|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
47-471 |
0e+00 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 741.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 47 AIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANR 126
Cdd:cd17382 1 AIMAGLGFCISFGIRCNLGVAIVRMVNNFTDAYGGKVIVHKAEFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 127 VFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLA 206
Cdd:cd17382 81 VFGLAIFVTSTLNMLIPIAARVHYGCVIFVRILQGLVEGVTYPACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 207 GILVQYTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVY 286
Cdd:cd17382 161 GILVQYVGWSSPFYVYGVFGIIWYMFWMLVS---------------------------------------------MPVY 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 287 AIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGF 366
Cdd:cd17382 196 AIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILSALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGGF 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 367 GMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSR 446
Cdd:cd17382 276 GMEATFLLVVAFSHSPTVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGIGTLSGMVCPVIVGALTKHKTR 355
|
410 420
....*....|....*....|....*
gi 568947277 447 EEWQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17382 356 EEWQYVFLIASLVHFFGVIFYAIFA 380
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
47-471 |
4.17e-180 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 512.55 E-value: 4.17e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 47 AIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGK-------VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIA 119
Cdd:cd17318 1 AILLFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNtstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 120 SRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGA 199
Cdd:cd17318 81 EKYGAKRVLGYSILITALLTLLTPLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 200 VIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgamekfktpwrkF 279
Cdd:cd17318 161 VIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLW---------------------------------------------F 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 280 FTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVRK 359
Cdd:cd17318 196 FLVLPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRGILSTTTVRK 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 360 IMNCGGFGMEATLLLVVGY-SHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVG 438
Cdd:cd17318 276 LFTSIGFLGPGVFLIALGYlGSNATLAVVFLTLSVGLSGACYSGFLVNHLDLAPNYAGTLMGITNTAATIAGIISPLIVG 355
|
410 420 430
....*....|....*....|....*....|....
gi 568947277 439 AMTKNK-SREEWQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17318 356 AIVKNDqTIGQWRIVFFISAAIYILGAIFYLIFG 389
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
46-471 |
8.37e-129 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 382.21 E-value: 8.37e-129
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 46 IAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVI---------------KEKAKFNWDPETVGMIHGSFFWGYII 110
Cdd:cd17381 1 LALLAFFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSSnacpehssspsvehnETGKKYDWDAETQGWILGSFFYGYII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 111 TQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATT 190
Cdd:cd17381 81 TQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYLIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 191 SFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWllvsyespakhptitdeerryieesigesanllgame 270
Cdd:cd17381 161 SYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLW------------------------------------- 203
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 271 kfktpwrkFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQ 350
Cdd:cd17381 204 --------IWLVMPLWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLREKQ 275
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 351 ILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGV-AISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLS 429
Cdd:cd17381 276 NFSTVCVRKIFTLIGMIGPAVFLLAAGFTGCNYSlAVAFLTISSTLGGFSASGFNINHLDIAPSYAGILLGITNTFATIP 355
|
410 420 430 440
....*....|....*....|....*....|....*....|..
gi 568947277 430 GMVCPIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17381 356 GMVGPVIAKSLTHNNTVEEWQTVFYISAAINVFGAIFFTIFG 397
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
52-471 |
6.95e-101 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 309.10 E-value: 6.95e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 52 LGFCISFGIRCNLGVAIVDMVNnstihrggkvikekaKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAA 131
Cdd:cd17380 6 LATCICYADRVNMPIAIVPMAK---------------EFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLA 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 132 ILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ 211
Cdd:cd17380 71 VALWSLATLLTPLLAYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLE 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 212 YTGWSSVFYVYGSFGMVWYMFWLLVSyespakhptitdeerryieesigesanllgamekfktpwrkfftsMPVYAIIVA 291
Cdd:cd17380 151 YYGWPSVFYFFGLLGLLWALVWLIYL---------------------------------------------PPVWAIIVA 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 292 NFCRSWTFYLLLISQPAYFEEVFGfEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQIlSTTTVRKIMNCGGFGMEAT 371
Cdd:cd17380 186 HFCMNWGFYILLSWLPTYFHEVLV-PLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGW-TVTSVRKLMQSIGFLGPAL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 372 LLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA-MTKNKSreeWQ 450
Cdd:cd17380 264 FLLLLSHTDSFSLALLCMSVALGLSAFSSSGVLVNHQDIAPNYAGIVFGISNTAGTIPGIVGVYLTGYiLEATGS---WS 340
|
410 420
....*....|....*....|.
gi 568947277 451 YVFLIAALVHYGGVIFYALFA 471
Cdd:cd17380 341 LVFVLAAVVNLVGAVVFLLFG 361
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
43-484 |
8.96e-97 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 302.05 E-value: 8.96e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 43 RYIIAIMSGLGFCISFGIRCNLGVAIVDMVNNSTIHRGGKVIKEK-------AKFNWDPETVGMIHGSFFWGYIITQIPG 115
Cdd:TIGR00894 17 RLFLSFLLHICNVIIIAQRICLSLTMVAMVNKENSTDLACLSAENeldniknPNFKWSGALQGLILSSHFYGQIIIQIPV 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 116 GYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGS 195
Cdd:TIGR00894 97 GYLAGKYVFKWSIGIGMFLSSVISIVIPWAAGGGIALVVFCRVIQGLAQGSVSPATHKIIVKWAPPKERSRLLGMSTSGF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 196 YAGAVIAMPLAGILVQYT-GWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEERRYIEESIGESanllGAMEKFKT 274
Cdd:TIGR00894 177 QLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPADDPSIHPCISKFEKKYINSSLQGQ----KGSTRQSL 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 275 PWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILST 354
Cdd:TIGR00894 253 PIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPYLFAWLCSIFAGYLADFLKSSKTLSL 332
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 355 TTVRKIMN-CGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVC 433
Cdd:TIGR00894 333 TAARKIFNgIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSSGPLAGVLINSLDLAPRFLGFIKGITGLPGFIGGLIA 412
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|.
gi 568947277 434 PIIVGAMTKNKSREEWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEET 484
Cdd:TIGR00894 413 STLAGNILSQDSKNVWLIVFLIMAFVNILCVIFYLIFGSAERQDWAKEEKD 463
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
41-471 |
2.99e-48 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 171.59 E-value: 2.99e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 41 PRRYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIAS 120
Cdd:COG2271 6 RYRWRILALLFLAYFLNYLDRSNLSVAAPPL---------------QADLGLSAAQLGLLASAFFLGYALGQIPAGLLAD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 121 RLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAV 200
Cdd:COG2271 71 RFGRRRVLAIGLLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGA 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 201 IAMPLAGILVQYTGWSSVFYVYGSFGMVW--YMFWLLvsyespakhptitdeerryieesigesanllgamekfktpwrk 278
Cdd:COG2271 149 LAPPLLGWLLAAFGWRAAFLILGLPGLLLalLRFWLL------------------------------------------- 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 279 fftsmpvyaiIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKqilstttvR 358
Cdd:COG2271 186 ----------ALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR--------R 247
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 359 KIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSGMVCPIIV 437
Cdd:COG2271 248 KLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPkKARGTASGLVNTFGFLGGALGPLLV 327
|
410 420 430
....*....|....*....|....*....|....
