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Conserved domains on  [gi|568935150|ref|XP_006534769|]
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ecto-ADP-ribosyltransferase 3 isoform X1 [Mus musculus]

Protein Classification

ADP-ribosyltransferase family protein( domain architecture ID 1014)

ADP-ribosyltransferase family protein similar to mono (ADP-ribosyl) transferases, which exist in vertebrates and transfer ADP-ribose to arginine

CATH:  3.90.176.10
Gene Ontology:  GO:0016779

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
VIP2 super family cl00173
VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative ...
29-251 3.35e-69

VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of biological pathways distinct from classical A-B toxins. A novel family of insecticidal ADP-ribosyltransferses were isolated from Bacillus cereus during vegetative growth, where VIP1 likely targets insect cells and VIP2 ribosylates actin. VIP2 shares significant sequence similarity with enzymatic components of other binary toxins, Clostridium botulinum C2 toxin, C. perfringens iota toxin, C. piroforme toxin, C. piroforme toxin and C. difficile toxin.


The actual alignment was detected with superfamily member pfam01129:

Pssm-ID: 469640  Cd Length: 222  Bit Score: 216.93  E-value: 3.35e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150   29 LDMAENAFDDEYLKCKSRMESKyIPQMKREEWANDALLRMVWDNAEIQWEARKAQLFLPRNFKDTYGIALTAYVNEAQeq 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAK-APLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSSP-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150  109 tsFYHTFSSAVKMAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEKSYKtvVYSTSPDISFTFGEQN-QARLGNFTLAY 187
Cdd:pfam01129  78 --LYRLFNEAVREAGRSREDYIGNFHFKALHFYLTRALQLLRQSYQPCHQ--VYRGVKGTRFTYTGPGkSVRFGQFTSSS 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568935150  188 SAKPETA--DNQRVLTIQTCFGVAVGKFLNKEDDSVVLIPLSEVFQV---SRKGTSNDLVLQSINSTCS 251
Cdd:pfam01129 154 LHKQVAEffGQDTLFIIKTCLGVPIKPFSFFPSEDEVLIPPFEVFQVtgfSRTQGYNHIDLDSIGKTSS 222
 
Name Accession Description Interval E-value
ART pfam01129
NAD:arginine ADP-ribosyltransferase;
29-251 3.35e-69

NAD:arginine ADP-ribosyltransferase;


Pssm-ID: 279473  Cd Length: 222  Bit Score: 216.93  E-value: 3.35e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150   29 LDMAENAFDDEYLKCKSRMESKyIPQMKREEWANDALLRMVWDNAEIQWEARKAQLFLPRNFKDTYGIALTAYVNEAQeq 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAK-APLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSSP-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150  109 tsFYHTFSSAVKMAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEKSYKtvVYSTSPDISFTFGEQN-QARLGNFTLAY 187
Cdd:pfam01129  78 --LYRLFNEAVREAGRSREDYIGNFHFKALHFYLTRALQLLRQSYQPCHQ--VYRGVKGTRFTYTGPGkSVRFGQFTSSS 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568935150  188 SAKPETA--DNQRVLTIQTCFGVAVGKFLNKEDDSVVLIPLSEVFQV---SRKGTSNDLVLQSINSTCS 251
Cdd:pfam01129 154 LHKQVAEffGQDTLFIIKTCLGVPIKPFSFFPSEDEVLIPPFEVFQVtgfSRTQGYNHIDLDSIGKTSS 222
 
Name Accession Description Interval E-value
ART pfam01129
NAD:arginine ADP-ribosyltransferase;
29-251 3.35e-69

NAD:arginine ADP-ribosyltransferase;


Pssm-ID: 279473  Cd Length: 222  Bit Score: 216.93  E-value: 3.35e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150   29 LDMAENAFDDEYLKCKSRMESKyIPQMKREEWANDALLRMVWDNAEIQWEARKAQLFLPRNFKDTYGIALTAYVNEAQeq 108
Cdd:pfam01129   1 LDMAPNAFDDQYLGCVDRMEAK-APLLLKEEFAMNQALAVSWEQAKKRWQERKALLSLPMGFKDDHGIALLAYTSSSP-- 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568935150  109 tsFYHTFSSAVKMAGLSRRRYIYNFPFKAFHFYLVRALQLLRRPCEKSYKtvVYSTSPDISFTFGEQN-QARLGNFTLAY 187
Cdd:pfam01129  78 --LYRLFNEAVREAGRSREDYIGNFHFKALHFYLTRALQLLRQSYQPCHQ--VYRGVKGTRFTYTGPGkSVRFGQFTSSS 153
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 568935150  188 SAKPETA--DNQRVLTIQTCFGVAVGKFLNKEDDSVVLIPLSEVFQV---SRKGTSNDLVLQSINSTCS 251
Cdd:pfam01129 154 LHKQVAEffGQDTLFIIKTCLGVPIKPFSFFPSEDEVLIPPFEVFQVtgfSRTQGYNHIDLDSIGKTSS 222
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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