NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|568973131|ref|XP_006532998|]
View 

sphingosine-1-phosphate transporter SPNS2 isoform X2 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 13023647)

spinster family major facilitator superfamily (MFS) transporter may function as a sphingolipid transporter that plays a central role in endosome and/or lysosome storage

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 106-448 2.43e-157

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 457.47  E-value: 2.43e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340
                 ....*....|....*....|...
gi 568973131 426 YICIFVGETLLFSNWAITADILM 448
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILL 334
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 106-448 2.43e-157

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 457.47  E-value: 2.43e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340
                 ....*....|....*....|...
gi 568973131 426 YICIFVGETLLFSNWAITADILM 448
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILL 334
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
95-448 6.39e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 124.21  E-value: 6.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350
                 ....*....|....*....|....*....|....
gi 568973131 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILM 448
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAA 297
MFS_1 pfam07690
Major Facilitator Superfamily;
108-450 2.63e-28

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 116.36  E-value: 2.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340
                  ....*....|....*....|....
gi 568973131  427 ICIFVGETLLFSNWAITADILMGE 450
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPK 322
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 110-453 5.27e-19

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 89.70  E-value: 5.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568973131  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILMGEPAG 453
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNAPGNIAG 346
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
126-328 6.46e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 45.68  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLlvlsRGLV 203
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQtiDQLIYM----RFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAiPLgsgLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILI 279
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIA-PL---LAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFF 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973131 280 LVPATkrgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 165 FIPET---LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208
 
Name Accession Description Interval E-value
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 106-448 2.43e-157

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 457.47  E-value: 2.43e-157
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17328    2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV 265
Cdd:cd17328   82 SFAP--NFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 266 SPVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQV 345
Cdd:cd17328  160 TGVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFILSTLGFTAVSFVTGALAFWAPTFFLRAFG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 346 VqktaetcnSPPCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGA 425
Cdd:cd17328  240 V--------GDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKTPRADPLVCAVGLLAAAPFLFLALVLALSNLLLA 311

                        330       340
                 ....*....|....*....|...
gi 568973131 426 YICIFVGETLLFSNWAITADILM 448
Cdd:cd17328  312 WVLLFLGEFLLSLNWAPVFAILL 334
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
95-448 6.39e-31

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 124.21  E-value: 6.39e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 175 IFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2271   82 LLLWGLATLLFGFAT--SFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 255 AAGdWHWALRVSPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnrsyvfsSLATSAVSFATGALGM 334
Cdd:COG2271  160 AFG-WRAAFLILGLPGLLLALLRFWLL-------------------------------------ALAYFLVYFALYGFLT 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 335 WIPLYLHRAQVVqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAgatrWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2271  202 WLPTYLVEVRGL------------SLAQAGLLLSLPFLAGIVGSLLGG----WLSDRLGRRRKLVLAIGLLLAALALLLL 265

                        330       340       350
                 ....*....|....*....|....*....|....
gi 568973131 415 FVAakTSIVGAYICIFVGETLLFSNWAITADILM 448
Cdd:COG2271  266 ALL--PSPALAIALLFLAGFGLGGAFGLLWALAA 297
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
95-425 2.14e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 122.39  E-value: 2.14e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  95 ASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCG 174
Cdd:COG2814    2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 175 IFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:COG2814   82 LLLFALGSLLCALAPS--LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLAD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 255 AAGdWHWALRVSPVLGMITGTLILILVPATKRghadqlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGM 334
Cdd:COG2814  160 LFG-WRWVFLVNAVLALLALLLLLRLLPESRP----------AARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFT 228

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 335 WIPLYLHraqvvqktaETCNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLI 414
Cdd:COG2814  229 YLPLYLQ---------EVLGLSASAA--GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLW 297

                        330
                 ....*....|.
gi 568973131 415 FVAAKTSIVGA 425
Cdd:COG2814  298 LLLLALFLLGF 308
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 108-453 1.01e-29

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 120.99  E-value: 1.01e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG-DWHWALRVS 266
Cdd:cd06174   81 APS--FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGfGWRAVFLIA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 267 PVLGMITGTLILILVPATKrgHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRaqvv 346
Cdd:cd06174  159 AALALLAAILLLLVVPDPP--ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLD---- 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 347 qktaetcnsppCGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:cd06174  233 -----------LGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL 301

                        330       340
                 ....*....|....*....|....*..
gi 568973131 427 ICIFVGETLLFSNWAITADILMGEPAG 453
Cdd:cd06174  302 LLGFGLGGLLPLSFALIAELFPPEIRG 328
MFS_1 pfam07690
Major Facilitator Superfamily;
108-450 2.63e-28

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 116.36  E-value: 2.63e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  108 LSLGNVLNYLDRYTVAGVL-LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALpLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:pfam07690  81 FASS--LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG-WRAAFLIL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  267 PVLGMITGTLILILVPATKRGHADQLGGQLKARTSWLRDmkalIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKA----LLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLS 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  347 QKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRadpLVCAVGMLGSAIFICLIFVAAKTSIVGAY 426
Cdd:pfam07690 234 ALLA------------GLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLL---LALLLLILAALGLLLLSLTLSSLWLLLAL 298

                         330       340
                  ....*....|....*....|....
gi 568973131  427 ICIFVGETLLFSNWAITADILMGE 450
Cdd:pfam07690 299 LLLGFGFGLVFPALNALVSDLAPK 322
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 131-446 4.28e-25

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 107.28  E-value: 4.28e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17325   24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS--YWQLLLARFLQGLASAAV 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVPATKRGHAD 290
Cdd:cd17325  102 WPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPRPPPNK 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 291 QLGGQLKARTSwlrdMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETCnsppcgakdSLIFGAIT 370
Cdd:cd17325  181 RAVSAARLRSG----LRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYA--AELGGLSPAQI---------GLLFGAQG 245

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568973131 371 CFTGFLGVVTGAGATRWCRLRtqradplVCAVGMLGSAI-FICLIFVAAKTSIVGAYICIFVGETLLFSNW-AITADI 446
Cdd:cd17325  246 LASALSQPPAGKLSDRIGRKP-------LILIGLLLSAVaLLLLPLATSFWLLLLLLALLGLGLGLVFPATlALLADI 316
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 94-384 1.21e-21

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 95.65  E-value: 1.21e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:COG0477    5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 174 GIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVK 253
Cdd:COG0477   85 GLLLFGLASLLCGLAPS--PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 254 QAAGdWHWALRVSPVLGMItGTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALG 333
Cdd:COG0477  163 AALG-WRWIFLINAPLGLL-ALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALL 240

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 568973131 334 MWIPLYLHRAQVVQKTAETCNSPPCGAKDSLIFGAITCFTGFLGVVTGAGA 384
Cdd:COG0477  241 LLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLL 291
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 106-453 6.98e-21

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 94.56  E-value: 6.98e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17319    6 PLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALT 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWHWALRV 265
Cdd:cd17319   86 GFA--TSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWL-LLLFGWRWAFII 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 266 SPVLGMITGTLILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLHRAqv 345
Cdd:cd17319  163 EGLLGLLLAVLWWFYL-------------------------------RQVWGLALGYFGINYALYGLLTWLPTYLKQA-- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 346 vqktaetcnsppcGAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAakTSIVGA 425
Cdd:cd17319  210 -------------RGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLLAYLT--TSPVVA 274

                        330       340       350
                 ....*....|....*....|....*....|..
gi 568973131 426 YICIFVGETLLFSN----WAITADILMGEPAG 453
Cdd:cd17319  275 VILLSLAGFGIGAAspvfWSLPADLLPGEAAA 306
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 107-342 4.49e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 92.23  E-value: 4.49e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 107 ILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS 186
Cdd:cd17324    3 ALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 187 FIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVS 266
Cdd:cd17324   83 LAPS--FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLG-WRAAFLAI 159

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973131 267 PVLGMITGTLILILVPATKRGHADQLGgqlkartsWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHR 342
Cdd:cd17324  160 AVLALLAALLLWRLLPSLPPKKPGSLG--------LLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTD 227
2A0114 TIGR00893
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ...
 110-453 5.27e-19

