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Conserved domains on  [gi|578820852|ref|XP_006718406|]
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FHF complex subunit HOOK-interacting protein 1B isoform X1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
 97-426 5.59e-111

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


:

Pssm-ID: 370927  Cd Length: 357  Bit Score: 347.00  E-value: 5.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852   97 LEFALHEDLLTRVLTWQLQwdELGDGVeerRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLDACGRPVPssPALDEGL 176
Cdd:pfam10257   2 LEYLLQHKILETLCTLGKA--DYPPGM---KQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVG--SDVEKEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  177 VLLLSQLCVCVAQEPSLLEFFLQP----------------PPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMAL 240
Cdd:pfam10257  75 VQLLFGLCVKLRQDPSLLNFFFENksdqqraellvnpsveFAGATGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  241 SAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIE---VPGDDW---HCLRREDWLGVP---ALALFMSSLEFCNAVI 311
Cdd:pfam10257 155 ASRSPTLATYLIESSDLCPLLATGLGALYSLLPTSLPaptISSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  312 QVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLR-------TFLRFLLLHRHDTHTI 384
Cdd:pfam10257 235 QVAHSEVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQeflsfllGEEKSPETSDDDGHPL 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 578820852  385 LDTLVARIGSNS-RLCMVSLSLFRTLLNLSCEDVLLQLVLRYL 426
Cdd:pfam10257 315 RDTLIERCNHLSdELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
 752-845 2.72e-40

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


:

Pssm-ID: 466037  Cd Length: 94  Bit Score: 143.48  E-value: 2.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  752 TGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIENFAASQEDF 831
Cdd:pfam19314   1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80

                          90
                  ....*....|....
gi 578820852  832 PALLSKAKKYLIAR 845
Cdd:pfam19314  81 DALLRRARKRLLGR 94
KELAA pfam19311
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
 933-964 1.65e-08

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


:

Pssm-ID: 466035  Cd Length: 32  Bit Score: 50.96  E-value: 1.65e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820852  933 LRVKNAVYCAVIFPEFLKELAAISQAHAVTSP 964
Cdd:pfam19311   1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
KLF9_13_N-like super family cl41730
Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like ...
 449-559 7.56e-03

Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins; Kruppel/Krueppel-like transcription factors (KLFs) belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF9, KLF13, KLF14, KLF16, and similar proteins.


The actual alignment was detected with superfamily member cd21576:

Pssm-ID: 425361 [Multi-domain]  Cd Length: 195  Bit Score: 38.65  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852 449 AADKFLSLIPRCCRHHapSPPRPEHASWARGGPSRETGRREDITGPGSPSVDSS-SVTTVPRPSTP-----------SRL 516
Cdd:cd21576   11 AAECLVSMSAGAVLHR--RAPDPEGAGGAAGSEVGAAPPESALPGPGPPGPAWVpPLLQVPAPSPGaggaaphllaaSVL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578820852 517 ALFLRQQSLGGSESPGPAPCSPGLSASPASSPGrrPTPAEEPG 559
Cdd:cd21576   89 ADLRGGAGEGSREDSGEAPRASSGSSDPARGSS--PTLGSEPA 129
 
Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
 97-426 5.59e-111

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


Pssm-ID: 370927  Cd Length: 357  Bit Score: 347.00  E-value: 5.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852   97 LEFALHEDLLTRVLTWQLQwdELGDGVeerRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLDACGRPVPssPALDEGL 176
Cdd:pfam10257   2 LEYLLQHKILETLCTLGKA--DYPPGM---KQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVG--SDVEKEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  177 VLLLSQLCVCVAQEPSLLEFFLQP----------------PPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMAL 240
Cdd:pfam10257  75 VQLLFGLCVKLRQDPSLLNFFFENksdqqraellvnpsveFAGATGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  241 SAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIE---VPGDDW---HCLRREDWLGVP---ALALFMSSLEFCNAVI 311
Cdd:pfam10257 155 ASRSPTLATYLIESSDLCPLLATGLGALYSLLPTSLPaptISSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  312 QVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLR-------TFLRFLLLHRHDTHTI 384
Cdd:pfam10257 235 QVAHSEVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQeflsfllGEEKSPETSDDDGHPL 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 578820852  385 LDTLVARIGSNS-RLCMVSLSLFRTLLNLSCEDVLLQLVLRYL 426
Cdd:pfam10257 315 RDTLIERCNHLSdELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
 752-845 2.72e-40

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


Pssm-ID: 466037  Cd Length: 94  Bit Score: 143.48  E-value: 2.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  752 TGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIENFAASQEDF 831
Cdd:pfam19314   1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80

                          90
                  ....*....|....
gi 578820852  832 PALLSKAKKYLIAR 845
Cdd:pfam19314  81 DALLRRARKRLLGR 94
KELAA pfam19311
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
 933-964 1.65e-08

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


Pssm-ID: 466035  Cd Length: 32  Bit Score: 50.96  E-value: 1.65e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820852  933 LRVKNAVYCAVIFPEFLKELAAISQAHAVTSP 964
Cdd:pfam19311   1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 449-559 7.56e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 38.65  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852 449 AADKFLSLIPRCCRHHapSPPRPEHASWARGGPSRETGRREDITGPGSPSVDSS-SVTTVPRPSTP-----------SRL 516
Cdd:cd21576   11 AAECLVSMSAGAVLHR--RAPDPEGAGGAAGSEVGAAPPESALPGPGPPGPAWVpPLLQVPAPSPGaggaaphllaaSVL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578820852 517 ALFLRQQSLGGSESPGPAPCSPGLSASPASSPGrrPTPAEEPG 559
Cdd:cd21576   89 ADLRGGAGEGSREDSGEAPRASSGSSDPARGSS--PTLGSEPA 129
 
Name Accession Description Interval E-value
RAI16-like pfam10257
Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a ...
 97-426 5.59e-111

Retinoic acid induced 16-like protein; This is the conserved N-terminal 450 residues of a family of proteins described as retinoic acid-induced protein 16-like proteins. The exact function is not known. The proteins are found from worms to humans.


