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Conserved domains on  [gi|568932016|ref|XP_006539298|]
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matrix remodeling-associated protein 8 isoform X1 [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 10309807)

immunoglobulin (Ig) domain-containing protein with one or more Ig domains, which adopt a fold comprised of a sandwich of two beta sheets and may function in cell adhesion and/or pattern recognition; similar to matrix remodeling-associated protein 8 which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 168-288 4.36e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 68.25  E-value: 4.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016  168 EVLVVAHGAPALMTCinrahVWTDRHlEEAQQVVHWDRQLPGVSHDRadrLLDLYASGerraYGPPFLRDRVSVNTNaFA 247
Cdd:pfam07686   4 REVTVALGGSVTLPC-----TYSSSM-SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568932016  248 RGDFSLRIDELERADEGIYSCHLHHHYCGlHERRVFHLQVT 288
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 41-153 9.09e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016   41 AAGTQAVLRCQ-SPRMVWTQDRlhdrqrvVHWDLsGGPGSQRRRLVDMYSAGEQrVYEPRDRDRLLLSPSafhDGNFSLL 119
Cdd:pfam07686   9 ALGGSVTLPCTySSSMSEASTS-------VYWYR-QPPGKGPTFLIAYYSNGSE-EGVKKGRFSGRGDPS---NGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568932016  120 IRAVDRGDEGVYTCNLHHHYCHlDESLAVRLEVT 153
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 168-288 4.36e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 68.25  E-value: 4.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016  168 EVLVVAHGAPALMTCinrahVWTDRHlEEAQQVVHWDRQLPGVSHDRadrLLDLYASGerraYGPPFLRDRVSVNTNaFA 247
Cdd:pfam07686   4 REVTVALGGSVTLPC-----TYSSSM-SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568932016  248 RGDFSLRIDELERADEGIYSCHLHHHYCGlHERRVFHLQVT 288
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
199-268 3.42e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 3.42e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016   199 QVVHWDRQLPGvshdRADRLLdLYASGERRAYGPPFLRDRVSVNTNaFARGDFSLRIDELERADEGIYSC 268
Cdd:smart00406  16 YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 41-153 9.09e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016   41 AAGTQAVLRCQ-SPRMVWTQDRlhdrqrvVHWDLsGGPGSQRRRLVDMYSAGEQrVYEPRDRDRLLLSPSafhDGNFSLL 119
Cdd:pfam07686   9 ALGGSVTLPCTySSSMSEASTS-------VYWYR-QPPGKGPTFLIAYYSNGSE-EGVKKGRFSGRGDPS---NGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568932016  120 IRAVDRGDEGVYTCNLHHHYCHlDESLAVRLEVT 153
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 43-133 1.51e-04

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 41.05  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016  43 GTQAVLRCQ-SPRMVWTQdrlhdRQRVVHWDLSggpgsQRRRLVDMYSAGE--QRVYEPRDRDRLLLSPSAFHDGNFSLL 119
Cdd:cd20934   12 GTDATLRCSfSPEPGFSL-----AQLSVFWQLT-----DTKQLVHSFTESQdqGRDQGSAYANRTALFPDLLAQGNASLR 81

                         90
                 ....*....|....
gi 568932016 120 IRAVDRGDEGVYTC 133
Cdd:cd20934   82 LQRVRVADEGSYTC 95
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 213-268 1.55e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.20  E-value: 1.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568932016 213 DRADRLLDLYASGerRAYGP--PFLRDRVSVNTNaFARGDFSLRIDELERADEGIYSC 268
Cdd:cd20960   44 DKVEKVVITYSGD--RVYNHyyPALKGRVAFTSN-DLSGDASLNISNLKLSDTGTYQC 98
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 168-288 4.36e-14

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 68.25  E-value: 4.36e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016  168 EVLVVAHGAPALMTCinrahVWTDRHlEEAQQVVHWDRQLPGVSHDRadrLLDLYASGerraYGPPFLRDRVSVNTNaFA 247
Cdd:pfam07686   4 REVTVALGGSVTLPC-----TYSSSM-SEASTSVYWYRQPPGKGPTF---LIAYYSNG----SEEGVKKGRFSGRGD-PS 69