D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273326 [Multi-domain]  Cd Length: 399  Bit Score: 89.70  E-value: 5.27e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:TIGR00893   1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFA- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGY-ITGSSVkqAAGDWHWALRVSPV 268
Cdd:TIGR00893  80 -GAYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGpLVGWIL--IHFSWQWAFIIEGV 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  269 LGMITGTLILILVP----------------ATKRGHADQLGGQlkARTSWLRDMKALIRNRSYVFSSLATSAVSFATGAL 332
Cdd:TIGR00893 157 LGIIWGVLWLKFIPdppqkakwlteeekyiVVGGLLAEQQGKG--PSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFF 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  333 GMWIPLYLHRAQVVQktaetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQR---ADPLVCAVGMLGS-A 408
Cdd:TIGR00893 235 LTWFPTYLVQERGLS------------ILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSlvfARKTAIIAGLVLSlL 302

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568973131  409 IFICLIFVAAKTSIVGAYICIFvGETLLFSNWAITADILMGEPAG 453
Cdd:TIGR00893 303 MFATNYVNIPYAALALVALGFF-GLGAGAIGWALISDNAPGNIAG 346
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
99-431 2.69e-17

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 84.16  E-value: 2.69e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  99 RGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW 178
Cdd:COG2223    1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 179 SAVTFSSSFIPQqyFWLLVLSRGLVGIGE-ASYSTIAPTiIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG 257
Cdd:COG2223   81 GIGLLLLALAVS--YWLLLLLGLLLGIGGgGSFAVGIAL-VSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 258 dWHWALRVSPVLGMITGTLILILVPATKRGHADqlggqlKARTSwLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIP 337
Cdd:COG2223  158 -WRNAFLILGILLLVVAVLAWLFLRDPPAGAAA------AAKAS-LRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 338 LYLH-RAQVVQKTAetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLRTqradplvcAVGMLGSAIFICLIFV 416
Cdd:COG2223  230 PYLVdQFGLSAATA------------GLLAALFALLGALGRPLGGWLSDRIGGRRV--------LLIVFALMALGLLLLA 289

                        330
                 ....*....|....*
gi 568973131 417 AAKTSIVGAYICIFV 431
Cdd:COG2223  290 LALGSLWLFLVLFLL 304
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 106-432 1.72e-16

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 81.45  E-value: 1.72e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17380    2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPQQYFWLLVLSRGLVGIGEA-SYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17380   82 PLLAYSSLPLLILSRILLGLGEGvHFPSMT-SLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFY 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 265 VSPVLGMITGTLILILVPATkrghadqlggqlkartsWlrdmkALIrnrsyvfssLATSAVSFATGALGMWIPLYLHRAQ 344
Cdd:cd17380  160 FFGLLGLLWALVWLIYLPPV-----------------W-----AII---------VAHFCMNWGFYILLSWLPTYFHEVL 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 345 VVQktaetcnsppcgaKDSLIFGAITCFTGFL-GVVTGAGATRWC--RLRTQRADPLVCAVGMLGSAifICLIFVAAKTS 421
Cdd:cd17380  209 VPL-------------AKGWVFNVVPWLVMFPsSNVAGWLADHLIsrGWTVTSVRKLMQSIGFLGPA--LFLLLLSHTDS 273

                        330
                 ....*....|.
gi 568973131 422 IVGAYICIFVG 432
Cdd:cd17380  274 FSLALLCMSVA 284
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 107-431 6.15e-15

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 76.49  E-value: 6.15e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 107 ILSLGNVLNYLDRYTVAGVLLDIQQHF--GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17316    3 LAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWhWALR 264
Cdd:cd17316   83 IGLLPT--PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSGD-WGWR 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 265 VSPVLGMITGTLILilvpatkrghadqlggqlkartsWLRdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLhraq 344
Cdd:cd17316  160 ILFLIGALPALLAL-----------------------LLR--------RRTLLLILLWFFISFGYYGLTTFLPTYL---- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 345 vvqktAETCNSPPcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQradplvcAVGMLGSAIFICLIFVAAKTSIVG 424
Cdd:cd17316  205 -----QTVLGLSP--ATSSLYLLLISLGALVGALIAGLLSDRIGRKKTL-------VIGLILSGILALPLFYLLSGSPTL 270


                 ....*..
gi 568973131 425 AYICIFV 431
Cdd:cd17316  271 LLLLLFI 277
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
121-432 2.86e-14

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 74.89  E-value: 2.86e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSR 200
Cdd:COG0738   26 LWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS--YPLLLLAL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMlSVFYFAIPLGSGLGYITGSSV--KQAAGDWHWALrvspvlgMITGTLIL 278
Cdd:COG0738  104 FLLGLGLGLLDVAANPYVAALGPETAASRL-NLLHAFFSLGALLGPLLGGLLilLGLSLSWHLPY-------LILAVLLL 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 279 ILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQvvqktaetcnsppc 358
Cdd:COG0738  176 LLALLFLRSKLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVL-------------- 241

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973131 359 GAKDSLIFGAITCFTG--FLGVVTGAGATRWCRLRTqradplVCAVGMLGSAIFIcLIFVAAKTSIVGAYICIFVG 432
Cdd:COG0738  242 GLSEATAALGLSLFWGgmTIGRFLGGFLLKRFGPVR------LLRLSALLAAVGL-LLALLAPGPWLALIGLALVG 310
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 102-342 3.96e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 74.14  E-value: 3.96e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 102 GAAAAILSLGNVLnyldrytVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAV 181
Cdd:cd17474    5 FFATLLAVLGVSI-------VDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 182 TFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHW 261
Cdd:cd17474   78 GLLCGLSDS--FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLL--AAISWRY 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 262 ALRVSPVLGMITGTLILILVPATKRghadqlgGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLH 341
Cdd:cd17474  154 PFFLLAALIPVAFLAILFLLPEPKE-------KAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLE 226


                 .
gi 568973131 342 R 342
Cdd:cd17474  227 L 227
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 121-304 7.36e-14

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 73.38  E-value: 7.36e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 121 TVAGVLLDIQQHF-GVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLS 199
Cdd:cd17473   17 AIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDS--LYALLAS 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 200 RGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkqAAGDWHWalrvsPVLGMITGTLILI 279
Cdd:cd17473   95 RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL--AEIGWRA-----PFLVYLLALPVLI 167

                        170       180       190
                 ....*....|....*....|....*....|.
gi 568973131 280 LV------PATKRGHADQLGGQLKARTSWLR 304
Cdd:cd17473  168 LVllflpePARKSKSAASPGAATAAALPWKR 198
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
87-425 6.34e-13

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 70.67  E-value: 6.34e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  87 PSAPQPKPASLGRGRGAAAAILSLGNVLnyldRYTVAGV---LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGD 163
Cdd:COG2807    3 TTSSSARRSRRAGRWLLLLAIVLVALNL----RPAITSVgplLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 164 RFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSG 243
Cdd:COG2807   79 RFGLERTLLLALLLLAAGLLLRSLAPS--VALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAA 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 244 LGYITGSSVKQAAGdWHWALRVSPVLGMITgtlILILVPATKRGHADQlggqlkARTSWLRDMKALIRNRSYVFSSLATS 323
Cdd:COG2807  156 LAAGLTVPLAAALG-WRGALAVWALLALLA---LLLWLPLLRRRPAAA------AAAPAAASLRSLWRSPLAWLLTLFFG 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 324 AVSFATGALGMWIPLYLHRAQVVQKTAetcnsppcgakdslifGAITCFTGFLGVVTGAGATRWC-RLRTQRadPLVCAV 402
Cdd:COG2807  226 LQSLLYYAVVAWLPPILRDAGLSAATA----------------GLLLSLFQLAGIPGSLLVPLLAdRLGDRR--PLLLLL 287

                        330       340
                 ....*....|....*....|...
gi 568973131 403 GMLGSAIFICLIFVAAKTSIVGA 425
Cdd:COG2807  288 GLLGLAGLLGLLLAPGSLPWLWA 310
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
80-299 2.83e-12

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 69.16  E-value: 2.83e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  80 CAAAAKGPSAPQPKPASLGRGRGAAAA-----ILSLGNVLNYLDRYTVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMV 153
Cdd:COG2211  200 TFFGTKERPVPEEEKVSLKESLKALLKnrpflLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALL 279

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 154 AAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL-------FTKNT 226
Cdd:COG2211  280 GAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVvdydewkTGRRR 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 227 RTLMLSVFYFAIPLGSGLGYITGSSVKQAAG---------DWHWALRVS----PVLGMITGTLILILVPATKRGHAdQLG 293
Cdd:COG2211  360 EGLYFGIFTFAIKLGQALAGALAGLLLALFGyvagaaqspSALTGIRLLffllPAVLLLLAALLLLFYPLTRERHA-EIR 438


                 ....*.
gi 568973131 294 GQLKAR 299
Cdd:COG2211  439 AELAAR 444
Sugar_tr pfam00083
Sugar (and other) transporter;
104-282 8.74e-12

