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Conserved domains on  [gi|578809454|ref|XP_006714402|]
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tetratricopeptide repeat protein 29 isoform X7 [Homo sapiens]

Protein Classification

lipopolysaccharide assembly protein LapB( domain architecture ID 11459274)

lipopolysaccharide assembly protein LapB is a tetratricopeptide repeat (TPR) protein that modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 109-348 3.87e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 109 ELFALMERWDalrEAARVrslfwLQKPLEEQPDKLDYLYHyltRAEDAERKGQLLEAAEHYEAFHQLtqgriwkdetgRS 188
Cdd:COG2956   50 NLYRRRGEYD---RAIRI-----HQKLLERDPDRAEALLE---LAQDYLKAGLLDRAEELLEKLLEL-----------DP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 189 LNLLACESLLRTYrllsdkmLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckis 268
Cdd:COG2956  108 DDAEALRLLAEIY-------EQEGDWEKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEKA---- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 269 tdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrastMLGDIYNEKGYYNKASECFQQAFDTT 348
Cdd:COG2956  171 --LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP------RLAELYEKLGDPEEALELLRKALELD 242
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 109-348 3.87e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 109 ELFALMERWDalrEAARVrslfwLQKPLEEQPDKLDYLYHyltRAEDAERKGQLLEAAEHYEAFHQLtqgriwkdetgRS 188
Cdd:COG2956   50 NLYRRRGEYD---RAIRI-----HQKLLERDPDRAEALLE---LAQDYLKAGLLDRAEELLEKLLEL-----------DP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 189 LNLLACESLLRTYrllsdkmLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckis 268
Cdd:COG2956  108 DDAEALRLLAEIY-------EQEGDWEKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEKA---- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 269 tdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrastMLGDIYNEKGYYNKASECFQQAFDTT 348
Cdd:COG2956  171 --LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP------RLAELYEKLGDPEEALELLRKALELD 242
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 162-358 1.00e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 47.50  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 162 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 241
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 242 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 321
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578809454 322 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 358
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 174-344 4.03e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  174 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 251
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  252 EEYETALTVLDTyckiSTDLDDDlsLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEK 331
Cdd:TIGR02917 411 GDPSEAIADLET----AAQLDPE--LGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLGK 478

                         170
                  ....*....|...
gi 578809454  332 GYYNKASECFQQA 344
Cdd:TIGR02917 479 GDLAKAREAFEKA 491
TPR_12 pfam13424
Tetratricopeptide repeat;
281-346 5.01e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 5.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809454  281 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 346
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
 
Name Accession Description Interval E-value
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 109-348 3.87e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 63.21  E-value: 3.87e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 109 ELFALMERWDalrEAARVrslfwLQKPLEEQPDKLDYLYHyltRAEDAERKGQLLEAAEHYEAFHQLtqgriwkdetgRS 188
Cdd:COG2956   50 NLYRRRGEYD---RAIRI-----HQKLLERDPDRAEALLE---LAQDYLKAGLLDRAEELLEKLLEL-----------DP 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 189 LNLLACESLLRTYrllsdkmLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckis 268
Cdd:COG2956  108 DDAEALRLLAEIY-------EQEGDWEKAIEVLERLLKLGPE------NAHAYCELAELYLEQGDYDEAIEALEKA---- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 269 tdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrastMLGDIYNEKGYYNKASECFQQAFDTT 348
Cdd:COG2956  171 --LKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP------RLAELYEKLGDPEEALELLRKALELD 242
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 132-346 4.42e-10

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.13  E-value: 4.42e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 132 LQKPLEEQPDKLDYlyhYLTRAEDAERKGQLLEAAEHYEAFHQLTQGRiwkdetgrslnllaceslLRTYRLLSDKMLEN 211
Cdd:COG2956   31 LEEALELDPETVEA---HLALGNLYRRRGEYDRAIRIHQKLLERDPDR------------------AEALLELAQDYLKA 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 212 KEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQ 291
Cdd:COG2956   90 GLLDRAEELLEKLLELDPD------DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAH------AYCELAELYLEQ 157

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 578809454 292 GEMTEAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 346
Cdd:COG2956  158 GDYDEAIEALEKALKLDPDC------ARALLLLAELYLEQGDYEEAIAALERALE 206
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 137-346 4.99e-10

