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Conserved domains on  [gi|1907190543|ref|XP_006531295|]
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sulfotransferase family 5A, member 1 isoform X3 [Mus musculus]

Protein Classification

sulfotransferase domain-containing protein( domain architecture ID 10464534)

sulfotransferase domain-containing protein such as mammalian sulfotransferases that utilize 3'-phospho-5'-adenylyl sulfate (PAPS) as the sulfonate donor to catalyze the sulfate conjugation of a variety of substrates including catecholamines, phenolic drugs, neurotransmitters, heparan, and estrogen, among others

CATH:  3.40.50.300
EC:  2.8.2.-
Gene Ontology:  GO:0008146
PubMed:  9360604|31270211
SCOP:  4003933

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-193 6.20e-58

Sulfotransferase domain;


:

Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 182.54  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160


                  ....*...
gi 1907190543 186 VTYEELHQ 193
Cdd:pfam00685 161 LRYEDLKK 168
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-193 6.20e-58

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 182.54  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160


                  ....*...
gi 1907190543 186 VTYEELHQ 193
Cdd:pfam00685 161 LRYEDLKK 168
PLN02164 PLN02164
sulfotransferase
 32-191 3.59e-15

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 72.26  E-value: 3.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  32 FQFQDTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNlPTWAR-----VPWIEqISF------DSLHSKRNTswprLF 100
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIE-IDFpffpsvDVLKDKGNT----LF 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 101 TSHLNAKGLSPALMKSKAKVVYMARNPKDVLVSFFHF-HRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKG-WLSLQ 178
Cdd:PLN02164  149 STHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQ 228

                         170
                  ....*....|....
gi 1907190543 179 KDLT-LFFVTYEEL 191
Cdd:PLN02164  229 ENPDrILFLKYETM 242
 
Name Accession Description Interval E-value
Sulfotransfer_1 pfam00685
Sulfotransferase domain;
36-193 6.20e-58

Sulfotransferase domain;


Pssm-ID: 425820 [Multi-domain]  Cd Length: 253  Bit Score: 182.54  E-value: 6.20e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  36 DTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNLPT---WARVPWIEQISFD-------SLHSKRNTSWPRLFTSHLN 105
Cdd:pfam00685   1 DDDVLIVTYPKSGTTWLQEILSLIPNRGDFEKSEEPHLfnnHNRSPFLEWYPGDtyfdvaeGPVRLNALPSPRIIKTHLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 106 AKGLSPALMKSKAKVVYMARNPKDVLVSFFHFHRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKGWLSLQKDLTLFF 185
Cdd:pfam00685  81 LHLLPKSLWDPNAKIIYLVRNPKDVAVSYYHFFRMAKLLKAPGTPFEFVEDFLNGKVNCGSYFDHVKGWWKLRPPGNILF 160


                  ....*...
gi 1907190543 186 VTYEELHQ 193
Cdd:pfam00685 161 LRYEDLKK 168
PLN02164 PLN02164
sulfotransferase
 32-191 3.59e-15

sulfotransferase


Pssm-ID: 177822  Cd Length: 346  Bit Score: 72.26  E-value: 3.59e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  32 FQFQDTDILLVTFPKSGTTWMQQVLSLIFCEGHLWPIHNlPTWAR-----VPWIEqISF------DSLHSKRNTswprLF 100
Cdd:PLN02164   75 FQARPNDFLVCSYPKTGTTWLKALTFAIANRSRFDDSSN-PLLKRnphefVPYIE-IDFpffpsvDVLKDKGNT----LF 148

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 101 TSHLNAKGLSPALMKSKAKVVYMARNPKDVLVSFFHF-HRIAGFLPNPSSFEDFVDEFLEGTGFFGSWFDHVKG-WLSLQ 178
Cdd:PLN02164  149 STHIPYGLLPDSVVKSGCKMVYIWRDPKDTFISMWTFlHKERSQQGPLNSLEESFDMFCRGLSVYGPYLDHVLGyWKAYQ 228

                         170
                  ....*....|....
gi 1907190543 179 KDLT-LFFVTYEEL 191
Cdd:PLN02164  229 ENPDrILFLKYETM 242
Sulfotransfer_3 pfam13469
Sulfotransferase family;
39-191 1.26e-04

Sulfotransferase family;


Pssm-ID: 463887  Cd Length: 173  Bit Score: 40.74  E-value: 1.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543  39 ILLVTFPKSGTTWMQQVLSL---IFCEGHLWPIHnlptwARVPWIEQISFDSLHSKRNT-SWPRLFTSHL--NAKGLsPA 112
Cdd:pfam13469   1 IFIVGLPRSGTTLLHRLLAAhpdVRPPEETWFVI-----PRILALLQAWGKSLEALARVpSYARWLCDKSpsHLFHL-DL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1907190543 113 LMK--SKAKVVYMARNPKDVLV-SFFHFHRIAGflpnpssfEDFVDEFLEGTGFFGS-WFDHVKGWLSLQKDL---TLFF 185
Cdd:pfam13469  75 LLKafPDAKFIHLHRDPVDTVIsSYCSLFGFTL--------SSYSTAFLRDIGLALArWSRAYERLMAARARVppgRFLD 146


                  ....*.
gi 1907190543 186 VTYEEL 191
Cdd:pfam13469 147 VRYEDL 152
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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