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 67.68  E-value: 8.74e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  104 AAAILSLGNVLNYLDRYTVAGV--LLDIQQHFGVKDR-----GAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILS 172
Cdd:pfam00083   1 VALVAALGGFLFGYDTGVIGAFltLIDFFKNFGLSKSvsslaALSVLSGLIVSIFSVGCFIgslfAGKLGDRFGRKKSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  173 CGIFFWSAVTFSSSFIPQQY-FWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSS 251
Cdd:pfam00083  81 IANVLFVIGAVLQGAAKGKWsVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGLG 160

                         170       180       190
                  ....*....|....*....|....*....|.
gi 568973131  252 VKQAAGDWHWalRVSPVLGMITGTLILILVP 282
Cdd:pfam00083 161 LNKTSNSDGW--RIPLGLQLVPALLLIIGLL 189
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 123-282 9.35e-12

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 67.22  E-value: 9.35e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGL 202
Cdd:cd17323   19 SPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPN--IAMLIILRFL 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 203 VGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17323   97 QGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLG-WRWIFWFLAIISGFCLILIFLFLP 175
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 108-322 1.66e-11

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 66.04  E-value: 1.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 108 LSLGNVLNylDRYT--VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17478    1 LSLGHFLN--DFYQgfLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLL 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNtRTLMLSVFYFAIPLGSGLGYITGSSVKQaagdwHWALRV 265
Cdd:cd17478   79 GFAPN--YWLLLLLVALAGIGSAAFHPEGARLASQAAGGR-RGLAMSIFSVGGNLGFALGPLIAAALVA-----LFGGLG 150

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973131 266 SPVLGMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIR------NRSYVFSSLAT 322
Cdd:cd17478  151 LLILLIIPGLAVALLllrLRPLKKPEAKKAAAKSSARSTLKGVWRALLLlliivfLRSWVLSSLTT 216
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 110-340 2.53e-11

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 65.86  E-value: 2.53e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:TIGR00881   2 IGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFST 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVL 269
Cdd:TIGR00881  82 S--LWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGII 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  270 GMITGTLILILV---PATK----------RGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWI 336
Cdd:TIGR00881 160 AIIVSLICFLLLrdsPQSCglppaeempnEEPDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWS 239


                  ....
gi 568973131  337 PLYL 340
Cdd:TIGR00881 240 PLYL 243
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 153-439 6.56e-11

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 64.56  E-value: 6.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 153 VAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS 232
Cdd:cd17329   50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHS--PWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFS 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 233 VFYFAIPLGSGLGYITGSSVKQAAGDW-HWALRVSPVLGMItgtLILILVPATKRGHADQlggqlkARTSWLRDMKALIR 311
Cdd:cd17329  128 LLYWAINLGVAIGPLLGGLLLLYSFRLlFLAAAVLFLLAAL---VLLFLLPETRPKRRAA------EKTEILRGYKIVLR 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 312 NRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVQktaetcnsppcgakdSLIFGAITCFTGFLGVVTGAGATRWCRLR 391
Cdd:cd17329  199 DRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLG---------------ESLLGLLLALNALLIVLLQFPVARLVERF 263

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 568973131 392 TQRADPLVCAVGMlgSAIFICLIFVAAKTSIVGAYICIFVGETLLFSN 439
Cdd:cd17329  264 RLRKILMIGILLF--AIGFAVLAFANTLAVLILAMIVLTLGEMLVFPA 309
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 122-277 6.60e-11

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 64.52  E-value: 6.60e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRG 201
Cdd:cd17504   15 LSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN--LPVLIAGRA 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973131 202 LVGIGEASYsTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLI 277
Cdd:cd17504   93 LQGIGGAVF-PLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLG-WRWIFWTAAPVAVLLAALV 166
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 131-339 9.38e-11

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 63.77  E-value: 9.38e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASY 210
Cdd:cd17489   24 HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS--VALLLVLRLIHGIGWGAF 101

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 211 STIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdwHWALRVSPVLGMITGTLILILVPATKRGHad 290
Cdd:cd17489  102 TTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLG--FAVLFIVAAVLALLALLLVFLVKDPPPVA-- 177

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973131 291 qlggqlKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLY 339
Cdd:cd17489  178 ------AEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLY 220
OATP pfam03137
Organic Anion Transporter Polypeptide (OATP) family; This family consists of several ...
 129-416 9.45e-11

Organic Anion Transporter Polypeptide (OATP) family; This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins are also considered to be OATP family members. In addition, the methotrexate transporter OATK is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.


Pssm-ID: 460821 [Multi-domain]  Cd Length: 526  Bit Score: 64.53  E-value: 9.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAvtfsSSFI---PqqYFWLLVLSRGLVGI 205
Cdd:pfam03137  27 IEKRFGLPSSLSGLISSSYDIGNLLLIVFVSYFGGKGHRPRWIGVGALLMGL----GSLLfalP--HFLSFFLGQLLLGI 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  206 GEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWH-WALRVSPV---------LGMITGT 275
Cdd:pfam03137 101 GGTPIYTLGISYIDDNVKKKNSPLYLGILYAVRVLGPALGFLLGSLCLRIYVDIGkVSITLTPKdprwvgawwLGFLIAG 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  276 LILILV------------------------PATKRGHADQLGGQLKARTSWLRD----MKALIRNRSYVFSSLATsaVSF 327
Cdd:pfam03137 181 LLLLLTaipffffpkslpgaakrrakkkkePHSQDIADLKKTKSLKKLGPSLKDfpkaLKRLLKNPVYMLLTLAS--VFE 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  328 ATGALGMWI--PLYLhrAQVVQKTAetcnsppcgAKDSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGML 405
Cdd:pfam03137 259 FLLIAGYATflPKYI--ETQFGLSA---------STANLLTGVVAIPGAALGILLGGLIIKKFKLSAKGLAKFNVITSLV 327

                         330
                  ....*....|.
gi 568973131  406 GSAIFICLIFV 416
Cdd:pfam03137 328 SLLLSLLLFFL 338
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 127-281 1.08e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 63.75  E-value: 1.08e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 127 LDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17325  224 LYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATS--FWLLLLLLALLGLG 301

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 568973131 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILILV 281
Cdd:cd17325  302 LGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFG-FATPFLAAAALLLLAAVLFLLLR 375
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 121-432 9.68e-10

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 60.80  E-value: 9.68e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 121 TVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFfwsaVTFSSSFIPQQYFWLLVL 198
Cdd:cd17333   14 LLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRrtLILGLLLI----SLALALIFATPSIYLFVV 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 199 SRGLVGIGEASYSTIAPTIIGDLFtKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALrvspvlgMITGTLIL 278
Cdd:cd17333   90 LMFLAGLGAGILDTGANTFVGALF-EESSATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAY-------LIIGLIYL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 279 ILVPATKRGHADQLGG---QLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcns 355
Cdd:cd17333  162 LLAILILLTLFPELPSarnPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSSWVPSYLVEKKHV--------- 232

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973131 356 ppcGAKDSLIFGAITCFTGFLGVVTGAGATRwcrlrtqRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAYICIFVG 432
Cdd:cd17333  233 ---SDGLAGYLLSGFWVGITIGRLLGGPISR-------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLG 299
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 108-463 1.04e-09

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 60.65  E-value: 1.04e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSF 187
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 188 IPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSP 267
Cdd:cd17321   81 APS--LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFG-WRWIFLINV 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 268 VLGMItgtlILILVpatkrghadqlggqlkartswlrdmkalirnRSYVFSSLATSAVSFATGALGMWIPLYLhraQVVQ 347
Cdd:cd17321  158 PIGLV----ALLLA-------------------------------RTFSGAVLAAFLLGAALGGLLFLLPLYL---QGVL 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 348 ktaetcNSPPCGAkdSLIFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIficLIFVAAKTSIVGAYI 427
Cdd:cd17321  200 ------GYSPLQA--GLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLLLLAL---LGADSSVWLLLPGLV 268

                        330       340       350
                 ....*....|....*....|....*....|....*....
gi 568973131 428 CIFVGETLLFSnwAITADILMGEP---AGDASCIRESLR 463
Cdd:cd17321  269 LLGLGLGLFAT--PLTNAALSSVPkekAGAASGILNTAR 305
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 122-286 3.70e-09

