIASVEEGLI 561
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   562 LLLYGENMNSSEEESLTGAHIIAKFSKKLLEEDISIFSGSEMLPVVKGAFISVCRQIYGTCEGLQVLLPYGLHESIAKAW 641
Cdd:pfam14961  560 LLLYGGNLSSAEEESISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   642 KKTSLLSERIPTPVEGSDSVSSVSQVSPNSVAWEDNLLDDLLNFAATPKGLLLLQRTGAINECVTFMLSQYAKKPQVNRQ 721
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   722 KKFGYEVLVVQVASTAAGAVALQNSGFISALITELWSNLECGRDDVRLTHPRATPVDPIDRSCQKSFLALVNLL-SYPAV 800
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755533149   801 YELTANQELPNKAEYSLREVPTCIIDIMDRLIVLNSEAKIRSLLNYEQSHTFGLRSL 857
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLL 856
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
12-857 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 1473.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    12 LQAMLRQLFQSVKEKITGAPSLECAEEILLRLEETDENFHNYEFVKYLRQHICNMLGSMIEEEMEKCTSDQNQGEDSGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    92 TVVQHVTKRTQESKEYKEMMHSLKNIMMVVVEAMINKFEEDETRSEDRQRKM---QSGSCCTDNCSDSDSSFNQSYKF-C 167
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSqheQLSSHYTDNCSDSDSSFNQSYTFmS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   168 QGKLRLILDQLDPGQPKEVRYEALQTLCSAPPSDVLSCENWTTLCEKLTTSLSDPDPMFTDRILKFYAQTFTLSPLHMTK 247
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   248 EIYTSLAKYLEVYFLSRENHLPTLSTGVDITSPNVTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLSVKHE 327
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   328 QS--HLVPQKILDPIYFFALVDTKAVWFKKWMHAYYSRTAVLRLLEKKYKCLITTAVQQCVQYLELCEAMKADEI----L 401
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKTTeishS 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   402 RHPKHCGTKQKSFYySGQELQYIYFIHSLCLLGRLLIYTQGRKLFPIKLKNRKDSVSLTNLLVLFTQLIYYSPSCPKMTS 481
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   482 IMCSENYSPASMVTDVLRMLCDQKECAVECLYNSTVTEALLLPIHNLTKGTAAAPDCSETALIHIADILARIASVEEGLI 561
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   562 LLLYGENMNSSEEESLTGAHIIAKFSKKLLEEDISIFSGSEMLPVVKGAFISVCRQIYGTCEGLQVLLPYGLHESIAKAW 641
Cdd:pfam14961  560 LLLYGGNLSSAEEESISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   642 KKTSLLSERIPTPVEGSDSVSSVSQVSPNSVAWEDNLLDDLLNFAATPKGLLLLQRTGAINECVTFMLSQYAKKPQVNRQ 721
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   722 KKFGYEVLVVQVASTAAGAVALQNSGFISALITELWSNLECGRDDVRLTHPRATPVDPIDRSCQKSFLALVNLL-SYPAV 800
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755533149   801 YELTANQELPNKAEYSLREVPTCIIDIMDRLIVLNSEAKIRSLLNYEQSHTFGLRSL 857
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLL 856
 
Name Accession Description Interval E-value
BROMI pfam14961
Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase ...
12-857 0e+00

Broad-minded protein; Broad-minded protein (BROMI) interacts with cell cycle-related kinase (CCRK), together these proteins regulate ciliary membrane and axonemal growth.