gi 568947277 438 GAMTKNKSreeWQYVFLIAALVHYGGVIFYALFA 471
Cdd:COG2271 328 GYLLDATG---YQAAFLLLAALALLAALLALLLL 358
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
43-466 |
5.40e-47 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 167.75 E-value: 5.40e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 43 RYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRL 122
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTI---------------MKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRF 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 123 AANRVFGAAILLTSTLNMLIpSAARVHYGcVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIA 202
Cdd:cd17319 66 GARKVLAVSMLLWSLFTALT-GFATSLTS-LYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIG 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 203 MPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYEspakhptitdeerryieesigesanllgamekfktpwrkffts 282
Cdd:cd17319 144 PPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQ------------------------------------------- 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 283 mpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQilstttvRKIMN 362
Cdd:cd17319 181 --VWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGA-------RRLVI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 363 CGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPR-YASILMGISNGVGTLSGMVCPIIVGAMT 441
Cdd:cd17319 252 IIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGYLV 331
|
410 420
....*....|....*....|....*
gi 568947277 442 KNKSREEWQYVFLIAALVHYGGVIF 466
Cdd:cd17319 332 DATGSYTAAFLFLAAVALLAALLVL 356
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
90-432 |
1.59e-35 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 136.01 E-value: 1.59e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYP 169
Cdd:pfam07690 27 LGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWL--LLVLRVLQGLGAGALFP 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 170 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITD 249
Cdd:pfam07690 105 AALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 250 EERRyieesigesanllgameKFKTPWRKFFTSmPVYAIIVANFCRSWTFYLLLISQPAYfEEVFGFEISKVGMLSAVPH 329
Cdd:pfam07690 185 EARL-----------------SLIVAWKALLRD-PVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGG 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 330 LVMTIIVPIGGQIADFLRSKQILstttvrkIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLD 409
Cdd:pfam07690 246 LLGAIGRLLLGRLSDRLGRRRRL-------LLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSD 318
|
330 340
....*....|....*....|....
gi 568947277 410 IAP-RYASILMGISNGVGTLSGMV 432
Cdd:pfam07690 319 LAPkEERGTASGLYNTAGSLGGAL 342
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
90-467 |
4.69e-29 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 118.68 E-value: 4.69e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYP 169
Cdd:cd06174 26 FGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA--PSFWLLLLGRFLLGLGSGLIDP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 170 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY--TGWSSVFYVYGSFGMVWYMFWLLVsYESPAKHPTI 247
Cdd:cd06174 104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV-VPDPPESARA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 248 TDEERRYIEesigesanllgamekFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAV 327
Cdd:cd06174 183 KNEEASSKS---------------VLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 328 PHLVMTIIVPIGGQIADFLRSkqilstttVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNH 407
Cdd:cd06174 248 FGLAGALGSLLLGLLSDRLIG--------RKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIA 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 408 LDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknKSREEWQYVFLIAALVHYGGVIFY 467
Cdd:cd06174 320 ELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL--AATFGLTGAFLVLAVLLLLAAILL 377
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
42-430 |
2.12e-28 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 116.23 E-value: 2.12e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 42 RRYIIAIMSGLGFCISFGIRCnLGVAIVDMVnnstihrggkvikekAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASR 121
Cdd:COG2814 8 RWLALLALALGAFLSGLGIGI-VLPALPLIA---------------ADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 122 LAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVI 201
Cdd:COG2814 72 FGRRRVLLLGLLLFALGSLLCALAP--SLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPAL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 202 AMPLAGILVQYTGWSSVFYVYGSFGMVwymFWLLVsyespakhptitdeeRRYIEESIGESAnllgamEKFKTPWRKFFT 281
Cdd:COG2814 150 GPLLGGLLADLFGWRWVFLVNAVLALL---ALLLL---------------LRLLPESRPAAR------ARLRGSLRELLR 205
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 282 SMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILStttvrkim 361
Cdd:COG2814 206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLL-------- 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 362 ncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAP-RYASILMGISNGVGTLSG 430
Cdd:COG2814 278 --IGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPpEARGRASGLYNSAFFLGG 345
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
41-459 |
5.32e-26 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 109.97 E-value: 5.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 41 PRRYIIAIMSGLGFCISFGIRCNLGVAIVDMvnnstihrggkvikeKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIAS 120
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPL---------------AEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD 65
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 121 RLAANRVFGAAILLTSTLNMLIPSAarVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAV 200
Cdd:COG2223 66 RFGPRRVLLIGLLLLGIGLLLLALA--VSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAA 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 201 IAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesiGESANLLGAMEKFKTPWrkff 280
Cdd:COG2223 144 VAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRDPPAGAAA-------------AAKASLRDQLEALRDPR---- 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 281 tsmpVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSkqilstttvRKI 360
Cdd:COG2223 207 ----FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGG---------RRV 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 361 MNCGGFGMEATLLLVVGYSHTRGVAI-SFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGA 439
Cdd:COG2223 274 LLIVFALMALGLLLLALALGSLWLFLvLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGA 353
|
410 420
....*....|....*....|
gi 568947277 440 MtkNKSREEWQYVFLIAALV 459
Cdd:COG2223 354 L--LDATGSYTAAFLVFAVL 371
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
97-471 |
2.19e-24 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 104.97 E-value: 2.19e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 97 VGMIHGSFFWGYIITQIPGGYIASRLAANR--VFGAAILLTSTLnmLIPSAArvHYGCVIFVRILQGLVEGVTYPACHGI 174
Cdd:cd17325 33 IGLIVAAYALAQLLFSPPAGRLSDRFGRKRllLLGLLLLAVSTL--LFAFAT--SYWQLLLARFLQGLASAAVWPAAMAL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 175 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLVsyespakhptitdeerRY 254
Cdd:cd17325 109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALL--ALVLAL----------------LL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 255 IEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 334
Cdd:cd17325 171 LPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASAL 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 335 IVPIGGQIAD-FLRSKQILstttvrkimncggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL--DIA 411
Cdd:cd17325 251 SQPPAGKLSDrIGRKPLIL-------------IGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALlaDIV 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947277 412 PRYA-SILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17325 318 PPEGrGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG---FATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
104-436 |
2.03e-14 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 75.36 E-value: 2.03e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 104 FFWGYIITQIPGGYIASRLAANRVFGAAILLTSTlnMLIPSAARVHYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLE 183
Cdd:cd17327 50 FYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL--LTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREE 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 184 RSRLATTSFCGSYAGAVIamplaGILVQY-----------TGWSSVFYVYG--SFGM-VWYMFWLLVsyeSPAKHPTITD 249
Cdd:cd17327 128 QAKRIAFFYAAAGLGSIF-----GGLLAYgvfkilgvgglAGWRWLFIIEGliTIIIgLVIFFWLPD---NPSKAWFLTE 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 250 EERRYIEESIGESANLLGAMEKFKTPWRKFFTSMPVYAIIVANFCrSW-------TFYLLLISQpayfeevFGFEISKVG 322
Cdd:cd17327 200 EEKELAVERLRANQTGKGDQKFKWKQIKEAFKDPRTWLLFLFFFC-SQitnngisNFLPLILKS-------LGFYSLQTN 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 323 MLSAVPHLVMTIIVPIGGQIADFLRSKQILSTttvrkIMNCggFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISG 402
Cdd:cd17327 272 LLSVPIGALGAVSLLIAALLSDRFKKRGLFAI-----FACV--LALVGSIILLAAPNPPGAYFAAYILGGGSYAGFPILL 344
|
330 340 350
....*....|....*....|....*....|....*.