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 58.82  E-value: 3.70e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 122 VAGVLLDIQQHFGVKDRGAG---LLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSSSfipqQYFWLL 196
Cdd:cd17360   16 ISGALLYIKDDLGEVVLSTGwqeLIVSSTVAGAAVGAAIGGWLNDRFGRRpcILLADALFTIGAIVMAAA----PNKEVL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTL 276
Cdd:cd17360   92 IVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIG 171

                        170
                 ....*....|
gi 568973131 277 ILILvPATKR 286
Cdd:cd17360  172 LLFL-PESPR 180
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 140-286 7.89e-09

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 57.59  E-value: 7.89e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIpQQYFWLLVLSRGLVGIGeASYSTIAPTIIG 219
Cdd:cd17330   36 VGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAG-SAVSYVLLGL-SRNLWLLFLARFLDGLT-GGNVSVAQAYIA 112

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973131 220 DLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVLGMITGTLILILVPATKR 286
Cdd:cd17330  113 DITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGY-ALPFLVAAALALLNLVLVLFFLPPLRR 178
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 144-250 1.28e-08

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 56.82  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17317   31 QTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP--SYELFLVLRFLVGVTSAGIFTVGFVLGMEIVG 108

                         90       100       110
                 ....*....|....*....|....*....|.
gi 568973131 224 KNTRTLMLSVFYFAIPLG----SGLGYITGS 250
Cdd:cd17317  109 PKYRSFVGILFGLFWALGymllALLAYLIRD 139
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 108-284 1.28e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 57.21  E-value: 1.28e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 108 LSLGNVLNYLDRY--TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17365    1 LALCFLIIVLDGFdlAVMGFVApALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALr 264
Cdd:cd17365   81 TAFAQS--VLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFG-WRSVF- 156

                        170       180
                 ....*....|....*....|
gi 568973131 265 vspVLGMITGTLILILVPAT 284
Cdd:cd17365  157 ---LLGGVPPLILLPLLRGT 173
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 109-280 1.46e-08

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 57.20  E-value: 1.46e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 109 SLGNVLNYLDRYTVAGVLLDIQQHFGVKdrGAGLLQSVFICSFMVAAPI----FGYLGDRFNRKVILSCGIFFWSAVTFS 184
Cdd:cd17315    3 ALGGLLFGYDLGVINGALLYIAKDLGFG--LSTSLQGLVVSSLLLGAAIgslfGGPLADRFGRRKSLLIAAVLYVIGALL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 185 SSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ-AAGDWHWAL 263
Cdd:cd17315   81 SALAPN--VWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGLALSLsPPGWWRLMF 158

                        170
                 ....*....|....*..
gi 568973131 264 RVSPVLGMITGTLILIL 280
Cdd:cd17315  159 ALAAVPALLQLLLMFFL 175
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 124-250 1.81e-08

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 56.86  E-value: 1.81e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 124 GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFwSAVTFSSSFIPQqyfwLLVLSRGLV 203
Cdd:cd17336   24 STITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSIL-MGLGCFLLALPH----FLFVGQFLL 98

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 568973131 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17336   99 GIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGS 145
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
83-244 1.83e-08

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.52  E-value: 1.83e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  83 AAKGPSAPQPKPASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLdiQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLG 162
Cdd:COG2814  190 PAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYL--QEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 163 DRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGS 242
Cdd:COG2814  268 DRFGRRRLLLIGLLLLALGLLLLALAGS--LWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345


                 ..
gi 568973131 243 GL 244
Cdd:COG2814  346 PL 347
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 110-415 2.79e-08

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 56.16  E-value: 2.79e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIp 189
Cdd:cd17371    6 LGWALDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFA- 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 190 qQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDwHWALRVSPVL 269
Cdd:cd17371   85 -QNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPP-EIAWRVLFLL 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 270 GMITGTLILIL---VPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVV 346
Cdd:cd17371  163 GALPALLVLFIrrfVKEPPQWQAARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGL 242

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 347 QktaetcnsppcgAKDSLIFGAITCFTGFLG-VVTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIF 415
Cdd:cd17371  243 S------------FEGSAGYLVVTILGGFLGyLAGGFLADRIGRRNN-------FALFALGSAISILLYF 293
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
152-447 3.13e-08

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 56.45  E-value: 3.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 152 MVAAPIFGYLGDRFNRKV----------ILSCGIFFWsAVTFSSSFIPQQYFWLLVLSRGLVGIG----EASYSTIAPTI 217
Cdd:COG2211   60 AITDPLIGALSDRTRTRWgrrrpwiligAIPLALSFV-LLFTAPDLSPTGKLIYALVTYLLLGLAytlvNIPYSALGAEL 138

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 218 IGDlftKNTRTLMLSVFYFAIPLGSGLGYITGSS-VKQAAGDWHWALRVSPVLGMITGTL-ILILVPATKRGHADQlggq 295
Cdd:COG2211  139 TPD---YEERTRLSSWRFAFAGLGGLLASVLPPPlVAAFGGDAALGYRLTALIFAVLGLLaFLLTFFGTKERPVPE---- 211

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 296 lKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLhrAQVVQKTAETcnsppcgakdSLIFGAITCFTGF 375
Cdd:COG2211  212 -EEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLLYYF--KYVLGLSAAL----------VGLLLALYFLAAL 278

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973131 376 LGV-VTGAGATRWCRLRTqradplvCAVGMLGSAIFICLIFVAAKTSIVGAYICIFV---GETLLFSN-WAITADIL 447
Cdd:COG2211  279 LGApLWPRLAKRFGKKKA-------FIIGLLLAALGLLLLFFLGPGNLWLLLVLAALagiGLGAILVLpWAMLADVV 348
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 140-280 6.78e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 55.41  E-value: 6.78e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTIAPTIIG 219
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP-NYTVFLVF-RLLVGMGIGGIWVQAVVLNT 206

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568973131  220 DLFTKNTRTL--MLSVFYFAIplgsglGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILIL 280
Cdd:TIGR00898 207 EFLPKKQRAIvgTLIQVFFSL------GLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263
MFS_DtpA_like cd17346
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ...
 140-280 1.02e-07

Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340904 [Multi-domain]  Cd Length: 399  Bit Score: 54.50  E-value: 1.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFiCSFMVAAPIF-GYLGDRF--NRKVILSCGIFFwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 216
Cdd:cd17346   42 AASIYGAY-TALVYLTPIIgGWLADKVlgARRTVFIGGILM--ALGYLLLALSPFSVSMLYLGLALIIVGNGLFKPNISS 118

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 568973131 217 IIGDLFTKN--TRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVlGMITGTLILIL 280
Cdd:cd17346  119 LVGKLYDENdpRRDSGFSIFYMGINLGAFLAPLLCGTLGDNYG-YHYGFGLAAV-GMLLGLLIFLL 182
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 74-278 1.23e-07

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.35  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  74 IPSTPGCAAAAKGPSAPQPKPASLGRGRGA-AAAILSLGNVLNYLDRYTVAGVLLD-IQQHFGVKDRGAGLLQSVFICSF 151
Cdd:cd06174  173 VPDPPESARAKNEEASSKSVLKLLKRVLKNpGLWLLLLAIFLVNLAYYSFSTLLPLfLLDLGGLSVAVAGLLLSLFGLAG 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 152 MVAAPIFGYLGDR-FNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSrgLVGIGEASYSTIAPTIIGDLFTKNTRTLM 230
Cdd:cd06174  253 ALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLL--LLGFGLGGLLPLSFALIAELFPPEIRGTA 330

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 568973131 231 LSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLIL 278
Cdd:cd06174  331 FGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 110-281 1.74e-07

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 53.82  E-value: 1.74e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:cd17312   10 LGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFST 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 190 QqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVL 269
Cdd:cd17312   90 S--LWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAAFLVPGIV 166

                        170
                 ....*....|..
gi 568973131 270 GMITGTLILILV 281
Cdd:cd17312  167 GLVVAIILFFFL 178
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
107-286 2.27e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 53.34  E-value: 2.27e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 107 ILSLGNVLNYLDRYTVAGVLLDI-QQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:COG2271  184 LLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRV 265
Cdd:COG2271  264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLL 342

                        170       180
                 ....*....|....*....|.
gi 568973131 266 SPVLGMITGTLILILVPATKR 286
Cdd:COG2271  343 LAALALLAALLALLLLRETRK 363
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 152-304 2.50e-07