Pssm-ID: 464406  Cd Length: 1292  Bit Score: 1473.07  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    12 LQAMLRQLFQSVKEKITGAPSLECAEEILLRLEETDENFHNYEFVKYLRQHICNMLGSMIEEEMEKCTSDQNQGEDSGYD 91
Cdd:pfam14961    1 LQSLLRQLLQSVKEKISGAPSVECAEEILLHLEETDENFHNYEFVKYLRQYIESTLGSVIEEETEKCTSEEGQGEGSGQD 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149    92 TVVQHVTKRTQESKEYKEMMHSLKNIMMVVVEAMINKFEEDETRSEDRQRKM---QSGSCCTDNCSDSDSSFNQSYKF-C 167
Cdd:pfam14961   81 TLVQAVTKRTRESKEYKEMMHSLKNVMMVVVESLINKFEEDQMRKEEMHRKSqheQLSSHYTDNCSDSDSSFNQSYTFmS 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   168 QGKLRLILDQLDPGQPKEVRYEALQTLCSAPPSDVLSCENWTTLCEKLTTSLSDPDPMFTDRILKFYAQTFTLSPLHMTK 247
Cdd:pfam14961  161 QEQLQLIAEKLDPRQPKEVRWEALQTLCHAPPSDVLSCESWTSLRRNLMAALSDPDPALSDKILRFYAKTFSSSPLNITR 240
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   248 EIYTSLAKYLEVYFLSRENHLPTLSTGVDITSPNVTRLLKKVRLLNEYQKEAPSFWIRHPEKYMEEIVESTLSLLSVKHE 327
Cdd:pfam14961  241 EIYTSLAKHLESYFLSSKLSFPSLSAGLDINNPDVARLLKKIRLLNEFQKEVPSFWIRHPEKYMEEIVESTLSLLSLHHE 320
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   328 QS--HLVPQKILDPIYFFALVDTKAVWFKKWMHAYYSRTAVLRLLEKKYKCLITTAVQQCVQYLELCEAMKADEI----L 401
Cdd:pfam14961  321 QGlnSPGSDKVLDPIYFLALLDIKATWFKKWMHGYYSRTVVLRLLEKKYKSLIVAAVQQCIDYFESCEASVDKTTeishS 400
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   402 RHPKHCGTKQKSFYySGQELQYIYFIHSLCLLGRLLIYTQGRKLFPIKLKNRKDSVSLTNLLVLFTQLIYYSPSCPKMTS 481
Cdd:pfam14961  401 SHQQHIGNKQRTFY-TGKELQYIYFVHSLCLLGRLLIYTQGRKLFPIKLKNRKDPVSLTDLLVLLIRLIYYSPSLPKETP 479
                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   482 IMCSENYSPASMVTDVLRMLCDQKECAVECLYNSTVTEALLLPIHNLTKGTAAAPDCSETALIHIADILARIASVEEGLI 561
Cdd:pfam14961  480 HVGSDNYSPASLVMEVLQILCDRKECAAECLYQDTVIETLLQPIITLLNGKEAKLNCSETTLIHIADILARIASTERGLS 559
                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   562 LLLYGENMNSSEEESLTGAHIIAKFSKKLLEEDISIFSGSEMLPVVKGAFISVCRQIYGTCEGLQVLLPYGLHESIAKAW 641
Cdd:pfam14961  560 LLLYGGNLSSAEEESISAAHVIVQFTKKLLDKEIPVLSGSELLPSLKGAFIFVCRQMYNTCEGLQVLLPYGLHESIAEAW 639
                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   642 KKTSLLSERIPTPVEGSDSVSSVSQVSPNSVAWEDNLLDDLLNFAATPKGLLLLQRTGAINECVTFMLSQYAKKPQVNRQ 721
Cdd:pfam14961  640 KKASLLSERVPTPVPGADCSSSVSQESQNVVVWEETLLDNLLNFAATPKGLLLLQQTGAINECVTYMFSRFTKKLQVSRC 719
                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 755533149   722 KKFGYEVLVVQVASTAAGAVALQNSGFISALITELWSNLECGRDDVRLTHPRATPVDPIDRSCQKSFLALVNLL-SYPAV 800
Cdd:pfam14961  720 EKFGYGVMVTQVAATAPGAVALQSSGFVRALVLELWSVLECGRDDVRVTHPKSTPVDPIDRSCQKSFLALVNLLsSYPAV 799
                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 755533149   801 YELTANQELPNKAEYSLREVPTCIIDIMDRLIVLNSEAKIRSLLNYEQSHTFGLRSL 857
Cdd:pfam14961  800 YELLGNQELPNKTEYSLREMPTSIIDLIDRLIIINSEAKIHSLFNYEQSHTFGLRLL 856
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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