gi 568947277 403 FNVNhlDIAPRYAS--ILMGISNGVGTLSGMVCPII 436
Cdd:cd17327 345 SWIS--SNCAGYTKraTVLAIMLIFYNVGNIVAPQI 378
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
87-440 |
5.49e-14 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 73.93 E-value: 5.49e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 87 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGV 166
Cdd:TIGR00895 44 SAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLL--CALATNVTQLLILRFLAGLGLGG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG--MVWY-MFWLLVSYE-SPA 242
Cdd:TIGR00895 122 LMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYVGGIAPllLLLLlMRFLPESIDfLVS 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 243 KHPTITDEERRYIEESIGESANLLGAMEKFKTP-WRKFF-------TSMPVYAIIVANFCRSWTFYLLLISQPaYFEEVF 314
Cdd:TIGR00895 202 KRPETVRRIVNAIAPQMQAEAQSALPEQKSTQGtKRSVFkalfqgkTARITVLLWLLYFMLLVGVYFLTNWLP-KLMVEL 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 315 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILstttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVG 394
Cdd:TIGR00895 281 GFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTA-----------LLLLLGAVFAVLVGSTLFSPTLLLLLGAIAG 349
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 568947277 395 FsgFAISGFNVNHLDIAPRYASIL----MGISNGVGTLSGMVCPIIVGAM 440
Cdd:TIGR00895 350 F--FVNGGQSGLYALMALFYPTAIratgVGWAIGIGRLGAIIGPILAGYL 397
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
127-471 |
2.02e-12 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 68.75 E-value: 2.02e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 127 VFGAAILLTSTLNMLIpsaarvhygcviFVRILQGLVEGVTYPACHGIWSKWAPPLERSRL-----ATTSFcgsyaGAVI 201
Cdd:cd17473 77 IGGVAGLFLDSLYALL------------ASRALLGIGVAGIMTLATALIGDYFEGEERAKMlglqsAAMSL-----GGVV 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 202 AMPLAGILVQYtGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTitdeerryieesigesaNLLGAMEKFKTPWRkfft 281
Cdd:cd17473 140 FLLLGGALAEI-GWRAPFLVYLLALPVLILVLLFLPEPARKSKSA-----------------ASPGAATAAALPWK---- 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 282 smPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvphlVMTIIVPIGGQIADFLRSKqilstTTVRKIM 361
Cdd:cd17473 198 --RVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALA----IASLAGAIGALLFGRLKRR-----LGKRRLL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 362 nCGGFGMEATLLLVVGYSHTRGVAISFLVLaVGFsGFAISGFNVNH--LDIAPRYAS-ILMGISNGVGTLSGMVCPIIVG 438
Cdd:cd17473 267 -AIGFALMALGFLLLALASGLWVVLLGAIL-AGL-GFGLLLPTLNSwaMSLVPPELRgRAMGIVTSAFFLGQFLSPLVLG 343
|
330 340 350
....*....|....*....|....*....|...
gi 568947277 439 AMTKNKSREewQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17473 344 PLVNLTGGL--SGAFLILGVLALVLAIVLLLLR 374
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
97-281 |
1.06e-11 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 66.63 E-value: 1.06e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 97 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACHGIWS 176
Cdd:TIGR00881 32 LGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFF--GFSTSLWVMAALWALNGIFQGMGWPPCGRTVT 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 177 KWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQ-YTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKhPTITDEERRYI 255
Cdd:TIGR00881 110 KWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAeLYSWHWVFIVPGIIAIIVSLICFLLLRDSPQS-CGLPPAEEMPN 188
|
170 180
....*....|....*....|....*.