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 61.55  E-value: 4.99e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 137 EEQPDKLDYLYHYLTRAEDAERKGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRT-YRLLSDKMLENKEYK 215
Cdd:COG3914   16 ALLAAAAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAAlLELAALLLQALGRYE 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 216 QAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLdddlslGRGYEAIAKVLQSQGEMT 295
Cdd:COG3914   96 EALALYRRALALNPD------NAEALFNLGNLLLALGRLEEALAALRRALALNPDF------AEAYLNLGEALRRLGRLE 163

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 578809454 296 EAIKYLKKFVKIARNNfqsldlVRASTMLGDIYNEKGYYNKASECFQQAFD 346
Cdd:COG3914  164 EAIAALRRALELDPDN------AEALNNLGNALQDLGRLEEAIAAYRRALE 208
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 209-344 2.01e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.12  E-value: 2.01e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 209 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVL 288
Cdd:COG2956   19 LLNGQPDKAIDLLEEALELDPE------TVEAHLALGNLYRRRGEYDRAIRIHQKL------LERDPDRAEALLELAQDY 86

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809454 289 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 344
Cdd:COG2956   87 LKAGLLDRAEELLEKLLELDPDDAEAL------RLLAEIYEQEGDWEKAIEVLERL 136
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 132-344 2.09e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 2.09e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 132 LQKPLEEQPDKLDYLYHyltRAEDAERKGQLLEAAEHYEAFHQLTQGRIwkdetgrslnllacesllRTYRLLSDKMLEN 211
Cdd:COG2956   99 LEKLLELDPDDAEALRL---LAEIYEQEGDWEKAIEVLERLLKLGPENA------------------HAYCELAELYLEQ 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 212 KEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQ 291
Cdd:COG2956  158 GDYDEAIEALEKALKLDPD------CARALLLLAELYLEQGDYEEAIAALERA------LEQDPDYLPALPRLAELYEKL 225

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 578809454 292 GEMTEAIKYLKKFVKIARNNFQSLdlvrastMLGDIYNEKGYYNKASECFQQA 344
Cdd:COG2956  226 GDPEEALELLRKALELDPSDDLLL-------ALADLLERKEGLEAALALLERQ 271
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
136-344 2.32e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.55  E-value: 2.32e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 136 LEEQPDKLDYLYHyltRAEDAERKGQLLEAAEHYEAFHQLtqgriwKDETGRSLNLLAcesllRTYRLLsdkmlenKEYK 215
Cdd:COG0457    1 LELDPDDAEAYNN---LGLAYRRLGRYEEAIEDYEKALEL------DPDDAEALYNLG-----LAYLRL-------GRYE 59

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 216 QAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTyckiSTDLDDDLSlgRGYEAIAKVLQSQGEMT 295
Cdd:COG0457   60 EALADYEQALELDPD------DAEALNNLGLALQALGRYEEALEDYDK----ALELDPDDA--EALYNLGLALLELGRYD 127

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 578809454 296 EAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 344
Cdd:COG0457  128 EAIEAYERALELDPDDADAL------YNLGIALEKLGRYEEALELLEKL 170
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 238-346 3.25e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.34  E-value: 3.25e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 238 AEASYYLGLAHLAAEEYETALTVLDTYckistdLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldl 317
Cdd:COG4783    4 AEALYALAQALLLAGDYDEAEALLEKA------LELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPE---- 73

                         90       100
                 ....*....|....*....|....*....
gi 578809454 318 vrASTMLGDIYNEKGYYNKASECFQQAFD 346
Cdd:COG4783   74 --ARLNLGLALLKAGDYDEALALLEKALK 100
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 162-358 1.00e-05

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 47.50  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 162 LLEAAEhyEAFHQLTQGRIWKDEtgrslnllACESLLRTYRllsdkmlENKEYKQAIKIlikASEIAKEGsDKKMEAEas 241
Cdd:PRK11788 122 LLDRAE--ELFLQLVDEGDFAEG--------ALQQLLEIYQ-------QEKDWQKAIDV---AERLEKLG-GDSLRVE-- 178

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 242 yylgLAHLaaeeyetaltvldtYCKISTdldddlslgrgyEAIAkvlqsQGEMTEAIKYLKKFVKIARNNfqsldlVRAS 321
Cdd:PRK11788 179 ----IAHF--------------YCELAQ------------QALA-----RGDLDAARALLKKALAADPQC------VRAS 217