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 53.35  E-value: 2.50e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 152 MVAAPIFGYLGDRFNRK-VILSCGIFF---WSAVTFSSSFipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTR 227
Cdd:cd17358   55 LIGALLSGKLADRIGRKrTLLISAIPCilgWLLIAFAKDV------WMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVR 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 228 TLMLSVFYFAIPLGSGLGYITGSSVkqaagdwHWalRVSPVLGMI---TGTLILILVPAT-----KRGHADQLGGQLKar 299
Cdd:cd17358  129 GALGSLNQLLVNIGILLGYVLGSFL-------PW--RTLALIGAIppvVFLILLFFIPESprwlaKKGREEEAEKSLQ-- 197


                 ....*
gi 568973131 300 tsWLR 304
Cdd:cd17358  198 --FLR 200
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 118-328 2.96e-07

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 52.96  E-value: 2.96e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 118 DRYTVAgvLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLV 197
Cdd:cd17320   16 DMYLPA--LPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASS--IEQLL 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 198 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMIT 273
Cdd:cd17320   92 IARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSllmmILAIAPALAPLLG-----GLLLLFFGWRAIFVFLALLGLLL 166

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 568973131 274 GTLILILVPATKRGHAdqlGGQLKARTswLRDMKALIRNR---SYVFSSLATSAVSFA 328
Cdd:cd17320  167 LLLVLLFLPETLPEEK---RKPLLSSL--LRAYKRVLKNRrflGYALALGLSFAGLFA 219
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 122-286 6.15e-07

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 52.18  E-value: 6.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 122 VAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAV--TFSSSFipqqyfWLLV 197
Cdd:cd17359   20 INGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRktLLISAVLFFISALgsAFSPNF------TIFI 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 198 LSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGD-------WHWALRVSPVLG 270
Cdd:cd17359   94 IARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVNYLIANAGGAdwlgaegWRWMLGLEAIPA 173

                        170
                 ....*....|....*.
gi 568973131 271 MITGtLILILVPATKR 286
Cdd:cd17359  174 ILFL-LGMLFIPESPR 188
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
129-289 9.64e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 51.42  E-value: 9.64e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQyFWLLVLSRGLVGIGEA 208
Cdd:COG2223  232 LVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGS-LWLFLVLFLLLGLALG 310

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 209 SYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMItGTLILILVPATKRGH 288
Cdd:COG2223  311 GGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALV-ALVLTLLLYRRPRRA 389


                 .
gi 568973131 289 A 289
Cdd:COG2223  390 A 390
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 103-252 1.69e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 50.62  E-value: 1.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 103 AAAAILSLGNvlnyldrYTVAGVLLDIQQhFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVT 182
Cdd:cd17370  207 LAVALFALGN-------FSFAFLILRAQE-LGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAY 278

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 183 FssSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFaiplGSGLGYITGSSV 252
Cdd:cd17370  279 L--GFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPAELRGTAYGLFNT----VVGIGWLLASLI 342
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 140-257 1.73e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.67  E-value: 1.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIG 219
Cdd:cd17489  229 AGLFFTVYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFA--GSPWMLLLAAVLYGLGFGLLFPALQALAV 306

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 568973131 220 DLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAG 257
Cdd:cd17489  307 DLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFG 344
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 121-456 2.00e-06

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 50.27  E-value: 2.00e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 121 TVAGVLL-DIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKvilscGIFFWSAVTF-SSSFIP--QQYFWLL 196
Cdd:cd17503   13 TIVNVALpTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTR-----RLFLTALALFtLGSLLCglAPNLASL 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 197 VLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMItgtl 276
Cdd:cd17503   88 IIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLS-WRWIFYINLPIGIL---- 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 277 ILILVPatkrghadqlggqlkartswLRDMKALiRNRSYVFSSLATSAVSFATGALGMWIPLYLhraQVVQK-TAETcns 355
Cdd:cd17503  163 ALLLAP--------------------LLDLRLF-KDRNFTLGLLLSFLLGLGLFGAMFLLPLYL---QNVLGySAFE--- 215

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 356 ppcgAKDSLIFGAItcFTGFLGVVTGAgatrwcrlRTQRADP-LVCAVGMLGSAIFICLIFVAAKTS----IVGAYICIF 430
Cdd:cd17503  216 ----SGLVLAPGGL--ASAILSPLVGR--------LLDKFGPrLLLLAGLLLLALGTLLLAFLTPDTslwlIILPLFIRG 281

                        330       340
                 ....*....|....*....|....*.
gi 568973131 431 VGETLLFSnwAITADILMGEPAGDAS 456
Cdd:cd17503  282 LGMGLVFM--PLNTLALNSLPPEQIG 305
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 140-245 2.49e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 2.49e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIG 219
Cdd:cd17316  215 SSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLA 294

                         90       100
                 ....*....|....*....|....*.
gi 568973131 220 DLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:cd17316  295 ELFPTEVRATGVGLSYNLGRLGGGGA 320
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 144-261 2.98e-06

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 49.60  E-value: 2.98e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 144 QSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLVLSRGLVGIGEASYSTIAPTIIGDLFT 223
Cdd:cd17374   41 QSIFMAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPT--FPVYCVLRFLAGFAVSGISINTLILGTEWTT 118

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 568973131 224 KNTRTLM--LSVFYFAIplgsglGYITGSSVKQAAGDWHW 261
Cdd:cd17374  119 PRHRALAitLTSCFFSI------GQMLLAGLAYAIRDWRL 152
MFS_SVOP_like cd17372
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ...
 106-272 1.07e-05

Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340930 [Multi-domain]  Cd Length: 367  Bit Score: 47.91  E-value: 1.07e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 106 AILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGiFFWSAV-TFS 184
Cdd:cd17372    2 AYAGMGWVAEAMEMMLLSFVGPAVQCEWNLSAWQVALITSVVFAGMMIGSYLWGIVSDKYGRRKGLIIS-ALWTFYaGFL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 185 SSFIPqQYFWLLVLsRGLVGIGEASYSTIApTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALR 264
Cdd:cd17372   81 SAFAP-NYMWLIIL-RCLVGLGLGGGPQLA-SWYLEFLPAKSRGTWMVLFSVFWTVGTIFEASLAWLVMPRLG-WRWLLA 156


                 ....*...
gi 568973131 265 VSPVLGMI 272
Cdd:cd17372  157 FSSVPSSL 164
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 94-431 1.13e-05

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 48.12  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131   94 PASLGRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSC 173
Cdd:TIGR00895   8 KQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLW 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  174 GIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLG-SGLGYITGSSV 252
Cdd:TIGR00895  88 SILLFSVFTLLCAL--ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGaAVGGFLAGWLI 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  253 kqAAGDWHWALRVSPVLGMITGTLILILVP----------------------ATKRGHADQLGGQLKARTSWLRDMKALI 310
Cdd:TIGR00895 166 --PVFGWRSLFYVGGIAPLLLLLLLMRFLPesidflvskrpetvrrivnaiaPQMQAEAQSALPEQKSTQGTKRSVFKAL 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  311 ----RNRSYVFSSLATSAVSFATGALGMWIPLYlhraqvvqkTAETCNSPpcgaKDSLIFGAITCFTGFLGVVTGAGAtr 386
Cdd:TIGR00895 244 fqgkTARITVLLWLLYFMLLVGVYFLTNWLPKL---------MVELGFSL----SLAATGGALFNFGGVIGSIIFGWL-- 308

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 568973131  387 wcrlrTQRADPLVCAVGMLGSAIFICLIFvAAKTSIVGAYICIFV 431
Cdd:TIGR00895 309 -----ADRLGPRVTALLLLLGAVFAVLVG-STLFSPTLLLLLGAI 347
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 129-432 1.90e-05

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 47.23  E-value: 1.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFipQQYFWLLVLSRGLVGIGea 208
Cdd:cd17475   22 LQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMAL--VGSYPVLLVLLFLVGAG-- 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 209 sYSTIAPT---IIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILilvpatk 285
Cdd:cd17475   98 -YGSVQPGggrAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYG-WRAAFVVAGLVSILAAVLFW------- 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 286 RGHADQLGGQLKARTS--WLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHRAQVVqktaetcnSPPCGAkds 363
Cdd:cd17475  169 LFYREPPAASAATESAstLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGL--------SVVAAG--- 237

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 364 lIFGAITCFTGFLGVVTGAGATRwcRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGAY-ICIFVG 432
Cdd:cd17475  238 -ALLAVAQLGGALGRIGLGRVSD--RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVlLLILLG 304
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 107-282 1.92e-05

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 47.24  E-value: 1.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 107 ILSLGNVLNYLDRYTVA-GVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSS 185
Cdd:cd17327    9 LLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLT 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 186 SFIpqQYFWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGS--------GLGYITGSSVKQaag 257
Cdd:cd17327   89 AAV--KNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSifggllayGVFKILGVGGLA--- 163

                        170       180
                 ....*....|....*....|....*
gi 568973131 258 DWHWALRVSPVLGMITGTLILILVP 282
Cdd:cd17327  164 GWRWLFIIEGLITIIIGLVIFFWLP 188
MFS_1 pfam07690
Major Facilitator Superfamily;
129-245 3.32e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 46.26  E-value: 3.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP-QQYFWLLVLSRGLVGIGE 207
Cdd:pfam07690 226 YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSlTLSSLWLLLALLLLGFGF 305

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 568973131  208 ASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLG 245
Cdd:pfam07690 306 GLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MFSD6 cd17335
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ...
 131-215 3.67e-05

Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340893 [Multi-domain]  Cd Length: 375  Bit Score: 46.42  E-value: 3.67e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 131 QHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFN-RKVILSCGIFFWSAVTFSSSFIPQQYFWLLVlsrgLVGIGEAS 209
Cdd:cd17335   25 KQLGLSPTQIGILIGIRPFVRFLSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWLLLL----LVILGAFF 100


                 ....*.
gi 568973131 210 YSTIAP 215
Cdd:cd17335  101 SAPVVP 106
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 145-286 3.91e-05

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 46.49  E-value: 3.91e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 145 SVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPqqYFWLLVLSRGLVGIGEASYSTIAPTIIGDL 221
Cdd:cd17357   56 SIFFIGGAIGSFISAFLANRFGRKNGLlisNALLVVSSLLMFLSKSAK--SPELLIFGRFLVGIACGLSTGFVPMYLQEI 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 568973131 222 FTKNTRTLMlSVFY-----FAIPLGSGLG--YITGSSVKqaagdWHWALrVSPVLGMITGTLILILVPATKR 286
Cdd:cd17357  134 SPSELRGAL-GSLTqigvtLGILLGQVFGlpSVLGTETL-----WPYLL-FFPGIPALLQLAALPFFPESPK 198
MFS_SLCO5_OATP5 cd17404
Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of ...
 123-250 4.48e-05

Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 5 (SLCO5) or Organic anion transporting polypeptide 5 (OATP5) family contains only one subfamily, OATP5A, which contains only one mammalian member OATP5A1 (encoded by SLCO5A1). Deletion of the SLCO5A1 gene has been implicated in the pathogenesis of Mesomelia-synostoses syndrome (MSS), a rare autosomal-dominant disorder characterized by mesomelic limb shortening, acral synostoses, and multiple congenital malformations. OATP5A1 may be a non-classical OATP which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration. It seems to affect intracellular transport of drugs and may participate in chemoresistance of small cell lung cancer (SCLC by sequestration), rather than mediating cellular uptake. The SLCO5/OATP5 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340962 [Multi-domain]  Cd Length: 425  Bit Score: 46.19  E-value: 4.48e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 123 AGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyfwLLVLSR 200
Cdd:cd17404   23 NSVITTIEKRYSLKSSESGLIVSSYEIGSLLTVVFVSYFGGRGHRPRWIAVGGVLIAlgSFLFS---LPH----FFILAQ 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 568973131 201 GLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGS 250
Cdd:cd17404   96 ILIGMGGTPIFTLGTTYLDDHVKKESSSLYLAIMYVMGALGPAAGFLLGG 145
MFS_SVOPL cd17442
Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; ...
 151-281 5.26e-05

Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) of the Major Facilitator Superfamily; Synaptic vesicle 2 (SV2)-related protein-like (SVOPL) or SVOP-like protein is a transporter-like protein that shares structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. It belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341000 [Multi-domain]  Cd Length: 375  Bit Score: 45.95  E-value: 5.26e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 151 FMVAAPIFGYLGDRFNRKVILScGIFFWSA-VTFSSSFIPqQYFWLLVLsRGLVGIGEASYSTiAPTIIGDLFTKNTRTL 229
Cdd:cd17442   49 YMVFSILLGLLADRYGRWKILL-LSFVWGAyFSLLTSFAP-SYIWFVFL-RCMVGCGVSGHSQ-GLIIKTEFLPTKYRGY 124

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 568973131 230 ML---SVFYFAiplGSGLGYITGSSVKQAAGdWHWALRVSPVLGmitgtLILILV 281
Cdd:cd17442  125 MLplsQIFWLA---GSLLIIGLASVVIPTLG-WRWLIRFASIPG-----IILIVV 170
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 140-431 5.28e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.07  E-value: 5.28e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL---SCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPT 216
Cdd:cd06173   36 VGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLilaDLLRALLAAVLALLALLGSLSLWLLLVLAFLLGIASAFFGPARQA 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 217 IIGDLFTKNTRT----LMLSVFYFAIPLGSGLGyitgsSVKQAAGDWHWALRVSPVLGMITGTLILILVPATKRghadql 292
Cdd:cd06173  116 LLPELVPKEQLVranaLNSLATQLARIIGPALG-----GLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPA------ 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 293 gGQLKARTSWLRDMKA----LIRNRSYVFSSLATSAVSFATGALGMWIPLYlhraqvvqktaetcnsppcgAKDSLIFGA 368
Cdd:cd06173  185 -APGESSSLLLRDLREglryLRRSPLLRLLLLALALFALLGGALTVLLPLL--------------------AKEVLGGGA 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973131 369 ITcfTGFLGVVTGAGA---TRWC-RLRTQRADPLVCAVGMLGSAIFicLIFVAAKTSIVGAYICIFV 431
Cdd:cd06173  244 AG--YGLLLAAFGVGAllgALLLgRLSKRRRRGRLLLIGALLLGLA--LLVLGLSPSLWLLLAALFL 306
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
126-328 6.46e-05

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 45.68  E-value: 6.46e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 126 LLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLlvlsRGLV 203
Cdd:PRK11102  14 LPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQtiDQLIYM----RFLH 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 204 GIGEASYSTIAPTIIGDLFTKNTRTLMLS----VFYFAiPLgsgLGYITGSSVKQAAGdWHWALRVSPVLGMITGTLILI 279
Cdd:PRK11102  90 GLAAAAASVVINALMRDMFPKEEFSRMMSfvtlVMTIA-PL---LAPIIGGWLLVWFS-WHAIFWVLALAAILAAALVFF 164

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 568973131 280 LVPATkrgHADQLGGQLKARTSwLRDMKALIRNRSyVFSSLATSAVSFA 328
Cdd:PRK11102 165 FIPET---LPKERRQPFHLRTT-IRNFASLFRHKR-VLGYMLASGFSFA 208
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 108-261 6.98e-05

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 45.25  E-value: 6.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 108 LSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRgAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF------WSAV 181
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIfelgslLCGL 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 182 TFSSsfipqqyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGdWHW 261
Cdd:cd17502   80 APNM--------TMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLS-WRW 150
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 153-297 7.50e-05

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 45.70  E-value: 7.50e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 153 VAAPIFGYLGDRFNRKVILSCGIFFW---SAVTFSSSFIPQqyfwlLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTL 229
Cdd:cd06179   47 VLGPIVGRLSDLFGRRWFFIGGNLLGvvgSIVAGTAKSVNM-----LIGGQALIGIG-AGTQGLGAAVASELVPNKYRGL 120

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973131 230 MLSVFYFAIPLGSGLG-YITGSSVKQAAGDWHWALRVSPVLGMITGTLILILV--PATKRGHADQLGGQLK 297
Cdd:cd06179  121 VQGVVNLVASPGSALGpLIAGALVEANAAGWRWIFYINAIFNALALILLFFFYhpPPRPQLHGSSTRQKLK 191
MFS_SLCO4_OATP4 cd17403
Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of ...
 129-445 1.36e-04