gi 568947277 256 EESIGESANllgaMEKFKTPWRKFFT 281
Cdd:TIGR00881 189 EEPDGDAEK----KEEELTKKQIFLQ 210
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
90-236 |
2.62e-11 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 64.83 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILL---TSTLNMLIPSAArvhygCVIFVRILQGLVEGV 166
Cdd:COG0477 44 LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLfglASLLCGLAPSPE-----LLIAARALQGIGAGG 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLV 236
Cdd:COG0477 119 LMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
83-440 |
4.98e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 64.55 E-value: 4.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 83 VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTST---LNMLIPSaarvhYGCVIFVRIL 159
Cdd:cd17316 24 VLAAEFSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLatlLIGLLPT-----PILLLVLRFL 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 160 QGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILV----QYTGWSSVFYVYGSFGMVwyMFWLl 235
Cdd:cd17316 99 QGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIpllsGDWGWRILFLIGALPALL--ALLL- 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 236 vsyespakhptitdeerryieesigesanllgamekfktpwRKFFTsmpvyAIIVANFCRSWTFYLLLISQPAYFEEVFG 315
Cdd:cd17316 176 -----------------------------------------RRRTL-----LLILLWFFISFGYYGLTTFLPTYLQTVLG 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 316 FEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVgF 395
Cdd:cd17316 210 LSPATSSLYLLLISLGALVGALIAGLLSDRIG----------RKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFI-L 278
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 568947277 396 SGFAISGFNVNHLDIA----PRYASILMGISNGVGTLSGMVCPIIVGAM 440
Cdd:cd17316 279 SFFVGGVWGALYAYLAelfpTEVRATGVGLSYNLGRLGGGGAPPLIALL 327
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
90-458 |
3.71e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 61.80 E-value: 3.71e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLipSAARVHYGCVIFVRILQGLVEGVTYP 169
Cdd:cd17324 29 FGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL--AALAPSFALLLLARALAGLAHGGFWA 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 170 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFG---MVWYMFWLlvsyespakhPT 246
Cdd:cd17324 107 IAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLAllaALLLWRLL----------PS 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 247 ITDEERRyieeSIGESANLLGAmekFKTPwrKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvfgfeiSKVGMLSA 326
Cdd:cd17324 177 LPPKKPG----SLGLLSSLLLL---LRNP--RLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSS------SAIIGLLL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 327 VPHLVMTIIVPIGGQIADFLRSKQILSTttvrkimncGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFsGFAISGFNVN 406
Cdd:cd17324 242 LFGVAGVVGSPLAGRLADRGGRRALLIA---------LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF-FAAHSALQTR 311
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 568947277 407 HLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAAL 458
Cdd:cd17324 312 VLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGG---WAGVGWVGAA 360
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
87-472 |
1.82e-09 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 59.87 E-value: 1.82e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 87 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTStLNMLIPSAARvHYGCVIFVRILQGLVEGV 166
Cdd:COG0738 35 KDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA-LGLLLFALAP-SYPLLLLALFLLGLGLGL 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPPLERSRLATTSFCGSyAGAVIAMPLAGILVQY---TGWSSVFYVYGSFGMVWYMFWLLVSYespak 243
Cdd:COG0738 113 LDVAANPYVAALGPETAASRLNLLHAFFS-LGALLGPLLGGLLILLglsLSWHLPYLILAVLLLLLALLFLRSKL----- 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 244 hPTITDEErryiEESIGESANLLGAmekFKTPwrkfftsmPVYAIIVANFC--------RSWTfylllisqPAYFEEVFG 315
Cdd:COG0738 187 -PEIEEEE----EEAAGSAASLKSL---LKNP--------RLLLGGLAIFLyvgaegaiGDWL--------PLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 316 FEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgMEATLLLVVGYSHTRGVAISFLVLAvgf 395
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSAL----------LAAVGLLLALLAPGPWLALIGLALV--- 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 396 sGFAISGF--NVNHL--DIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVhYGGVIFYALFA 471
Cdd:COG0738 310 -GLGLSLMfpTIFSLalDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG---LRAAFLVPLVC-YLLILLLALAL 384
|
.
gi 568947277 472 S 472
Cdd:COG0738 385 K 385
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
288-483 |
4.10e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 58.20 E-value: 4.10e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 288 IIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRskqilstttVRKIMNCGGFG 367
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG---------RRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 368 MEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSre 447
Cdd:pfam07690 72 FALGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-- 149
|
170 180 190
....*....|....*....|....*....|....*.
gi 568947277 448 eWQYVFLIAALVHYGGVIFYALFASGEKQPWADPEE 483
Cdd:pfam07690 150 -WRAAFLILAILSLLAAVLLLLPRPPPESKRPKPAE 184
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
183-440 |
6.18e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 6.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 183 ERSRLATTSFCGSYAGAVIAMPLAGILVQY------TGWSSVFYVYGSFGMV--WYMFWLLVSYESPAKHPTitdeerry 254
Cdd:COG2211 144 ERTRLSSWRFAFAGLGGLLASVLPPPLVAAfggdaaLGYRLTALIFAVLGLLafLLTFFGTKERPVPEEEKV-------- 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 255 ieesigesanllgameKFKTPWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAVPHLVMTI 334
Cdd:COG2211 216 ----------------SLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALL 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 335 IVPIGGQIADFLRSKQILstttvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVgfSGFAISGFNVNHL----DI 410
Cdd:COG2211 280 GAPLWPRLAKRFGKKKAF----------IIGLLLAALGLLLLFFLGPGNLWLLLVLAAL--AGIGLGAILVLPWamlaDV 347
|
250 260 270
....*....|....*....|....*....|....*...
gi 568947277 411 AP--------RYASILMGISNGVGTLSGMVCPIIVGAM 440
Cdd:COG2211 348 VDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
93-241 |
4.15e-08 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 55.36 E-value: 4.15e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 93 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGLVEGVTYPACH 172
Cdd:cd17312 36 SKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFM--GFSTSLWFFAVLWGLNGLFQSMGWPPCV 113
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568947277 173 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 241
Cdd:cd17312 114 KLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLRDSP 182
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
97-470 |
1.66e-07 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 53.37 E-value: 1.66e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 97 VGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAILLTSTLNMLIPSAARVhygcVIFVRILQGLVEGVTYPACHGI 174
Cdd:cd17489 33 AGLVVGLFTLAALLARPFAGRLLDRFGRKRLllIGLLIFALATLLYLLATSVAL----LLVLRLIHGIGWGAFTTAAATL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 175 WSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEER-- 252
Cdd:cd17489 109 VADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAAEEAEAGTRaf 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 253 -RYIEESIGESANLLgamekfktpwrkFFTSMPVYAIIvanfcrswTFYlllisqPAYFEEVFgfeISKVGMLSAVPHLV 331
Cdd:cd17489 189 rRLVEKKVLPPALIL------------FLASIAYGAIS--------TFL------PLYAAERG---ISNAGLFFTVYAIA 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 332 MTIIVPIGGQIADFLRskqilstttvRKIMNCGGFGMEATLLLVVGYSHT-RGVAISFLVLAVGFsGFAISGFNVNHLDI 410
Cdd:cd17489 240 LLLSRPFSGKLSDRKG----------PKTVIIPGLLLLALGLLLLSFAGSpWMLLLAAVLYGLGF-GLLFPALQALAVDL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568947277 411 APRYA-SILMGISNGVGTLSGMVCPIIVGAMTknksrEEWQY--VFLIAALVHYGGVIFYALF 470
Cdd:cd17489 309 VPPHRrGAANGTFFIFFDLGIGLGGLLLGLVA-----ELFGYraMFLLAAVVVLLALVLYIFL 366
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
87-241 |
9.36e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 51.02 E-value: 9.36e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 87 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRL-AANRVFGAAILLTSTLNMLIPSAARVHYGCVIFVrILQGLVEG 165
Cdd:COG2271 208 VEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAALALLLLALLPSPALAIALL-FLAGFGLG 286
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568947277 166 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESP 241
Cdd:COG2271 287 GAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRETR 362
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
154-395 |
6.49e-06 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 48.44 E-value: 6.49e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 154 IFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMpLAGILVQYT---------GWSSVFYVYGS 224
Cdd:cd17367 105 LLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYSSFQYVTLIGGQLLAL-GVLLVLQHTlgedqmaawGWRIPFLLGGV 183
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 225 FGMVwyMFWLlvsyespakhptitdeeRRYIEESIgESANLLGAMEKFKTPWRKFFtSMPVYAIIVANFCRSWT--FYLL 302
Cdd:cd17367 184 LAVV--VLWL-----------------RRGLEETE-SFEAIAESNEASAGTLRELR-RHPRELLLVVGLTAGGTlaFYTW 242
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 303 LISQPAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggFGMEATLLLVVGYSHTR 382
Cdd:cd17367 243 TTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRIGRRPLLLFFGI--------GGTLATVPLLSALDHTD 314
|
250
....*....|...