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 578809454 322 TMLGDIYNEKGYYNKASECFQQAFDTTVELMSM---PLMD 358
Cdd:PRK11788 218 ILLGDLALAQGDYAAAIEALERVEEQDPEYLSEvlpKLME 257
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 242-347 1.62e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.26  E-value: 1.62e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 242 YYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQsldlvrAS 321
Cdd:COG2956   12 YFKGLNYLLNGQPDKAIDLLEEALELDPETVE------AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAE------AL 79

                         90       100
                 ....*....|....*....|....*.
gi 578809454 322 TMLGDIYNEKGYYNKASECFQQAFDT 347
Cdd:COG2956   80 LELAQDYLKAGLLDRAEELLEKLLEL 105
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 209-344 2.41e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 44.03  E-value: 2.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 209 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKIStdlDDDLSLgrgYEAIAKVL 288
Cdd:COG4783   15 LLAGDYDEAEALLEKALELDPD------NPEAFALLGEILLQLGDLDEAIVLLHEALELD---PDEPEA---RLNLGLAL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809454 289 QSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEKGYYNKASECFQQA 344
Cdd:COG4783   83 LKAGDYDEALALLEKALKLDPEHPEAYLR------LARAYRALGRPDEAIAALEKA 132
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 174-344 4.03e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 46.23  E-value: 4.03e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  174 QLTQGRIWKDET--GRSLNLLACESLLRTyrLLSDKMLENKEYKQAIKILIKASEIAKEGSDKKMEaeasyyLGLAHLAA 251
Cdd:TIGR02917 339 QLRLGRVDEAIAtlSPALGLDPDDPAALS--LLGEAYLALGDFEKAAEYLAKATELDPENAAARTQ------LGISKLSQ 410

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  252 EEYETALTVLDTyckiSTDLDDDlsLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDLvrastmLGDIYNEK 331
Cdd:TIGR02917 411 GDPSEAIADLET----AAQLDPE--LGRADLLLILSYLRSGQFDKALAAAKKLEKKQPDNASLHNL------LGAIYLGK 478

                         170
                  ....*....|...
gi 578809454  332 GYYNKASECFQQA 344
Cdd:TIGR02917 479 GDLAKAREAFEKA 491
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 201-311 5.40e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 42.87  E-value: 5.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 201 YRLLSDKMLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDdlslgrG 280
Cdd:COG4783   41 FALLGEILLQLGDLDEAIVLLHEALELDPD------EPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPE------A 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 578809454 281 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNN 311
Cdd:COG4783  109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
COG3899 COG3899
Predicted ATPase [General function prediction only];
150-350 1.85e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 44.08  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  150 LTRAEDAERKGQLLEAAEHYEAFHQltqgriwKDETGRsLNLLACEsllrtyrllsdKMLENKEYKQAIKILIKASEIAK 229
Cdd:COG3899   676 LEARGPEPLEERLFELAHHLNRAGE-------RDRAAR-LLLRAAR-----------RALARGAYAEALRYLERALELLP 736

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  230 EGSDKKME-------AEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLqsQGEMTEAIKYLK 302
Cdd:COG3899   737 PDPEEEYRlalllelAEALYLAGRFEEAEALLERALAARALAALAALRHGNPPASARAYANLGLLL--LGDYEEAYEFGE 814

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 578809454  303 KFVKIARNNFQSLDLVRASTMLGDIYNEKGYYNKASECFQQAFDTTVE 350
Cdd:COG3899   815 LALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREALEAGLE 862
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 238-347 2.98e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 40.76  E-value: 2.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 238 AEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSlgrgyeAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDL 317
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALL------DLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                         90       100       110
                 ....*....|....*....|....*....|
gi 578809454 318 vrastmLGDIYNEKGYYNKASECFQQAFDT 347
Cdd:COG4235   91 ------LGLAAFQQGDYAEAIAAWQKLLAL 114
COG3899 COG3899
Predicted ATPase [General function prediction only];
146-320 3.03e-04

Predicted ATPase [General function prediction only];


Pssm-ID: 443106 [Multi-domain]  Cd Length: 1244  Bit Score: 43.31  E-value: 3.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  146 LYHYLTRA-EDAERKGQLLEAAEHYEAFHQLTQGRIWKDETGRsLNLLACESLLRTYRLlsDKMLENkeYKQAIKILIKA 224
Cdd:COG3899   704 AARLLLRAaRRALARGAYAEALRYLERALELLPPDPEEEYRLA-LLLELAEALYLAGRF--EEAEAL--LERALAARALA 778

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  225 SEIAKEGSDKKMEAEAsyYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKF 304
Cdd:COG3899   779 ALAALRHGNPPASARA--YANLGLLLLGDYEEAYEFGELALALAERLGDRRLEARALFNLGFILHWLGPLREALELLREA 856

                         170
                  ....*....|....*.
gi 578809454  305 VKIARNNFQSLDLVRA 320
Cdd:COG3899   857 LEAGLETGDAALALLA 872
TPR_12 pfam13424
Tetratricopeptide repeat;
281-346 5.01e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.52  E-value: 5.01e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809454  281 YEAIAKVLQSQGEMTEAIKYLKKFVKIARNNF--QSLDLVRASTMLGDIYNEKGYYNKASECFQQAFD 346
Cdd:pfam13424   6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpDHPLTATTLLNLGRLYLELGRYEEALELLERALA 73
TPR_12 pfam13424
Tetratricopeptide repeat;
196-261 8.19e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 8.19e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 578809454  196 SLLRTYRLLSDKMLENKEYKQAIKILIKASEIAKE--GSDKKMEAEASYYLGLAHLAAEEYETALTVL 261
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALEIARRllGPDHPLTATTLLNLGRLYLELGRYEEALELL 68
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 142-308 2.53e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 38.40  E-value: 2.53e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 142 KLDYLYHYLTRAEDAERKGQLLEAAEHYEAFHQLTQGRIWKDETGRSLNLLACESLLRTYRLLsdkMLENKEYKQAIKIL 221
Cdd:COG5010    1 ARALEGFDRLPLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNL---YNKLGDFEESLALL 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 222 IKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDddlslgRGYEAIAKVLQSQGEMTEAIKYL 301
Cdd:COG5010   78 EQALQLDPN------NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNP------NAYSNLAALLLSLGQDDEAKAAL 145


                 ....*..
gi 578809454 302 KKFVKIA 308
Cdd:COG5010  146 QRALGTS 152
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 246-343 4.28e-03

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 36.89  E-value: 4.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 246 LAHLAAEEYETALTVLDtycKISTDLDDDLSLGRGYEAIAKVLQSQGEMTEAIKYLKKFVKIARNNFQSLDlvrASTMLG 325
Cdd:COG1729    1 KALLKAGDYDEAIAAFK---AFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPD---ALLKLG 74

                         90
                 ....*....|....*...
gi 578809454 326 DIYNEKGYYNKASECFQQ 343
Cdd:COG1729   75 LSYLELGDYDKARATLEE 92
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
209-313 4.43e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 36.30  E-value: 4.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 209 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALtvldtycKISTDLDDDLSLGRGYEAIAKVL 288
Cdd:COG3063    3 LKLGDLEEAEEYYEKALELDPD------NADALNNLGLLLLEQGRYDEAI-------ALEKALKLDPNNAEALLNLAELL 69

                         90       100
                 ....*....|....*....|....*
gi 578809454 289 QSQGEMTEAIKYLKKFVKIARNNFQ 313
Cdd:COG3063   70 LELGDYDEALAYLERALELDPSALR 94
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 198-320 5.35e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 36.91  E-value: 5.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454 198 LRTYRLLSDKMLENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTyckiSTDLDDDLSL 277
Cdd:COG4235   17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLDPD------NADALLDLAEALLAAGDTEEAEELLER----ALALDPDNPE 86

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 578809454 278 GRGYEAIAkvLQSQGEMTEAIKYLKKFVKIARNNFQSLDLVRA 320
Cdd:COG4235   87 ALYLLGLA--AFQQGDYAEAIAAWQKLLALLPADAPARLLEAS 127
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 209-344 6.49e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 6.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578809454  209 LENKEYKQAIKILIKASEIAKEgsdkkmEAEASYYLGLAHLAAEEYETALTVLDTYCKISTDLDDDLSLgrgyeaIAKVL 288
Cdd:TIGR02917 272 FQKKNYEDARETLQDALKSAPE------YLPALLLAGASEYQLGNLEQAYQYLNQILKYAPNSHQARRL------LASIQ 339

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 578809454  289 QSQGEMTEAIKYLKKFVKIARNNFQSLdlvrasTMLGDIYNEKGYYNKASECFQQA 344
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAAL------SLLGEAYLALGDFEKAAEYLAKA 389
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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