Solute carrier organic anion transporter 4 family of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 4 (SLCO4) or Organic anion transporting polypeptide 4 (OATP4) family contains two families: OATP4A and OATP4C, each containing one mammalian member, OATP4A1 and OATP4C1, respectively. OATP4A1 (encoded by SLCO4A1), is ubiquitously expressed and mediates the Na(+)-independent transport of the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and other organic anions such as estrone sulfate and taurocholate. OATP4C1 (encoded by SLCO4C1) is capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate, cAMP, and uremic toxins, which accumulate in patients with chronic kidney diseases (CKDs). The SLCO4/OATP4 family belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340961 [Multi-domain]  Cd Length: 420  Bit Score: 44.55  E-value: 1.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWS--AVTFSssfIPQqyFWLLVLSRGLVGIG 206
Cdd:cd17403   30 IEKRFGLTSTQTGLIASSYDIASVLLLLFVSYFGGRGHKPRWLGIGAFIMGigSLVFA---LPH--FTVFILAQLLHGAG 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 207 EASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHwalrvspvlgmiTGTLILILVPATKR 286
Cdd:cd17403  105 ATPLYTLGVTYLDENVSTKMSPLYIGIFYAMAILGPAIGYVLGGFLLNLYTDID------------QVDSELGLTPDDPR 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 287 --GhADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYLHraqvvqktaETCNSPPCGAkdSL 364
Cdd:cd17403  173 wvG-AWWLGFLISGALALIIAFPLLGFPPTFMFLNLAGASEGMLLAGFATFLPKLIE---------SQFSLSASLA--AL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 365 IFGAITCFTGFLGVVTGAGATRWCRLRTQRADPLVCAVGMLGSAIFICLIFVAAKTSIVGayICIFVGETLLFSNWAITA 444
Cdd:cd17403  241 LVGVVVVPGGILGTFLGGLIVKKLKLKCKGILKFCIVCSIVAFLFSFILLIYCPNAPFAG--VTVPYGNSPLEGTSNLTS 318


                 .
gi 568973131 445 D 445
Cdd:cd17403  319 T 319
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 103-279 2.03e-04

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 44.27  E-value: 2.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  103 AAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGvKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSA 180
Cdd:pfam06609  44 ASFAAFSLNVCATYFVLQASASALPNILQDIG-QSENQGLFSTLWTMGQAVSILMMGRLTDRFGRRpfVIATHIIGLVGA 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  181 VTFSSSfipqQYFWLLVLSRGLVGIGeASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVkQAAGDWH 260
Cdd:pfam06609 123 IVGCTA----NKFNTLLAAMTLLGVA-AGPAGASPLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRL-AIQGNWR 196

                         170
                  ....*....|....*....
gi 568973131  261 WALRVSPVLGMITGTLILI 279
Cdd:pfam06609 197 WIFYIYIIMSAIAVLLIII 215
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 105-286 2.62e-04

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 43.78  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 105 AAILSLGNVLNYLDRYTVAGVL--LDIQQHFGVKDRGAGLLQSV--FICSFMVAAPIFG-----YLGDRFNRKVILSCGI 175
Cdd:cd17356    3 CAFVSLGGFLFGYDTGSISGILnmKSFQKYFADNTGTYYPSSSRqgLIVSIVNLGSFFGalissFLSDRIGRKKSIQIGC 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 176 FFWS-AVTFSSSFIPQQyfWLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQ 254
Cdd:cd17356   83 VIYIiGAIIQVAAIGKW--YQLIVGRIIAGLGVGFASVLVPVYQSEVAPKHIRGTLVSLYQLAITIGILVAYCINYGTHK 160

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 568973131 255 AAGDWHWalRVSPVLGMITGTLILI---LVPATKR 286
Cdd:cd17356  161 LDGSAQW--RIPLGLQIVWGLLLLIgmfFLPESPR 193
PTR2 pfam00854
POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton ...
 175-280 4.44e-04

POT family; The POT (proton-dependent oligopeptide transport) family all appear to be proton dependent transporters.


Pssm-ID: 425909 [Multi-domain]  Cd Length: 392  Bit Score: 43.08  E-value: 4.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131  175 IFFWSAVtfsSSFIPQQYFWLLVLSRGLVGIGeasYSTIAPTI---IGDLFTKNT---RTLMLSVFYFAIPLGSGLGYIT 248
Cdd:pfam00854  17 LLALSAI---PSLRPPVHVALFFIGLALIALG---TGGIKPNVssfGGDQFEETDprrRSRFFSIFYFSINAGSLISTII 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 568973131  249 GSSVKQAAGdWHWALRVsPVLGMITGTLILIL 280
Cdd:pfam00854  91 TPYLQQNYG-YPLGFGL-PAVGMIIALLVFLL 120
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 140-252 4.95e-04

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 42.65  E-value: 4.95e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRK-------VILSCGIFfwsAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYST 212
Cdd:cd17364   41 SGLVNAAALVGTIIGQLFFGFLGDRFGRKrvygvelIIMIIGTI---LSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYP 117

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 568973131 213 IAPTIIGDLFTKNTR-TLMLSVFYFaiplgSGLGYITGSSV 252
Cdd:cd17364  118 LSATIMSEYANKKRRgALIAAVFAM-----QGFGILAGAIV 153
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 140-249 6.17e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.21  E-value: 6.17e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF----WSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASySTIAP 215
Cdd:cd17390   33 IGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLtalgYVLLGFSTSLA------LLFLSRIPLGIFKHT-QSLCK 105

                         90       100       110
                 ....*....|....*....|....*....|....
gi 568973131 216 TIIGDLFTKNTRTLMLSVFYFAiplgSGLGYITG 249
Cdd:cd17390  106 AYLSDLVSEQERSRVLGRFNAA----SSLGFILG 135
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 122-280 1.11e-03

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 1.11e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 122 VAGVLLDIQQHFGVKDRGAGLLqSVFICSFMVAA--PIFGYLGDRFNRK----VILSCGIFFWSAVTFSSSfipqqYFWL 195
Cdd:cd17353  232 LIGQAKPIGQEFAGLDAGIAAL-AVSILSIFNGGgrPFWGWLSDKIGRKntlsIAFLIQGVAMFLLPFIGS-----VAVL 305

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 196 LVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQaAGDWHWALRVSPVLGMITGT 275
Cdd:cd17353  306 FVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLY-TGGYNAAFIIAAALSLVALA 384


                 ....*
gi 568973131 276 LILIL 280
Cdd:cd17353  385 LALLL 389
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 141-227 1.49e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 41.11  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 141 GLLQSVFicSFM--VAAPIFGYLGDRFNRK-VILSC--GIFFWSAV-TFSSSFIpqqyfwLLVLSRGLVGIGEASYStIA 214
Cdd:cd17389   67 GLIGSLF--SLLqfLSSPITGAASDVYGRKpVLLLTmiGLAISYALwAVSRSFT------IFLLSRIVGGISKGNVS-LS 137

                         90
                 ....*....|...
gi 568973131 215 PTIIGDLFTKNTR 227
Cdd:cd17389  138 TAIVADVTSPKKR 150
PRK12307 PRK12307
MFS transporter;
110-442 2.35e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 40.68  E-value: 2.35e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 110 LGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP 189
Cdd:PRK12307  25 LGYVFDGFDFMLIFYIMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLAS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 190 QQYfwLLVLSRGLVGIGEASYSTIAPTIIGDLFTKNTRTlMLSVFYFAiplGSGLGYITGSS-VKQAAGDWHWalRVSPV 268
Cdd:PRK12307 105 GVI--MLTLSRFIVGMGMAGEYACASTYAVESWPKHLKS-KASAFLVS---GFGIGNIIAAYfMPSFAEAYGW--RAAFF 176

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 269 LGMITGTLILIL---VPATKRGHADQLGGQLK----ARTSWLRDMKALIrNRSYVFSSLATSAVSF----ATGALGMWIP 337
Cdd:PRK12307 177 VGLLPVLLVIYIrarAPESKEWEEAKLSGKGKhsqsAWSVFSLSMKGLF-NRAQFPLTLCVFIVLFsifgANWPIFGLLP 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 338 LYLHRAQVvqktaetcnsppcgakDSLIFGAITCFTGFlGVVTGAGATRWCRLRTQRADPLVcaVGMLGSAIFIC-LIFV 416
Cdd:PRK12307 256 TYLAGEGF----------------DTGVVSNLMTAAAF-GTVLGNIVWGLCADRIGLKKTFS--IGLLMSFLFIFpLFRI 316

                        330       340
                 ....*....|....*....|....*..
gi 568973131 417 AAK-TSIVGAyiCIFvgeTLLFSNWAI 442
Cdd:PRK12307 317 PQDnYLLLGA--CLF---GLMATNVGV 338
MFS_SLC22A16_CT2 cd17375
Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major ...
 140-203 2.56e-03