gi 568947277 383 GVAISFLVLAVGF 395
Cdd:cd17367 315 SPYTAFALVLVGL 327
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
92-473 |
1.11e-05 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 48.01 E-value: 1.11e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 92 WDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYGCVIFV--RILQGLVEGVTYP 169
Cdd:cd17345 35 LSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPSATSSVGLMFilLFLNGWFQGMGWP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 170 ACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTG---WSSVFYVYGSFGMVWYMFWLLVSYESPAKH-- 244
Cdd:cd17345 115 PSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFGdgwWRGAFIFPAIIAIIVAVIVLFLGKDTPESEgl 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 245 PTITDEERRYIEESIGEsanllgAMEKFKTPWRKFFTSM----PVYAIIVAN----FCR----SWTfylllisqPAYFEE 312
Cdd:cd17345 195 PPIEEYKGDYPEEADGE------EEEQELSAWEIFVKYVlknkLLWYIAIANvfvyLVRygilDWA--------PTYLSE 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 313 VFGFEISKVGM------LSAVPHlvmTIIVpigGQIAD-FLRSKqilstttvRKIMNCggFGMEATLLLVVGYSHTRGVA 385
Cdd:cd17345 261 VKGFSKAQAMWafslfeWAAIPG---TLLA---GWLSDkLFKGR--------RAPTGI--IFMILVIVALIVYWLAPNVL 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 386 ISFLVLAvgFSGFAISG----FNVNHLDIAPRYAsilmgisngVGTLSGM--VCPIIVGAMTKNksreewqyvFLIAALV 459
Cdd:cd17345 325 VDLIALI--ALGFLIYGpvmlIGLQALELVPKKA---------AGTAAGLtgLFGYLGGSVLAT---------ALIGIIV 384
|
410
....*....|....*.
gi 568947277 460 -HYG-GVIFYALFASG 473
Cdd:cd17345 385 dHFGwNGGFIVLLASC 400
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
275-459 |
1.21e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 47.66 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 275 PWRKFFTSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILst 354
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL-- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 355 ttvrkimnCGGFGMEATLLLVVGYSHTrgvaISFLVLAVGFSGFAISGFNVNHLDIAPRYAS-----ILMGISNGVGTLS 429
Cdd:COG2814 79 --------LLGLLLFALGSLLCALAPS----LWLLLAARFLQGLGAGALFPAALALIADLVPperrgRALGLLGAGLGLG 146
|
170 180 190
....*....|....*....|....*....|
gi 568947277 430 GMVCPIIVGAMTKNKSreeWQYVFLIAALV 459
Cdd:COG2814 147 PALGPLLGGLLADLFG---WRWVFLVNAVL 173
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
93-238 |
2.02e-05 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 46.81 E-value: 2.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 93 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTYPACH 172
Cdd:cd17365 32 SPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQ--LALLRFLTGLGLGAAMPNAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 173 GIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYV------------------YGSFGMVWYMFWL 234
Cdd:cd17365 110 TLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLggvpplillpllrgtlllWVTFFMGLLLVYL 189
|
....
gi 568947277 235 LVSY 238
Cdd:cd17365 190 LNSW 193
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
89-228 |
2.81e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 46.42 E-value: 2.81e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 89 KFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVHYgcVIFVRILQGLVEGVTY 168
Cdd:cd17325 229 LGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWL--LLLLLALLGLGLGLVF 306
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568947277 169 PACHGIWSKWAPPLERSR-LATTSFCGSyAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMV 228
Cdd:cd17325 307 PATLALLADIVPPEGRGTaMGLFNTAFS-LGMVLGPLLGGFLYDAFGFATPFLAAAALLLL 366
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
293-488 |
4.44e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.88 E-value: 4.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 293 FCRSWTFYLLLISQPAY--FEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADflrskqilsTTTVRKIMNCGGFGMEA 370
Cdd:cd06174 3 LGFFLTGLARGLISPLLpaLLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD---------RFGRRPVLLLGLLLFAL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 371 TLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSrEEWQ 450
Cdd:cd06174 74 GALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLG-FGWR 152
|
170 180 190
....*....|....*....|....*....|....*...
gi 568947277 451 YVFLIAALVhyGGVIFYALFASGEKQPWADPEETSEEK 488
Cdd:cd06174 153 AVFLIAAAL--ALLAAILLLLVVPDPPESARAKNEEAS 188
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
252-432 |
8.56e-05 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 44.85 E-value: 8.56e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 252 RRYIEESIGESANLLGAMEKFKTPWRkfftsmPVYAIIVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSAvpHLV 331
Cdd:cd17478 170 RPLKKPEAKKAAAKSSARSTLKGVWR------ALLLLLIIVFLRSWVLSSLTTFLPFYLVQRGYSLVFAGLLLSL--FLF 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 332 MTII-VPIGGQIADFLRSKQILSTTTVrkimncggfgmeATLLLVVGYSHTRGVAISFLVLAVGFsgFAISGFNVNHL-- 408
Cdd:cd17478 242 AGAIgTLIGGPLSDRFGRRRVIIASLL------------LAAPFLLLFLLTPGIWSYILLVLAGF--LLFASFPVTVVla 307
|
170 180
....*....|....*....|....*....