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 568932016  248 RGDFSLRIDELERADEGIYSCHLHHHYCGlHERRVFHLQVT 288
Cdd:pfam07686  70 NGDGSLTIQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IGv smart00406
Immunoglobulin V-Type;
199-268 3.42e-08

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 50.46  E-value: 3.42e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016   199 QVVHWDRQLPGvshdRADRLLdLYASGERRAYGPPFLRDRVSVNTNaFARGDFSLRIDELERADEGIYSC 268
Cdd:smart00406  16 YYVSWVRQPPG----KGLEWL-GYIGSNGSSYYQESYKGRFTISKD-TSKNDVSLTISNLRVEDTGTYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 41-153 9.09e-08

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 50.15  E-value: 9.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016   41 AAGTQAVLRCQ-SPRMVWTQDRlhdrqrvVHWDLsGGPGSQRRRLVDMYSAGEQrVYEPRDRDRLLLSPSafhDGNFSLL 119
Cdd:pfam07686   9 ALGGSVTLPCTySSSMSEASTS-------VYWYR-QPPGKGPTFLIAYYSNGSE-EGVKKGRFSGRGDPS---NGDGSLT 76

                          90       100       110
                  ....*....|....*....|....*....|....
gi 568932016  120 IRAVDRGDEGVYTCNLHHHYCHlDESLAVRLEVT 153
Cdd:pfam07686  77 IQNLTLSDSGTYTCAVIPSGEG-VFGKGTRLTVL 109
IgV_B7-H3 cd20934
Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint ...
 43-133 1.51e-04

Immunoglobulin Variable (IgV) domain of B7-H3, a member of the B7 family of immune checkpoint molecules; The members here are composed of the immunoglobulin variable (IgV) domain of B7-H3 also known as CD276), a member of the B7 family of immune checkpoint molecules. B7-H3 is an important immune checkpoint member of the B7 family and shares homology with other B7 ligands such as programmed death ligand 1 (PD-L1). The B7 family molecules interact with CD28 on T-cells to provide co-stimulatory signals that regulate T-cell activation and T-helper cell differentiation. Although B7-H3 has been shown to have both co-stimulatory and co-inhibitory effects on T-cell responses, the most current studies describe B7-H3 as a T cell inhibitor that promotes tumor aggressiveness and proliferation. Moreover, B7-H3 is highly overexpressed on a wide range of human solid cancers and promotes tumor growth, metastasis, and drug resistance. Thus, B7-H3 expression in tumors often correlates with both negative prognosis and poor clinical outcome in cancer patients. B7-H3 protein contains a predicted signal peptide, V- and C-like Ig domains (IgV and IgC), a transmembrane region, and an intracellular tail.


Pssm-ID: 409528  Cd Length: 115  Bit Score: 41.05  E-value: 1.51e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568932016  43 GTQAVLRCQ-SPRMVWTQdrlhdRQRVVHWDLSggpgsQRRRLVDMYSAGE--QRVYEPRDRDRLLLSPSAFHDGNFSLL 119
Cdd:cd20934   12 GTDATLRCSfSPEPGFSL-----AQLSVFWQLT-----DTKQLVHSFTESQdqGRDQGSAYANRTALFPDLLAQGNASLR 81

                         90
                 ....*....|....
gi 568932016 120 IRAVDRGDEGVYTC 133
Cdd:cd20934   82 LQRVRVADEGSYTC 95
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 213-268 1.55e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.20  E-value: 1.55e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568932016 213 DRADRLLDLYASGerRAYGP--PFLRDRVSVNTNaFARGDFSLRIDELERADEGIYSC 268
Cdd:cd20960   44 DKVEKVVITYSGD--RVYNHyyPALKGRVAFTSN-DLSGDASLNISNLKLSDTGTYQC 98
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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