Pssm-ID: 370927  Cd Length: 357  Bit Score: 347.00  E-value: 5.59e-111
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852   97 LEFALHEDLLTRVLTWQLQwdELGDGVeerRAEQLKLFEMLVSEARQPLLRHGPVREALLTLLDACGRPVPssPALDEGL 176
Cdd:pfam10257   2 LEYLLQHKILETLCTLGKA--DYPPGM---KQEVLKFYNKLLSHERQPLLHHINVHRPLQKLLRSCGEPVG--SDVEKEL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  177 VLLLSQLCVCVAQEPSLLEFFLQP----------------PPEPGAAPRLLLFSRLVPFVHREGTLGQQARDALLLLMAL 240
Cdd:pfam10257  75 VQLLFGLCVKLRQDPSLLNFFFENksdqqraellvnpsveFAGATGKEDFNLFSLLLPLVHREGRLGVFAREGLLLLMSL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  241 SAGSPTVGRYIADHSYFCPVLATGLSALYSSLPRKIE---VPGDDW---HCLRREDWLGVP---ALALFMSSLEFCNAVI 311
Cdd:pfam10257 155 ASRSPTLATYLIESSDLCPLLATGLGALYSLLPTSLPaptISSIDWrldHSIAPEDLATFPgkrALDSFLSWLDFCNDLI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  312 QVAHPLVQKQLVDYIHNGFLVPVMGPALHKTSVEEMIASTAYLELFLRSISEPALLR-------TFLRFLLLHRHDTHTI 384
Cdd:pfam10257 235 QVAHSEVADALLDAIYEGFLVPVLYPSLLQTSEGSILAVTAYLDRILRSITSPALLQeflsfllGEEKSPETSDDDGHPL 314

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 578820852  385 LDTLVARIGSNS-RLCMVSLSLFRTLLNLSCEDVLLQLVLRYL 426
Cdd:pfam10257 315 RDTLIERCNHLSdELSIVTLRLFETLLQLPCEDILLDLVLRNL 357
DUF5917 pfam19314
Family of unknown function (DUF5917); This short presumed domain is found close to the ...
 752-845 2.72e-40

Family of unknown function (DUF5917); This short presumed domain is found close to the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins.


Pssm-ID: 466037  Cd Length: 94  Bit Score: 143.48  E-value: 2.72e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852  752 TGPFMAVLFAKLENMLQNSVYVNFLLTGLVAQLACHPQPLLRSFLLNTNMVFQPSVKSLLQVLGSVKNKIENFAASQEDF 831
Cdd:pfam19314   1 EGPFLRMLFNKLENLLSQSYEVNLQLTGVISRLASYPQPLLHSYLLNPSLPLQPSVRSLYTVLSSLKEEIEERAASIPDF 80

                          90
                  ....*....|....
gi 578820852  832 PALLSKAKKYLIAR 845
Cdd:pfam19314  81 DALLRRARKRLLGR 94
KELAA pfam19311
KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins ...
 933-964 1.65e-08

KELAA motif; This short motif is found at the C-terminus of FHIP proteins, FAM160B proteins and UPF0518 family proteins. It has a conserved KELAA sequence for which it is named.


Pssm-ID: 466035  Cd Length: 32  Bit Score: 50.96  E-value: 1.65e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 578820852  933 LRVKNAVYCAVIFPEFLKELAAISQAHAVTSP 964
Cdd:pfam19311   1 ERHKNLLEAAIVLEEFCKELAAIAFVKSHHSV 32
KLF14_N cd21576
N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as ...
 449-559 7.56e-03

N-terminal domain of Kruppel-like factor 14; Kruppel-like factor 14 (KLF14; also known as Krueppel-like factor 14 or basic transcription element-binding protein 5/BTEB5) is a protein that in humans is encoded by the KLF14 gene. KLF14 regulates the transcription of various genes, including TGFbetaRII (the type II receptor for TGFbeta). KLF14 is expressed in many tissues, lacks introns, and is subject to parent-specific expression. It also appears to be a master regulator of gene expression in adipose tissue. KLF14 is associated with coronary artery disease, hypercholesterolemia, and type 2 diabetes. KLF9, KLF10, KLF11, KLF13, KLF14, and KLF16 share a conserved alpha-helical motif AA/VXXL that mediates their binding to Sin3A and their activities as transcriptional repressors. KLF14 belongs to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the N-terminal domain of KLF14.


Pssm-ID: 409238 [Multi-domain]  Cd Length: 195  Bit Score: 38.65  E-value: 7.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578820852 449 AADKFLSLIPRCCRHHapSPPRPEHASWARGGPSRETGRREDITGPGSPSVDSS-SVTTVPRPSTP-----------SRL 516
Cdd:cd21576   11 AAECLVSMSAGAVLHR--RAPDPEGAGGAAGSEVGAAPPESALPGPGPPGPAWVpPLLQVPAPSPGaggaaphllaaSVL 88

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578820852 517 ALFLRQQSLGGSESPGPAPCSPGLSASPASSPGrrPTPAEEPG 559
Cdd:cd21576   89 ADLRGGAGEGSREDSGEAPRASSGSSDPARGSS--PTLGSEPA 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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