gi 568947277 409 -DIAPRYA----SILMGISNGVGTLSGMV 432
Cdd:cd17478 308 qELLPGNVglasGLMMGLSFGLGGIGAPV 336
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
93-470 |
1.12e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 44.53 E-value: 1.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 93 DPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVfgaaILLTSTLNMLI-------PSAARVHYGCVIFVRILQGLVEG 165
Cdd:cd06173 32 SALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRL----LILADLLRALLaavlallALLGSLSLWLLLVLAFLLGIASA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 166 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYG-SFGMVWYMFWLLvsyesPAKH 244
Cdd:cd06173 108 FFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINAlSFLLSALLLLFI-----RRPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 245 PTITDEERRYIEESIGESanllgamekfktpWRKFFTSMPVYAIIVANFCrSWTFYLLLISQ-PAYFEEVFGFEISKVGM 323
Cdd:cd06173 183 PAAPGESSSLLLRDLREG-------------LRYLRRSPLLRLLLLALAL-FALLGGALTVLlPLLAKEVLGGGAAGYGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 324 LSAVPhlvmtiivPIGGQIADFLRSKqILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGF 403
Cdd:cd06173 249 LLAAF--------GVGALLGALLLGR-LSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLN 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568947277 404 NVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAMTknkSREEWQYVFLIAALVHYGGVIFYALF 470
Cdd:cd06173 320 TLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA---DALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
88-457 |
1.23e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 44.52 E-value: 1.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 88 AKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV-------FGAAILLTS---TLNMLIpsaarvhygcvIFVR 157
Cdd:cd17353 31 SALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAiliggilFGLGFILSAfaiSLPLLF-----------LGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 158 ILQGLVEGVTYPACHGIWSKWAPplERSRLAT-TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGS-FGMVWYMFWLL 235
Cdd:cd17353 100 VLGGIGAGIGYITPVSTAVKWFP--DKRGLATgIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIiFLIIIVIGAFL 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 236 VSYESPAKHPTITDEERRYIEESIGEsanllgamekfKTPWRKFFTsmPVYAIIVANFCRSWTFYLLLISQPAYF-EEVF 314
Cdd:cd17353 178 IRDPPKGWVPPGVDPLANNAENSPRD-----------YTPREMLRT--PTFWLLWLMFFLNATAGLMLIGQAKPIgQEFA 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 315 GFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQILSTTTVrkimnCGGFGMeatLLLVvgysHTRGVAISFlVLAVG 394
Cdd:cd17353 245 GLDAGIAALAVSILSIFNGGGRPFWGWLSDKIGRKNTLSIAFL-----IQGVAM---FLLP----FIGSVAVLF-VLGVA 311
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568947277 395 FSGFAISGFnvnhLDIAPRYASILMGISNgVGT----------LSGMVCPIIVGAMTKNKSreeWQYVFLIAA 457
Cdd:cd17353 312 LIGFCYGGG----FALFPALTADFFGTKN-AGTnygllytakgVGGLIGPIIAAYVLYTGG---YNAAFIIAA 376
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
90-400 |
1.25e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 44.49 E-value: 1.25e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITqIP-GGYIASRLAANRVFGAAIL---LTSTLNMLIPSAARVhygcvIFVRILQGLVEG 165
Cdd:cd17503 26 LGASLDTVQWVITSYLLALAIM-IPlSGWLADRFGTRRLFLTALAlftLGSLLCGLAPNLASL-----IIFRILQGFGGG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 166 VTYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwymfwllvsyespakhp 245
Cdd:cd17503 100 VLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGIL----------------- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 246 titdeerryieesigesANLLGAMEKFKTPWRKFFTSMpVYAIIVANFCRSWTFYLLlisqPAYFEEVFGFEISKVGMLS 325
Cdd:cd17503 163 -----------------ALLLAPLLDLRLFKDRNFTLG-LLLSFLLGLGLFGAMFLL----PLYLQNVLGYSAFESGLVL 220
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568947277 326 AVPHLVMTIIVPIGGQIADFLrskqilsttTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAI 400
Cdd:cd17503 221 APGGLASAILSPLVGRLLDKF---------GPRLLLLAGLLLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGL 286
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
113-440 |
1.54e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 44.09 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 113 IPGGYIASRLAANRVF--GAAI-LLTSTLNMLIPSAArvhygCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLAT 189
Cdd:cd17321 49 LLAGRLGDRFGRKRVFliGLALfGLASLLCALAPSLA-----FLIAARALQGIGAAAIMPASLALIAATFPGERRGRALG 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 190 TSFCGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwyMFWLLvsyespakhptitdeerryieesigesanllgam 269
Cdd:cd17321 124 LWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV--ALLLA---------------------------------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 270 ekfktpwRKFFTSMpvyaiiVANFCRSWTFYLLLISQPAYFEEVFGFEISKVGMLSaVPHLVMTIIV-PIGGQIADflrs 348
Cdd:cd17321 168 -------RTFSGAV------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLAL-LPLALAMLVAaPLAGRLAD---- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 349 kqilsTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAV-GF-SGFAISGFNVNHLDIAPR-YASILMGISNGV 425
Cdd:cd17321 230 -----RFGPRLVLVAGLLLTAVGLLLLALLGADSSVWLLLPGLVLlGLgLGLFATPLTNAALSSVPKeKAGAASGILNTA 304
|
330
....*....|....*
gi 568947277 426 GTLSGMVCPIIVGAM 440
Cdd:cd17321 305 RQLGGALGVALLGAL 319
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
153-440 |
3.83e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.95 E-value: 3.83e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 153 VIFVRILQGLVEGVTyPACHGIWSKWAPPlERSRLATTSFCGSYA-GAVIAMPLAGILVQYTGWSSVFYVYGSFGMVwym 231
Cdd:cd17504 87 LIAGRALQGIGGAVF-PLAFALVREEFPP-ERVPVAQGILSATFGiGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL--- 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 232 FWLLVsyespakhPTITdeeRRYIEESIGESANLLGAMEKfktpwrkfFTSMPVYAIIVAnfcrswtfyllLISQPAYFE 311
Cdd:cd17504 162 LAALV--------PLID---LRLLRRRNVLLANITALLAG--------FGMFMVFQLLPQ-----------LLQLPTPTG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 312 evFGFEISKVGMLSAVPHLVMTIIVPIGGQIAdflrskqilSTTTVRKIMNCGGFGMeATLLLVVGYSHTRGVAISF--L 389
Cdd:cd17504 212 --FGLGITEAGLLLLPGALVMLIAGPLAGRLI---------ARVGPRRVLLIGLVIS-AVGLLLLALLHSSLWALVValL 279
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 568947277 390 VLAVGFSGFAISGFNVNHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM 440
Cdd:cd17504 280 LIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAI 330
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
90-432 |
3.99e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 42.95 E-value: 3.99e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRV--FGAAI-LLTSTLNMLIPSaarvhYGCVIFVRILQGLVEGV 166
Cdd:cd17320 29 LGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVllAGLLLfILASLLCALASS-----IEQLLIARFLQGLGAAA 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPPLERSRLAttsfcgSYAGAVIAM-----PLAG-ILVQYTGWSSVFYVYGSFGMV---WYMFWLlvs 237
Cdd:cd17320 104 GSVVARAIVRDLYSGAELAKIF------SLLMMILAIapalaPLLGgLLLLFFGWRAIFVFLALLGLLlllLVLLFL--- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 238 yespakhPTITDEERRyieeSIGESANLLGAMEKFKTpwRKFFTSMPVYAIIVAnfcrswTFYLLLISQPAYFEEVFGFE 317
Cdd:cd17320 175 -------PETLPEEKR----KPLLSSLLRAYKRVLKN--RRFLGYALALGLSFA------GLFAYLAAAPFIYIEQLGLS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 318 ISKVGMLsavphLVMTIIVPIGGQIAdflrSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVG--F 395
Cdd:cd17320 236 PAQFGLL-----FALNAIALILGSLL----NGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFliF 306
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 568947277 396 SGFAISGFNVNHLDIAPRY-----ASILMG-ISNGVGTLSGMV 432
Cdd:cd17320 307 FGFGLIFPNATSLALEPFPhvagtASALLGfLQFLIGALAGAL 349
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
96-439 |
4.67e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 42.61 E-value: 4.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 96 TVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIW 175
Cdd:cd17475 32 QVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS--YPVLLVLLFLVGAGYGSVQPGGGRAI 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 176 SKWAPPLERSrLAT----TSFcgSYAGAVIAMPLAGILVQYtGWSSVFYVYGSFGMVW-YMFWL-LVSYESPAKHPTITD 249
Cdd:cd17475 110 MRWFPPRERG-LAMgirqTGV--PLGGALAAALLPPLALHY-GWRAAFVVAGLVSILAaVLFWLfYREPPAASAATESAS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 250 EERRYIEESIGESANLLGAmekfktpWRKFFTSMPVYAIIVanfcrswtfYLLLisqpaYFEEVFGFEISKVGMLsavph 329
Cdd:cd17475 186 TLLRSLKEVLRNRDVWLIA-------IAGALLVAPQFALLT---------FLLL-----FLHDHLGLSVVAAGAL----- 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 330 LVMTIIVPIGGQIADFLRSKQILSTTTVRKIMNCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGFSGFAISGFNVNHL- 408
Cdd:cd17475 240 LAVAQLGGALGRIGLGRVSDRVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVa 319
|
330 340 350
....*....|....*....|....*....|..