Solute carrier family 22 member 16 (also called Carnitine transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 16 (SLC22A16) is also called carnitine transporter 2 (CT2), fly-like putative transporter 2 (FLIPT2), organic cation transporter OKB1, or organic cation/carnitine transporter 6 (OCT6). It is a partially sodium-ion dependent high affinity carnitine transporter. It also transports organic cations such as tetraethylammonium (TEA) and doxorubicin. It is one of several organic cation transporters (OCTs) that falls into the SLC22 (solute carrier 22) family. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. SLC22A16 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340933 [Multi-domain]  Cd Length: 341  Bit Score: 40.50  E-value: 2.56e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 568973131 140 AGLLQSVFICSFMVAAPIFGYLGDRFNRKVIL----SCGIFFWSAVTFSS---SFIPQQYFWLLVLSRGLV 203
Cdd:cd17375   37 AKLIQPIFMLGVLLGAVIFGDIADRIGRRPVLwftsTGQFVFGIAVAFTFdyySFVIVRFLLAMVSSGYLV 107
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 141-285 2.62e-03

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 40.41  E-value: 2.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 141 GLLQSVFICSFMVAAPIFGYLGDRFNRK--VILSCGIFFWSAVTFSssfIPQQYFWLLVlSRGLVGIGEASYSTIAPTII 218
Cdd:cd17362   42 GLVVSGSLLGALLGSLVAGALIDRLGRRkeLILAALLYLVGSLVTG---LAPSYPVLLV-GRLIYGVGIGLAMHAAPVYI 117

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 568973131 219 GDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPATK 285
Cdd:cd17362  118 AETSPSHIRGLLVSLKELFIVLGILLGYVSGYAFADVVGGWRYMYGLAAPPALLLGIGMWFLPPSPR 184
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 98-208 4.27e-03

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 40.35  E-value: 4.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131   98 GRGRGAAAAILSLGNVLNYLDRYTVAGVLLDIQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFF 177
Cdd:TIGR01299 162 GRFQWALFFVLGLALMADGVEVFVVGFVLPSAEKDLCIPDSGKGMLGLIVYLGMMVGAFFWGGLADKLGRKQCLLICLSV 241

                          90       100       110
                  ....*....|....*....|....*....|.
gi 568973131  178 WSAVTFSSSFIPQQYFWLLVLSRGLVGIGEA 208
Cdd:TIGR01299 242 NGFFAFFSSFVQGYGFFLFCRLLSGFGIGGA 272
MFS_SLCO2B_OATP2B cd17460
Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of ...
 129-252 4.46e-03

Solute carrier organic anion transporter 2B subfamily of the Major Facilitator Superfamily of transporters; The Solute carrier organic anion transporter 2B (SLCO2B), also called Organic anion-transporting polypeptide 2B (OATP2B), subfamily has one mammalian member, OATP2B1 (encoded by SLCO2B1). It mediates the Na(+)-independent transport of various organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost. It also mediates the transport of endogenous sex steroid conjugates such as dehydroepiandrosterone sulfate (DHEAS). SLCO2B1 variations result in differential expression and uptake of DHEAS, which impacts subsequent resistance to androgen-deprivation therapy (ADT), the primary treatment of metastatic prostate cancer. The SLCO2B/OATP2B subfamily belongs to the Solute carrier organic anion transporter [SLCO, also called organic anion transporting polypeptides (OATPs) or Solute carrier family 21] family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341018 [Multi-domain]  Cd Length: 479  Bit Score: 39.75  E-value: 4.46e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 129 IQQHFGVKDRGAGLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSS---FIPQQY-FWLLVLSRGLVG 204
Cdd:cd17460   29 IEKRFGLSSQTSGLLASFNEVGNTVLIVFVSYFGSRVHRPRFIGCGAILVSLAGFLMAlphFISEPYeYGILFLGQLLLG 108

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 568973131 205 IGEASYSTIAPTIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 252
Cdd:cd17460  109 IGGVPIQPFGISYIDDFASESNSPLYLGILFAVTVLGPGFGFMLGSAM 156
MFS_SLC37A3 cd17342
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ...
 141-252 6.56e-03

Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340900 [Multi-domain]  Cd Length: 399  Bit Score: 39.22  E-value: 6.56e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyfWLLVLSRGLVGIGEASY----STIAP- 215
Cdd:cd17342   66 GVLDTIFLFSYAIGLFISGWLGDRLNLRLVLAFGMCSSAITVFLFGVLTE---WLHFYNKYLYCILWVLNgllqSTGWPc 142

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 568973131 216 --TIIGDLFTKNTRTLMLSVFYFAIPLGSGLGYITGSSV 252
Cdd:cd17342  143 vvAIMGNWFGKSSRGFVLGLWSACASVGNIIGALLASSV 181
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 142-239 7.36e-03

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 38.94  E-value: 7.36e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 142 LLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFW----SAVTFSSSFIPQQYFWLLVlSRGLVGIGEASYS------ 211
Cdd:cd17446   37 LAQSIYMAGVLVGAIVFGGLSDRFGRRPLLIWSYLQMavsgTCAAFSPSFPIYCVFRFLT-GMALSGIVLNSVSlnvewm 115

                         90       100       110
                 ....*....|....*....|....*....|...
gi 568973131 212 -----TIAPTIIGDLFTknTRTLMLSVFYFAIP 239
Cdd:cd17446  116 ptrvrAVVGTLLGYCYT--LGQLILAGVAYAIR 146
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 119-340 7.96e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 38.79  E-value: 7.96e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 119 RYTVAGVLLDIQQHFGVkDRGA-GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQqyFWLLV 197
Cdd:cd17355   19 RYYFGVFIIPIIAEFGW-SRAViSLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATS--LWQLY 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 198 LSRGLVGIGEAS--YSTIAPTIIGDLFTKNtRTLMLSVfyfaIPLGSGLGYITGSSVKQAAGD---WHWALRVSPVLGMI 272
Cdd:cd17355   96 LLWGLLGGGGAGtlAAVAFATVAAWWFERR-RGLALGI----LTAGGGLGSLVFLPLGAALIEafgWRTALLVLALLALL 170

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 568973131 273 TgTLILILVPATKRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYL 340
Cdd:cd17355  171 V-LVPVLLLLRRRPADLALRAYDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYL 237
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 141-340 8.70e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 38.76  E-value: 8.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 141 GLLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIP--QQYFWLLVLSRGLVGI-----GEASYSTI 213
Cdd:cd17345   41 GLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAIINILIGFVPsaTSSVGLMFILLFLNGWfqgmgWPPSGRTM 120

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 214 AptiigDLFTKNTRTLMLSVFYFAIPLGSGL--GYITGSSVKQAAGDWHWALRVSPVLGMITGTLILILVPAT------- 284
Cdd:cd17345  121 V-----HWFSKKERGTWTSIWNISHNVGGGLvgPLAGLGLAIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKDTpeseglp 195

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 568973131 285 -------KRGHADQLGGQLKARTSWLRDMKALIRNRSYVFSSLATSAVSFATGALGMWIPLYL 340
Cdd:cd17345  196 pieeykgDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIANVFVYLVRYGILDWAPTYL 258
MFS_SLC22A7_OAT2 cd17447
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ...
 142-273 8.76e-03

Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341005 [Multi-domain]  Cd Length: 341  Bit Score: 38.56  E-value: 8.76e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 142 LLQSVFICSFMVAAPIFGYLGDRFNRKVILS----CGIFFWSAVTFSSSFIpqqyfwLLVLSRGLVGIGEASYSTIAPTI 217
Cdd:cd17447   39 ATATFFFAGVTMGAVAFGYLSDRFGRKRMLLvayvLSLVFGLASAFSVSYV------MFAITRTLTGFALTGFSIISMVL 112

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 568973131 218 IGDLFTKNTRTlmlsVFYFAIPLGSGLGYITGSSVKQAAGDWHWALRV--SP-VLGMIT 273
Cdd:cd17447  113 CVEWVDIEHRT----VAGVLISLFWTVGNMLLALVAYLIRDWRWLILAvtLPcAPGIIT 167
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 142-285 9.54e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 38.74  E-value: 9.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 142 LLQSVFICSFMVAAPIFGYLGDRFNRKVILSCGIFFWSAVTFSSSFIPQQYFWLLVLSRGLVGIGEASYSTIAPTIIGDL 221
Cdd:cd17332  260 LLLLLILSGALLALLPWPPLKKRFGKKKAFFIGLLLAILGLLLLFFLPPGNLVLILVLAVLAGIGYGGANLLPWAMLADV 339

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 568973131 222 FT-------KNTRTLMLSVFYFAIPLGSGL------------GYITGSSVKQAAGDWH--WALRVSPVLGMITGTLILIL 280
Cdd:cd17332  340 IDygelktgKRREGIFYSVMTFFRKLGLALagalvglilslaGYVANAAAQSASALNGirLLIAVLPAVLLLLALILMSF 419


                 ....*
gi 568973131 281 VPATK 285
Cdd:cd17332  420 YPLDK 424
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH