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Conserved domains on  [gi|578801079|ref|XP_006711439|]
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SUN domain-containing ossification factor isoform X3 [Homo sapiens]

Protein Classification

Sad1_UNC and OmpH domain-containing protein( domain architecture ID 12082773)

Sad1_UNC and OmpH domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 286-408 3.91e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


:

Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.69  E-value: 3.91e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   286 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 359
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578801079   360 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 408
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 892-947 5.06e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


:

Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 5.06e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801079   892 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 947
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC super family cl34566
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
833-969 1.70e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


The actual alignment was detected with superfamily member COG3206:

Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079  833 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 909
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801079  910 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 969
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 286-408 3.91e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.69  E-value: 3.91e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   286 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 359
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578801079   360 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 408
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 892-947 5.06e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 5.06e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801079   892 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 947
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
833-969 1.70e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079  833 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 909
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801079  910 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 969
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 796-970 3.16e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.63  E-value: 3.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   796 EAKMNIADTAKQTLISVVDSSslpevkEEEQSPEDalLRGLQRTATDFYAELQNST-----DLGYANGNLVHGSNQKESV 870
Cdd:pfam05483  230 EYKKEINDKEKQVSLLLIQIT------EKENKMKD--LTFLLEESRDKANQLEEKTklqdeNLKELIEKKDHLTKELEDI 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   871 FMRLNNRI---KALEVNMSLSGRYLEELSQRYRKQMEEMQKA----------FNKTIVKLQNTSRIAEEQDQRQTEAIQL 937
Cdd:pfam05483  302 KMSLQRSMstqKALEEDLQIATKTICQLTEEKEAQMEELNKAkaahsfvvteFEATTCSLEELLRTEQQRLEKNEDQLKI 381

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 578801079   938 L-------QAQLTNMTQLVSNLSATVAELKREVSDRQSYL 970
Cdd:pfam05483  382 ItmelqkkSSELEEMTKFKNNKEVELEELKKILAEDEKLL 421
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 888-970 4.19e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079  888 SGRYLEELSQRYRKQMEEMQKafnkTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQ 967
Cdd:COG4942   137 RLQYLKYLAPARREQAEELRA----DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA 212


                  ...
gi 578801079  968 SYL 970
Cdd:COG4942   213 AEL 215
 
Name Accession Description Interval E-value
Sad1_UNC pfam07738
Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that ...
 286-408 3.91e-46

Sad1 / UNC-like C-terminal; The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localizes at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2. The SUN domain of Sun2 has been demonstrated to be in the periplasm.


Pssm-ID: 400199  Cd Length: 130  Bit Score: 161.69  E-value: 3.91e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   286 NPEAKSTSAILIENmdlYMLNPC----STKIWFVIELCEPIQVKQLDIANYE--LFSSTPKDFLVSISDRYPTNKWIKLG 359
Cdd:pfam07738    2 NYEAKPPKVILQPD---YMPGPCwsfkGSRGFVVIELSEFIIVEAITLEHVEksVFSSAPKDFEVSGSDRYPTTKWVLLG 78

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 578801079   360 TFH-GRDERNVQSFPLDEQMY--AKYVKVELLSHFGSEHFCPLSLIRVFGTS 408
Cdd:pfam07738   79 EFSyDLDGKTIQTFQLENPPDiwVKYVKLRILSNYGNEHYTCLYRFRVHGTV 130
OmpH pfam03938
Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH ...
 892-947 5.06e-04

Outer membrane protein (OmpH-like); This family includes outer membrane proteins such as OmpH among others. Skp (OmpH) has been characterized as a molecular chaperone that interacts with unfolded proteins as they emerge in the periplasm from the Sec translocation machinery.


Pssm-ID: 461098 [Multi-domain]  Cd Length: 140  Bit Score: 41.41  E-value: 5.06e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 578801079   892 LEELSQRYRKQMEEMQKAFNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQ 947
Cdd:pfam03938   24 LEKKFKKRQAELEAKQKELQKLYEELQKDGALLEEEREEKEQELQKKEQELQQLQQ 79
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
833-969 1.70e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 42.70  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079  833 LRGLQRTATDFYAELQNSTDLGYANGNLVHGSnqkeSVFMRLNNRIKALEVNMS-LSGRYLEELS--QRYRKQMEEMQKA 909
Cdd:COG3206   231 ARAELAEAEARLAALRAQLGSGPDALPELLQS----PVIQQLRAQLAELEAELAeLSARYTPNHPdvIALRAQIAALRAQ 306

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 578801079  910 FNKTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREV-SDRQSY 969
Cdd:COG3206   307 LQQEAQRILASLEAELEALQAREASLQAQLAQLEARLAELPELEAELRRLEREVeVARELY 367
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 796-970 3.16e-03

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 41.63  E-value: 3.16e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   796 EAKMNIADTAKQTLISVVDSSslpevkEEEQSPEDalLRGLQRTATDFYAELQNST-----DLGYANGNLVHGSNQKESV 870
Cdd:pfam05483  230 EYKKEINDKEKQVSLLLIQIT------EKENKMKD--LTFLLEESRDKANQLEEKTklqdeNLKELIEKKDHLTKELEDI 301

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   871 FMRLNNRI---KALEVNMSLSGRYLEELSQRYRKQMEEMQKA----------FNKTIVKLQNTSRIAEEQDQRQTEAIQL 937
Cdd:pfam05483  302 KMSLQRSMstqKALEEDLQIATKTICQLTEEKEAQMEELNKAkaahsfvvteFEATTCSLEELLRTEQQRLEKNEDQLKI 381

                          170       180       190       200
                   ....*....|....*....|....*....|....*....|
gi 578801079   938 L-------QAQLTNMTQLVSNLSATVAELKREVSDRQSYL 970
Cdd:pfam05483  382 ItmelqkkSSELEEMTKFKNNKEVELEELKKILAEDEKLL 421
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 888-970 4.19e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.90  E-value: 4.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079  888 SGRYLEELSQRYRKQMEEMQKafnkTIVKLQNTSRIAEEQDQRQTEAIQLLQAQLTNMTQLVSNLSATVAELKREVSDRQ 967
Cdd:COG4942   137 RLQYLKYLAPARREQAEELRA----DLAELAALRAELEAERAELEALLAELEEERAALEALKAERQKLLARLEKELAELA 212


                  ...
gi 578801079  968 SYL 970
Cdd:COG4942   213 AEL 215
MbeD_MobD pfam04899
MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the ...
 892-961 4.21e-03

MbeD/MobD like; The MbeD and MobD proteins are plasmid encoded, and are involved in the plasmids mobilization and transfer in the presence of conjugative plasmids.


Pssm-ID: 113664  Cd Length: 70  Bit Score: 37.15  E-value: 4.21e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 578801079   892 LEELSQRYRKQMEEMQKAFnktiVKLQNTSriaeEQDQRQTEAiqlLQAQLTNMTQLVSNLSATVAELKR 961
Cdd:pfam04899   12 LEQLQQDYEQRLQEWESAF----AELQRMF----GLTQRENAA---LSEQVTGLSQQVQSLSEQVRRLSR 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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