gi 568947277 409 DIAP-RYASILMGISNGVGTLSGMVCPIIVGA 439
Cdd:cd17475 320 ESAGpEQAGTALGLANTINFIGIAIGPPLFGL 351
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
97-438 |
5.38e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 42.31 E-value: 5.38e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 97 VGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVhYGCVIFVRIL---QGLVEGVTYPACHG 173
Cdd:cd17333 33 VSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSI-YLFVVLMFLAglgAGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 174 IWSKWAPplerSRLATTSFCGSyAGAVIAMPLAGILV-QYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEER 252
Cdd:cd17333 112 LFEESSA----TRLNVLHGFFG-LGALIGPLIATSLLtSELSWSWAYLIIGLIYLLLAILILLTLFPELPSARNPQQSVG 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 253 RYIEESIGESAN---LLGAMEKFktpwrkfftsmpVYAIIVANFCrSWTfylllisqPAYFEEVFGFEISKVGMLSAVPH 329
Cdd:cd17333 187 AFSASASRLLRNpsiILGALALF------------LYVGAETAFS-SWV--------PSYLVEKKHVSDGLAGYLLSGFW 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 330 LVMTIIVPIGGQIADFLRSKQILSTTTVrkimncggfgmEATLLLVVGYSHTRGVAISFLVLAVGFSgfaISG----FNV 405
Cdd:cd17333 246 VGITIGRLLGGPISRRIKPHTLLVLSGS-----------GALLGLLILLLAPTLVVGLVATALLGLF---MAAlfptILS 311
|
330 340 350
....*....|....*....|....*....|...
gi 568947277 406 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVG 438
Cdd:cd17333 312 LGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
115-223 |
6.68e-04 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 42.26 E-value: 6.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 115 GGYIASRLAANRVFGAAILLTSTLNMLIPSAARvhYGCVIFVRILQGLVEGVTYPACHGIWSKWAPPLERSRLATTSFCG 194
Cdd:PRK11551 70 GGRLADRIGRKRILIVSVALFGLFSLATAQAWD--FPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCG 147
|
90 100
....*....|....*....|....*....
gi 568947277 195 SYAGAVIAMPLAGILVQYTGWSSVFYVYG 223
Cdd:PRK11551 148 VPFGGALASVIGVLAAGDAAWRHIFYVGG 176
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
87-471 |
6.76e-04 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 42.29 E-value: 6.76e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 87 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 166
Cdd:cd17371 26 IAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQ--NYWQLLILRALAGLGFGG 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIAMPLAGILVQY----TGWSSVFYVYG--SFgMVWYMFWLLVSYES 240
Cdd:cd17371 104 EWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLlppeIAWRVLFLLGAlpAL-LVLFIRRFVKEPPQ 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 241 PAKHPTITDEERRYIEESIGESANLLGAMekfktpwrkFFTSMPVyaiIVANFcrswTFYLLLISQPAYFEEVFGFEISK 320
Cdd:cd17371 183 WQAARAARRHFADRPSLRELFSPPLLRTT---------LLASLLA---TGALG----GYYGITTWLPSYLTGERGLSFEG 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 321 VGMLSAVPHLVMTIIVPIGGQIADFLRSKQILStttvrkIMNCGGFgmeATLLLVVGYSHTRGVaISFLVLAVGFSGFAI 400
Cdd:cd17371 247 SAGYLVVTILGGFLGYLAGGFLADRIGRRNNFA------LFALGSA---ISILLYFFLPLSPTL-ILILGFPLGFFASGP 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568947277 401 SGFNVNHLDIA--PRYASILMGISNGVGTLSGMVCPIIVGAMTKNKSreeWQYVFLIAALVHYGGVIFYALFA 471
Cdd:cd17371 317 FSGMGAYLTELfpTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGS---LGTAIAVFAAVYYIAGLVLALLL 386
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
90-459 |
8.59e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 41.78 E-value: 8.59e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 90 FNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLtstlnMLIPSAARV---HYGCVIFVRILQGLVEGV 166
Cdd:COG2807 48 LGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLL-----LAAGLLLRSlapSVALLLAGTALIGAGIAV 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 167 TYPACHGIWSKWAPplERSRLATTSF-CGSYAGAVIAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHP 245
Cdd:COG2807 123 GNVLLPGLIKRWFP--DRVGLMTGLYtAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRPAAAA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 246 TITDEERryieesigesanllgamekFKTPWRkfftSMPVYAIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLS 325
Cdd:COG2807 201 AAPAAAS-------------------LRSLWR----SPLAWLLTLFFGLQSLLYYAVVAWLPPILRD-AGLSAATAGLLL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 326 AVPHLVMTIIVPIGGQIADFLRSKQILSTTtvrkimnCGGFGMEATLLLVVGYSHTRGVAISFLVLAVGfSGFAISGFNV 405
Cdd:COG2807 257 SLFQLAGIPGSLLVPLLADRLGDRRPLLLL-------LGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQG-GLFPLALTLI 328
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 568947277 406 NHLDIAPRYASILMGISNGVGTLSGMVCPIIVGAM---TKNksreeWQYVFLIAALV 459
Cdd:COG2807 329 GLRARTPAEAAALSGMAQSVGYLLAALGPLLVGALhdaTGS-----WTAALLLLAAL 380
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
98-470 |
1.10e-03 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 41.55 E-value: 1.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 98 GMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAARVhygcVIFVRI--LQGLVEGVTYPACHGIW 175
Cdd:cd17343 41 GLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSV----WVFSILwfLNGLAQGLGWPPCAKIL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 176 SKWAPPLE----RSRLATTSfcgSYAGAViAMPLAGILVQYTGWSSVFYVYGSFGMVWYMFWLLVSYESPAKHPTITDEE 251
Cdd:cd17343 117 RKWFSPSQfgtwWSVLSTSM---NLAGSL-GPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEE 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 252 RRYIEESIGESANLLGAMEKFKTP--WRKFFTSMPVYAIIVAnfCRSWTfYLLLI---SQPAYFE-------EVFGFeis 319
Cdd:cd17343 193 EESKGKKKKSPRGESTLKELLLSPflWLLSLGYLVVFGVKTA--VTDWG-QLFLIqdkGQSALTGssfmsslEVGGF--- 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 320 kVGMLSAvphlvmtiivpigGQIADFLRSKQILST------TTVRKIMncggFGMEATL--LLVVGYSHTRGVAISFLVL 391
Cdd:cd17343 267 -VGSIAA-------------GYLSDWAVAKHGSSSrgnprmPLALVFM----AGLTVSLhlFRVHITSDSSELFILLLGF 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 392 AVGFSGFA-ISGFNVNHLDIAPryaSILMGISNGVGTLSGMVCPIIVG-AMTKNKSREEWQYVFLIAALVHYGGVIFYAL 469
Cdd:cd17343 329 LIGFSLYGpIAIFGVIANESAP---SHLCGTSHAIVALAANVGGVLAGlPFSYIAKHYDWRTAFLLLEILCAITVVILFL 405
|
.
gi 568947277 470 F 470
Cdd:cd17343 406 L 406
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
83-441 |
3.02e-03 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 39.87 E-value: 3.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 83 VIKEKAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIpsAARVHYGCVIFVRILQGL 162
Cdd:cd17330 22 YVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLL--GLSRNLWLLFLARFLDGL 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 163 VeGVTYPACHGIWSKWAPPLERSR-LATTSFCGSyAGAVIAMPLAGILVQYTGWSSVFYVYG--SFGMVWYMFWLLvsye 239
Cdd:cd17330 100 T-GGNVSVAQAYIADITDEEERAKaFGIISAAFG-LGFILGPALGGFLSTPYGYALPFLVAAalALLNLVLVLFFL---- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 240 spakhptitdeerryieesigesanllgamekfKTPWRKFFTSMpVYAIIVANFcrSWTFYLLLISQpayfeevFGFEIS 319
Cdd:cd17330 174 ---------------------------------PPLRRLLLVYF-LIALAFAGL--ESVFSLFLKDR-------FGFSPS 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 320 KVGMLSAVPHLVMTIIvpiggQIADFLRSKQILSTttvRKIMnCGGFGMEATLLLVVGYSHTRG---VAISFLVLAVGFS 396
Cdd:cd17330 211 QIGLLLALVGIAGILA-----QLLLIPRLAKRLGE---RKLL-RLGLLLAIIGLLLLPFASSVPllvLAAAILAFGTGIV 281
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 568947277 397 GFAISGFNVNHLDIAPRyaSILMGISNGVGTLSGMVCPIIVGAMT 441
Cdd:cd17330 282 FPALSALLSKSVPSKEQ--GKAQGIIQSLQSLARIIGPLLAGPLY 324
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
307-473 |
3.36e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 39.89 E-value: 3.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 307 PAYFEEVFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFLRSKQ------ILSTTtvrkIMNCGGFgmeaTLLLVVGYSH 380
Cdd:COG2211 34 LYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWgrrrpwILIGA----IPLALSF----VLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 381 TRGVAISFLVLAVGFsGFAISGFNVNHL----DIAPRYA--SILMGISNGVGTLSGMVCPIIVGAMTKN---KSREEWQY 451
Cdd:COG2211 106 PTGKLIYALVTYLLL-GLAYTLVNIPYSalgaELTPDYEerTRLSSWRFAFAGLGGLLASVLPPPLVAAfggDAALGYRL 184
|
170 180
....*....|....*....|..
gi 568947277 452 VFLIAALVhygGVIFYALFASG 473
Cdd:COG2211 185 TALIFAVL---GLLAFLLTFFG 203
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
87-202 |
4.02e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 39.57 E-value: 4.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 87 KAKFNWDPETVGMIHGSFFWGYIITQIPGGYIASRLAANRVFGAAILLTSTLNMLIPSAArvHYGCVIFVRILQGLVEGV 166
Cdd:COG2814 235 QEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAG--SLWLLLLALFLLGFGFGL 312
|
90 100 110
....*....|....*....|....*....|....*.
gi 568947277 167 TYPACHGIWSKWAPPLERSRLATTSFCGSYAGAVIA 202
Cdd:COG2814 313 LFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
287-474 |
4.53e-03 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 39.41 E-value: 4.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 287 AIIVANFCRSWTFYLLLISQPAYFEEvFGFEISKVGMLSAVPHLVMTIIVPIGGQIADFL-RskqilstttvRKIMNCGG 365
Cdd:COG0477 18 ALALGTFLEGLDFTIVNVALPSIAAD-LGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYgR----------KRVLLIGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 366 FGMEATLLLvVGYSHTrgvaISFLVLAVGFSGFAISGFNVNHL----DIAP-RYASILMGISNGVGTLSGMVCPIIVGAM 440
Cdd:COG0477 87 LLFGLASLL-CGLAPS----PELLIAARALQGIGAGGLMPGALaliaELFPaRERGRALGLWGAAIGLGLALGPLLGGLL 161
|
170 180 190
....*....|....*....|....*....|....
gi 568947277 441 TKNKSreeWQYVFLIAALVhyGGVIFYALFASGE 474
Cdd:COG0477 162 VAALG---WRWIFLINAPL--GLLALVLRLRLPE 190
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
92-228 |
6.88e-03 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 39.09 E-value: 6.88e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568947277 92 WDPETVGMIHGSFFWGYIITQIPGGYIASRLAANR---VFGAAILLTSTLNMLI-PSAARVhygcvIFVrILQGLVEGVT 167
Cdd:COG2807 247 LSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRpllLLLGLLGLAGLLGLLLaPGSLPW-----LWA-VLLGLGQGGL 320
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568947277 168 YPACHGIWSKWAP-PLERSRLATTSFCGSYAGAVIAMPLAGILVQYTG-WSSVFYVYGSFGMV 228
Cdd:COG2807 321 FPLALTLIGLRARtPAEAAALSGMAQSVGYLLAALGPLLVGALHDATGsWTAALLLLAALAVL 383
|
|
| |
